{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T03:00:42Z","timestamp":1790996442929,"version":"4.1.0"},"reference-count":78,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2025,8,30]],"date-time":"2025-08-30T00:00:00Z","timestamp":1756512000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Science Foundation","award":["2315654"],"award-info":[{"award-number":["2315654"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioengineering"],"abstract":"<jats:p>This perspective article presents an innovative concept for a biomanufacturing Knowledge Hub (KH), designed as a data-driven learning platform supporting the entire lifecycle of biomedical products. By integrating advanced data sharing and processing technologies, the KH aspires to connect patients, bioengineers, clinicians, regulators, companies, and investors to accelerate product development, reduce redundancies, and ultimately fast-track the delivery of biomedical innovations to patients. We discuss current challenges in accessing and sharing data within biomanufacturing and outline novel approaches for building an ecosystem that links data stores, integrates digital twins, and leverages advanced analytics. The KH offers transformative capabilities, enabling the development of new products at a substantial increased speed. It is built as a secure, quantum-resistant platform that encrypts data and allows access through advanced algorithms, creating an intelligent, collaborative environment. Users can harness collective knowledge to enhance products, launch innovations, integrate technologies, and unlock revenue opportunities based on data quality and usage. This KH aims to revolutionize biomanufacturing, offering unprecedented opportunities for innovation, better patient outcomes, and commercialization with far reaching applications beyond biomanufacturing in the future.<\/jats:p>","DOI":"10.3390\/bioengineering12090938","type":"journal-article","created":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T16:05:22Z","timestamp":1756829122000},"page":"938","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["A Collaborative Data Sharing Platform to Accelerate Translation of Biomedical Innovations"],"prefix":"10.3390","volume":"12","author":[{"given":"Zohreh","family":"Izadifar","sequence":"first","affiliation":[{"name":"Boston Children\u2019s Hospital, Harvard Medical School, Boston, MA 02115, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greg","family":"Storm","sequence":"additional","affiliation":[{"name":"Tripleblind, 800 W 47th St #600, Kansas City, MO 64112, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3023-6749","authenticated-orcid":false,"given":"Amol M.","family":"Joshi","sequence":"additional","affiliation":[{"name":"School of Business, Wake Forest University, Winston-Salem, NC 27109, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Hochberg","sequence":"additional","affiliation":[{"name":"ReMDO, Winston-Salem, NC 27101, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Hadjisavas","sequence":"additional","affiliation":[{"name":"p-Chip Corporation, Chicago, IL 60661, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Rodrigue","sequence":"additional","affiliation":[{"name":"Allbright Consulting, Telluride, CO 81435, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2831-846X","authenticated-orcid":false,"given":"Steven R.","family":"Bauer","sequence":"additional","affiliation":[{"name":"Wake Forest Institute for Regenerative Medicine (WFIRM), Winston-Salem, NC 27101, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James B.","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Durendal AI Inc., Winston-Salem, NC 27101, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sita","family":"Somara","sequence":"additional","affiliation":[{"name":"Durendal AI Inc., Winston-Salem, NC 27101, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8186-2160","authenticated-orcid":false,"given":"Anthony","family":"Atala","sequence":"additional","affiliation":[{"name":"Wake Forest Institute for Regenerative Medicine (WFIRM), Winston-Salem, NC 27101, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8104-6235","authenticated-orcid":false,"given":"Izabele","family":"Heyward","sequence":"additional","affiliation":[{"name":"College of Engineering, North Carolina Agricultural and Technical State University, Greensboro, NC 27411, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6116-2105","authenticated-orcid":false,"given":"Salil","family":"Desai","sequence":"additional","affiliation":[{"name":"College of Engineering, North Carolina Agricultural and Technical State University, Greensboro, NC 27411, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Hunsberger","sequence":"additional","affiliation":[{"name":"ReMDO, Winston-Salem, NC 27101, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/bs.pbr.2014.12.008","article-title":"Chapter 11\u2014Bench to bedside: Challenges of clinical translation","volume":"218","author":"Steeves","year":"2015","journal-title":"Prog. 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