{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T15:08:20Z","timestamp":1762182500185,"version":"build-2065373602"},"reference-count":31,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T00:00:00Z","timestamp":1761868800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Natural Science Foundation of China-General Program","award":["52477237","8237021476"],"award-info":[{"award-number":["52477237","8237021476"]}]},{"name":"Interdisciplinary Integration Special Project of Air Force Medical University","award":["2024JC047"],"award-info":[{"award-number":["2024JC047"]}]},{"name":"Cross-integration Project of Xijing Hospital","award":["XJZT24JC37"],"award-info":[{"award-number":["XJZT24JC37"]}]},{"name":"Key Research and Development Projects of the Science and Technology Committee","award":["2022YFC2404803"],"award-info":[{"award-number":["2022YFC2404803"]}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program","doi-asserted-by":"publisher","award":["2023ZD0504400"],"award-info":[{"award-number":["2023ZD0504400"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Health Development Promotion Project","award":["QSXFGCTX-0006"],"award-info":[{"award-number":["QSXFGCTX-0006"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioengineering"],"abstract":"<jats:p>Mannitol dehydration is routinely used to prevent and treat cerebral damage after total aortic arch replacement (TAAR), but existing neuroimaging technologies cannot achieve bedside real-time quantitative assessment of its impact on cerebral perfusion in different patients. This study applied dynamic cerebral perfusion electrical impedance tomography (DCP-EIT), a non-invasive neuroimaging technique, for bedside cerebral perfusion monitoring in TAAR patients during dehydration. Seventeen patients with normal neurological function and nineteen with neurological dysfunction (ND) were enrolled. The variation patterns and differences in perfusion impedance, images, and the relative ratios (RY) of mean perfusion velocity (MV), height of systolic wave (Hs), inflow volume velocity (IV), and angle between the ascending branch and baseline (Aab) were analyzed. Results showed DCP-EIT could visualize cerebral perfusion changes, with detected poorly perfused regions showing good consistency with ischemic areas identified by computed tomography (CT). RY of normal patients fluctuated around 0.97\u20131.04, with no significant difference from baseline. RY of ND patients peaked at 14\u201320 min after dehydration and remained higher than baseline even at 100 min (p &lt; 0.001). DCP-EIT holds potential to optimize individualized cerebral protection strategies for other cerebral damage scenarios and neurocritical care.<\/jats:p>","DOI":"10.3390\/bioengineering12111187","type":"journal-article","created":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T13:22:36Z","timestamp":1762176156000},"page":"1187","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dynamic Cerebral Perfusion Electrical Impedance Tomography: A Neuroimaging Technique for Bedside Cerebral Perfusion Monitoring During Mannitol Dehydration"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-5584-1210","authenticated-orcid":false,"given":"Weice","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering, Shaanxi Provincial Key Laboratory of Bioelectromagnetic Detection and Intelligent Perception, Air Force Medical University, Xi\u2019an 710032, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lihua","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Xijing Hospital, Air Force Medical University, Xi\u2019an 710032, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0728-3544","authenticated-orcid":false,"given":"Canhua","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Shaanxi Provincial Key Laboratory of Bioelectromagnetic Detection and Intelligent Perception, Air Force Medical University, Xi\u2019an 710032, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1574-4108","authenticated-orcid":false,"given":"Mingxu","family":"Zhu","sequence":"additional","affiliation":[{"name":"Institute of Medical Research, Northwestern Polytechnical University, Xi\u2019an 710072, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3531-2103","authenticated-orcid":false,"given":"Yitong","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Diagnosis, Tangdu Hospital, Air Force Medical University, Xi\u2019an 710038, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Xijing Hospital, Air Force Medical University, Xi\u2019an 710032, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weixun","family":"Duan","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Xijing Hospital, Air Force Medical University, Xi\u2019an 710032, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8005-2827","authenticated-orcid":false,"given":"Yu","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Medical Research, Northwestern Polytechnical University, Xi\u2019an 710072, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0586-816X","authenticated-orcid":false,"given":"Zhenxiao","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Xijing Hospital, Air Force Medical University, Xi\u2019an 710032, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3552-9479","authenticated-orcid":false,"given":"Xuetao","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Shaanxi Provincial Key Laboratory of Bioelectromagnetic Detection and Intelligent Perception, Air Force Medical University, Xi\u2019an 710032, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Costa, F.G., Hakimi, N., and Van Bel, F. 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