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insufficient biological healing; leukocyte-rich PRP may enhance tendon\u2013bone integration through inflammatory modulation and growth factor release. Methods: Four databases including PubMed, Embase, Cochrane Library, and Web of Science were searched until March 2025. Literature screening, quality evaluation, and data extraction were performed according to inclusion and exclusion criteria. GRADE was used to grade the strength of the evidence and the results. Results: The main finding of this study was that leukocyte-rich platelet-rich plasma combined with arthroscopic surgery for rotator cuff injuries can improve the Constant Score (MD = 1.13, 95% CI: 0.19, 2.07, p = 0.02, I2 = 47%), American Shoulder and Elbow Surgeons score (MD = 6.02, 95% CI: 4.67, 7.36, p &lt; 0.01, I2 = 0%), and University of California, Los Angeles score (MD = 1.20, 95% CI: 0.34, 2.06, p &lt; 0.01, I2 = 0%) of patients with rotator cuff tear after treatment, and reduce the postoperative Visual Analog Scale score (MD = \u22120.62, 95% CI: \u22121.16, \u22120.08, p = 0.02, I2 = 83%) of patients. However, there were no statistical differences regarding the Simple Shoulder Test (MD = 0.08, 95% CI: \u22120.23, 0.39, p = 0.61, I2 = 5%). Conclusions: Based on current evidence, the use of LR-PRP in arthroscopic rotator cuff repair could lessen postoperative pain and improve postoperative functional scores in individuals with rotator cuff injuries.<\/jats:p>","DOI":"10.3390\/bioengineering12060617","type":"journal-article","created":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T08:34:32Z","timestamp":1749112472000},"page":"617","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Leukocyte-Rich Platelet-Rich Plasma\u2019s Clinical Effectiveness in Arthroscopic Rotator Cuff Repair: A Meta-Analysis of Randomized Controlled Trials"],"prefix":"10.3390","volume":"12","author":[{"given":"Peiyuan","family":"Tang","sequence":"first","affiliation":[{"name":"Department of Orthopedics, Xiangya Hospital, Central South University, Changsha 410008, China"},{"name":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meihui","family":"Huang","sequence":"additional","affiliation":[{"name":"Xiangya School of Medicine, Central South University, Changsha 410008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenfeng","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Xiangya Hospital, Central South University, Changsha 410008, China"},{"name":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Xiangya Hospital, Central South University, Changsha 410008, China"},{"name":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4455-035X","authenticated-orcid":false,"given":"Pavel","family":"Volotovsky","sequence":"additional","affiliation":[{"name":"Republican Scientific and Practical Center of Traumatology and Orthopedics, 220024 Minsk, Belarus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikhail","family":"Gerasimenko","sequence":"additional","affiliation":[{"name":"Republican Scientific and Practical Center of Traumatology and Orthopedics, 220024 Minsk, Belarus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyao","family":"Chu","sequence":"additional","affiliation":[{"name":"Republican Scientific and Practical Center of Traumatology and Orthopedics, 220024 Minsk, Belarus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuguang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Joint Surgery, Honghui Hospital, Xi\u2019an Jiaotong University, Xi\u2019an 710054, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Changde Hospital, Xiangya School of Medicine, Central South University (The First People\u2019s Hospital of Changde City), Changde 415003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusheng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Xiangya Hospital, Central South University, Changsha 410008, China"},{"name":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1016\/j.jse.2014.08.001","article-title":"A systematic review and pooled analysis of the prevalence of rotator cuff disease with increasing age","volume":"23","author":"Teunis","year":"2014","journal-title":"J. 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