{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T12:36:41Z","timestamp":1771504601444,"version":"3.50.1"},"reference-count":49,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:00:00Z","timestamp":1771459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioengineering"],"abstract":"<jats:p>Background: Stress urinary incontinence (SUI) is one of the most common pelvic floor disorders in women, often impairing quality of life (QoL). Pelvic floor muscle training (PFMT) is the standard conservative therapy, while autologous platelet-rich plasma (PRP) is a newer minimally invasive regenerative option. Objective: To compare the effectiveness of three periurethral PRP injections versus PFMT in women with SUI. Methods: This prospective cohort study included 169 women diagnosed with SUI, divided into a PRP group (n = 131), receiving three periurethral PRP injections at 4\u20136-month intervals, and a PFMT group (n = 38), completing a 12-week PFMT program. Outcomes were measured using the Stamey incontinence scale, visual analogue scale (VAS), and the King\u2019s Health Questionnaire (KHQ). Results: At baseline, PRP patients had more severe symptoms and worse QoL scores. After one injection, PRP achieved improvements in Stamey and VAS scores comparable to PFMT (lower scores), though KHQ remained superior in PFMT (significantly higher baseline scores in the PRP group than the PFMT group). The PRP group showed consistently larger within-group improvements across all scales (p &lt; 0.001), in contrast to the PFMT group, which produced smaller and less consistent changes. Conclusions: Repeated PRP treatment provides greater, controlled, and more consistent benefits than PFMT for SUI.<\/jats:p>","DOI":"10.3390\/bioengineering13020242","type":"journal-article","created":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T11:44:27Z","timestamp":1771501467000},"page":"242","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparing Regenerative and Rehabilitative Strategies for Female Stress Urinary Incontinence: Platelet-Rich Plasma vs. Pelvic Floor Muscle Training\u2014A Prospective Study Evaluating Quality of Life"],"prefix":"10.3390","volume":"13","author":[{"given":"Andreea","family":"Borislavschi","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 8 Eroii Sanitari Blvd., 050474 Bucharest, Romania"},{"name":"Department of Obstetrics and Gynecology, Elias University Emergency Hospital, 17 M\u0103r\u0103\u0219ti Blvd., 050474 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4396-8081","authenticated-orcid":false,"given":"Cristian-Valentin","family":"Toma","sequence":"additional","affiliation":[{"name":"Department of Urology, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 8 Eroii Sanitari Blvd., 050474 Bucharest, Romania"},{"name":"Department of Urology, \u201cProf. Dr. Th. Burghele\u201d Clinical Hospital, 20 Panduri Street, 050659 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4496-1535","authenticated-orcid":false,"given":"R\u0103zvan-Cosmin","family":"Petca","sequence":"additional","affiliation":[{"name":"Department of Urology, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 8 Eroii Sanitari Blvd., 050474 Bucharest, Romania"},{"name":"Department of Urology, \u201cProf. Dr. Th. Burghele\u201d Clinical Hospital, 20 Panduri Street, 050659 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R\u0103zvan","family":"D\u0103n\u0103u","sequence":"additional","affiliation":[{"name":"Department of Urology, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 8 Eroii Sanitari Blvd., 050474 Bucharest, Romania"},{"name":"Department of Urology, \u201cProf. Dr. Th. Burghele\u201d Clinical Hospital, 20 Panduri Street, 050659 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4890-0978","authenticated-orcid":false,"given":"Aida","family":"Petca","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 8 Eroii Sanitari Blvd., 050474 Bucharest, Romania"},{"name":"Department of Obstetrics and Gynecology, General Hospital CF Number 2, 63 M\u0103r\u0103\u0219ti Blvd., 011163 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,2,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.eururo.2024.12.017","article-title":"Prevalence, Diagnosis, and Management of Stress Urinary Incontinence in Women: A Collaborative Review","volume":"87","author":"Moris","year":"2025","journal-title":"Eur. 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