{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T19:13:17Z","timestamp":1790881997526,"version":"4.1.0"},"reference-count":140,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T00:00:00Z","timestamp":1758931200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Sao Paulo Research Foundation","award":["#2018\/06510-4"],"award-info":[{"award-number":["#2018\/06510-4"]}]},{"name":"Sao Paulo Research Foundation","award":["2018\/24069-3"],"award-info":[{"award-number":["2018\/24069-3"]}]},{"name":"Sao Paulo Research Foundation","award":["#2024\/21942-9"],"award-info":[{"award-number":["#2024\/21942-9"]}]},{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"crossref","award":["#102260\/2024-9"],"award-info":[{"award-number":["#102260\/2024-9"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"crossref","award":["#308079\/2021-3"],"award-info":[{"award-number":["#308079\/2021-3"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"crossref","award":["#302641\/2025-4"],"award-info":[{"award-number":["#302641\/2025-4"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Institute of Science and Technology in Bioanalytics\u2014Lauro Kubota","award":["#408338\/2024-5"],"award-info":[{"award-number":["#408338\/2024-5"]}]}],"content-domain":{"domain":["www.mdpi.com"],"crossmark-restriction":true},"short-container-title":["Bioengineering"],"abstract":"<jats:p>The underlying causes fof major mental illnesses, including anxiety disorders (ADs), depression, and bipolar disorder (BD), remain insufficiently understood, limiting the availability of effective, patient-friendly treatments and accurate diagnostic tests. For instance, anxiety disorders encompass a diverse spectrum of subtypes and may emerge at different stages of mental illness, each with distinct symptom profiles. This heterogeneity often complicates differential diagnosis, leading, in many cases, to delayed treatment or inappropriate management. In recent years, technological advances have enabled the development of artificial intelligence (AI)-based approaches that, when integrated with multi-omics data, offer substantial advantages over traditional statistical methods, particularly for analysing large-scale datasets and integrating clinical with bioanalytical information. This review analyses current efforts to identify biomarkers for mental illness and explores the application of machine learning, deep learning, and computational modelling in advancing personalised and precise diagnostics.<\/jats:p>","DOI":"10.3390\/bioengineering12101039","type":"journal-article","created":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T08:00:32Z","timestamp":1759132832000},"page":"1039","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Artificial Intelligence-Based Methods and Omics for Mental Illness Diagnosis: A Review"],"prefix":"10.3390","volume":"12","author":[{"given":"Glenda Santos","family":"de Oliveira","sequence":"first","affiliation":[{"name":"Laboratory of Biological Chemistry, Institute of Chemistry, Universidade Estadual de Campinas, Campinas 13083-970, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F\u00e1bio Henrique dos Santos","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Laboratory of Biological Chemistry, Institute of Chemistry, Universidade Estadual de Campinas, Campinas 13083-970, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9369-7809","authenticated-orcid":false,"given":"Jo\u00e3o Guilherme de Moraes","family":"Pontes","sequence":"additional","affiliation":[{"name":"Laboratory of Biological Chemistry, Institute of Chemistry, Universidade Estadual de Campinas, Campinas 13083-970, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2930-7332","authenticated-orcid":false,"given":"Ljubica","family":"Tasic","sequence":"additional","affiliation":[{"name":"Laboratory of Biological Chemistry, Institute of Chemistry, Universidade Estadual de Campinas, Campinas 13083-970, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,27]]},"reference":[{"key":"ref_1","unstructured":"(2025, June 07). 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