{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T19:29:20Z","timestamp":1785526160295,"version":"3.56.0"},"reference-count":47,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2025,7,8]],"date-time":"2025-07-08T00:00:00Z","timestamp":1751932800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Natural Science Foundation of China","award":["12472327"],"award-info":[{"award-number":["12472327"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioengineering"],"abstract":"<jats:p>Hallux valgus (HV) is described as a lateral deviation of the great toe at the first metatarsophalangeal joint (MTP), which is a very common foot deformity in the clinic. This deformity extends beyond localized foot mechanics to affect the entire lower extremity kinetic chain, potentially increasing dynamic instability during locomotion. This study aimed to characterize the kinematics of ankle and knee joints during walking in HV patients compared to controls. In total, 23 patients with bilateral HV and matched healthy controls were recruited. The 6-DOF kinematics data of ankles and knees were collected using a joint motion function analysis system while level walking at adaptive speed. HV patients demonstrated significant kinematic alterations in the ankle joint at IC, including decreased varus by 2.87\u00b0 (p &lt; 0.001), decreased internal rotation by 1.77\u00b0 (p = 0.035), and decreased plantarflexion by 4.39\u00b0 (p &lt; 0.001) compared with healthy subjects. Concurrent compensatory changes in the knee joint included increased varus rotation by 1.41\u00b0 (p = 0.023), reduced anterior translation by 0.84 mm (p &lt; 0.001), and increased lateral translation by 0.26 mm (p = 0.036). HV patients showed increased ankle dorsiflexion of 3.61\u00b0 (p = 0.06) and decreased ankle internal rotation of 2.69\u00b0 (p = 0.043), with concurrent increased knee internal rotation of 2.59\u00b0 (p = 0.009) at SPF. The ripple effect during walking in the HV population may elevate the risk of knee pathologies. These findings may inform both conservative management strategies and post-surgical rehabilitation regimens.<\/jats:p>","DOI":"10.3390\/bioengineering12070744","type":"journal-article","created":{"date-parts":[[2025,7,8]],"date-time":"2025-07-08T04:18:11Z","timestamp":1751948291000},"page":"744","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The Ripple Effect: How Hallux Valgus Deformity Influences Ankle and Knee Joint Kinematics During Gait"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-2729-0604","authenticated-orcid":false,"given":"Longzhou","family":"Hua","sequence":"first","affiliation":[{"name":"School of Exercise and Health, Shanghai University of Sport, 200 Hengren Road, Shanghai 200438, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenglin","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, The Sixth People\u2019s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200233, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Luo","sequence":"additional","affiliation":[{"name":"School of Exercise and Health, Shanghai University of Sport, 200 Hengren Road, Shanghai 200438, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longxiang","family":"Li","sequence":"additional","affiliation":[{"name":"School of Exercise and Health, Shanghai University of Sport, 200 Hengren Road, Shanghai 200438, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingwei","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Exercise and Health, Shanghai University of Sport, 200 Hengren Road, Shanghai 200438, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8217-201X","authenticated-orcid":false,"given":"Aoqing","family":"Huang","sequence":"additional","affiliation":[{"name":"School of Exercise and Health, Shanghai University of Sport, 200 Hengren Road, Shanghai 200438, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangfang","family":"Li","sequence":"additional","affiliation":[{"name":"School of Exercise and Health, Shanghai University of Sport, 200 Hengren Road, Shanghai 200438, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongmin","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, The Sixth People\u2019s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200233, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaobai","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Exercise and Health, Shanghai University of Sport, 200 Hengren Road, Shanghai 200438, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/s13047-023-00661-9","article-title":"Global Prevalence and Incidence of Hallux Valgus: A Systematic Review and Meta-analysis","volume":"16","author":"Cai","year":"2023","journal-title":"J. Foot Ankle Res."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"110","DOI":"10.2522\/ptj.20080298","article-title":"Hallux Valgus and the First Metatarsal Arch Segment: A Theoretical Biomechanical Perspective","volume":"90","author":"Glasoe","year":"2010","journal-title":"Phys. Ther."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1177\/1071100715576994","article-title":"A New Measure of Tibial Sesamoid Position in Hallux Valgus in Relation to the Coronal Rotation of the First Metatarsal in CT Scans","volume":"36","author":"Kim","year":"2015","journal-title":"Foot Ankle Int."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.gaitpost.2014.02.011","article-title":"Gait Changes in Individuals with Bilateral Hallux Valgus Reduce First Metatarsophalangeal Loading but Increase Knee Abductor Moments","volume":"40","author":"Shih","year":"2014","journal-title":"Gait Posture"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.gaitpost.2007.12.073","article-title":"Compensatory Mechanism Involving the Knee Joint of the Intact Limb during Gait in Unilateral Below-Knee Amputees","volume":"28","author":"Beyaert","year":"2008","journal-title":"Gait Posture"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"3523","DOI":"10.1016\/j.jbiomech.2008.08.021","article-title":"A Knee Osteoarthritis Connected with Hallux Valgus-Related Pes Planus","volume":"41","author":"Kaymak","year":"2008","journal-title":"J. Biomech."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"146","DOI":"10.3113\/FAI.2010.0146","article-title":"Motion of the Multisegmental Foot in Hallux Valgus","volume":"31","author":"Canseco","year":"2010","journal-title":"Foot Ankle Int."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"141","DOI":"10.3113\/FAI.2012.0141","article-title":"Multisegmental Foot and Ankle Motion Analysis After Hallux Valgus Surgery","volume":"33","author":"Canseco","year":"2012","journal-title":"Foot Ankle Int."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Zeidan, H., Ryo, E., Suzuki, Y., Iijima, H., Kajiwara, Y., Harada, K., Nakai, K., Shimoura, K., Fujimoto, K., and Takahashi, M. (2020). Detailed Analysis of the Transverse Arch of Hallux Valgus Feet with and without Pain Using Weightbearing Ultrasound Imaging and Precise Force Sensors. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0226914"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1186\/s13018-017-0622-z","article-title":"Loading Pattern of Postoperative Hallux Valgus Feet with and without Transfer Metatarsalgia: A Case Control Study","volume":"12","author":"Geng","year":"2017","journal-title":"J. Orthop. Surg. Res."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Hofmann, U.K., G\u00f6tze, M., Wiesenreiter, K., M\u00fcller, O., W\u00fcnschel, M., and Mittag, F. (2019). Transfer of Plantar Pressure from the Medial to the Central Forefoot in Patients with Hallux Valgus. BMC Musculoskelet Disord., 20.","DOI":"10.1186\/s12891-019-2531-2"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"49","DOI":"10.5507\/ag.2011.026","article-title":"The Influence of Hallux Valgus on Pelvis and Lower Extremity Movement during Gait","volume":"41","author":"Janura","year":"2011","journal-title":"Acta Gymnica"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.gaitpost.2019.08.009","article-title":"The Effects of Marathon Running on Three-Dimensional Knee Kinematics during Walking and Running in Recreational Runners","volume":"75","author":"Tian","year":"2020","journal-title":"Gait Posture"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"3132","DOI":"10.1177\/0363546516658026","article-title":"Anterior Cruciate Ligament Injuries Alter the Kinematics of Knees With or Without Meniscal Deficiency","volume":"44","author":"Zhang","year":"2016","journal-title":"Am. J. Sports Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"021910","DOI":"10.1118\/1.4773871","article-title":"Quantitative Error Analysis for Computer Assisted Navigation: A Feasibility Study: Quantitative Error Analysis for Computer Assisted Navigation","volume":"40","author":"Kral","year":"2013","journal-title":"Med. Phys."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/j.gaitpost.2015.01.020","article-title":"Motion Analysis of Chinese Normal Knees during Gait Based on a Novel Portable System","volume":"41","author":"Zhang","year":"2015","journal-title":"Gait Posture"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"10225536221125951","DOI":"10.1177\/10225536221125951","article-title":"Kinematic Alterations of the Ankle in Subjects with Generalized Joint Hypermobility Compared with the Controls: A Cross-Sectional Study","volume":"30","author":"Chen","year":"2022","journal-title":"J. Orthop. Surg."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/S0966-6362(99)00048-X","article-title":"Knee Joint Kinematics from Familiarised Treadmill Walking Can Be Generalised to Overground Walking in Young Unimpaired Subjects","volume":"11","author":"Matsas","year":"2000","journal-title":"Gait Posture"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1148\/rg.2020190145","article-title":"High-Resolution MRI of the First Metatarsophalangeal Joint: Gross Anatomy and Injury Characterization","volume":"40","author":"Hallinan","year":"2020","journal-title":"RadioGraphics"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Kawakami, W., Iwamoto, Y., Ota, M., Ishii, Y., and Takahashi, M. (2024). Individuals with Asymptomatic Hallux Valgus Exhibit Altered Foot Kinematics during Gait Regardless of Their Foot Posture. Clin. Biomech., 118.","DOI":"10.1016\/j.clinbiomech.2024.106319"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Kawakami, W., Iwamoto, Y., Takeuchi, Y., Takeuchi, R., Sekiya, J., Ishii, Y., and Takahashi, M. (2022). Young Females with Hallux Valgus Show Lower Foot Joint Movement Stability Compared to Controls: An Investigation of Coordination Patterns and Variability. Clin. Biomech., 94.","DOI":"10.1016\/j.clinbiomech.2022.105624"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Martin, H., Bahlke, U., Dietze, A., Zschorlich, V., Schmitz, K.-P., and Mittlmeier, T. (2012). Investigation of First Ray Mobility during Gait by Kinematic Fluoroscopic Imaging-a Novel Method. BMC Musculoskelet. Disord., 13.","DOI":"10.1186\/1471-2474-13-14"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1097\/01.PHM.0000064718.24109.26","article-title":"Muscle Imbalance in Hallux Valgus: An Electromyographic Study","volume":"82","author":"Erdem","year":"2003","journal-title":"Am. J. Phys. Med. Rehabil."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.gaitpost.2025.01.025","article-title":"High Risk of Falling in Elderly with Hallux Valgus Evaluated by Muscle and Kinematic Synergistic Analysis","volume":"118","author":"Liu","year":"2025","journal-title":"Gait Posture"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Liu, R., Liu, Y., Zhou, L., Qian, L., Chen, C., Wan, X., Wang, Y., Yu, W., Liu, G., and Ouyang, J. (2024). Muscle Synergy and Kinematic Synergy Analyses during Sit-to-Stand Motions in Hallux Valgus Patients before and after Treatment with Kinesio Taping. BioMed. Eng. OnLine, 23.","DOI":"10.1186\/s12938-024-01268-2"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1177\/10711007231166667","article-title":"Biokinetic Evaluation of Hallux Valgus during Gait: A Systematic Review","volume":"44","author":"Rosemberg","year":"2023","journal-title":"Foot Ankle Int."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.gaitpost.2022.02.026","article-title":"Gait Biomechanics Evaluation of the Treatment Effects for Hallux Valgus Patients: A Systematic Review and Meta-Analysis","volume":"94","author":"Xiang","year":"2022","journal-title":"Gait Posture"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Biswas, D.K., Sinclair, M., Le, T., Pullano, S.A., Fiorillo, A.S., and Mahbub, I. (2020). Modeling and Characterization of Scaling Factor of Flexible Spiral Coils for Wirelessly Powered Wearable Sensors. Sensors, 20.","DOI":"10.3390\/s20082282"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Geng, X., Shi, J., Chen, W., Ma, X., Wang, X., Zhang, C., and Chen, L. (2019). Impact of First Metatarsal Shortening on Forefoot Loading Pattern: A Finite Element Model Study. BMC Musculoskelet. Disord., 20.","DOI":"10.1186\/s12891-019-2973-6"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.gaitpost.2021.01.017","article-title":"Increased Knee Flexion and Varus Moments during Gait with High-Heeled Shoes: A Systematic Review and Meta-Analysis","volume":"85","author":"Nguyen","year":"2021","journal-title":"Gait Posture"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1007\/s00776-012-0322-9","article-title":"In Vivo Pre- and Postoperative Three-Dimensional Knee Kinematics in Unicompartmental Knee Arthroplasty","volume":"18","author":"Mochizuki","year":"2013","journal-title":"J. Orthop. Sci."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1016\/j.arth.2010.12.023","article-title":"Retrospective Analysis of Total Knee Arthroplasty Cases for Visual, Histological, and Clinical Eligibility of Unicompartmental Knee Arthroplasties","volume":"26","author":"Arno","year":"2011","journal-title":"J. Arthroplast."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.arthro.2014.09.010","article-title":"A Review of the Anterolateral Ligament of the Knee: Current Knowledge Regarding Its Incidence, Anatomy, Biomechanics, and Surgical Dissection","volume":"31","author":"Pomajzl","year":"2015","journal-title":"Arthrosc. J. Arthrosc. Relat. Surg."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1016\/j.arthro.2019.04.007","article-title":"Editorial Commentary: Anterolateral Ligament\u2014Anatomy, Evaluation, and Future Applications to Knee Stability","volume":"35","author":"Shea","year":"2019","journal-title":"Arthrosc. J. Arthrosc. Relat. Surg."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"3259","DOI":"10.1007\/s00167-014-3169-0","article-title":"Gait Changes of the ACL-Deficient Knee 3D Kinematic Assessment","volume":"23","author":"Shabani","year":"2015","journal-title":"Knee Surg. Sports Traumatol. Arthrosc."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.gaitpost.2014.10.025","article-title":"Increased Unilateral Foot Pronation Affects Lower Limbs and Pelvic Biomechanics during Walking","volume":"41","author":"Resende","year":"2015","journal-title":"Gait Posture"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s00167-014-3321-x","article-title":"The Effect of Tibial Rotation on Knee Medial and Lateral Compartment Contact Pressure","volume":"24","author":"Yazdi","year":"2016","journal-title":"Knee Surg. Sports Traumatol. Arthrosc."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"2602","DOI":"10.1007\/s00167-015-3843-x","article-title":"Influence of Mediolateral Tibial Baseplate Position in TKA on Knee Kinematics and Retropatellar Pressure","volume":"25","author":"Fottner","year":"2017","journal-title":"Knee Surg. Sports Traumatol. Arthrosc."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"505","DOI":"10.5603\/FM.a2020.0106","article-title":"Current Concepts on the Morphology of Popliteus Tendon and Its Clinical Implications","volume":"80","author":"Huri","year":"2021","journal-title":"Folia Morphol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1007\/s00167-019-05434-1","article-title":"Cartilage Survival of the Knee Strongly Depends on Malalignment: A Survival Analysis from the Osteoarthritis Initiative (OAI)","volume":"28","author":"Faschingbauer","year":"2020","journal-title":"Knee Surg. Sports Traumatol. Arthrosc."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1016\/j.jbiomech.2013.02.010","article-title":"A Novel Dual Fluoroscopic Imaging Method for Determination of THA Kinematics: In-Vitro and in-Vivo Study","volume":"46","author":"Tsai","year":"2013","journal-title":"J. Biomech."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"476","DOI":"10.3390\/signals5030025","article-title":"Development of an Integrated System of sEMG Signal Acquisition, Processing, and Analysis with AI Techniques","volume":"5","author":"Angiulli","year":"2024","journal-title":"Signals"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Lin, Z., Du, H., Cheng, J., Han, X., Wang, D., Liu, Z., and Huang, Y. (2025). Can Foot Orthoses Be an Effective Supplement to Brace Therapy for Adolescent Idiopathic Scoliosis? A Systematic Review and Meta-Analysis of Randomized Controlled Trials. J. Back Musculoskelet. Rehabil., 10538127251337689.","DOI":"10.1177\/10538127251337689"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1177\/1071100716683347","article-title":"Effects of Corrective Taping on Balance and Gait in Patients With Hallux Valgus","volume":"38","author":"Gur","year":"2017","journal-title":"Foot Ankle Int."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"e069872","DOI":"10.1136\/bmjopen-2022-069872","article-title":"Effects of Custom Insoles for Symptomatic Hallux Valgus: Protocol for a Sham-Controlled Randomised Trial","volume":"13","author":"Cavalcanti","year":"2023","journal-title":"BMJ Open"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"110519","DOI":"10.1016\/j.ijmecsci.2025.110519","article-title":"Data-Driven Deep Learning for Predicting Ligament Fatigue Failure Risk Mechanisms","volume":"301","author":"Xu","year":"2025","journal-title":"Int. J. Mech. Sci."},{"key":"ref_47","first-page":"1","article-title":"Integration of LSTM and U-Net Models for Monitoring Electrical Absorption With a System of Sensors and Electronic Circuits","volume":"74","author":"Oliva","year":"2025","journal-title":"IEEE Trans. Instrum. Meas."}],"container-title":["Bioengineering"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2306-5354\/12\/7\/744\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:06:17Z","timestamp":1760033177000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2306-5354\/12\/7\/744"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,8]]},"references-count":47,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2025,7]]}},"alternative-id":["bioengineering12070744"],"URL":"https:\/\/doi.org\/10.3390\/bioengineering12070744","relation":{},"ISSN":["2306-5354"],"issn-type":[{"value":"2306-5354","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,8]]}}}