{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T23:00:57Z","timestamp":1791846057809,"version":"4.3.4"},"reference-count":298,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T00:00:00Z","timestamp":1747958400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Natural Science Foundation of China","award":["82471074"],"award-info":[{"award-number":["82471074"]}]},{"name":"National Natural Science Foundation of China","award":["2024A1515013058"],"award-info":[{"award-number":["2024A1515013058"]}]},{"name":"National Natural Science Foundation of China","award":["202206080005"],"award-info":[{"award-number":["202206080005"]}]},{"name":"National Natural Science Foundation of China","award":["BX20240440"],"award-info":[{"award-number":["BX20240440"]}]},{"name":"National Natural Science Foundation of China","award":["824B2040"],"award-info":[{"award-number":["824B2040"]}]},{"name":"Guangdong Basic and Applied Basic Research Foundation","award":["82471074"],"award-info":[{"award-number":["82471074"]}]},{"name":"Guangdong Basic and Applied Basic Research Foundation","award":["2024A1515013058"],"award-info":[{"award-number":["2024A1515013058"]}]},{"name":"Guangdong Basic and Applied Basic Research Foundation","award":["202206080005"],"award-info":[{"award-number":["202206080005"]}]},{"name":"Guangdong Basic and Applied Basic Research Foundation","award":["BX20240440"],"award-info":[{"award-number":["BX20240440"]}]},{"name":"Guangdong Basic and Applied Basic Research Foundation","award":["824B2040"],"award-info":[{"award-number":["824B2040"]}]},{"name":"Science and Technology Program of Guangzhou, China","award":["82471074"],"award-info":[{"award-number":["82471074"]}]},{"name":"Science and Technology Program of Guangzhou, China","award":["2024A1515013058"],"award-info":[{"award-number":["2024A1515013058"]}]},{"name":"Science and Technology Program of Guangzhou, China","award":["202206080005"],"award-info":[{"award-number":["202206080005"]}]},{"name":"Science and Technology Program of Guangzhou, China","award":["BX20240440"],"award-info":[{"award-number":["BX20240440"]}]},{"name":"Science and Technology Program of Guangzhou, China","award":["824B2040"],"award-info":[{"award-number":["824B2040"]}]},{"name":"China National Postdoctoral Program for Innovative Talents","award":["82471074"],"award-info":[{"award-number":["82471074"]}]},{"name":"China National Postdoctoral Program for Innovative Talents","award":["2024A1515013058"],"award-info":[{"award-number":["2024A1515013058"]}]},{"name":"China National Postdoctoral Program for Innovative Talents","award":["202206080005"],"award-info":[{"award-number":["202206080005"]}]},{"name":"China National Postdoctoral Program for Innovative Talents","award":["BX20240440"],"award-info":[{"award-number":["BX20240440"]}]},{"name":"China National Postdoctoral Program for Innovative Talents","award":["824B2040"],"award-info":[{"award-number":["824B2040"]}]},{"name":"National Natural Science Foundation of China","award":["82471074"],"award-info":[{"award-number":["82471074"]}]},{"name":"National Natural Science Foundation of China","award":["2024A1515013058"],"award-info":[{"award-number":["2024A1515013058"]}]},{"name":"National Natural Science Foundation of China","award":["202206080005"],"award-info":[{"award-number":["202206080005"]}]},{"name":"National Natural Science Foundation of China","award":["BX20240440"],"award-info":[{"award-number":["BX20240440"]}]},{"name":"National Natural Science Foundation of China","award":["824B2040"],"award-info":[{"award-number":["824B2040"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioengineering"],"abstract":"<jats:p>The process of aging exerts profound effects on various physiological systems, leading to the progression of chronic degenerative disorders and pathologies associated with advancing age. Cellular senescence plays a central role in the aging process and the onset of various eye conditions associated with advancing age, including age-related macular degeneration (AMD), diabetic retinopathy (DR), glaucoma, cataracts, and ocular surface disorders. The accumulation of senescent cells (SnCs) and their secretion of pro-inflammatory and tissue-remodeling factors, collectively known as the senescence-associated secretory phenotype (SASP), exacerbate chronic inflammation, oxidative stress, and tissue dysfunction, contributing to disease progression. This study is the first to systematically integrate the multifaceted mechanisms of cellular senescence in ocular diseases, revealing differential regulatory mechanisms of specific signaling pathways across different ocular pathologies, thereby providing novel insights into the pathogenesis of these disorders. SnC-targeted therapies such as senolytics, senomorphics, SASP modulators, mitochondrial-targeted antioxidants, and epigenetic reprogramming are emerging as regenerative therapies, demonstrating potent anti-inflammatory effects, restoration of normal tissue physiology, and successful regeneration of ocular defects in preclinical models and clinical trials, while slowing senescence-associated disease progression. This review not only summarizes the role of cellular senescence in ocular diseases but also delves into potential therapeutic strategies, particularly highlighting novel perspectives for root-cause-targeted therapies from the unique angle of senescence biology, which may pioneer new directions for the treatment of ocular pathologies.<\/jats:p>","DOI":"10.3390\/bioengineering12060563","type":"journal-article","created":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T09:58:09Z","timestamp":1747994289000},"page":"563","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["New Insights into the Role of Cellular Senescence and Its Therapeutic Implications in Ocular Diseases"],"prefix":"10.3390","volume":"12","author":[{"given":"Junying","family":"Wu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou 510060, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5855-6624","authenticated-orcid":false,"given":"Xiuxing","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou 510060, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yidan","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou 510060, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0506-6362","authenticated-orcid":false,"given":"Wenru","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yehong","family":"Zhuo","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou 510060, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1038\/nature13193","article-title":"The role of senescent cells in ageing","volume":"509","year":"2014","journal-title":"Nature"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1101\/gad.343129.120","article-title":"Senescence and the SASP: Many therapeutic avenues","volume":"34","author":"Birch","year":"2020","journal-title":"Genes. Dev."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"3067","DOI":"10.1007\/s00417-023-06070-9","article-title":"Cellular senescence and ophthalmic diseases: Narrative review","volume":"261","author":"Soleimani","year":"2023","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1021\/acsnano.2c05824","article-title":"Highly Retina-Permeating and Long-Acting Resveratrol\/Metformin Nanotherapeutics for Enhanced Treatment of Macular Degeneration","volume":"17","author":"Nguyen","year":"2023","journal-title":"ACS Nano"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1038\/s41581-022-00601-z","article-title":"Cellular senescence: The good, the bad and the unknown","volume":"18","author":"Huang","year":"2022","journal-title":"Nat. Rev. Nephrol."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Liao, Z., Yeo, H.L., Wong, S.W., and Zhao, Y. (2021). Cellular Senescence: Mechanisms and Therapeutic Potential. Biomedicines, 9.","DOI":"10.3390\/biomedicines9121769"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Roger, L., Tomas, F., and Gire, V. (2021). Mechanisms and Regulation of Cellular Senescence. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms222313173"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.cell.2019.10.005","article-title":"Cellular Senescence: Defining a Path Forward","volume":"179","author":"Gorgoulis","year":"2019","journal-title":"Cell"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Ramos, I., Stamatakis, K., Oeste, C.L., and P\u00e9rez-Sala, D. (2020). Vimentin as a Multifaceted Player and Potential Therapeutic Target in Viral Infections. Int. J. Mol. Sci., 21.","DOI":"10.20944\/preprints202005.0041.v1"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Kumari, R., and Jat, P. (2021). Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype. Front. Cell Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.645593"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1016\/j.cell.2013.10.019","article-title":"Programmed cell senescence during mammalian embryonic development","volume":"155","author":"Maraver","year":"2013","journal-title":"Cell"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1016\/j.cell.2013.10.041","article-title":"Senescence is a developmental mechanism that contributes to embryonic growth and patterning","volume":"155","author":"Storer","year":"2013","journal-title":"Cell"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1038\/nrm3823","article-title":"Cellular senescence: From physiology to pathology","volume":"15","author":"Serrano","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"e05505","DOI":"10.7554\/eLife.05505","article-title":"Recurrent turnover of senescent cells during regeneration of a complex structure","volume":"4","author":"Yun","year":"2015","journal-title":"Elife"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.ejcb.2012.08.002","article-title":"Role of cellular senescence in hepatic wound healing and carcinogenesis","volume":"91","author":"Ramakrishna","year":"2012","journal-title":"Eur. J. Cell Biol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/j.devcel.2014.11.012","article-title":"An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA","volume":"31","author":"Demaria","year":"2014","journal-title":"Dev. Cell"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/nm.4054","article-title":"p16(Ink4a)-induced senescence of pancreatic beta cells enhances insulin secretion","volume":"22","author":"Helman","year":"2016","journal-title":"Nat. Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"aaa5612","DOI":"10.1126\/science.aaa5612","article-title":"The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4","volume":"349","author":"Kang","year":"2015","journal-title":"Science"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1038\/nrd.2017.116","article-title":"Senescent cells: An emerging target for diseases of ageing","volume":"16","author":"Childs","year":"2017","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/nrm.2016.171","article-title":"Telomeres in cancer: Tumour suppression and genome instability","volume":"18","author":"Maciejowski","year":"2017","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1038\/s41568-019-0156-2","article-title":"Unmasking senescence: Context-dependent effects of SASP in cancer","volume":"19","author":"Faget","year":"2019","journal-title":"Nat. Rev. Cancer"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/j.trecan.2020.05.004","article-title":"Senescent Cells in Cancer Therapy: Friends or Foes?","volume":"6","author":"Wang","year":"2020","journal-title":"Trends Cancer"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1152\/physrev.00020.2018","article-title":"Cellular Senescence: Aging, Cancer, and Injury","volume":"99","author":"Calcinotto","year":"2019","journal-title":"Physiol. Rev."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Vasileiou, P.V.S., Evangelou, K., Vlasis, K., Fildisis, G., Panayiotidis, M.I., Chronopoulos, E., Passias, P.G., Kouloukoussa, M., Gorgoulis, V.G., and Havaki, S. (2019). Mitochondrial Homeostasis and Cellular Senescence. Cells, 8.","DOI":"10.3390\/cells8070686"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.pharmthera.2018.08.006","article-title":"Senescence and senotherapeutics: A new field in cancer therapy","volume":"193","author":"Myrianthopoulos","year":"2019","journal-title":"Pharmacol. Ther."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1038\/ncb2811","article-title":"Transmitting senescence to the cell neighbourhood","volume":"15","author":"Hoare","year":"2013","journal-title":"Nat. Cell Biol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"549","DOI":"10.5483\/BMBRep.2015.48.10.122","article-title":"From cell senescence to age-related diseases: Differential mechanisms of action of senescence-associated secretory phenotypes","volume":"48","author":"Byun","year":"2015","journal-title":"BMB Rep."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/j.cell.2008.03.039","article-title":"Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network","volume":"133","author":"Kuilman","year":"2008","journal-title":"Cell"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2583601","DOI":"10.1155\/2020\/2583601","article-title":"The Emerging Role of Senescence in Ocular Disease","volume":"2020","author":"Sreekumar","year":"2020","journal-title":"Oxid. Med. Cell Longev."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1101\/gad.625811","article-title":"Senescent cells develop a PARP-1 and nuclear factor-{kappa}B-associated secretome (PNAS)","volume":"25","author":"Ohanna","year":"2011","journal-title":"Genes. Dev."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1111\/febs.16325","article-title":"p53 in senescence\u2014it\u2019s a marathon, not a sprint","volume":"290","author":"Sheekey","year":"2023","journal-title":"FEBS J."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Korbecki, J., Kupnicka, P., Chlubek, M., Gor\u0105cy, J., Gutowska, I., and Baranowska-Bosiacka, I. (2022). CXCR2 Receptor: Regulation of Expression, Signal Transduction, and Involvement in Cancer. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23042168"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.cell.2007.12.032","article-title":"Oncogenic BRAF induces senescence and apoptosis through pathways mediated by the secreted protein IGFBP7","volume":"132","author":"Wajapeyee","year":"2008","journal-title":"Cell"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1038\/ncb2784","article-title":"A complex secretory program orchestrated by the inflammasome controls paracrine senescence","volume":"15","author":"Acosta","year":"2013","journal-title":"Nat. Cell Biol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"dev151837","DOI":"10.1242\/dev.151837","article-title":"Cellular senescence in development, regeneration and disease","volume":"146","author":"Rhinn","year":"2019","journal-title":"Development"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.1101\/gad.17276711","article-title":"Control of the senescence-associated secretory phenotype by NF-\u03baB promotes senescence and enhances chemosensitivity","volume":"25","author":"Chien","year":"2011","journal-title":"Genes. Dev."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"C565","DOI":"10.1152\/ajpcell.00124.2023","article-title":"The aged extracellular matrix and the profibrotic role of senescence-associated secretory phenotype","volume":"325","author":"Mebratu","year":"2023","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1038\/ncb3225","article-title":"mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype","volume":"17","author":"Herranz","year":"2015","journal-title":"Nat. Cell Biol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1038\/ncb3195","article-title":"MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation","volume":"17","author":"Laberge","year":"2015","journal-title":"Nat. Cell Biol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1161\/CIRCULATIONAHA.116.017513","article-title":"Endothelial Microparticles From Acute Coronary Syndrome Patients Induce Premature Coronary Artery Endothelial Cell Aging and Thrombogenicity: Role of the Ang II\/AT1 Receptor\/NADPH Oxidase-Mediated Activation of MAPKs and PI3-Kinase Pathways","volume":"135","author":"Abbas","year":"2017","journal-title":"Circulation"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1089\/ten.tea.2016.0525","article-title":"MicroRNA-183-5p Increases with Age in Bone-Derived Extracellular Vesicles, Suppresses Bone Marrow Stromal (Stem) Cell Proliferation, and Induces Stem Cell Senescence","volume":"23","author":"Davis","year":"2017","journal-title":"Tissue Eng. Part A"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"e12734","DOI":"10.1111\/acel.12734","article-title":"Emerging roles of extracellular vesicles in cellular senescence and aging","volume":"17","author":"Takasugi","year":"2018","journal-title":"Aging Cell"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1111\/acel.12484","article-title":"Secreted microvesicular miR-31 inhibits osteogenic differentiation of mesenchymal stem cells","volume":"15","author":"Weilner","year":"2016","journal-title":"Aging Cell"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.freeradbiomed.2019.11.032","article-title":"Extracellular vesicles and redox modulation in aging","volume":"149","author":"Borras","year":"2020","journal-title":"Free Radic. Biol. Med."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"O\u2019Loghlen, A. (2018). Role for extracellular vesicles in the tumour microenvironment. Philos. Trans. R. Soc. B Biol. Sci., 373.","DOI":"10.1098\/rstb.2016.0488"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"6328","DOI":"10.1073\/pnas.0914843107","article-title":"Functional delivery of viral miRNAs via exosomes","volume":"107","author":"Pegtel","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"D516","DOI":"10.1093\/nar\/gky1029","article-title":"Vesiclepedia 2019: A compendium of RNA, proteins, lipids and metabolites in extracellular vesicles","volume":"47","author":"Pathan","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/j.cell.2008.03.038","article-title":"Chemokine signaling via the CXCR2 receptor reinforces senescence","volume":"133","author":"Acosta","year":"2008","journal-title":"Cell"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"aaf4445","DOI":"10.1126\/science.aaf4445","article-title":"Tissue damage and senescence provide critical signals for cellular reprogramming in vivo","volume":"354","author":"Mosteiro","year":"2016","journal-title":"Science"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1101\/gad.290635.116","article-title":"The senescence-associated secretory phenotype induces cellular plasticity and tissue regeneration","volume":"31","author":"Ritschka","year":"2017","journal-title":"Genes. Dev."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1158\/2159-8290.CD-16-0241","article-title":"Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse","volume":"7","author":"Demaria","year":"2017","journal-title":"Cancer Discov."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"3329","DOI":"10.1016\/j.celrep.2019.08.049","article-title":"SILAC Analysis Reveals Increased Secretion of Hemostasis-Related Factors by Senescent Cells","volume":"28","author":"Wiley","year":"2019","journal-title":"Cell Rep."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s41232-022-00197-8","article-title":"The roles and mechanisms of senescence-associated secretory phenotype (SASP): Can it be controlled by senolysis?","volume":"42","author":"Ohtani","year":"2022","journal-title":"Inflamm. Regen."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.cell.2013.03.020","article-title":"Non-cell-autonomous tumor suppression by p53","volume":"153","author":"Lujambio","year":"2013","journal-title":"Cell"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.cell.2008.06.049","article-title":"Senescence of activated stellate cells limits liver fibrosis","volume":"134","author":"Krizhanovsky","year":"2008","journal-title":"Cell"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1146\/annurev-pathol-121808-102144","article-title":"The senescence-associated secretory phenotype: The dark side of tumor suppression","volume":"5","author":"Desprez","year":"2010","journal-title":"Annu. Rev. Pathol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.ccell.2016.09.003","article-title":"Distinct Functions of Senescence-Associated Immune Responses in Liver Tumor Surveillance and Tumor Progression","volume":"30","author":"Eggert","year":"2016","journal-title":"Cancer Cell"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1093\/gerona\/glu057","article-title":"Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases","volume":"69","author":"Franceschi","year":"2014","journal-title":"J. Gerontol. Ser. A Biomed. Sci. Med. Sci."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/nature10600","article-title":"Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders","volume":"479","author":"Baker","year":"2011","journal-title":"Nature"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/nature16932","article-title":"Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan","volume":"530","author":"Baker","year":"2016","journal-title":"Nature"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1038\/s41591-018-0092-9","article-title":"Senolytics improve physical function and increase lifespan in old age","volume":"24","author":"Xu","year":"2018","journal-title":"Nat. Med."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.cmet.2015.11.011","article-title":"Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype","volume":"23","author":"Wiley","year":"2016","journal-title":"Cell Metab."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1007\/s13238-020-00762-2","article-title":"A human circulating immune cell landscape in aging and COVID-19","volume":"11","author":"Zheng","year":"2020","journal-title":"Protein Cell"},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Hadziahmetovic, M., and Malek, G. (2020). Age-Related Macular Degeneration Revisited: From Pathology and Cellular Stress to Potential Therapies. Front. Cell Dev. Biol., 8.","DOI":"10.3389\/fcell.2020.612812"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"112718","DOI":"10.1016\/j.exger.2025.112718","article-title":"Cellular senescence and glaucoma","volume":"202","author":"Guo","year":"2025","journal-title":"Exp. Gerontol."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Bu, J., Liu, Y., Zhang, R., Lin, S., Zhuang, J., Sun, L., Zhang, L., He, H., Zong, R., and Wu, Y. (2024). Potential New Target for Dry Eye Disease-Oxidative Stress. Antioxidants, 13.","DOI":"10.3390\/antiox13040422"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"e108946","DOI":"10.15252\/embj.2021108946","article-title":"Pharmacological CDK4\/6 inhibition reveals a p53-dependent senescent state with restricted toxicity","volume":"41","author":"Wang","year":"2022","journal-title":"EMBO J."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1016\/j.cmet.2021.03.008","article-title":"Oxylipin biosynthesis reinforces cellular senescence and allows detection of senolysis","volume":"33","author":"Wiley","year":"2021","journal-title":"Cell Metab."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"15729","DOI":"10.1038\/ncomms15728","article-title":"Small extracellular vesicles secreted from senescent cells promote cancer cell proliferation through EphA2","volume":"8","author":"Takasugi","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"3956","DOI":"10.1016\/j.celrep.2019.05.095","article-title":"Small Extracellular Vesicles Are Key Regulators of Non-cell Autonomous Intercellular Communication in Senescence via the Interferon Protein IFITM3","volume":"27","author":"Borghesan","year":"2019","journal-title":"Cell Rep."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.cell.2010.01.040","article-title":"The inflammasomes","volume":"140","author":"Schroder","year":"2010","journal-title":"Cell"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/s41586-018-0784-9","article-title":"L1 drives IFN in senescent cells and promotes age-associated inflammation","volume":"566","author":"Ito","year":"2019","journal-title":"Nature"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1083\/jcb.201212110","article-title":"Lysosome-mediated processing of chromatin in senescence","volume":"202","author":"Ivanov","year":"2013","journal-title":"J. Cell Biol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1038\/emboj.2011.69","article-title":"p38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype","volume":"30","author":"Freund","year":"2011","journal-title":"EMBO J."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"2707","DOI":"10.1038\/onc.2011.1","article-title":"NF-\u03baB-dependent cytokine secretion controls Fas expression on chemotherapy-induced premature senescent tumor cells","volume":"30","author":"Crescenzi","year":"2011","journal-title":"Oncogene"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"2356","DOI":"10.1038\/onc.2010.611","article-title":"Activation of nuclear factor-kappa B signalling promotes cellular senescence","volume":"30","author":"Rovillain","year":"2011","journal-title":"Oncogene"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"17031","DOI":"10.1073\/pnas.0905299106","article-title":"Cell surface-bound IL-1alpha is an upstream regulator of the senescence-associated IL-6\/IL-8 cytokine network","volume":"106","author":"Orjalo","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"e104296","DOI":"10.15252\/embj.2019104296","article-title":"Transcriptional repression of NFKBIA triggers constitutive IKK- and proteasome-independent p65\/RelA activation in senescence","volume":"40","author":"Kolesnichenko","year":"2021","journal-title":"EMBO J."},{"key":"ref_79","first-page":"3738","article-title":"I\u03baB\u03b6 is a regulator of the senescence-associated secretory phenotype in DNA damage- and oncogene-induced senescence","volume":"126","author":"Alexander","year":"2013","journal-title":"J. Cell Sci."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"110752","DOI":"10.1016\/j.exger.2019.110752","article-title":"Regulation of senescence and the SASP by the transcription factor C\/EBP\u03b2","volume":"128","author":"Salotti","year":"2019","journal-title":"Exp. Gerontol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"7683","DOI":"10.1073\/pnas.1310972111","article-title":"Protein kinase D1 is essential for Ras-induced senescence and tumor suppression by regulating senescence-associated inflammation","volume":"111","author":"Wang","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"e45274","DOI":"10.15252\/embr.201745274","article-title":"CD36 initiates the secretory phenotype during the establishment of cellular senescence","volume":"19","author":"Chong","year":"2018","journal-title":"EMBO Rep."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1159\/000492352","article-title":"Membrane-Bound CD40L Promotes Senescence and Initiates Senescence-Associated Secretory Phenotype via NF-\u03baB Activation in Lung Adenocarcinoma","volume":"48","author":"Xu","year":"2018","journal-title":"Cell Physiol. Biochem."},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Cinat, D., Coppes, R.P., and Barazzuol, L. (2021). DNA Damage-Induced Inflammatory Microenvironment and Adult Stem Cell Response. Front. Cell Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.729136"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1038\/s41580-024-00727-x","article-title":"The senescence-associated secretory phenotype and its physiological and pathological implications","volume":"25","author":"Wang","year":"2024","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/nature05529","article-title":"Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas","volume":"445","author":"Xue","year":"2007","journal-title":"Nature"},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Wiley, C.D., Schaum, N., Alimirah, F., Lopez-Dominguez, J.A., Orjalo, A.V., Scott, G., Desprez, P.Y., Benz, C., Davalos, A.R., and Campisi, J. (2018). Small-molecule MDM2 antagonists attenuate the senescence-associated secretory phenotype. Sci. Rep., 8.","DOI":"10.1038\/s41598-018-20000-4"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"7350","DOI":"10.1158\/0008-5472.CAN-07-0200","article-title":"Induction of p53-dependent senescence by the MDM2 antagonist nutlin-3a in mouse cells of fibroblast origin","volume":"67","author":"Efeyan","year":"2007","journal-title":"Cancer Res."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"36396","DOI":"10.1074\/jbc.M111.257071","article-title":"Tumor suppressor and aging biomarker p16(INK4a) induces cellular senescence without the associated inflammatory secretory phenotype","volume":"286","author":"Rodier","year":"2011","journal-title":"J. Biol. Chem."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"eabb3420","DOI":"10.1126\/science.abb3420","article-title":"p21 produces a bioactive secretome that places stressed cells under immunosurveillance","volume":"374","author":"Sturmlechner","year":"2021","journal-title":"Science"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"3290","DOI":"10.18632\/aging.202640","article-title":"Suppression of p16 alleviates the senescence-associated secretory phenotype","volume":"13","author":"Buj","year":"2021","journal-title":"Aging"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1158\/2159-8290.CD-13-0743","article-title":"p38MAPK plays a crucial role in stromal-mediated tumorigenesis","volume":"4","author":"Alspach","year":"2014","journal-title":"Cancer Discov."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1038\/s41467-018-04010-4","article-title":"The senescence-associated secretory phenotype is potentiated by feedforward regulatory mechanisms involving Zscan4 and TAK1","volume":"9","author":"Zhang","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.1016\/j.molcel.2021.03.018","article-title":"Physiological hypoxia restrains the senescence-associated secretory phenotype via AMPK-mediated mTOR suppression","volume":"81","author":"Wang","year":"2021","journal-title":"Mol. Cell"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"E6301","DOI":"10.1073\/pnas.1515386112","article-title":"JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age","volume":"112","author":"Xu","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Habibi-Kavashkohie, M.R., Scorza, T., and Oubaha, M. (2023). Senescent Cells: Dual Implications on the Retinal Vascular System. Cells, 12.","DOI":"10.3390\/cells12192341"},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Wang, W., Xia, X., Mao, L., and Wang, S. (2019). The CCAAT\/Enhancer-Binding Protein Family: Its Roles in MDSC Expansion and Function. Front. Immunol., 10.","DOI":"10.3389\/fimmu.2019.01804"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.cyto.2019.01.013","article-title":"The senescence-associated secretory phenotype and its regulation","volume":"117","author":"Rowell","year":"2019","journal-title":"Cytokine"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"3242","DOI":"10.1128\/MCB.01674-12","article-title":"C\/EBP\u03b3 suppresses senescence and inflammatory gene expression by heterodimerizing with C\/EBP\u03b2","volume":"33","author":"Huggins","year":"2013","journal-title":"Mol. Cell Biol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1038\/ncb3397","article-title":"NOTCH1 mediates a switch between two distinct secretomes during senescence","volume":"18","author":"Hoare","year":"2016","journal-title":"Nat. Cell Biol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/j.tcb.2017.07.004","article-title":"Spatial and Temporal Control of Senescence","volume":"27","author":"Ito","year":"2017","journal-title":"Trends Cell Biol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1038\/s41392-021-00791-1","article-title":"The JAK\/STAT signaling pathway: From bench to clinic","volume":"6","author":"Hu","year":"2021","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.phrs.2016.05.015","article-title":"Perspective: Targeting the JAK\/STAT pathway to fight age-related dysfunction","volume":"111","author":"Xu","year":"2016","journal-title":"Pharmacol. Res."},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Chen, M., Xiao, L., Dai, G., Lu, P., Zhang, Y., Li, Y., Ni, M., and Rui, Y. (2021). Inhibition of JAK-STAT Signaling Pathway Alleviates Age-Related Phenotypes in Tendon Stem\/Progenitor Cells. Front. Cell Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.650250"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.tips.2020.06.007","article-title":"Targeting JAK-STAT Signaling to Control Cytokine Release Syndrome in COVID-19","volume":"41","author":"Luo","year":"2020","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s41232-020-00146-3","article-title":"How COVID-19 induces cytokine storm with high mortality","volume":"40","author":"Hojyo","year":"2020","journal-title":"Inflamm. Regen."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1038\/ncb3586","article-title":"Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence","volume":"19","author":"Guey","year":"2017","journal-title":"Nat. Cell Biol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"E4612","DOI":"10.1073\/pnas.1705499114","article-title":"cGAS is essential for cellular senescence","volume":"114","author":"Yang","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1038\/nature24050","article-title":"Cytoplasmic chromatin triggers inflammation in senescence and cancer","volume":"550","author":"Dou","year":"2017","journal-title":"Nature"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1038\/s41467-018-03555-8","article-title":"Downregulation of cytoplasmic DNases is implicated in cytoplasmic DNA accumulation and SASP in senescent cells","volume":"9","author":"Takahashi","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1038\/s41467-020-14652-y","article-title":"Topoisomerase 1 cleavage complex enables pattern recognition and inflammation during senescence","volume":"11","author":"Zhao","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"4979","DOI":"10.1038\/s41467-020-18734-9","article-title":"G3BP1 controls the senescence-associated secretome and its impact on cancer progression","volume":"11","author":"Omer","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"eaaw0254","DOI":"10.1126\/sciadv.aaw0254","article-title":"The innate immune sensor Toll-like receptor 2 controls the senescence-associated secretory phenotype","volume":"5","author":"Hari","year":"2019","journal-title":"Sci. Adv."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"eaao6047","DOI":"10.1126\/science.aao6047","article-title":"BAK\/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis","volume":"359","author":"McArthur","year":"2018","journal-title":"Science"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1038\/s41586-023-06373-1","article-title":"cGAS-STING drives ageing-related inflammation and neurodegeneration","volume":"620","author":"Gulen","year":"2023","journal-title":"Nature"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1016\/j.cell.2013.05.039","article-title":"The hallmarks of aging","volume":"153","author":"Blasco","year":"2013","journal-title":"Cell"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"e13566","DOI":"10.1111\/acel.13566","article-title":"Accumulation of systematic TPM1 mediates inflammation and neuronal remodeling by phosphorylating PKA and regulating the FABP5\/NF-\u03baB signaling pathway in the retina of aged mice","volume":"21","author":"Li","year":"2022","journal-title":"Aging Cell"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1038\/nn.3772","article-title":"LKB1 and AMPK regulate synaptic remodeling in old age","volume":"17","author":"Samuel","year":"2014","journal-title":"Nat. Neurosci."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"e2311028121","DOI":"10.1073\/pnas.2311028121","article-title":"Senolytic and senomorphic agent procyanidin C1 alleviates structural and functional decline in the aged retina","volume":"121","author":"Liu","year":"2024","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"e1221","DOI":"10.1016\/S2214-109X(17)30393-5","article-title":"Global causes of blindness and distance vision impairment 1990-2020: A systematic review and meta-analysis","volume":"5","author":"Flaxman","year":"2017","journal-title":"Lancet Glob. Health"},{"key":"ref_121","doi-asserted-by":"crossref","unstructured":"Liu, H., and Prokosch, V. (2021). Energy Metabolism in the Inner Retina in Health and Glaucoma. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22073689"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"362ra144","DOI":"10.1126\/scitranslmed.aaf9440","article-title":"Senescence-associated secretory phenotype contributes to pathological angiogenesis in retinopathy","volume":"8","author":"Oubaha","year":"2016","journal-title":"Sci. Transl. Med."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.tcb.2018.03.003","article-title":"Cellular Senescence in Postmitotic Cells: Beyond Growth Arrest","volume":"28","author":"Sapieha","year":"2018","journal-title":"Trends Cell Biol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"Orsf60","DOI":"10.1167\/iovs.13-12716","article-title":"Glaucoma: A disease of early cellular senescence","volume":"54","author":"Caprioli","year":"2013","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"11181","DOI":"10.1073\/pnas.1402819111","article-title":"Caspase-8 promotes NLRP1\/NLRP3 inflammasome activation and IL-1\u03b2 production in acute glaucoma","volume":"111","author":"Chi","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"664","DOI":"10.14336\/AD.2018.0720","article-title":"Reactive Astrocytes in Neurodegenerative Diseases","volume":"10","author":"Li","year":"2019","journal-title":"Aging Dis."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"100886","DOI":"10.1016\/j.preteyeres.2020.100886","article-title":"Role of glia in optic nerve","volume":"81","author":"Yazdankhah","year":"2021","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nature21029","article-title":"Neurotoxic reactive astrocytes are induced by activated microglia","volume":"541","author":"Liddelow","year":"2017","journal-title":"Nature"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/j.immuni.2017.06.006","article-title":"Reactive Astrocytes: Production, Function, and Therapeutic Potential","volume":"46","author":"Liddelow","year":"2017","journal-title":"Immunity"},{"key":"ref_130","doi-asserted-by":"crossref","unstructured":"Ashok, A., Pooranawattanakul, S., Tai, W.L., Cho, K.S., Utheim, T.P., Cestari, D.M., and Chen, D.F. (2022). Epigenetic Regulation of Optic Nerve Development, Protection, and Repair. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23168927"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"18810","DOI":"10.1073\/pnas.2009425117","article-title":"Redistribution of metabolic resources through astrocyte networks mitigates neurodegenerative stress","volume":"117","author":"Cooper","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"Garc\u00eda-Berm\u00fadez, M.Y., Freude, K.K., Mouhammad, Z.A., van Wijngaarden, P., Martin, K.K., and Kolko, M. (2021). Glial Cells in Glaucoma: Friends, Foes, and Potential Therapeutic Targets. Front. Neurol., 12.","DOI":"10.3389\/fneur.2021.624983"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.exer.2013.03.019","article-title":"Lipofuscin in human glaucomatous optic nerves","volume":"111","author":"Mullins","year":"2013","journal-title":"Exp. Eye Res."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/978-3-319-17121-0_11","article-title":"Aging Changes in Retinal Microglia and their Relevance to Age-related Retinal Disease","volume":"854","author":"Ma","year":"2016","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1146\/annurev-vision-112122-020950","article-title":"Structure, Function, and Molecular Landscapes of the Aging Retina","volume":"9","author":"Zhu","year":"2023","journal-title":"Annu. Rev. Vis. Sci."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1007\/s00335-015-9568-9","article-title":"Genomic regulation of senescence and innate immunity signaling in the retinal pigment epithelium","volume":"26","author":"Chaum","year":"2015","journal-title":"Mamm. Genome"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/978-3-030-66014-7_7","article-title":"AMD Genetics: Methods and Analyses for Association, Progression, and Prediction","volume":"1256","author":"Yan","year":"2021","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"e168945","DOI":"10.1172\/jci.insight.168945","article-title":"Activated cGAS\/STING signaling elicits endothelial cell senescence in early diabetic retinopathy","volume":"8","author":"Liu","year":"2023","journal-title":"JCI Insight"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"441","DOI":"10.4093\/dmj.2022.0416","article-title":"Regulation of Cellular Senescence in Type 2 Diabetes Mellitus: From Mechanisms to Clinical Applications","volume":"47","author":"Iwasaki","year":"2023","journal-title":"Diabetes Metab. J."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"101735","DOI":"10.1016\/j.arr.2022.101735","article-title":"Interplay between aging and other factors of the pathogenesis of age-related macular degeneration","volume":"81","author":"Blasiak","year":"2022","journal-title":"Ageing Res. Rev."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"9813","DOI":"10.18632\/aging.205900","article-title":"Targeting cGAS-STING signaling protects retinal ganglion cells from DNA damage-induced cell loss and promotes visual recovery in glaucoma","volume":"16","author":"Zhang","year":"2024","journal-title":"Aging"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"108709","DOI":"10.1016\/j.exer.2021.108709","article-title":"Hallmarks of lens aging and cataractogenesis","volume":"210","author":"Wishart","year":"2021","journal-title":"Exp. Eye Res."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"e180248","DOI":"10.1172\/jci.insight.180248","article-title":"Neutrophil extracellular traps potentiate effector T cells via endothelial senescence in uveitis","volume":"10","author":"Li","year":"2025","journal-title":"JCI Insight"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"e089827","DOI":"10.1136\/bmjopen-2024-089827","article-title":"Multicentre, 26-week, open-label phase 2 trial of the JAK inhibitor filgotinib in Beh\u00e7et\u2019s disease, idiopathic inflammatory myopathies and IgG4-related disease: DRIMID study protocol","volume":"15","author":"Raaphorst","year":"2025","journal-title":"BMJ Open"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.preteyeres.2015.08.001","article-title":"The progress in understanding and treatment of diabetic retinopathy","volume":"51","author":"Stitt","year":"2016","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/s41574-020-00451-4","article-title":"Current understanding of the molecular and cellular pathology of diabetic retinopathy","volume":"17","author":"Antonetti","year":"2021","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"101051","DOI":"10.1016\/j.preteyeres.2022.101051","article-title":"It is time for a moonshot to find \u201cCures\u201d for diabetic retinal disease","volume":"90","author":"Levine","year":"2022","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.preteyeres.2019.01.001","article-title":"Retinal capillary perfusion: Spatial and temporal heterogeneity","volume":"70","author":"Yu","year":"2019","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/j.cmet.2019.01.021","article-title":"Targeted Elimination of Senescent Beta Cells Prevents Type 1 Diabetes","volume":"29","author":"Thompson","year":"2019","journal-title":"Cell Metab."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.cmet.2019.05.006","article-title":"Acceleration of \u03b2 Cell Aging Determines Diabetes and Senolysis Improves Disease Outcomes","volume":"30","author":"Andle","year":"2019","journal-title":"Cell Metab."},{"key":"ref_151","doi-asserted-by":"crossref","unstructured":"Su, L., Kong, X., Loo, S.J., Gao, Y., Kovalik, J.P., Su, X., Ma, J., and Ye, L. (2021). Diabetic Endothelial Cells Differentiated From Patient iPSCs Show Dysregulated Glycine Homeostasis and Senescence Associated Phenotypes. Front. Cell Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.667252"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"eaay5356","DOI":"10.1126\/science.aay5356","article-title":"Neutrophil extracellular traps target senescent vasculature for tissue remodeling in retinopathy","volume":"369","author":"Binet","year":"2020","journal-title":"Science"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1016\/j.cmet.2021.01.011","article-title":"Pathological angiogenesis in retinopathy engages cellular senescence and is amenable to therapeutic elimination via BCL-xL inhibition","volume":"33","author":"Tsuruda","year":"2021","journal-title":"Cell Metab."},{"key":"ref_154","doi-asserted-by":"crossref","unstructured":"Shosha, E., Xu, Z., Narayanan, S.P., Lemtalsi, T., Fouda, A.Y., Rojas, M., Xing, J., Fulton, D., Caldwell, R.W., and Caldwell, R.B. (2018). Mechanisms of Diabetes-Induced Endothelial Cell Senescence: Role of Arginase 1. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19041215"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"e13234","DOI":"10.1111\/acel.13234","article-title":"Type I interferons and related pathways in cell senescence","volume":"19","author":"Frisch","year":"2020","journal-title":"Aging Cell"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/nature23449","article-title":"cGAS surveillance of micronuclei links genome instability to innate immunity","volume":"548","author":"Mackenzie","year":"2017","journal-title":"Nature"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"831","DOI":"10.15252\/embj.201593339","article-title":"Ribonuclease H2 mutations induce a cGAS\/STING-dependent innate immune response","volume":"35","author":"Mackenzie","year":"2016","journal-title":"EMBO J."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.1016\/j.celrep.2019.01.105","article-title":"The N-Terminal Domain of cGAS Determines Preferential Association with Centromeric DNA and Innate Immune Activation in the Nucleus","volume":"26","author":"Gentili","year":"2019","journal-title":"Cell Rep."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"e106","DOI":"10.1016\/S2214-109X(13)70145-1","article-title":"Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: A systematic review and meta-analysis","volume":"2","author":"Wong","year":"2014","journal-title":"Lancet Glob. Health"},{"key":"ref_160","first-page":"493","article-title":"Updates on the Epidemiology of Age-Related Macular Degeneration","volume":"6","author":"Jonas","year":"2017","journal-title":"Asia Pac. J. Ophthalmol."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.mcna.2021.01.003","article-title":"Age-Related Macular Degeneration","volume":"105","author":"Thomas","year":"2021","journal-title":"Med. Clin. N. Am."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1038\/eye.2016.216","article-title":"Structural and molecular changes in the aging choroid: Implications for age-related macular degeneration","volume":"31","author":"Chirco","year":"2017","journal-title":"Eye"},{"key":"ref_163","doi-asserted-by":"crossref","unstructured":"Yeo, N.J.Y., Chan, E.J.J., and Cheung, C. (2019). Choroidal Neovascularization: Mechanisms of Endothelial Dysfunction. Front. Pharmacol., 10.","DOI":"10.3389\/fphar.2019.01363"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1167\/iovs.62.3.12","article-title":"Exploring the Relationship Between Multilayered Choroidal Neovascularization and Choriocapillaris Flow Deficits in AMD","volume":"62","author":"Nesper","year":"2021","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"108918","DOI":"10.1016\/j.exer.2021.108918","article-title":"Mechanisms of RPE senescence and potential role of \u03b1B crystallin peptide as a senolytic agent in experimental AMD","volume":"215","author":"Sreekumar","year":"2022","journal-title":"Exp. Eye Res."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.preteyeres.2017.03.002","article-title":"The impact of oxidative stress and inflammation on RPE degeneration in non-neovascular AMD","volume":"60","author":"Datta","year":"2017","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"3242","DOI":"10.1167\/iovs.14-16274","article-title":"Lipofuscin redistribution and loss accompanied by cytoskeletal stress in retinal pigment epithelium of eyes with age-related macular degeneration","volume":"56","author":"Ach","year":"2015","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"109254","DOI":"10.1016\/j.exer.2022.109254","article-title":"Does senescence play a role in age-related macular degeneration?","volume":"225","author":"Malek","year":"2022","journal-title":"Exp. Eye Res."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/978-3-030-66014-7_10","article-title":"Mitochondria: The Retina\u2019s Achilles\u2019 Heel in AMD","volume":"1256","author":"Ferrington","year":"2021","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_170","doi-asserted-by":"crossref","unstructured":"Cheng, M., Lin, N., Dong, D., Ma, J., Su, J., and Sun, L. (2021). PGAM5: A crucial role in mitochondrial dynamics and programmed cell death. Eur. J. Cell Biol., 100.","DOI":"10.1016\/j.ejcb.2020.151144"},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"2549","DOI":"10.1038\/s41467-020-16312-7","article-title":"Mitochondrial phosphatase PGAM5 modulates cellular senescence by regulating mitochondrial dynamics","volume":"11","author":"Yu","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.mcna.2021.01.004","article-title":"Glaucoma","volume":"105","author":"Kang","year":"2021","journal-title":"Med. Clin. N. Am."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"100916","DOI":"10.1016\/j.preteyeres.2020.100916","article-title":"Inflammation in Glaucoma: From the back to the front of the eye, and beyond","volume":"83","author":"Baudouin","year":"2021","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1038\/s41588-023-01428-5","article-title":"Large-scale multitrait genome-wide association analyses identify hundreds of glaucoma risk loci","volume":"55","author":"Han","year":"2023","journal-title":"Nat. Genet."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"101066","DOI":"10.1016\/j.preteyeres.2022.101066","article-title":"The genetic basis for adult onset glaucoma: Recent advances and future directions","volume":"90","author":"Wang","year":"2022","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"79","DOI":"10.5005\/jp-journals-10078-1403","article-title":"Prevalence of Glu323Lys Mutation of the TIGR\/MYOC Gene and Risk Factors amongst Primary Open-angle Glaucoma Patients in Ouagadougou, Burkina Faso","volume":"17","author":"Sanou","year":"2023","journal-title":"J. Curr. Glaucoma Pract."},{"key":"ref_177","doi-asserted-by":"crossref","unstructured":"Huang, C., Xie, L., Wu, Z., Cao, Y., Zheng, Y., Pang, C.P., and Zhang, M. (2018). Detection of mutations in MYOC, OPTN, NTF4, WDR36 and CYP1B1 in Chinese juvenile onset open-angle glaucoma using exome sequencing. Sci. Rep., 8.","DOI":"10.1038\/s41598-018-22337-2"},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"e143359","DOI":"10.1172\/jci.insight.143359","article-title":"Autophagy stimulation reduces ocular hypertension in a murine glaucoma model via autophagic degradation of mutant myocilin","volume":"6","author":"Kasetti","year":"2021","journal-title":"JCI Insight"},{"key":"ref_179","doi-asserted-by":"crossref","unstructured":"Want, A., Gillespie, S.R., Wang, Z., Gordon, R., Iomini, C., Ritch, R., Wolosin, J.M., and Bernstein, A.M. (2016). Autophagy and Mitochondrial Dysfunction in Tenon Fibroblasts from Exfoliation Glaucoma Patients. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0157404"},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/bs.apcsb.2019.09.005","article-title":"LOXL1 folding in exfoliation glaucoma","volume":"118","author":"Bernstein","year":"2019","journal-title":"Adv. Protein Chem. Struct. Biol."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.expneurol.2017.07.001","article-title":"Age-related accumulation of phosphorylated mitofusin 2 protein in retinal ganglion cells correlates with glaucoma progression","volume":"296","author":"Nivison","year":"2017","journal-title":"Exp. Neurol."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1080\/02713683.2019.1657462","article-title":"Mitochondria and Autophagy Dysfunction in Glucocorticoid-Induced Ocular Hypertension\/Glaucoma Mice Model","volume":"45","author":"Zeng","year":"2020","journal-title":"Curr. Eye Res."},{"key":"ref_183","doi-asserted-by":"crossref","unstructured":"Park, H.L., Kim, J.H., and Park, C.K. (2018). Different contributions of autophagy to retinal ganglion cell death in the diabetic and glaucomatous retinas. Sci. Rep., 8.","DOI":"10.1038\/s41598-018-30165-7"},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/s41420-020-0257-4","article-title":"Age related retinal Ganglion cell susceptibility in context of autophagy deficiency","volume":"6","author":"Bell","year":"2020","journal-title":"Cell Death Discov."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.ajo.2014.09.044","article-title":"Copy number variations of TBK1 in Australian patients with primary open-angle glaucoma","volume":"159","author":"Awadalla","year":"2015","journal-title":"Am. J. Ophthalmol."},{"key":"ref_186","doi-asserted-by":"crossref","unstructured":"Sirohi, K., Kumari, A., Radha, V., and Swarup, G. (2015). A Glaucoma-Associated Variant of Optineurin, M98K, Activates Tbk1 to Enhance Autophagosome Formation and Retinal Cell Death Dependent on Ser177 Phosphorylation of Optineurin. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0138289"},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.exer.2019.02.004","article-title":"Altered unfolded protein response and proteasome impairment in pseudoexfoliation pathogenesis","volume":"181","author":"Hayat","year":"2019","journal-title":"Exp. Eye Res."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1038\/s41420-018-0077-y","article-title":"Contribution of autophagy to ocular hypertension and neurodegeneration in the DBA\/2J spontaneous glaucoma mouse model","volume":"4","author":"Hirt","year":"2018","journal-title":"Cell Death Discov."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.pop.2015.05.012","article-title":"Cataracts","volume":"42","author":"Thompson","year":"2015","journal-title":"Prim. Care"},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1111\/aos.13370","article-title":"Exposure to subthreshold dose of UVR-B induces apoptosis in the lens epithelial cells and does not in the lens cortical fibre cells","volume":"95","author":"Galichanin","year":"2017","journal-title":"Acta Ophthalmol."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"20150391","DOI":"10.1098\/rsif.2015.0391","article-title":"A dimensionless ordered pull-through model of the mammalian lens epithelium evidences scaling across species and explains the age-dependent changes in cell density in the human lens","volume":"12","author":"Wu","year":"2015","journal-title":"J. R. Soc. Interface"},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s11010-014-2294-x","article-title":"The mechanism of UVB irradiation induced-apoptosis in cataract","volume":"401","author":"Ji","year":"2015","journal-title":"Mol. Cell Biochem."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/s41419-021-04489-8","article-title":"Autophagy facilitates age-related cell apoptosis-a new insight from senile cataract","volume":"13","author":"Huang","year":"2022","journal-title":"Cell Death Dis."},{"key":"ref_194","doi-asserted-by":"crossref","unstructured":"Cui, X., Feng, R., Wang, J., Du, C., Pi, X., Chen, D., Li, J., Li, H., Zhang, J., and Zhang, J. (2020). Heat shock factor 4 regulates lysosome activity by modulating the \u03b1B-crystallin-ATP6V1A-mTOR complex in ocular lens. Biochim. Biophys. Acta Gen. Subj., 1864.","DOI":"10.1016\/j.bbagen.2019.129496"},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"3323","DOI":"10.1080\/15548627.2021.1872188","article-title":"Rapamycin relieves the cataract caused by ablation of Gja8b through stimulating autophagy in zebrafish","volume":"17","author":"Ping","year":"2021","journal-title":"Autophagy"},{"key":"ref_196","doi-asserted-by":"crossref","unstructured":"Quinlan, R.A., and Clark, J.I. (2022). Insights into the biochemical and biophysical mechanisms mediating the longevity of the transparent optics of the eye lens. J. Biol. Chem., 298.","DOI":"10.1016\/j.jbc.2022.102537"},{"key":"ref_197","doi-asserted-by":"crossref","unstructured":"Hazen, P., Trossi-Torres, G., Timsina, R., Khadka, N.K., and Mainali, L. (2024). Association of Alpha-Crystallin with Human Cortical and Nuclear Lens Lipid Membrane Increases with the Grade of Cortical and Nuclear Cataract. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25031936"},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1056\/NEJMra1407936","article-title":"Dry Eye","volume":"378","author":"Clayton","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/j.jtos.2017.08.003","article-title":"TFOS DEWS II Report Executive Summary","volume":"15","author":"Craig","year":"2017","journal-title":"Ocul. Surf."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1167\/iovs.18-25822","article-title":"InflammAging at Ocular Surface: Clinical and Biomolecular Analyses in Healthy Volunteers","volume":"60","author":"Micera","year":"2019","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_201","doi-asserted-by":"crossref","unstructured":"Barabino, S. (2022). Is dry eye disease the same in young and old patients? A narrative review of the literature. BMC Ophthalmol., 22.","DOI":"10.1186\/s12886-022-02269-2"},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"3996","DOI":"10.1167\/iovs.15-18467","article-title":"Functional and Morphologic Changes of Meibomian Glands in an Asymptomatic Adult Population","volume":"57","author":"Yeotikar","year":"2016","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"5046","DOI":"10.1167\/iovs.14-14689","article-title":"Androgen deficiency and dry eye syndrome in the aging male","volume":"55","author":"Azcarate","year":"2014","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_204","doi-asserted-by":"crossref","unstructured":"Li, J., Ma, J., Hu, M., Yu, J., and Zhao, Y. (2020). Assessment of tear film lipid layer thickness in patients with Meibomian gland dysfunction at different ages. BMC Ophthalmol., 20.","DOI":"10.1186\/s12886-020-01667-8"},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.clae.2010.03.002","article-title":"Tear film evaporation--effect of age and gender","volume":"33","author":"Guillon","year":"2010","journal-title":"Cont. Lens Anterior Eye"},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/eye.2009.21","article-title":"Age- and gender-related tear function changes in normal population","volume":"24","author":"Ozdemir","year":"2010","journal-title":"Eye"},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1136\/bjophthalmol-2015-307848","article-title":"Ageing and ocular surface immunity","volume":"101","author":"Mashaghi","year":"2017","journal-title":"Br. J. Ophthalmol."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.jtos.2021.02.007","article-title":"The ocular surface immune system through the eyes of aging","volume":"20","author":"Galletti","year":"2021","journal-title":"Ocul. Surf."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.ajpath.2020.10.013","article-title":"Modulation of Oxidative Stress and Inflammation in the Aged Lacrimal Gland","volume":"191","author":"Yu","year":"2021","journal-title":"Am. J. Pathol."},{"key":"ref_210","doi-asserted-by":"crossref","unstructured":"Yoon, C.H., Ryu, J.S., Hwang, H.S., and Kim, M.K. (2020). Comparative Analysis of Age-Related Changes in Lacrimal Glands and Meibomian Glands of a C57BL\/6 Male Mouse Model. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21114169"},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"5725","DOI":"10.4049\/jimmunol.1500319","article-title":"A CD153+CD4+ T follicular cell population with cell-senescence features plays a crucial role in lupus pathogenesis via osteopontin production","volume":"194","author":"Tahir","year":"2015","journal-title":"J. Immunol."},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.jtos.2023.11.003","article-title":"Recent advances in age-related meibomian gland dysfunction (ARMGD)","volume":"30","author":"Moreno","year":"2023","journal-title":"Ocul. Surf."},{"key":"ref_213","first-page":"518","article-title":"Transcriptome analysis of aging mouse meibomian glands","volume":"22","author":"Parfitt","year":"2016","journal-title":"Mol. Vis."},{"key":"ref_214","doi-asserted-by":"crossref","unstructured":"Sledge, S., Henry, C., Borchman, D., Yappert, M.C., Bhola, R., Ramasubramanian, A., Blackburn, R., Austin, J., Massey, K., and Sayied, S. (2017). Human Meibum Age, Lipid-Lipid Interactions and Lipid Saturation in Meibum from Infants. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18091862"},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.jtos.2021.10.003","article-title":"Alteration in meibum lipid composition and subjective symptoms due to aging and meibomian gland dysfunction","volume":"26","author":"Suzuki","year":"2022","journal-title":"Ocul. Surf."},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"825","DOI":"10.18632\/aging.100615","article-title":"Absence of ductal hyper-keratinization in mouse age-related meibomian gland dysfunction (ARMGD)","volume":"5","author":"Parfitt","year":"2013","journal-title":"Aging"},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1097\/ICO.0b013e31820ca468","article-title":"Evaluation of age-related changes in human palpebral conjunctiva and meibomian glands by in vivo confocal microscopy","volume":"30","author":"Wei","year":"2011","journal-title":"Cornea"},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1097\/ICO.0000000000000815","article-title":"Epidemiology of Meibomian Gland Dysfunction in an Elderly Population","volume":"35","author":"Alghamdi","year":"2016","journal-title":"Cornea"},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"103160","DOI":"10.1016\/j.jaut.2023.103160","article-title":"Single-cell sequencing of the retina shows that LDHA regulates pathogenesis of autoimmune uveitis","volume":"143","author":"Peng","year":"2024","journal-title":"J. Autoimmun."},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1001\/jamaophthalmol.2016.3229","article-title":"Prevalence of Noninfectious Uveitis in the United States: A Claims-Based Analysis","volume":"134","author":"Thorne","year":"2016","journal-title":"JAMA Ophthalmol."},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1172\/JCI15155","article-title":"A humanized model of experimental autoimmune uveitis in HLA class II transgenic mice","volume":"111","author":"Pennesi","year":"2003","journal-title":"J. Clin. Investig."},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1111\/imr.12399","article-title":"Lymph node\u2014An organ for T-cell activation and pathogen defense","volume":"271","author":"Gasteiger","year":"2016","journal-title":"Immunol. Rev."},{"key":"ref_223","doi-asserted-by":"crossref","unstructured":"Richner, J.M., Gmyrek, G.B., Govero, J., Tu, Y., van der Windt, G.J., Metcalf, T.U., Haddad, E.K., Textor, J., Miller, M.J., and Diamond, M.S. (2015). Age-Dependent Cell Trafficking Defects in Draining Lymph Nodes Impair Adaptive Immunity and Control of West Nile Virus Infection. PLoS Pathog., 11.","DOI":"10.1371\/journal.ppat.1005027"},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1111\/imm.12727","article-title":"Structural and functional changes to lymph nodes in ageing mice","volume":"151","author":"Turner","year":"2017","journal-title":"Immunology"},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1007\/s13238-021-00882-3","article-title":"Aging weakens Th17 cell pathogenicity and ameliorates experimental autoimmune uveitis in mice","volume":"13","author":"Li","year":"2022","journal-title":"Protein Cell"},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1038\/mi.2016.83","article-title":"Age-related spontaneous lacrimal keratoconjunctivitis is accompanied by dysfunctional T regulatory cells","volume":"10","author":"Coursey","year":"2017","journal-title":"Mucosal Immunol."},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.molmed.2020.03.005","article-title":"Reducing Senescent Cell Burden in Aging and Disease","volume":"26","author":"Pignolo","year":"2020","journal-title":"Trends Mol. Med."},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1158\/2159-8290.CD-16-0062","article-title":"Role of Telomeres and Telomerase in Aging and Cancer","volume":"6","author":"Shay","year":"2016","journal-title":"Cancer Discov."},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/nature05159","article-title":"Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a","volume":"443","author":"Janzen","year":"2006","journal-title":"Nature"},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1186\/s13287-024-03915-w","article-title":"Obesity modulates hematopoietic stem cell fate decision via IL-1\u03b2 induced p38\/MAPK signaling pathway","volume":"15","author":"Yan","year":"2024","journal-title":"Stem Cell Res. Ther."},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1111\/acel.12344","article-title":"The Achilles\u2019 heel of senescent cells: From transcriptome to senolytic drugs","volume":"14","author":"Zhu","year":"2015","journal-title":"Aging Cell"},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.molmed.2018.08.002","article-title":"Cellular Senescence: The Sought or the Unwanted?","volume":"24","author":"Sun","year":"2018","journal-title":"Trends Mol. Med."},{"key":"ref_233","doi-asserted-by":"crossref","unstructured":"Knoppert, S.N., Valentijn, F.A., Nguyen, T.Q., Goldschmeding, R., and Falke, L.L. (2019). Cellular Senescence and the Kidney: Potential Therapeutic Targets and Tools. Front. Pharmacol., 10.","DOI":"10.3389\/fphar.2019.00770"},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"e163762","DOI":"10.1172\/jci.insight.163762","article-title":"Inhibition of antiapoptotic BCL-2 proteins with ABT-263 induces fibroblast apoptosis, reversing persistent pulmonary fibrosis","volume":"8","author":"Cooley","year":"2023","journal-title":"JCI Insight"},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/nm.4010","article-title":"Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice","volume":"22","author":"Chang","year":"2016","journal-title":"Nat. Med."},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1111\/acel.12445","article-title":"Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors","volume":"15","author":"Zhu","year":"2016","journal-title":"Aging Cell"},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1038\/s41467-017-00314-z","article-title":"Identification of HSP90 inhibitors as a novel class of senolytics","volume":"8","author":"Ling","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_238","doi-asserted-by":"crossref","first-page":"e12780","DOI":"10.1111\/acel.12780","article-title":"Oxidation resistance 1 is a novel senolytic target","volume":"17","author":"Zhang","year":"2018","journal-title":"Aging Cell"},{"key":"ref_239","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1101\/gad.349585.122","article-title":"Senescence-induced endothelial phenotypes underpin immune-mediated senescence surveillance","volume":"36","author":"Yin","year":"2022","journal-title":"Genes. Dev."},{"key":"ref_240","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1038\/s41586-020-2403-9","article-title":"Senolytic CAR T cells reverse senescence-associated pathologies","volume":"583","author":"Amor","year":"2020","journal-title":"Nature"},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1038\/s41586-022-05388-4","article-title":"Blocking PD-L1-PD-1 improves senescence surveillance and ageing phenotypes","volume":"611","author":"Wang","year":"2022","journal-title":"Nature"},{"key":"ref_242","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1038\/nm.4385","article-title":"Targeting cellular senescence prevents age-related bone loss in mice","volume":"23","author":"Farr","year":"2017","journal-title":"Nat. Med."},{"key":"ref_243","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1016\/j.celrep.2017.12.092","article-title":"Cellular Senescence Is Induced by the Environmental Neurotoxin Paraquat and Contributes to Neuropathology Linked to Parkinson\u2019s Disease","volume":"22","author":"Chinta","year":"2018","journal-title":"Cell Rep."},{"key":"ref_244","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/j.tcb.2020.07.002","article-title":"A Senescence-Centric View of Aging: Implications for Longevity and Disease","volume":"30","author":"Borghesan","year":"2020","journal-title":"Trends Cell Biol."},{"key":"ref_245","doi-asserted-by":"crossref","first-page":"111347","DOI":"10.1016\/j.mad.2020.111347","article-title":"AMPK alleviates oxidative stress-induced premature senescence via inhibition of NF-\u03baB\/STAT3 axis-mediated positive feedback loop","volume":"191","author":"Han","year":"2020","journal-title":"Mech. Ageing Dev."},{"key":"ref_246","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s12974-021-02088-0","article-title":"Cellular senescence in the aging retina and developments of senotherapies for age-related macular degeneration","volume":"18","author":"Lee","year":"2021","journal-title":"J. Neuroinflamm."},{"key":"ref_247","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1126\/science.aaw1299","article-title":"Senolytic therapies for healthy longevity","volume":"364","year":"2019","journal-title":"Science"},{"key":"ref_248","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/s41591-024-02802-4","article-title":"Therapeutic targeting of cellular senescence in diabetic macular edema: Preclinical and phase 1 trial results","volume":"30","author":"Fournier","year":"2024","journal-title":"Nat. Med."},{"key":"ref_249","doi-asserted-by":"crossref","first-page":"155375","DOI":"10.1016\/j.cyto.2020.155375","article-title":"RNA-Seq analysis reveals gene expression changes induced by IL-6 trans-signaling activation in retinal endothelial cells","volume":"139","author":"Robinson","year":"2021","journal-title":"Cytokine"},{"key":"ref_250","doi-asserted-by":"crossref","unstructured":"Robinson, R., Srinivasan, M., Shanmugam, A., Ward, A., Ganapathy, V., Bloom, J., Sharma, A., and Sharma, S. (2020). Interleukin-6 trans-signaling inhibition prevents oxidative stress in a mouse model of early diabetic retinopathy. Redox Biol., 34.","DOI":"10.1016\/j.redox.2020.101574"},{"key":"ref_251","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.exer.2018.09.009","article-title":"Inhibition of interleukin-6 trans-signaling prevents inflammation and endothelial barrier disruption in retinal endothelial cells","volume":"178","author":"Valle","year":"2019","journal-title":"Exp. Eye Res."},{"key":"ref_252","doi-asserted-by":"crossref","first-page":"109721","DOI":"10.1016\/j.exer.2023.109721","article-title":"Blockade of interleukin-6 trans-signaling prevents mitochondrial dysfunction and cellular senescence in retinal endothelial cells","volume":"237","author":"Hoffman","year":"2023","journal-title":"Exp. Eye Res."},{"key":"ref_253","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1038\/s41467-020-15719-6","article-title":"A BET family protein degrader provokes senolysis by targeting NHEJ and autophagy in senescent cells","volume":"11","author":"Wakita","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_254","first-page":"149","article-title":"Epigenetic intervention with a BET inhibitor ameliorates acute retinal ganglion cell death in mice","volume":"23","author":"Li","year":"2017","journal-title":"Mol. Vis."},{"key":"ref_255","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1083\/jcb.201708092","article-title":"Senescence and aging: Causes, consequences, and therapeutic avenues","volume":"217","author":"McHugh","year":"2018","journal-title":"J. Cell Biol."},{"key":"ref_256","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1111\/ceo.13834","article-title":"Retinal pigment epithelium and age-related macular degeneration: A review of major disease mechanisms","volume":"48","author":"Somasundaran","year":"2020","journal-title":"Clin. Exp. Ophthalmol."},{"key":"ref_257","doi-asserted-by":"crossref","first-page":"108391","DOI":"10.1016\/j.exer.2020.108391","article-title":"Evolution of oxidative stress, inflammation and neovascularization in the choroid and retina in a subretinal lipid induced age-related macular degeneration model","volume":"203","author":"Kim","year":"2021","journal-title":"Exp. Eye Res."},{"key":"ref_258","doi-asserted-by":"crossref","first-page":"575","DOI":"10.2174\/1566524019666190107154250","article-title":"Inhibition of Sumoylation Alleviates Oxidative Stress-induced Retinal Pigment Epithelial Cell Senescence and Represses Proinflammatory Gene Expression","volume":"18","author":"Sun","year":"2018","journal-title":"Curr. Mol. Med."},{"key":"ref_259","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1007\/s12035-012-8391-5","article-title":"The ubiquitin-proteasome system in retinal health and disease","volume":"47","author":"Campello","year":"2013","journal-title":"Mol. Neurobiol."},{"key":"ref_260","doi-asserted-by":"crossref","unstructured":"Jun, B., Mukherjee, P.K., Asatryan, A., Kautzmann, M.A., Heap, J., Gordon, W.C., Bhattacharjee, S., Yang, R., Petasis, N.A., and Bazan, N.G. (2017). Elovanoids are novel cell-specific lipid mediators necessary for neuroprotective signaling for photoreceptor cell integrity. Sci. Rep., 7.","DOI":"10.1038\/s41598-017-05433-7"},{"key":"ref_261","doi-asserted-by":"crossref","first-page":"24317","DOI":"10.1073\/pnas.1912959116","article-title":"Elovanoids counteract oligomeric \u03b2-amyloid-induced gene expression and protect photoreceptors","volume":"116","author":"Do","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_262","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1167\/iovs.15-17053","article-title":"The Mitochondrial-Derived Peptide Humanin Protects RPE Cells From Oxidative Stress, Senescence, and Mitochondrial Dysfunction","volume":"57","author":"Sreekumar","year":"2016","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_263","doi-asserted-by":"crossref","first-page":"3347","DOI":"10.1038\/s41467-019-11262-1","article-title":"A systems biology approach towards understanding and treating non-neovascular age-related macular degeneration","volume":"10","author":"Handa","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_264","doi-asserted-by":"crossref","first-page":"Amd83","DOI":"10.1167\/iovs.18-23893","article-title":"A Perspective of AMD Through the Eyes of Immunology","volume":"59","author":"Copland","year":"2018","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_265","doi-asserted-by":"crossref","unstructured":"Liu, J., Copland, D.A., Horie, S., Wu, W.K., Chen, M., Xu, Y., Paul Morgan, B., Mack, M., Xu, H., and Nicholson, L.B. (2013). Myeloid cells expressing VEGF and arginase-1 following uptake of damaged retinal pigment epithelium suggests potential mechanism that drives the onset of choroidal angiogenesis in mice. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0072935"},{"key":"ref_266","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1002\/path.4816","article-title":"Interleukin-33 regulates tissue remodelling and inhibits angiogenesis in the eye","volume":"241","author":"Theodoropoulou","year":"2017","journal-title":"J. Pathol."},{"key":"ref_267","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.cellimm.2018.01.020","article-title":"Macrophages and lipid metabolism","volume":"330","author":"Remmerie","year":"2018","journal-title":"Cell Immunol."},{"key":"ref_268","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1111\/imr.13145","article-title":"Age-related macular degeneration: A disease of extracellular complement amplification","volume":"313","author":"Tang","year":"2023","journal-title":"Immunol. Rev."},{"key":"ref_269","doi-asserted-by":"crossref","first-page":"101130","DOI":"10.1016\/j.preteyeres.2022.101130","article-title":"Potential therapeutic targets for age-related macular degeneration: The nuclear option","volume":"94","author":"Choudhary","year":"2023","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_270","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.jconrel.2023.11.035","article-title":"Extracellular vesicles in degenerative retinal diseases: A new therapeutic paradigm","volume":"365","author":"Manai","year":"2024","journal-title":"J. Control Release"},{"key":"ref_271","doi-asserted-by":"crossref","first-page":"102322","DOI":"10.1016\/j.arr.2024.102322","article-title":"Treatment avenues for age-related macular degeneration: Breakthroughs and bottlenecks","volume":"98","author":"Kumbhar","year":"2024","journal-title":"Ageing Res. Rev."},{"key":"ref_272","doi-asserted-by":"crossref","first-page":"e178296","DOI":"10.1172\/JCI178296","article-title":"Complement regulation in the eye: Implications for age-related macular degeneration","volume":"134","author":"Wilke","year":"2024","journal-title":"J. Clin. Investig."},{"key":"ref_273","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.cell.2022.12.027","article-title":"Loss of epigenetic information as a cause of mammalian aging","volume":"186","author":"Yang","year":"2023","journal-title":"Cell"},{"key":"ref_274","doi-asserted-by":"crossref","first-page":"546","DOI":"10.14336\/AD.2023.0630-1","article-title":"Aging, Cellular Senescence, and Glaucoma","volume":"15","author":"Zhang","year":"2024","journal-title":"Aging Dis."},{"key":"ref_275","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1016\/j.survophthal.2021.12.001","article-title":"Nutritional supplementation in the prevention and treatment of glaucoma","volume":"67","author":"Chaudhry","year":"2022","journal-title":"Surv. Ophthalmol."},{"key":"ref_276","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.cmet.2019.12.007","article-title":"The Antioxidant Role of Non-mitochondrial CoQ10: Mystery Solved!","volume":"31","author":"Santoro","year":"2020","journal-title":"Cell Metab."},{"key":"ref_277","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1167\/iovs.13-12564","article-title":"Coenzyme Q10 inhibits glutamate excitotoxicity and oxidative stress-mediated mitochondrial alteration in a mouse model of glaucoma","volume":"55","author":"Lee","year":"2014","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_278","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1126\/science.aal0092","article-title":"Vitamin B3 modulates mitochondrial vulnerability and prevents glaucoma in aged mice","volume":"355","author":"Williams","year":"2017","journal-title":"Science"},{"key":"ref_279","doi-asserted-by":"crossref","first-page":"9175806","DOI":"10.1155\/2017\/9175806","article-title":"Epigenetics and Oxidative Stress in Aging","volume":"2017","author":"Calabria","year":"2017","journal-title":"Oxid. Med. Cell Longev."},{"key":"ref_280","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.ijbiomac.2020.11.129","article-title":"Triphenylphosphonium-conjugated glycol chitosan microspheres for mitochondria-targeted drug delivery","volume":"167","author":"Lee","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_281","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.redox.2016.12.022","article-title":"The mitochondria-targeted antioxidant MitoQ ameliorated tubular injury mediated by mitophagy in diabetic kidney disease via Nrf2\/PINK1","volume":"11","author":"Xiao","year":"2017","journal-title":"Redox Biol."},{"key":"ref_282","doi-asserted-by":"crossref","first-page":"892","DOI":"10.2741\/4343","article-title":"Mitochondria-targeted antioxidant SkQ1 reverses glaucomatous lesions in rabbits","volume":"20","author":"Iomdina","year":"2015","journal-title":"Front. Biosci."},{"key":"ref_283","doi-asserted-by":"crossref","first-page":"724","DOI":"10.15252\/embj.201592862","article-title":"Mitochondria are required for pro-ageing features of the senescent phenotype","volume":"35","author":"Marques","year":"2016","journal-title":"EMBO J."},{"key":"ref_284","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1164\/rccm.201810-1975TR","article-title":"Cellular Senescence as a Mechanism and Target in Chronic Lung Diseases","volume":"200","author":"Barnes","year":"2019","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_285","doi-asserted-by":"crossref","unstructured":"Ahmed, Z., Morgan-Warren, P.J., Berry, M., Scott, R.A.H., and Logan, A. (2019). Effects of siRNA-Mediated Knockdown of GSK3\u03b2 on Retinal Ganglion Cell Survival and Neurite\/Axon Growth. Cells, 8.","DOI":"10.3390\/cells8090956"},{"key":"ref_286","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1186\/s13148-021-01158-7","article-title":"Cellular reprogramming and epigenetic rejuvenation","volume":"13","author":"Simpson","year":"2021","journal-title":"Clin. Epigenetics"},{"key":"ref_287","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1038\/s41586-020-2975-4","article-title":"Reprogramming to recover youthful epigenetic information and restore vision","volume":"588","author":"Lu","year":"2020","journal-title":"Nature"},{"key":"ref_288","doi-asserted-by":"crossref","unstructured":"Gao, F.J., Zhang, S.H., Xu, P., Yang, B.Q., Zhang, R., Cheng, Y., Zhou, X.J., Huang, W.J., Wang, M., and Chen, J.Y. (2017). Quercetin Declines Apoptosis, Ameliorates Mitochondrial Function and Improves Retinal Ganglion Cell Survival and Function in In Vivo Model of Glaucoma in Rat and Retinal Ganglion Cell Culture In Vitro. Front. Mol. Neurosci., 10.","DOI":"10.3389\/fnmol.2017.00285"},{"key":"ref_289","doi-asserted-by":"crossref","unstructured":"Zhou, X., Li, G., Yang, B., and Wu, J. (2019). Quercetin Enhances Inhibitory Synaptic Inputs and Reduces Excitatory Synaptic Inputs to OFF- and ON-Type Retinal Ganglion Cells in a Chronic Glaucoma Rat Model. Front. Neurosci., 13.","DOI":"10.3389\/fnins.2019.00672"},{"key":"ref_290","doi-asserted-by":"crossref","first-page":"e13089","DOI":"10.1111\/acel.13089","article-title":"Early removal of senescent cells protects retinal ganglion cells loss in experimental ocular hypertension","volume":"19","author":"Rocha","year":"2020","journal-title":"Aging Cell"},{"key":"ref_291","doi-asserted-by":"crossref","unstructured":"El-Nimri, N.W., Moore, S.M., Zangwill, L.M., Proudfoot, J.A., Weinreb, R.N., Skowronska-Krawczyk, D., and Baxter, S.L. (2020). Evaluating the neuroprotective impact of senolytic drugs on human vision. Sci. Rep., 10.","DOI":"10.1038\/s41598-020-78802-4"},{"key":"ref_292","first-page":"6","article-title":"HO-1-Mediated Autophagic Restoration Protects Lens Epithelial Cells Against Oxidative Stress and Cellular Senescence","volume":"64","author":"Wang","year":"2023","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_293","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.exer.2018.12.020","article-title":"Kojic acid inhibits senescence of human corneal endothelial cells via NF-\u03baB and p21 signaling pathways","volume":"180","author":"Wei","year":"2019","journal-title":"Exp. Eye Res."},{"key":"ref_294","doi-asserted-by":"crossref","first-page":"9348","DOI":"10.18632\/aging.202719","article-title":"miR-30c-1 encourages human corneal endothelial cells to regenerate through ameliorating senescence","volume":"13","author":"Bae","year":"2021","journal-title":"Aging"},{"key":"ref_295","doi-asserted-by":"crossref","unstructured":"Gidfar, S., Milani, F.Y., Milani, B.Y., Shen, X., Eslani, M., Putra, I., Huvard, M.J., Sagha, H., and Djalilian, A.R. (2017). Rapamycin Prolongs the Survival of Corneal Epithelial Cells in Culture. Sci. Rep., 7.","DOI":"10.1038\/srep40308"},{"key":"ref_296","doi-asserted-by":"crossref","first-page":"10778","DOI":"10.1096\/fj.201900218R","article-title":"Senescence-associated secretory phenotype promotes chronic ocular graft-vs-host disease in mice and humans","volume":"34","author":"Yamane","year":"2020","journal-title":"FASEB J."},{"key":"ref_297","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.cell.2017.02.031","article-title":"Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging","volume":"169","author":"Baar","year":"2017","journal-title":"Cell"},{"key":"ref_298","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.ebiom.2019.08.069","article-title":"Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease","volume":"47","author":"Hickson","year":"2019","journal-title":"EBioMedicine"}],"container-title":["Bioengineering"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2306-5354\/12\/6\/563\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:39:24Z","timestamp":1760031564000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2306-5354\/12\/6\/563"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,23]]},"references-count":298,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2025,6]]}},"alternative-id":["bioengineering12060563"],"URL":"https:\/\/doi.org\/10.3390\/bioengineering12060563","relation":{},"ISSN":["2306-5354"],"issn-type":[{"value":"2306-5354","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,23]]}}}