{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T03:40:09Z","timestamp":1773286809220,"version":"3.50.1"},"reference-count":24,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T00:00:00Z","timestamp":1773187200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioengineering"],"abstract":"<jats:p>Background: Lumbosacral plexopathy (LSP) is characterized by severe neuropathic pain, motor weakness, and sensory deficits in the lumbosacral plexus region, often leading to significant functional impairment and reduced quality of life. Post-traumatic LSP is particularly challenging to treat due to its neuropathic nature and limited response to conventional pharmacologic therapies. Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive neuromodulation technique that has shown therapeutic potential for chronic neuropathic pain. Case Report: We report the case of a 16-year-old female who developed LSP following multiple pelvic fractures and subsequently exhibited disabling pain, depressive symptoms, and poor quality of life. High-frequency motor cortex rTMS resulted in meaningful clinical improvement in pain intensity (an NRS reduction from 8 to 2), mood, and daily functioning. Conclusions: This suggests the potential role of rTMS as an adjunctive treatment for refractory neuropathic pain secondary to traumatic LSP.<\/jats:p>","DOI":"10.3390\/bioengineering13030325","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T11:44:52Z","timestamp":1773229492000},"page":"325","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Repetitive Transcranial Magnetic Stimulation for Intractable Neuropathic Pain Following Post-Traumatic Lumbosacral Plexopathy: A Case Report"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3345-2727","authenticated-orcid":false,"given":"Jae-In","family":"You","sequence":"first","affiliation":[{"name":"Department of Physical Medicine & Rehabilitation, Eulji University Hospital, Daejeon 35233, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8713-0489","authenticated-orcid":false,"given":"Jae-Hyung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine & Rehabilitation, Chonnam National University Hwasun Hospital, Jeollanam-do 58128, Republic of Korea"},{"name":"Department of Physical Medicine & Rehabilitation, Chonnam National University Medical School, Gwangju 61469, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1212\/01.CON.0000455877.60932.d3","article-title":"Lumbosacral plexopathy","volume":"20","author":"Dyck","year":"2014","journal-title":"Continuum (Minneap Minn)"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e766","DOI":"10.1097\/MD.0000000000000766","article-title":"Painful lumbosacral plexopathy: A case report","volume":"94","author":"Ehler","year":"2015","journal-title":"Medicine"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.cnp.2020.07.005","article-title":"Brachial and lumbosacral plexopathies: A review","volume":"5","author":"Rubin","year":"2020","journal-title":"Clin. Neurophysiol. Pract."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Foreman, M., Maddy, K., Patel, A., Reddy, A., Costello, M., and Lucke-Wold, B. (2023). Differentiating lumbar spinal etiology from peripheral plexopathies. Biomedicines, 11.","DOI":"10.3390\/biomedicines11030756"},{"key":"ref_5","first-page":"786","article-title":"The value of MR neurography for evaluating extraspinal neuropathic leg pain: A pictorial essay","volume":"22","author":"Moore","year":"2001","journal-title":"Am. J. Neuroradiol."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Zhang, H., Zheng, X., and Zhang, B. (2025). Anti-Inflammatory Pathways Mediating tDCS\u2019s Effects on Neuropathic Pain. Biology, 14.","DOI":"10.3390\/biology14070892"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/S1474-4422(14)70251-0","article-title":"Pharmacotherapy for neuropathic pain in adults: A systematic review and meta-analysis","volume":"14","author":"Finnerup","year":"2015","journal-title":"Lancet Neurol."},{"key":"ref_8","first-page":"1","article-title":"Neuropathic pain: Current definition and review of clinical management","volume":"27","author":"Kim","year":"2014","journal-title":"Korean J. Pain."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1093\/pm\/pnz075","article-title":"A comprehensive algorithm for management of neuropathic pain","volume":"20","author":"Bates","year":"2019","journal-title":"Pain Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.clinph.2019.11.002","article-title":"Evidence-based guidelines on the therapeutic use of repetitive transcranial magnetic stimulation (rTMS): An update (2014\u20132018)","volume":"131","author":"Lefaucheur","year":"2020","journal-title":"Clin. Neurophysiol."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Pereira, G.S., da Silva, M.L., Oliveira, A.B., and Ferreira, L.M.A. (2026). Non-Invasive Neuromodulation for Pain Management in Children and Adolescents: A Systematic Review of Randomized Controlled Trials. Future, 4.","DOI":"10.3390\/future4010005"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0987-7053(01)00260-X","article-title":"Interventional neurophysiology for pain control: Duration of pain relief following repetitive transcranial magnetic stimulation of the motor cortex","volume":"31","author":"Lefaucheur","year":"2001","journal-title":"Neurophysiol. Clin."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1136\/jnnp.2004.055806","article-title":"Longlasting antalgic effects of daily sessions of repetitive transcranial magnetic stimulation in central and peripheral neuropathic pain","volume":"76","author":"Khedr","year":"2005","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1111\/ner.12760","article-title":"Advancing Transcranial Magnetic Stimulation Methods for Complex Regional Pain Syndrome: An Open-Label Study of Paired Theta Burst and High-Frequency Stimulation","volume":"21","author":"Gaertner","year":"2018","journal-title":"Neuromodulation"},{"key":"ref_15","first-page":"89","article-title":"Non-invasive brain stimulation for pain management","volume":"27","author":"Park","year":"2014","journal-title":"Korean J. Pain."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Bak, M.S., Park, H., and Kim, S.K. (2021). Neural plasticity in the brain during neuropathic pain. Biomedicines, 9.","DOI":"10.3390\/biomedicines9060624"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Varrassi, G., Leoni, M.L.G., Far\u00ec, G., Al-Alwany, A.A., Al-Sharie, S., and Fornasari, D. (2025). Neuromodulatory Signaling in Chronic Pain Patients: A Narrative Review. Cells, 14.","DOI":"10.20944\/preprints202507.2351.v1"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1016\/j.pain.2012.02.030","article-title":"Endogenous opioids mediate left dorsolateral prefrontal cortex rTMS-induced analgesia","volume":"153","author":"Taylor","year":"2012","journal-title":"Pain"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1212\/01.wnl.0000242731.10074.3c","article-title":"Motor cortex rTMS restores defective intracortical inhibition in chronic neuropathic pain","volume":"67","author":"Lefaucheur","year":"2006","journal-title":"Neurology"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.brs.2014.10.012","article-title":"Safety of Noninvasive Brain Stimulation in Children and Adolescents","volume":"8","author":"Krishnan","year":"2015","journal-title":"Brain Stimul."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2433","DOI":"10.1001\/archinte.163.20.2433","article-title":"Depression and pain comorbidity: A literature review","volume":"163","author":"Bair","year":"2003","journal-title":"Arch. Intern. Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1523\/JNEUROSCI.3822-08.2009","article-title":"Mood influences supraspinal pain processing separately from attention","volume":"29","author":"Villemure","year":"2009","journal-title":"J. Neurosci."},{"key":"ref_23","first-page":"9724371","article-title":"The link between depression and chronic pain: Neural mechanisms in the brain","volume":"19","author":"Sheng","year":"2017","journal-title":"Neural Plast."},{"key":"ref_24","first-page":"E303","article-title":"Repetitive transcranial magnetic stimulation at different frequencies for postherpetic neuralgia: A double-blind, sham-controlled, randomized trial","volume":"22","author":"Pei","year":"2019","journal-title":"Pain Physician"}],"container-title":["Bioengineering"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2306-5354\/13\/3\/325\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T11:56:59Z","timestamp":1773230219000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2306-5354\/13\/3\/325"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,11]]},"references-count":24,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,3]]}},"alternative-id":["bioengineering13030325"],"URL":"https:\/\/doi.org\/10.3390\/bioengineering13030325","relation":{},"ISSN":["2306-5354"],"issn-type":[{"value":"2306-5354","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,11]]}}}