{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:26:47Z","timestamp":1760059607113,"version":"build-2065373602"},"reference-count":67,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T00:00:00Z","timestamp":1750809600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Key R&amp;D Program of China","award":["2023YFC3603400","82472522","92268115","W2421123","2024JJ2089"],"award-info":[{"award-number":["2023YFC3603400","82472522","92268115","W2421123","2024JJ2089"]}]},{"name":"National Natural Science Foundation of China","award":["2023YFC3603400","82472522","92268115","W2421123","2024JJ2089"],"award-info":[{"award-number":["2023YFC3603400","82472522","92268115","W2421123","2024JJ2089"]}]},{"name":"Projects of International Cooperation and Exchanges NSFC","award":["2023YFC3603400","82472522","92268115","W2421123","2024JJ2089"],"award-info":[{"award-number":["2023YFC3603400","82472522","92268115","W2421123","2024JJ2089"]}]},{"name":"Hunan Provincial Science Fund for Distinguished Young Scholars","award":["2023YFC3603400","82472522","92268115","W2421123","2024JJ2089"],"award-info":[{"award-number":["2023YFC3603400","82472522","92268115","W2421123","2024JJ2089"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioengineering"],"abstract":"<jats:p>While the central mechanisms of fibromyalgia have gained attention, the causal effects between brain networks and fibromyalgia remain unclear. Two-sample Mendelian randomization and Linkage Disequilibrium Score Regression were performed to investigate the relationship between 191 rsfMRI traits and 8 fibromyalgia-related traits. A total of 4 rsfMRI traits were genetically correlated with trouble falling asleep, 11 with back pain for 3+ months, 16 with pain all over the body, 14 with insomnia, 5 with fibromyalgia, 4 with fibromyalgia, and 3 with malaise and fatigue. Pheno801 has significant causal effects on malaise and fatigue (OR = 1.0022, p = 0.01), fibromyalgia (finngen) (OR = 1.5055, p = 0.03), and insomnia (OR = 1.4063, p = 0.04). Pheno1696 significantly impacts fibromyalgia-related comorbidities (OR = 1.002, p = 0.02), trouble falling asleep (OR = 1.0285, p = 0.04), malaise and fatigue (OR = 1.0011, p = 0.04), and pain all over the body (OR = 0.9967, p = 0.04). Pheno103 has marked effects on fibromyalgia (finngen) (OR = 0.7477, p = 0.02), malaise and fatigue (OR = 0.9987, p = 0.03), and pain all over the body (OR = 1.0033, p = 0.03). Our findings suggest that targeting these networks could effectively prevent or alleviate fibromyalgia.<\/jats:p>","DOI":"10.3390\/bioengineering12070692","type":"journal-article","created":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T03:53:02Z","timestamp":1750823582000},"page":"692","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Casual Associations Between Brain Functional Networks and Fibromyalgia: A Large-Scale Genetic Correlation and Mendelian Randomization Study"],"prefix":"10.3390","volume":"12","author":[{"given":"Yiqun","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Orthopedics, Xiangya Hospital, Central South University, Changsha 410000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guang","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Xiangya Hospital, Central South University, Changsha 410000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0522-8269","authenticated-orcid":false,"given":"Zhenhan","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China"},{"name":"Geriatrics Center, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shengwu","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China"},{"name":"Geriatrics Center, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusheng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Xiangya Hospital, Central South University, Changsha 410000, China"},{"name":"National Clinical Research Center for Geriatric Disorders, Department of Geriatrics, Xiangya Hospital, Central South University, Changsha 410000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenfeng","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Xiangya Hospital, Central South University, Changsha 410000, China"},{"name":"National Clinical Research Center for Geriatric Disorders, Department of Geriatrics, Xiangya Hospital, Central South University, Changsha 410000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bangbao","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Xiangya Hospital, Central South University, Changsha 410000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-2276-4320","authenticated-orcid":false,"given":"Xiongbai","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China"},{"name":"Geriatrics Center, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/s41584-020-00506-w","article-title":"Fibromyalgia: An update on clinical characteristics, aetiopathogenesis and treatment","volume":"16","author":"Giorgi","year":"2020","journal-title":"Nat. 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