{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T02:44:46Z","timestamp":1792291486506,"version":"4.4.0"},"reference-count":123,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T00:00:00Z","timestamp":1745280000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioengineering"],"abstract":"<jats:p>(1) Background: Tannic acid (TA), a water-soluble polyphenol extensively found in numerous plant species, possesses antimicrobial, anti-inflammatory, antioxidant, and adhesive properties. This scoping review aims to synthesize existing knowledge on TA applications and unveil its potential uses in dentistry. (2) Methods: A comprehensive search across six electronic databases (PubMed, Cochrane, Embase, Scopus, Web of Science, and Opengrey) was conducted in October 2024. Two reviewers performed the screening and risk of bias analysis independently following the PRISMA-ScR guidelines. The findings are presented in a narrative summary. (3) Results: Five hundred and twelve records were identified from the electronic databases. After removing duplicates and applying eligibility criteria, ninety-six studies were ultimately included in this review. Results indicate that TA has been employed in managing dentin hypersensitivity, dental caries, periodontal and mucosal diseases, as well as dentition defects with prostheses. Furthermore, TA displays potential in enhancing the performance of bonding adhesives, root canal irrigants, and root canal filling materials. However, it is noteworthy that the included studies exhibit varied experimental settings, inconsistent outcome measures, a lack of extensive clinical research, and insufficient observation periods. (4) Conclusions: TA is a promising biomaterial with applications to various dental fields, such as endodontics, periodontology, prosthodontics, and dental public health. Its antimicrobial, anti-inflammatory, antioxidant, and adhesive properties warrant future exploration to unleash these potentials and provide robust scientific evidence that guides clinical practice and advances oral healthcare.<\/jats:p>","DOI":"10.3390\/bioengineering12050438","type":"journal-article","created":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T20:24:52Z","timestamp":1745353492000},"page":"438","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Unleashing the Potential of Tannic Acid in Dentistry: A Scoping Review of Applications"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-1303-4498","authenticated-orcid":false,"given":"Xiaoqian","family":"Ding","sequence":"first","affiliation":[{"name":"Paediatric Dentistry and Orthodontics, Faculty of Dentistry, The University of Hong Kong, 34 Hospital Road, Sai Ying Pun, Hong Kong 999077, China"},{"name":"Outpatient Department at Longfor Guangnian, The Affiliated Stomatological Hospital of Chongqing Medical University, No.426 Songshi North Road, Yubei District, Chongqing 401147, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanning","family":"Zhang","sequence":"additional","affiliation":[{"name":"Paediatric Dentistry and Orthodontics, Faculty of Dentistry, The University of Hong Kong, 34 Hospital Road, Sai Ying Pun, Hong Kong 999077, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4090-6205","authenticated-orcid":false,"given":"Cynthia Kar Yung","family":"Yiu","sequence":"additional","affiliation":[{"name":"Paediatric Dentistry and Orthodontics, Faculty of Dentistry, The University of Hong Kong, 34 Hospital Road, Sai Ying Pun, Hong Kong 999077, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6979-1037","authenticated-orcid":false,"given":"Xin","family":"Li","sequence":"additional","affiliation":[{"name":"Restorative Dental Sciences, Faculty of Dentistry, The University of Hong Kong, 34 Hospital Road, Sai Ying Pun, Hong Kong 999077, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1774-6186","authenticated-orcid":false,"given":"Zhiyi","family":"Shan","sequence":"additional","affiliation":[{"name":"Paediatric Dentistry and Orthodontics, Faculty of Dentistry, The University of Hong Kong, 34 Hospital Road, Sai Ying Pun, Hong Kong 999077, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1007\/s10856-008-3675-z","article-title":"Tannic Acid Incorporation in Chitosan-Based Microparticles and in Vitro Controlled Release","volume":"20","author":"Aelenei","year":"2009","journal-title":"J. Mater. Sci Mater. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1126\/science.1237265","article-title":"One-Step Assembly of Coordination Complexes for Versatile Film and Particle Engineering","volume":"341","author":"Ejima","year":"2013","journal-title":"Science"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"134146","DOI":"10.1016\/j.cej.2021.134146","article-title":"Advances in Tannic Acid-Incorporated Biomaterials: Infection Treatment, Regenerative Medicine, Cancer Therapy, and Biosensing","volume":"432","author":"Bigham","year":"2022","journal-title":"Chem. Eng. J."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Nikkerdar, N., Seyedi, H., Mirzaeei, S., Safari-Faramani, R., and Golshah, A. (2024). Comparative Effects of Three Mucoadhesive Gels Containing Lidocaine, Zinc Acetate, and Tannic Acid on the Gag Reflex of Dental Patients: A Randomized Double-Blind Clinical Trial. BMC Oral Health, 24.","DOI":"10.1186\/s12903-024-05248-9"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1016\/j.foodres.2018.11.034","article-title":"Formation and Characterization of Tannic Acid\/Beta-Glucan Complexes: Influence of pH, Ionic Strength, and Temperature","volume":"120","author":"Li","year":"2019","journal-title":"Food Res. Int."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"124090","DOI":"10.1016\/j.polymer.2021.124090","article-title":"Gelation and the Antioxidant and Antibacterial Properties of Silk Fibroin\/Tannic Acid\/Zn2+ Mixtures","volume":"230","author":"Bae","year":"2021","journal-title":"Polymer"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1080\/09205063.2022.2112480","article-title":"Tannic Acid-Crosslinked O-Carboxymethyl Chitosan Hydrogels for Enhanced Antibacterial Activity and Rapid Hemostasis","volume":"34","author":"Li","year":"2023","journal-title":"J. Biomater. Sci. Polym. Ed."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Chen, X., Zhang, Q., Wang, Y., Meng, J., Wu, M., Xu, H., Du, L., and Yang, X. (2023). Fabrication and Characterization of Electrospun Poly(Caprolactone)\/Tannic Acid Scaffold as an Antibacterial Wound Dressing. Polymers, 15.","DOI":"10.3390\/polym15030593"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Zhang, Z., Xu, P., Liu, C., Chen, J., Ren, B., Du, E., Guo, S., Li, P., Li, L., and Ding, B. (2024). Effect of Tannic Acid on Antioxidant Function, Immunity, and Intestinal Barrier of Broilers Co-Infected with Coccidia and Clostridium Perfringens. Animals, 14.","DOI":"10.3390\/ani14060955"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.1080\/14786419.2017.1366485","article-title":"Antimicrobial and Anti-Biofilm Activity of Tannic Acid against Staphylococcus Aureus","volume":"32","author":"Dong","year":"2018","journal-title":"Nat. Prod. Res."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2870","DOI":"10.1007\/s12035-020-01924-3","article-title":"Tannic Acid Provides Neuroprotective Effects Against Traumatic Brain Injury Through the PGC-1\u03b1\/Nrf2\/HO-1 Pathway","volume":"57","author":"Salman","year":"2020","journal-title":"Mol. Neurobiol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"5186","DOI":"10.1002\/jsfa.13343","article-title":"Tannic Acid Alleviates ETEC K88-induced Intestinal Damage through Regulating the p62-keap1-Nrf2 and TLR4-NF-\u03baB-NLRP3 Pathway in IPEC-J2 Cells","volume":"104","author":"Liu","year":"2024","journal-title":"J. Sci. Food Agric."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Jin, W., Xue, Y., Xue, Y., Han, X., Song, Q., Zhang, J., Li, Z., Cheng, J., Guan, S., and Sun, S. (2020). Tannic Acid Ameliorates Arsenic Trioxide-Induced Nephrotoxicity, Contribution of NF-\u03baB and Nrf2 Pathways. Biomed. Pharmacother., 126.","DOI":"10.1016\/j.biopha.2020.110047"},{"key":"ref_14","first-page":"2306","article-title":"Tannic Acid Attenuates Hepatic Oxidative Stress, Apoptosis and Inflammation by Activating the Keap1-Nrf2\/ARE Signaling Pathway in Arsenic Trioxide-toxicated Rats","volume":"44","author":"Li","year":"2020","journal-title":"Oncol. Rep."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0022-3913(98)70212-4","article-title":"A Scanning Electron Microscopic Study of Tooth Surface Changes Induced by Tannic Acid","volume":"79","author":"Sabbak","year":"1998","journal-title":"J. Prosthet. Dent."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1080\/01913123.2020.1749198","article-title":"Sealing Effects of Different Chinese Herbal Medicines on Dentinal Tubules: A Scanning Electron Microscopic Observation","volume":"44","author":"Li","year":"2020","journal-title":"Ultrastruct. Pathol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1159\/000451036","article-title":"Effect of Tannic Acid on the Protective Properties of the in Situ Formed Pellicle","volume":"51","author":"Hertel","year":"2017","journal-title":"Caries Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"447","DOI":"10.2174\/1874210601711010447","article-title":"Comparison of Composition and Anticaries Effect of Galla Chinensis Extracts with Different Isolation Methods","volume":"11","author":"Huang","year":"2017","journal-title":"Open Dent. J."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"20180799","DOI":"10.1098\/rsif.2018.0799","article-title":"Bioinspired Polydopamine and Polyphenol Tannic Acid Functionalized Titanium Suppress Osteoclast Differentiation: A Facile and Efficient Strategy to Regulate Osteoclast Activity at Bone-Implant Interface","volume":"16","author":"Steffi","year":"2019","journal-title":"J. R. Soc. Interface"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"22601","DOI":"10.1021\/acsami.0c04475","article-title":"Effect of the Buffer on the Buildup and Stability of Tannic Acid\/Collagen Multilayer Films Applied as Antibacterial Coatings","volume":"12","author":"Iqbal","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/0109-5641(92)90048-H","article-title":"Effects of Dentin Surface Treatments on the Shear Bond Strength of Vitrabond","volume":"8","author":"Prati","year":"1992","journal-title":"Dent. Mater."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1177\/0022034509342556","article-title":"Mechanical Properties of Tannic-Acid-Treated Dentin Matrix","volume":"88","author":"Yoo","year":"2009","journal-title":"J. Dent. Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"110347","DOI":"10.1016\/j.matdes.2021.110347","article-title":"A Mussel-Inspired Wet-Adhesion Hydrogel with Hemostasis and Local Anti-Inflammation for Managing the Development of Acute Wounds","volume":"213","author":"Zhu","year":"2022","journal-title":"Mater. Des."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1080\/09205063.2022.2068948","article-title":"Glucose-Sensitive Delivery of Tannic Acid by a Photo-Crosslinked Chitosan Hydrogel Film for Antibacterial and Anti-Inflammatory Therapy","volume":"33","author":"Liu","year":"2022","journal-title":"J. Biomater. Sci. Polym. Ed."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/0030-4220(89)90366-6","article-title":"A 25% Tannic Acid Solution as a Root Canal Irrigant Cleanser: A Scanning Electron Microscope Study","volume":"67","author":"Bitter","year":"1989","journal-title":"Oral Surg. Oral Med. Oral Pathol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/0022-3913(83)90252-4","article-title":"Iron Discoloration of Acrylic Resin Exposed to Chlorhexidine or Tannic Acid: A Model Study","volume":"49","author":"Attramadal","year":"1983","journal-title":"J. Prosthet. Dent."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"e356","DOI":"10.4317\/jced.52284","article-title":"Haemostatic Agents on the Shear Bond Strength of Self-Adhesive Resin","volume":"7","author":"Anil","year":"2015","journal-title":"J. Clin. Exp. Dent."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"3340","DOI":"10.1021\/acsbiomaterials.9b00566","article-title":"In Vitro Performance of Bioinspired Phenolic Nanocoatings for Endosseous Implant Applications","volume":"5","author":"Wiedmer","year":"2019","journal-title":"ACS Biomater. Sci. Eng."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Tran, L., Tam, D.N.H., Elshafay, A., Dang, T., Hirayama, K., and Huy, N.T. (2021). Quality Assessment Tools Used in Systematic Reviews of in Vitro Studies: A Systematic Review. BMC Med. Res. Methodol., 21.","DOI":"10.1186\/s12874-021-01295-w"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1111\/j.1600-051X.1987.tb01532.x","article-title":"Dentine Hypersensitivity. The Effects in Vitro of Acids and Dietary Substances on Root-Planed and Burred Dentine","volume":"14","author":"Addy","year":"1987","journal-title":"J. Clin. Periodontol."},{"key":"ref_31","first-page":"77","article-title":"Obturation of Dentinal Tubules with Tannin-Fluoride Preparation (HY Agent) Incorporated into Glass Ionomer Cement","volume":"27","author":"Yamaga","year":"1993","journal-title":"J. Osaka Dent. Univ."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"253","DOI":"10.4012\/dmj.17.253","article-title":"Dentinal Tubule Occlusion with Lanthanum Fluoride and Powdered Apatite Glass Ceramics In Vitro","volume":"17","author":"Mukai","year":"1998","journal-title":"Dent. Mater. J."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"585","DOI":"10.4012\/dmj.23.585","article-title":"Durability of FTLA Treatment as a Medicament for Dentin Hypersensitivity: Abrasion Resistance and Profiles of Fluoride Release","volume":"23","author":"Tomiyama","year":"2004","journal-title":"Dent. Mater. J."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Oh, D.X., Prajatelistia, E., Ju, S.-W., Jeong Kim, H., Baek, S.-J., Joon Cha, H., Ho Jun, S., Ahn, J.-S., and Soo Hwang, D. (2015). A Rapid, Efficient and Facile Solution for Dental Hypersensitivity: The Tannin\u2013Iron Complex. Sci. Rep., 5.","DOI":"10.1038\/srep10884"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"e2303153","DOI":"10.1002\/adhm.202303153","article-title":"A Drop-By-Drop Self-Assembled All-Natural Hydrogel as a Desensitizer for Rapid and Enduring Management of Dentin Hypersensitivity","volume":"13","author":"Gao","year":"2024","journal-title":"Adv. Healthc. Mater."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1177\/00220345820610120801","article-title":"Materials Science: Improved Adhesion of a Glass Ionomer Cement to Dentin and Enamel","volume":"61","author":"Powis","year":"1982","journal-title":"J. Dent. Res."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/0109-5641(89)90072-9","article-title":"Effects of Acid and Cleansing Agents on Shear Bond Strength and Marginal Microleakage of Glass-Ionomer Cements","volume":"5","author":"Prati","year":"1989","journal-title":"Dent. Mater."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/0022-3913(89)90023-1","article-title":"Tannic Acid for Smear Layer Removal: Pilot Study with Scanning Electron Microscope","volume":"61","author":"Bitter","year":"1989","journal-title":"J. Prosthet. Dent."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/0022-3913(90)90145-3","article-title":"The Effect of 25% Tannic Acid on Prepared Dentin: A Scanning Electron Microscope-Methylene Blue Dye Study","volume":"64","author":"Bitter","year":"1990","journal-title":"J. Prosthet. Dent."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0022-3913(90)90262-B","article-title":"A Medicated Polycarboxylate Cement to Prevent Complications in Composite Resin Therapy","volume":"63","author":"Okamoto","year":"1990","journal-title":"J. Prosthet. Dent."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1111\/j.1365-2842.1991.tb00073.x","article-title":"Effects of Phosphoric Acid and Tannic Acid on Dentine Collagen","volume":"18","author":"Okamoto","year":"1991","journal-title":"J. Oral Rehabil."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1023\/A:1008953126544","article-title":"Effect of Tannic Acid Solution on Collagen Structures for Dental Restoration","volume":"10","author":"Natsir","year":"1999","journal-title":"J. Mater. Sci. Mater. Med."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1177\/0974909820020202","article-title":"Comparative Evaluation of Tannic Acid, Citric Acid and Phosphoric Acid as Etching Agents for Direct Bonding","volume":"36","author":"Kapoor","year":"2002","journal-title":"J. Indian. Orthod. Soc."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1016\/j.archoralbio.2007.04.002","article-title":"Smear Layer and Surface State Affect Dentin Fluoride Uptake","volume":"52","author":"Buchalla","year":"2007","journal-title":"Arch. Oral Biol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/S0022-3913(10)60134-5","article-title":"The Effect of Dentin Pretreatment on the Microtensile Bond Strength of Self-Adhesive Resin Cements","volume":"104","author":"Pavan","year":"2010","journal-title":"J. Prosthet. Dent."},{"key":"ref_46","first-page":"125","article-title":"Effect of Tannic Acid Application on Durability of Bond of Etch and Rinse Adhesive Resins","volume":"6","author":"Boruziniat","year":"2017","journal-title":"J. Dent. Mater. Tech."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"34","DOI":"10.5005\/jp-journals-10024-1984","article-title":"Effect of Tannic Acid on Bond Strength of Etch and Rinse and Self-Etch Adhesive Systems in Dentin of Primary Teeth","volume":"18","author":"Abdollahi","year":"2017","journal-title":"J. Contemp. Dent. Pract."},{"key":"ref_48","first-page":"365","article-title":"Efficacy of Natural Collagen Crosslinkers on the Compromised Adhesive Bond Strength to NaOCl-Treated Pulp Chamber Dentin","volume":"20","author":"Cecchin","year":"2018","journal-title":"J. Adhes. Dent."},{"key":"ref_49","first-page":"126","article-title":"Effect of Tannic Acid and Quercetin Antioxidants on Bond Strength of Resin Cement to Dentin after Internal Bleaching","volume":"30","author":"Fattah","year":"2022","journal-title":"Eur. J. Prosthodont. Restor. Dent."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"4338","DOI":"10.1007\/s12274-023-6336-0","article-title":"Bioinspired Mineral-in-Shell Nanoarchitectonics: Functional Empowerment of Mineral Precursors for Guiding Intradentinal Mineralization","volume":"17","author":"Zheng","year":"2023","journal-title":"Nano Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1159\/000261536","article-title":"The Effect of a Tannin-Fluoride Mixture on Human Dental Enamel","volume":"27","author":"Yu","year":"1993","journal-title":"Caries Res."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/0300-5712(95)98975-9","article-title":"Effects of Several Tea Components on Acid Resistance of Human Tooth Enamel","volume":"23","author":"Yu","year":"1995","journal-title":"J. Dent."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/S0022-3913(97)70032-5","article-title":"Clinical Observations of Noncoping Overdenture Abutments Protected by Tannin-Fluoride Preparation","volume":"78","author":"Yamaga","year":"1997","journal-title":"J. Prosthet. Dent."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4012\/dmj.16.1","article-title":"Effects of Various Collagen Crosslinking Techniques on Mechanical Properties of Collagen Film","volume":"16","author":"Koide","year":"1997","journal-title":"Dent. Mater. J."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1177\/0022034509338671","article-title":"Efficacy of Silver Diamine Fluoride for Arresting Caries Treatment","volume":"88","author":"Yee","year":"2009","journal-title":"J. Dent. Res."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"3553","DOI":"10.1021\/acsbiomaterials.7b00623","article-title":"Bioinspired Peptide-Decorated Tannic Acid for in Situ Remineralization of Tooth Enamel: In Vitro and in Vivo Evaluation","volume":"3","author":"Yang","year":"2017","journal-title":"ACS Biomater. Sci. Eng."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"103482","DOI":"10.1016\/j.jdent.2020.103482","article-title":"The Effect of Polyphenol-Containing Solutions on in Situ Biofilm Formation on Enamel and Dentin","volume":"102","author":"Xi","year":"2020","journal-title":"J. Dent."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Schestakow, A., and Hannig, M. (2020). Effects of Experimental Agents Containing Tannic Acid or Chitosan on the Bacterial Biofilm Formation in Situ. Biomolecules, 10.","DOI":"10.3390\/biom10091315"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Schestakow, A., Guth, M.S., Eisenmenger, T.A., and Hannig, M. (2021). Evaluation of Anti-Biofilm Activity of Mouthrinses Containing Tannic Acid or Chitosan on Dentin In Situ. Molecules, 26.","DOI":"10.3390\/molecules26051351"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"104236","DOI":"10.1016\/j.jdent.2022.104236","article-title":"Influence of Periodic Polyphenol Treatment on the Anti-Erosive Potential of the Acquired Enamel Pellicle\u2014A Qualitative Exploratory Study","volume":"124","author":"Schestakow","year":"2022","journal-title":"J. Dent."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1177\/00220345221114783","article-title":"Mussel-Inspired Hydrogels for Fluoride Delivery and Caries Prevention","volume":"101","author":"Zhen","year":"2022","journal-title":"J. Dent. Res."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"3454","DOI":"10.1039\/D1RA07887A","article-title":"Tannic Acid Induces Dentin Biomineralization by Crosslinking and Surface Modification","volume":"12","author":"Kong","year":"2022","journal-title":"RSC Adv."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"106568","DOI":"10.1016\/j.micpath.2024.106568","article-title":"Treatment of Dental Biofilm-Forming Bacterium Streptococcus Mutans Using Tannic Acid-Mediated Gold Nanoparticles","volume":"189","author":"Selvaraj","year":"2024","journal-title":"Microb. Pathog."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.colsurfb.2017.09.006","article-title":"Antibacterial and Anti-Biofouling Coating on Hydroxyapatite Surface Based on Peptide-Modified Tannic Acid","volume":"160","author":"Yang","year":"2017","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"9870","DOI":"10.1002\/chem.201902358","article-title":"Silicate-Phenolic Networks: Coordination-Mediated Deposition of Bioinspired Tannic Acid Coatings","volume":"25","author":"Weber","year":"2019","journal-title":"Chem. A Eur. J."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"3327","DOI":"10.1021\/acs.langmuir.8b04208","article-title":"Silicic Acid-Mediated Formation of Tannic Acid Nanocoatings","volume":"35","author":"Weber","year":"2019","journal-title":"Langmuir"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1021\/acsabm.9b01017","article-title":"Lysozyme (Lys), Tannic Acid (TA), and Graphene Oxide (GO) Thin Coating for Antibacterial and Enhanced Osteogenesis","volume":"3","author":"Li","year":"2020","journal-title":"ACS Appl. Bio. Mater."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"7994","DOI":"10.1021\/acs.chemmater.1c01957","article-title":"A Stable Cell Membrane-Based Coating with Antibiofouling and Macrophage Immunoregulatory Properties for Implants at the Macroscopic Level","volume":"33","author":"Dong","year":"2021","journal-title":"Chem. Mater."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Wang, G., Zhu, Y., Zan, X., and Li, M. (2021). Endowing Orthopedic Implants\u2019 Antibacterial, Antioxidation, and Osteogenesis Properties Through a Composite Coating of Nano-Hydroxyapatite, Tannic Acid, and Lysozyme. Front. Bioeng. Biotechnol., 9.","DOI":"10.3389\/fbioe.2021.718255"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1002\/jbm.a.37377","article-title":"Characterization of the Foreign Body Response of Titanium Implants Modified with Polyphenolic Coatings","volume":"110","author":"Weber","year":"2022","journal-title":"J. Biomed. Mater. Res. Part. A"},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Weber, F., Dornelas-Figueira, L.M., Hafiane, N., Zaytseva-Zotova, D., Barrantes, A., Petersen, F.C., and Tiainen, H. (2022). Can Polyphenolic Surface Modifications Prevent Fungal Colonization of Titanium Dental Implants?. Colloids Surf. B Biointerfaces, 219.","DOI":"10.1016\/j.colsurfb.2022.112813"},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Kim, K.-H., Mai, H.-N., Hyun, D.-C., and Lee, D.-H. (2022). New Autonomous Water-Enabled Self-Healing Coating Material with Antibacterial-Agent-Releasing Properties. Pharmaceutics, 14.","DOI":"10.3390\/pharmaceutics14051005"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"13040","DOI":"10.1021\/acs.iecr.2c01646","article-title":"Mussel-Inspired Organic\u2013Inorganic Implant Coating Based on a Layer-by-Layer Method for Anti-Infection and Osteogenesis","volume":"61","author":"Liu","year":"2022","journal-title":"Ind. Eng. Chem. Res."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"10128","DOI":"10.1039\/D2TB01804G","article-title":"Metal\u2013Phenolic Networks Acted as a Novel Bio-Filler of a Barrier Membrane to Improve Guided Bone Regeneration via Manipulating Osteoimmunomodulation","volume":"10","author":"Ren","year":"2022","journal-title":"J. Mater. Chem. B"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"2301733","DOI":"10.1002\/adhm.202301733","article-title":"A Dual-Antioxidative Coating on Transmucosal Component of Implant to Repair Connective Tissue Barrier for Treatment of Peri-Implantitis","volume":"12","author":"Li","year":"2023","journal-title":"Adv. Healthc. Mater."},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Shen, L., Hu, J., Yuan, Y., Wang, X., and Jiang, Q. (2023). Photothermal-Promoted Multi-Functional Gallic Acid Grafted Chitosan Hydrogel Containing Tannic Acid Miniaturized Particles for Peri-Implantitis. Int. J. Biol. Macromol., 253.","DOI":"10.1016\/j.ijbiomac.2023.127366"},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Zhao, B., Dong, Y., Shen, X., He, W., Jin, H., Yao, L., Zheng, S., Zan, X., and Liu, J. (2023). Construction of Multifunctional Coating with Cationic Amino Acid-Coupled Peptides for Osseointegration of Implants. Mater. Today Bio, 23.","DOI":"10.1016\/j.mtbio.2023.100848"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/0003-9969(90)90203-M","article-title":"Inhibition of Protease Activities of Periodontopathic Bacteria by Extracts of Plants Used in Kenya as Chewing Sticks (Mswaki)","volume":"35","author":"Homer","year":"1990","journal-title":"Arch. Oral Biol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.3892\/ijo.2015.3098","article-title":"Tannic Acid Inhibits the Jak2\/STAT3 Pathway and Induces G1\/S Arrest and Mitochondrial Apoptosis in YD-38 Gingival Cancer Cells","volume":"47","author":"Darvin","year":"2015","journal-title":"Int. J. Oncol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1111\/jop.12685","article-title":"Effects of Polyphenols on Doxorubicin-Induced Oral Keratinocyte Cytotoxicity and Anticancer Potency against Oral Cancer Cells","volume":"47","author":"Sheng","year":"2018","journal-title":"J. Oral Pathol. Med."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"4340","DOI":"10.1039\/C9TB02156F","article-title":"A Self-Healable, Moldable and Bioactive Biomaterial Gum for Personalised and Wearable Drug Delivery","volume":"8","author":"Shahbazi","year":"2020","journal-title":"J. Mater. Chem. B"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"112144","DOI":"10.1016\/j.msec.2021.112144","article-title":"Influence of the New Formulation Based on Silver Alginate Microcapsules Loaded with Tannic Acid on the Microcirculation of the Experimental Periodontitis in Rats","volume":"126","author":"Lengert","year":"2021","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1177\/00220345221085192","article-title":"Mucoadhesive Nucleoside-Based Hydrogel Delays Oral Leukoplakia Canceration","volume":"101","author":"Ding","year":"2022","journal-title":"J. Dent. Res."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/s41368-022-00198-w","article-title":"Stem Cell Microencapsulation Maintains Stemness in Inflammatory Microenvironment","volume":"14","author":"Zhao","year":"2022","journal-title":"Int. J. Oral Sci."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"53575","DOI":"10.1021\/acsami.2c18664","article-title":"Low-Swelling Adhesive Hydrogel with Rapid Hemostasis and Potent Anti-Inflammatory Capability for Full-Thickness Oral Mucosal Defect Repair","volume":"14","author":"Zhu","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1111\/odi.14412","article-title":"Manganese Suppresses the Development of Oral Leukoplakia by Activating the Immune Response","volume":"30","author":"Shi","year":"2022","journal-title":"Oral Dis."},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Cheng, X., Yang, Y., Liao, Z., Yi, Q., Zhou, Y., Dai, X., Liu, Y., and Liu, O. (2023). Drug-Loaded Mucoadhesive Microneedle Patch for the Treatment of Oral Submucous Fibrosis. Front. Bioeng. Biotechnol., 11.","DOI":"10.3389\/fbioe.2023.1251583"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"123607","DOI":"10.1016\/j.ijpharm.2023.123607","article-title":"A Polyglutamic Acid\/Tannic Acid-Based Nano Drug Delivery System: Antibacterial, Immunoregulation and Sustained Therapeutic Strategies for Oral Ulcers","volume":"648","author":"He","year":"2023","journal-title":"Int. J. Pharm."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"3180","DOI":"10.1039\/D2BM01721K","article-title":"Dual-Light Defined in Situ Oral Mucosal Lesion Therapy through a Mode Switchable Anti-Bacterial and Anti-Inflammatory Mucoadhesive Hydrogel","volume":"11","author":"Liu","year":"2023","journal-title":"Biomater. Sci."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.1600-9657.1997.tb00058.x","article-title":"Apical Leakage in Canals Filled with Glass Ionomer Sealer and Gutta-Percha after Dentin Conditioning","volume":"13","author":"Raiden","year":"1997","journal-title":"Endod. Dent. Traumatol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0099-2399(98)80183-0","article-title":"Dowel Space Preparation in Root Canals Filled with Glass Ionomer Cement","volume":"24","author":"Raiden","year":"1998","journal-title":"J. Endod."},{"key":"ref_92","first-page":"67","article-title":"Setting Time and Sealing Ability of Alpha-Tricalcium Phosphate Cement Containing Titanic Oxide","volume":"32","author":"Yoshikawa","year":"1998","journal-title":"J. Osaka Dent. Univ."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1002\/1097-4636(2000)53:4<430::AID-JBM18>3.0.CO;2-E","article-title":"Reconstruction of Alveolar Bone Defect by Calcium Phosphate Compounds","volume":"53","author":"Yoshikawa","year":"2000","journal-title":"J. Biomed. Mater. Res."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"345","DOI":"10.4028\/www.scientific.net\/KEM.240-242.345","article-title":"Pulpal and Periapical Tissue Responses to a Calcium Phosphate Cement Containing Barium Sulfate","volume":"240\u2013242","author":"Yoshikawa","year":"2003","journal-title":"Key Eng. Mater."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"353","DOI":"10.4028\/www.scientific.net\/KEM.218-220.353","article-title":"Effects of Tannic Acid in \u03b1-Tricalcium Phophate Cement for the Physical Properties and Tissue Responses","volume":"218\u2013220","author":"Yoshikawa","year":"2001","journal-title":"Key Eng. Mater."},{"key":"ref_96","first-page":"641","article-title":"Tannin-Fluoride Preparation Attenuates Prostaglandin E2 Production by Dental Pulp Cells","volume":"4","author":"Nakamura","year":"2011","journal-title":"Mol. Med. Rep."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"161","DOI":"10.4103\/0972-0707.178702","article-title":"The Effect of Three Different Antioxidants on the Dentinal Tubular Penetration of Resilon and Real Seal SE on Sodium Hypochlorite-Treated Root Canal Dentin: An In Vitro Study","volume":"19","author":"Christopher","year":"2016","journal-title":"J. Conserv. Dent."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.jcis.2020.12.115","article-title":"Tannic Acid Speeds up the Setting of Mineral Trioxide Aggregate Cements and Improves Its Surface and Bulk Properties","volume":"589","author":"Kharouf","year":"2021","journal-title":"J. Colloid. Interface Sci."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"4640","DOI":"10.1039\/D2TB00944G","article-title":"Antibacterial Ability and Osteogenic Activity of Polyphenol-Tailored Calcium Silicate Bone Cement","volume":"10","author":"Wu","year":"2022","journal-title":"J. Mater. Chem. B"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1002\/term.3346","article-title":"Development of a Biomimetic Bioreactor for Regenerative Endodontics Research","volume":"16","author":"Louvrier","year":"2022","journal-title":"J. Tissue Eng. Regen. Med."},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Zhou, L., Shi, W., Zhang, X., Liu, M., Zhang, L., Jiang, X., and Chen, Z. (2024). Injectable Tannin-Containing Hydroxypropyl Chitin Hydrogel as Novel Bioactive Pulp Capping Material Accelerates Repair of Inflamed Dental Pulp. Biomolecules, 14.","DOI":"10.3390\/biom14091129"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"211","DOI":"10.2334\/josnusd1959.27.211","article-title":"Ultrastructural Visualization of Complex Carbohydrates in Odontoblasts, Predentin, and Dentin Matrix by the Tannic Acid-Uranyl Acetate Method","volume":"27","author":"Kageyama","year":"1985","journal-title":"J. Nihon Univ. Sch. Dent."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1002\/ar.1092250404","article-title":"Differential Distribution and Ultrastructural Staining of Oxytalan and Elastic Fibers in the Periodontal Ligament of Alligator Mississippiensis","volume":"225","author":"Takagi","year":"1989","journal-title":"Anat. Rec."},{"key":"ref_104","first-page":"139","article-title":"Features of the Aperiodic Microfibrils Associated with Mouse Dental Basement Membrane Demonstrated by Ultrastructural Histochemistry","volume":"173","author":"Ishizeki","year":"1990","journal-title":"J. Anat."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0040-8166(94)90081-7","article-title":"Ultrastructure of Quick-Frozen Secretory Ameloblasts of the Rat Molar Tooth","volume":"26","author":"Kim","year":"1994","journal-title":"Tissue Cell"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1111\/j.1600-0722.2004.00166.x","article-title":"Ellipsometry Analysis of the in Vitro Adsorption of Tea Polyphenols onto Salivary Pellicles","volume":"112","author":"Joiner","year":"2004","journal-title":"Eur. J. Oral Sci."},{"key":"ref_107","first-page":"e200","article-title":"Combined Effects of Electric Toothbrushing and Dentifrice on Artificial Stain Removal: An in Vitro Study","volume":"10","author":"Haruyama","year":"2018","journal-title":"J. Clin. Exp. Dent."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"e9","DOI":"10.4317\/jced.58708","article-title":"Combined Use of Baking Soda and Electric Toothbrushing for Removal of Artificial Extrinsic Stain on Enamel Surface: An In Vitro Study","volume":"14","author":"Haruyama","year":"2022","journal-title":"J. Clin. Exp. Dent."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"2773","DOI":"10.1007\/s00784-019-03140-3","article-title":"Breaking the Rules: Tooth Whitening by Means of a Reducing Agent","volume":"24","author":"Marquillas","year":"2020","journal-title":"Clin. Oral Investig."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1159\/000525505","article-title":"Incorporation of Green Capping Agents to Reduce Silver-Mediated Dentine Staining","volume":"56","author":"Asghar","year":"2022","journal-title":"Caries Res."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.ajodo.2023.08.012","article-title":"The Complex of Tannic Acid and Cetylpyridinium Chloride: An Antibacterial and Staining-Removal Cleaner for the Aligners","volume":"165","author":"Cen","year":"2023","journal-title":"Am. J. Orthod. Dentofac. Orthop."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"184","DOI":"10.4103\/jispcd.JISPCD_59_18","article-title":"A Novel Herbal Formulation versus Chlorhexidine Mouthwash in Efficacy against Oral Microflora","volume":"8","author":"Vinod","year":"2018","journal-title":"J. Int. Soc. Prev. Community Dent."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"RCR5108","DOI":"10.59761\/RCR5108","article-title":"Progress in Dental Materials: Application of Natural Ingredients","volume":"93","author":"Yudaev","year":"2024","journal-title":"Russ. Chem. Rev."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"441","DOI":"10.2174\/1567201819666220418104042","article-title":"Oral Candidiasis and Novel Therapeutic Strategies: Antifungals, Phytotherapy, Probiotics, and Photodynamic Therapy","volume":"20","author":"Contaldo","year":"2023","journal-title":"Curr. Drug Deliv."},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"Valenti, C., Pagano, S., Bozza, S., Ciurnella, E., Lomurno, G., Capobianco, B., Coniglio, M., Cianetti, S., and Marinucci, L. (2021). Use of the Er:YAG Laser in Conservative Dentistry: Evaluation of the Microbial Population in Carious Lesions. Materials, 14.","DOI":"10.3390\/ma14092387"},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Gholami, L., Shahabi, S., Jazaeri, M., Hadilou, M., and Fekrazad, R. (2022). Clinical Applications of Antimicrobial Photodynamic Therapy in Dentistry. Front. Microbiol., 13.","DOI":"10.3389\/fmicb.2022.1020995"},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Yan, R., Liu, J., Dong, Z., and Peng, Q. (2023). Nanomaterials-Mediated Photodynamic Therapy and Its Applications in Treating Oral Diseases. Biomater. Adv., 144.","DOI":"10.1016\/j.bioadv.2022.213218"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.pdpdt.2016.03.005","article-title":"Evaluation of Temperature Change during Antimicrobial Photodynamic Therapy with Two Different Photosensitizers in Dental Caries","volume":"14","author":"Mirzaie","year":"2016","journal-title":"Photodiagn. Photodyn. Ther."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"2707","DOI":"10.1007\/s10103-022-03544-w","article-title":"A Histological Evaluation of the Mice Oral Mucosal Tissue Wounds Excised with Diode Laser, Er:YAG Laser, and Cold Scalpel","volume":"37","author":"Li","year":"2022","journal-title":"Lasers Med. Sci."},{"key":"ref_120","doi-asserted-by":"crossref","unstructured":"Hu, N., Qin, H., Chen, X., Huang, Y., Xu, J., and He, H. (2022). Tannic Acid Assisted Metal-Chelate Interphase toward Highly Stable Zn Metal Anodes in Rechargeable Aqueous Zinc-Ion Batteries. Front. Chem., 10.","DOI":"10.3389\/fchem.2022.981623"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"7525","DOI":"10.1007\/s11581-024-05759-z","article-title":"Tannic Acid as a Pioneering Chelating Agent for Nickel\u2013Cobalt Supercapacitor Electrodes","volume":"30","author":"Li","year":"2024","journal-title":"Ionics"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"7314","DOI":"10.1039\/C9TB01587F","article-title":"A Tannic Acid-Modified Fluoride Pre-Treated Mg-Zn-Y-Nd Alloy with Antioxidant and Platelet-Repellent Functionalities for Vascular Stent Application","volume":"7","author":"Wang","year":"2019","journal-title":"J. Mater. Chem. B Mater. Biol. Med."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"125300","DOI":"10.1016\/j.seppur.2023.125300","article-title":"Preparation of Forward Osmosis Composite Membrane with Chitosan\/Tannic Acid Co-Deposition Interlayer and Its Fluoride Removal Performance","volume":"330","author":"Zhang","year":"2024","journal-title":"Sep. Purif. Technol."}],"container-title":["Bioengineering"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2306-5354\/12\/5\/438\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:19:34Z","timestamp":1760030374000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2306-5354\/12\/5\/438"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,22]]},"references-count":123,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2025,5]]}},"alternative-id":["bioengineering12050438"],"URL":"https:\/\/doi.org\/10.3390\/bioengineering12050438","relation":{},"ISSN":["2306-5354"],"issn-type":[{"value":"2306-5354","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,22]]}}}