{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:54:26Z","timestamp":1790142866262,"version":"4.0.1"},"reference-count":24,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T00:00:00Z","timestamp":1766102400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioengineering"],"abstract":"<jats:p>Background\/Objectives: Endovascular aneurysm repair (EVAR) is the standard treatment for abdominal aortic aneurysms, but the risk of endoleak compromises its effectiveness. Type IA endoleak, stemming from an inadequate proximal seal, is the most critical complication associated with the highest risk of rupture. Current preoperative planning relies on static anatomical measurements from computed tomography angiography that fail to predict seal failure due to dynamic biomechanical forces. This study aimed to retrospectively validate the predictive accuracy of a novel physics-informed digital twin and artificial intelligence (AI) model for predicting type IA endoleak risk compared to conventional static planning methods. Methods: This was a retrospective, single-center proof-of-concept validation study involving 15 patients who underwent elective EVAR (5 with confirmed type IA endoleak and 10 without type IA endoleak). A patient-specific digital twin was created for each case to simulate stent-graft deployment and capture the dynamic biomechanical interaction with the aortic wall. A logistic regression AI model processed over 16,000 biomechanical measurements to generate a single, objective metric of the endoleak risk index (ERI). The predictive performance of the ERI (using a cutoff of 0.80) was assessed and compared against a 1:3 propensity score-matched conventional control group (n = 45) who received traditional anatomical-based planning. Results: The mean ERI was significantly higher in the endoleak-positive group (0.85 \u00b1 0.10) compared to the endoleak-negative group (0.39 \u00b1 0.11) (p = 0.011). The digital twin\/AI model demonstrated superior predictive capability, achieving an overall accuracy of 80% (95% CI: 51.9\u201395.7) and an area under the curve (AUC) of 0.85 (95% CI: 0.58\u20130.99). Crucially, the model achieved a sensitivity of 100% and a negative predictive value (NPV) of 100%, correctly identifying all high-risk cases and ruling out endoleak in all low-risk cases. In stark contrast, the matched conventional planning group achieved an overall accuracy of only 51.1% and an AUC of 0.54. Conclusion: This physics-informed digital twin and AI framework successfully validated its capability to accurately and objectively predict the risk of type IA endoleak following EVAR. The derived ERI offers a significant quantitative advantage over traditional static anatomical measurements, establishing it as a highly reliable safety tool (100% NPV) for ruling out endoleak risk. This technology represents a critical advancement toward personalized EVAR planning, enabling surgeons to proactively identify high-risk anatomies and adjust treatment strategies to minimize post-procedural complications. Further large-scale, multicenter prospective trials are necessary to confirm these findings and support clinical adoption.<\/jats:p>","DOI":"10.3390\/bioengineering13010001","type":"journal-article","created":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T11:03:46Z","timestamp":1766142226000},"page":"1","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Digital Twin and Artificial Intelligence Technologies to Assess the Type IA Endoleak"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2502-4204","authenticated-orcid":false,"given":"Sungsin","family":"Cho","sequence":"first","affiliation":[{"name":"Department of Surgery, Kyung Hee University Hospital at Gangdong, Kyung Hee University School of Medicine, Seoul 05278, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2021-815X","authenticated-orcid":false,"given":"Hyangkyoung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Surgery, Ewha Womans University College of Medicine, Ewha Womans University Medical Center, Seoul 07985, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8533-6755","authenticated-orcid":false,"given":"Jinhyun","family":"Joh","sequence":"additional","affiliation":[{"name":"Department of Surgery, Kyung Hee University Hospital at Gangdong, Kyung Hee University School of Medicine, Seoul 05278, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,12,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1056\/NEJMoa0909305","article-title":"Endovascular versus open repair of abdominal aortic aneurysm","volume":"362","author":"Greenhalgh","year":"2010","journal-title":"N. 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