{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T07:46:57Z","timestamp":1782978417055,"version":"3.54.5"},"reference-count":18,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T00:00:00Z","timestamp":1746748800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioengineering"],"abstract":"<jats:p>Objective: The aim of this study was to assess and compare the diagnostic accuracy of two MRI techniques for identifying structural bone lesions (fatty lesions [BMFs], subchondral erosions [BMEs], sclerosis [BMS], and ankylosis [A]) in the dorso-lumbar joints. This assessment specifically focused on the application of MRI Dixon sequence fat\u2013water separation techniques (T2w Dixon FSTs) when acquiring T1-weighted (T1w) images as the reference standard, among patients diagnosed with axial spondyloarthritis (SpA). Methods: Conducted at a single center, this study involved the recruitment of patients who underwent both spinal and sacroiliac (SI) joint MRI between 2019 and 2022, with follow-up continuing until 2023. In 2023, three independent readers reassessed the initial MRI datasets to evaluate specific radiological features of SpA. They recorded confidence estimates regarding the use of T2w Dixon FSTs when acquiring T1w images. The centralized MRI interpretations were then compared to established rheumatologic diagnoses. Results: A total of 73 patients (42 men and 31 women) were included in the study. The mean sensitivity, specificity, and accuracy of T2w Dixon FSTs (fat-only images) were at least 75%, 100%, and 96%, respectively, based on the 2023 assessment for all considered items. The diagnostic performance of T2w Dixon FSTs was comparable to that of T1w images. Conclusions: The diagnostic performance of T2w Dixon FSTs (fat-only images) matched that of T1w images not only in assessing structural and fatty lesions, but also in the evaluation of subchondral erosions, sclerosis, and ankylosis in the dorso-lumbar joints of patients with a rheumatologic diagnosis of SpA. These findings suggest the potential avoidance of T1-weighted images when employing multi-parameter, multi-sequence imaging, such as the Dixon sequence.<\/jats:p>","DOI":"10.3390\/bioengineering12050502","type":"journal-article","created":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T11:25:53Z","timestamp":1746789953000},"page":"502","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["An Evaluation of Magnetic Resonance Imaging Dixon Sequence Fat\u2013Water Separation Techniques (T2w Dixon FSTs) to Detect Dorso-Lumbar Structural Lesions in Patients with Axial Spondyloarthritis"],"prefix":"10.3390","volume":"12","author":[{"given":"David","family":"Fadli","sequence":"first","affiliation":[{"name":"Centre D\u2019imagerie Ost\u00e9oarticulaire, Clinique du Sport, Bordeaux M\u00e9rignac, 2, rue Georges-N\u00e9grevergne, 33700 M\u00e9rignac, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre-Francois","family":"Lintingre","sequence":"additional","affiliation":[{"name":"Clinique du Sport de Bordeaux-M\u00e9rignac, 33700 M\u00e9rignac, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Dallet","sequence":"additional","affiliation":[{"name":"Centre de R\u00e9sonance Magn\u00e9tique, CNRS\/University of Bordeaux, 33000 Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Raoult","sequence":"additional","affiliation":[{"name":"Centre D\u2019imagerie Ost\u00e9oarticulaire, Clinique du Sport, Bordeaux M\u00e9rignac, 2, rue Georges-N\u00e9grevergne, 33700 M\u00e9rignac, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5553-4578","authenticated-orcid":false,"given":"Julien","family":"Gay-Depassier","sequence":"additional","affiliation":[{"name":"Centre D\u2019imagerie Ost\u00e9oarticulaire, Clinique du Sport, Bordeaux M\u00e9rignac, 2, rue Georges-N\u00e9grevergne, 33700 M\u00e9rignac, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8300-5653","authenticated-orcid":false,"given":"Nicolas","family":"Bouguennec","sequence":"additional","affiliation":[{"name":"Clinique du Sport de Bordeaux-M\u00e9rignac, 33700 M\u00e9rignac, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lionel","family":"Pesquer","sequence":"additional","affiliation":[{"name":"Clinique du Sport de Bordeaux-M\u00e9rignac, 33700 M\u00e9rignac, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Dallaudi\u00e8re","sequence":"additional","affiliation":[{"name":"Centre D\u2019imagerie Ost\u00e9oarticulaire, Clinique du Sport, Bordeaux M\u00e9rignac, 2, rue Georges-N\u00e9grevergne, 33700 M\u00e9rignac, France"},{"name":"Centre de R\u00e9sonance Magn\u00e9tique, CNRS\/University of Bordeaux, 33000 Bordeaux, France"},{"name":"Department of Radiology, University Hospital of Bordeaux, Centre de R\u00e9sonance Magn\u00e9tique, CNRS\/University of Bordeaux, 33000 Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1038\/nrrheum.2012.33","article-title":"Diagnosis and classification in spondyloarthritis: Identifying a chameleon","volume":"8","author":"Weber","year":"2012","journal-title":"Nat. Rev. Rheumatol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1136\/ard.2011.151563","article-title":"2010 Update of the international ASAS recommendations for the use of anti-TNF agents in patients with axial spondyloarthritis","volume":"70","author":"Sieper","year":"2011","journal-title":"Ann. Rheum. Dis."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2645","DOI":"10.1002\/art.38070","article-title":"The Impact of TNF-inhibitors on radiographic progression in Ankylosing Spondylitis","volume":"65","author":"Haroon","year":"2013","journal-title":"Arthritis Rheum."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1136\/annrheumdis-2014-206971","article-title":"EULAR recommendations for the use of imaging in the diagnosis and management of spondyloarthritis in clinical practice","volume":"74","author":"Mandl","year":"2015","journal-title":"Ann. Rheum. Dis."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"110793","DOI":"10.1016\/j.ejrad.2023.110793","article-title":"Role of advanced MRI techniques for sacroiliitis assessment and quantification","volume":"163","author":"Aguilar","year":"2023","journal-title":"Eur. J. Radiol."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Du, M.S., Xiong, X.Q., Liu, H., Qin, X., Hu, X.F., and Chen, W. (2021). The evaluation of bone marrow edema in sacroiliac joint in patients with ankylosing spondylitis using magnetic resonance imaging Dixon sequence. BMC Musculoskelet. Disord., 22.","DOI":"10.1186\/s12891-021-04716-5"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"e783","DOI":"10.1016\/j.crad.2022.06.017","article-title":"The effect of subchondral oedema in T2-weighted Dixon MRI sequence evaluation of sacroiliac joint erosion in axial spondyloarthropathy","volume":"77","author":"Chien","year":"2022","journal-title":"Clin. Radiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.3348\/kjr.2020.0953","article-title":"Use of Quantitative Vertebral Bone Marrow Fat Fraction to Assess Disease Activity and Chronicity in Patients with Ankylosing Spondylitis","volume":"22","author":"Ahn","year":"2021","journal-title":"Korean J. Radiol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1136\/ard.2011.150680","article-title":"Descriptions of spinal MRI lesions and definition of a positive MRI of the spine in axial spondyloarthritis: A consensual approach by the ASAS\/OMERACT MRI study group","volume":"71","author":"Hermann","year":"2012","journal-title":"Ann. Rheum. Dis."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1002\/acr.21893","article-title":"Development and Validation of a Magnetic Resonance Imaging Reference Criterion for Defining a Positive Sacroiliac Joint Magnetic Resonance Imaging Finding in Spondyloarthritis: MRI Reference Criterion for SpA in SI Joints","volume":"65","author":"Weber","year":"2013","journal-title":"Arthritis Care Res."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1002\/art.21445","article-title":"Spondyloarthritis research Consortium of Canada magnetic resonance imaging index for assessment of sacroiliac joint inflammation in ankylosing spondylitis","volume":"53","author":"Maksymowych","year":"2005","journal-title":"Arthritis Rheum."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.2214\/AJR.17.19429","article-title":"Diagnostic Accuracy of MRI-Based Sacroiliitis Scoring Systems: A Systematic Review","volume":"212","author":"Swami","year":"2019","journal-title":"Am. J. Roentgenol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1136\/ard.2009.108233","article-title":"The development of Assessment of SpondyloArthritis international Society classification criteria for axial spondyloarthritis (part II): Validation and final selection","volume":"68","author":"Rudwaleit","year":"2009","journal-title":"Ann. Rheum. Dis."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1007\/s00256-013-1789-y","article-title":"Assessment of MRI abnormalities of the sacroiliac joints and their ability to predict axial spondyloarthritis: A retrospective pilot study on 110 patients","volume":"43","author":"Larbi","year":"2014","journal-title":"Skelet. Radiol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1136\/ard.2007.073098","article-title":"MRI in predicting a major clinical response to anti-tumour necrosis factor treatment in ankylosing spondylitis","volume":"67","author":"Rudwaleit","year":"2007","journal-title":"Ann. Rheum. Dis."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"603","DOI":"10.2214\/AJR.16.16774","article-title":"The Value of the T2-Weighted Multipoint Dixon Sequence in MRI of Sacroiliac Joints for the Diagnosis of Active and Chronic Sacroiliitis","volume":"208","year":"2017","journal-title":"AJR Am. J. Roentgenol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"321.e13","DOI":"10.1016\/j.crad.2019.12.011","article-title":"Qualitative and quantitative assessment of sacroiliitis in axial spondyloarthropathy: Can a single T2-weighted dixon sequence replace the standard protocol?","volume":"75","author":"Huang","year":"2020","journal-title":"Clin. Radiol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"6810","DOI":"10.1007\/s00330-021-07785-1","article-title":"Improved detection of subchondral erosions in the sacroiliac joints with T1-weighted fat-suppressed MRI","volume":"31","author":"Crema","year":"2021","journal-title":"Eur. 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