{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:22:30Z","timestamp":1760059350193,"version":"build-2065373602"},"reference-count":54,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T00:00:00Z","timestamp":1749081600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Key Research and Development Program of China","award":["2023YFC2508400","82101231","81701673","2021CFB547"],"award-info":[{"award-number":["2023YFC2508400","82101231","81701673","2021CFB547"]}]},{"name":"National Natural Science Foundation of China","award":["2023YFC2508400","82101231","81701673","2021CFB547"],"award-info":[{"award-number":["2023YFC2508400","82101231","81701673","2021CFB547"]}]},{"name":"Hubei Provincial Natural Science Foundation of China","award":["2023YFC2508400","82101231","81701673","2021CFB547"],"award-info":[{"award-number":["2023YFC2508400","82101231","81701673","2021CFB547"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioengineering"],"abstract":"<jats:p>Unilateral sudden sensorineural hearing loss (SSHL) presents substantial clinical challenges owing to its abrupt onset and multifactorial, poorly understood etiology. This study investigates the static and dynamic changes in local brain connectivity using regional homogeneity (ReHo) analyses in 102 SSHL patients and 73 healthy controls. A static ReHo analysis reveals pronounced disruptions in local synchronization within motor and cognitive-related brain regions in SSHL patients compared to controls. A dynamic ReHo analysis uncovers increased temporal variability, particularly in frontal regions, indicating potential adaptive neural plasticity to auditory deficits through enhanced neural plasticity. The correlation analyses further associate these neural changes with clinical parameters, highlighting the significant positive correlations between static ReHo in the left precentral gyrus and tinnitus severity (R = 0.39, p &lt; 0.001), as well as the negative correlations between dynamic ReHo in the middle frontal gyrus and the duration of hearing loss (R = \u22120.35, p &lt; 0.001). These findings underscore the complex interplay between static neural dysregulation and dynamic adaptive mechanisms in the pathophysiology of SSHL. Emphasizing dynamic metrics, our study provides a novel temporal perspective on how the brain reorganizes in response to acute sensory loss.<\/jats:p>","DOI":"10.3390\/bioengineering12060619","type":"journal-article","created":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T11:04:06Z","timestamp":1749121446000},"page":"619","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Static and Dynamic Changes in Local Brain Connectivity in Unilateral Sudden Sensorineural Hearing Loss"],"prefix":"10.3390","volume":"12","author":[{"given":"Junchao","family":"Zeng","sequence":"first","affiliation":[{"name":"Medical Ultrasound Laboratory, Department of Biomedical Engineering, College of Life Science and Technology, Advanced Bio-Medical Imaging Facility, Huazhong University of Science and Technology, Wuhan 430074, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China"},{"name":"Hubei Provincial Clinical Research Center for Precision Radiology & Interventional Medicine, Wuhan 430022, China"},{"name":"Hubei Province Key Laboratory of Molecular Imaging, Wuhan 430022, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1642-9867","authenticated-orcid":false,"given":"Bo","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qun","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China"},{"name":"Hubei Provincial Clinical Research Center for Precision Radiology & Interventional Medicine, Wuhan 430022, China"},{"name":"Hubei Province Key Laboratory of Molecular Imaging, Wuhan 430022, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziqiao","family":"Lei","sequence":"additional","affiliation":[{"name":"Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China"},{"name":"Hubei Provincial Clinical Research Center for Precision Radiology & Interventional Medicine, Wuhan 430022, China"},{"name":"Hubei Province Key Laboratory of Molecular Imaging, Wuhan 430022, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5718-9420","authenticated-orcid":false,"given":"Fan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China"},{"name":"Hubei Provincial Clinical Research Center for Precision Radiology & Interventional Medicine, Wuhan 430022, China"},{"name":"Hubei Province Key Laboratory of Molecular Imaging, Wuhan 430022, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3933-1205","authenticated-orcid":false,"given":"Mingyue","family":"Ding","sequence":"additional","affiliation":[{"name":"Medical Ultrasound Laboratory, Department of Biomedical Engineering, College of Life Science and Technology, Advanced Bio-Medical Imaging Facility, Huazhong University of Science and Technology, Wuhan 430074, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8949-6775","authenticated-orcid":false,"given":"Wenliang","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China"},{"name":"Hubei Provincial Clinical Research Center for Precision Radiology & Interventional Medicine, Wuhan 430022, China"},{"name":"Hubei Province Key Laboratory of Molecular Imaging, Wuhan 430022, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"108565","DOI":"10.1016\/j.heares.2022.108565","article-title":"Idiopathic sudden sensorineural hearing loss: A critique on corticosteroid therapy","volume":"422","author":"Murray","year":"2022","journal-title":"Hear. 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