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To address this, we propose a novel framework, the Spectrum-Aided Vision Enhancer (SAVE), especially designed to transform standard white light (WLI) endoscopic images into spectrally enriched representations that emulate both hyperspectral imaging (HSI) and NBI formats. By leveraging color calibration through the Macbeth Color Checker, gamma correction, CIE 1931 XYZ transformation, and principal component analysis (PCA), SAVE reconstructs detailed spectral information from conventional RGB inputs. Performance was evaluated using the Kvasir-v2 dataset, which includes 6490 annotated images spanning eight GI-related categories. Deep learning models like Inception-Net V3, MobileNetV2, MobileNetV3, and AlexNet were trained on both original WLI- and SAVE-enhanced images. Among these, MobileNetV2 achieved an F1-score of 96% for polyp classification using SAVE, and AlexNet saw a notable increase in average accuracy to 84% when applied to enhanced images. Image quality assessment showed high structural similarity (SSIM scores of 93.99% for Olympus endoscopy and 90.68% for WCE), confirming the fidelity of the spectral transformations. Overall, the SAVE framework offers a practical, software-based enhancement strategy that significantly improves diagnostic accuracy in GI imaging, with strong implications for low-cost, non-invasive diagnostics using capsule endoscopy systems.<\/jats:p>","DOI":"10.3390\/bioengineering12090953","type":"journal-article","created":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T09:18:57Z","timestamp":1756977537000},"page":"953","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Emulating Hyperspectral and Narrow-Band Imaging for Deep-Learning-Driven Gastrointestinal Disorder Detection in Wireless Capsule Endoscopy"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2588-6883","authenticated-orcid":false,"given":"Chu-Kuang","family":"Chou","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chia-Yi 60002, Taiwan"},{"name":"Obesity Center, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chia-Yi 60002, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6811-4614","authenticated-orcid":false,"given":"Kun-Hua","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Trauma, Changhua Christian Hospital, No. 135, Nanxiao St., Changhua City 50006, Taiwan"},{"name":"Department of Mechanical Engineering, National Chung Cheng University, No. 168, University Rd., Min Hsiung, Chia-Yi 62102, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riya","family":"Karmakar","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering, National Chung Cheng University, No. 168, University Rd., Min Hsiung, Chia-Yi 62102, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7741-3722","authenticated-orcid":false,"given":"Arvind","family":"Mukundan","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering, National Chung Cheng University, No. 168, University Rd., Min Hsiung, Chia-Yi 62102, Taiwan"},{"name":"Department of Biomedical Imaging, Chennai Institute of Technology, Sarathy Nagar, Chennai 600069, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pratham Chandraskhar","family":"Gade","sequence":"additional","affiliation":[{"name":"Information Technology Department, Sanjivani College of Engineering, Kopargaon 423603, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3210-8388","authenticated-orcid":false,"given":"Devansh","family":"Gupta","sequence":"additional","affiliation":[{"name":"Computer Science and Engineering Department, Thapar Institute of Engineering & Technology, Patiala 147001, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang-Chao","family":"Su","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chia-Yi 60002, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1542-1495","authenticated-orcid":false,"given":"Tsung-Hsien","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chia-Yi 60002, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chou-Yuan","family":"Ko","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Kaohsiung Armed Forces General Hospital, No. 2, Zhongzheng 1st. 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