{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T20:05:43Z","timestamp":1776801943413,"version":"3.51.2"},"reference-count":28,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T00:00:00Z","timestamp":1746144000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioengineering"],"abstract":"<jats:p>Background: The Upper Limb Neural Tension Test (ULNTT) is a common assessment for neurodynamic function, yet the relationship between ULNTT findings and specific spinal biomechanical patterns remains poorly understood, particularly in the context of cervicobrachial neuralgia. This study aimed to investigate the association between ULNTT asymmetry and cervicothoracic spine biomechanics using advanced motion capture analysis. Methods: A longitudinal experimental study was conducted on two groups of asymptomatic participants: one with ULNTT asymmetry &gt; 10\u00b0 (AS group, n = 12) and another with symmetrical ULNTT (S group, n = 11). Neurodynamic testing and 3D motion capture of spinal kinematics during head lateral bending were performed at baseline. The AS group then underwent manual medicine intervention targeting spinal mobility impairments, followed by post-intervention reassessment. Spine biomechanics data, focusing on the C5-T4 region, were analyzed using the least squares approximation method to derive parameters describing upper thoracic (T1-T4_VERT) and lower cervical (C5-T1_CONC) lateral bending, and their interrelationship (ANGLE_TANG). Results: At baseline, the AS group showed significant differences between sides in neurodynamic parameters and T1-T4_VERT, with limited upper thoracic lateral bending contralateral to the side of the restricted ULNTT. Significant intergroup differences were also observed for these parameters. Following intervention in the AS group, significant improvements were noted in neurodynamic parameters and T1-T4_VERT, with no significant between-side differences post-intervention. Conclusions: These are preliminary results and preliminary conclusions based on the first study on a small group of patients. Given the limitations, this study provides evidence for a relationship between ULNTT asymmetry and upper thoracic spine biomechanics, specifically a contralateral limitation in lateral bending. These findings suggest a functional link between brachial plexus neurodynamics and upper thoracic spine mobility, offering potential insights into the pathophysiology of cervicobrachial conditions and highlighting the potential role of manual therapy in addressing both neurodynamic and biomechanical impairments. The developed motion capture analysis method offers a novel approach to quantify fine spinal motion patterns.<\/jats:p>","DOI":"10.3390\/bioengineering12050487","type":"journal-article","created":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T07:44:23Z","timestamp":1746171863000},"page":"487","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Upper Limb Neural Tension Test and Spinal Biomechanics: Insights from a Longitudinal Pilot Study"],"prefix":"10.3390","volume":"12","author":[{"given":"Massimo","family":"Rossi","sequence":"first","affiliation":[{"name":"Scuolaecomskbo, Istituto Ortopedico Rizzoli, Via Giulio Cesare Pupilli 1, 40100 Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianna","family":"Signorini","sequence":"additional","affiliation":[{"name":"Dipartimento di Ingegneria Matematica, Politecnico di Milano, Via A.M. Ampere 2, 20133 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6081-5963","authenticated-orcid":false,"given":"Ali","family":"Baram","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, IRCCS Humanitas Research Hospital, Via Alessandro Manzoni 56, 20089 Rozzano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5669-2286","authenticated-orcid":false,"given":"Mario","family":"De Robertis","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, IRCCS Humanitas Research Hospital, Via Alessandro Manzoni 56, 20089 Rozzano, Italy"},{"name":"Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, 20090 Pieve Emanuele, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2810-7622","authenticated-orcid":false,"given":"Gabriele","family":"Capo","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, IRCCS Humanitas Research Hospital, Via Alessandro Manzoni 56, 20089 Rozzano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4643-6451","authenticated-orcid":false,"given":"Marco","family":"Riva","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, IRCCS Humanitas Research Hospital, Via Alessandro Manzoni 56, 20089 Rozzano, Italy"},{"name":"Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, 20090 Pieve Emanuele, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurizio","family":"Fornari","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, IRCCS Humanitas Research Hospital, Via Alessandro Manzoni 56, 20089 Rozzano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federico","family":"Pessina","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, IRCCS Humanitas Research Hospital, Via Alessandro Manzoni 56, 20089 Rozzano, Italy"},{"name":"Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, 20090 Pieve Emanuele, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3356-3144","authenticated-orcid":false,"given":"Carlo","family":"Brembilla","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, IRCCS Humanitas Research Hospital, Via Alessandro Manzoni 56, 20089 Rozzano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1097\/BRS.0000000000000686","article-title":"Cervical Nerve Root Displacement and Strain During Upper Limb Neural Tension Testing","volume":"40","author":"Lohman","year":"2015","journal-title":"Spine"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0268-0033(99)00042-X","article-title":"Upper limb tension tests as tools in the diagnosis of nerve and plexus lesions. 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