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Exosome-based therapies have recently emerged as a safe and effective modality for radiation damage, and their functional capacity can be further potentiated through tailored preconditioning strategies\u2014such as nanoparticle induction or physical stimulation. This study developed a novel exosome-based therapy by preconditioning bone marrow mesenchymal stem cells (BMSCs) with Iron oxide (Fe3O4) magnetic nanoparticles (MNPs, 50 \u00b5g\/mL) and a static magnetic field (SMF, 100 mT). Exosomes derived from these preconditioned cells (BMSC-Fe3O4-SMF-Exos) exhibited enhanced yield and dual functionality. In irradiated BMSCs, BMSC-Fe3O4-SMF-Exos significantly promoted osteogenic differentiation, restoring alkaline phosphatase activity, mineralization, and expression of RUNX2, OCN, and COL1A1. They concurrently alleviated oxidative stress by scavenging reactive oxygen species, reducing malondialdehyde, and boosting superoxide dismutase activity. Mechanistically, miR-429 was found to be highly enriched in BMSC-Fe3O4-SMF-Exos, which directly targeted Noggin (NOG). Our functional validation experiments also confirmed that overexpression of miR-429 could inhibit NOG, alleviate oxidative stress and rescue the osteogenic differentiation of irradiated BMSCs. In conclusion, exosomes derived from preconditioning BMSCs with Fe3O4 MNPs and SMF mitigate radiation-induced damage via the miR-429\/NOG pathway, presenting a promising cell-free strategy for bone regeneration.<\/jats:p>","DOI":"10.3390\/bioengineering13040402","type":"journal-article","created":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T12:11:44Z","timestamp":1774872704000},"page":"402","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Fe3O4 Magnetic Nanoparticles and Static Magnetic Field Stimulated BMSC-Derived Exosomes Promoted Osteogenesis and Alleviated Oxidative Stress in Irradiated BMSCs Through miR-429\/NOG Pathway"],"prefix":"10.3390","volume":"13","author":[{"given":"Ting","family":"Mou","sequence":"first","affiliation":[{"name":"School of Stomatology, Jiamusi University, Jiamusi 154007, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2168-6523","authenticated-orcid":false,"given":"Chong","family":"Huang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, School of Stomatology, The Fourth Military Medical University, Xi\u2019an 710032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyue","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, School of Stomatology, The Fourth Military Medical University, Xi\u2019an 710032, 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Cell Death and Its Mechanisms","volume":"123","author":"Jiao","year":"2022","journal-title":"Health Phys."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"566","DOI":"10.3892\/etm.2022.11503","article-title":"The role of human antigen R (HuR) in modulating proliferation, senescence and radiosensitivity of skin cells","volume":"24","author":"Yu","year":"2022","journal-title":"Exp. Ther. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"S371","DOI":"10.1088\/1361-6498\/ac270e","article-title":"Basic concepts of radiation emergency medicine","volume":"41","year":"2021","journal-title":"J. Radiol. Prot."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s43556-025-00358-4","article-title":"Ionizing radiation: Molecular mechanisms, biological effects, and therapeutic targets","volume":"7","author":"Wei","year":"2026","journal-title":"Mol. Biomed."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e11","DOI":"10.1111\/1346-8138.16953","article-title":"Atypical radiation recall dermatitis induced by radiotherapy targeting a different site from the previously irradiated site","volume":"51","author":"Oya","year":"2024","journal-title":"J. Dermatol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"e168","DOI":"10.1002\/mco2.168","article-title":"Interferon regulatory factor 1-triggered free ubiquitin protects the intestines against radiation-induced injury via CXCR4\/FGF2 signaling","volume":"3","author":"Jiao","year":"2022","journal-title":"MedComm (2020)"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.oooo.2012.09.008","article-title":"Onset of mandible and tibia osteoradionecrosis: A comparative pilot study in the rat","volume":"115","author":"Both","year":"2013","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Zhao, Y., Wang, J., Xu, L., Xu, H., Yan, Y., Zhao, H., and Yan, Y. (2025). Beyond Bone Loss: A Biology Perspective on Osteoporosis Pathogenesis, Multi-Omics Approaches, and Interconnected Mechanisms. Biomedicines, 13.","DOI":"10.3390\/biomedicines13061443"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"213","DOI":"10.3892\/mmr.2015.4539","article-title":"Irradiation alters the differentiation potential of bone marrow mesenchymal stem cells","volume":"13","author":"Wang","year":"2016","journal-title":"Mol. Med. Rep."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1080\/09553002.2023.2295298","article-title":"Radiation-induced multi-organ injury","volume":"100","author":"DiCarlo","year":"2024","journal-title":"Int. J. Radiat. Biol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2298","DOI":"10.1016\/j.freeradbiomed.2012.10.536","article-title":"Loss of Nrf2 accelerates ionizing radiation-induced bone loss by upregulating RANKL","volume":"53","author":"Rana","year":"2012","journal-title":"Free Radic. Biol. Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1002\/jcb.29247","article-title":"Amifostine inhibited the differentiation of RAW264.7 cells into osteoclasts by reducing the production of ROS under 2\u2009Gy radiation","volume":"121","author":"Zhang","year":"2020","journal-title":"J. Cell Biochem."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Aseervatham, J. (2023). Dynamic Role of Exosome microRNAs in Cancer Cell Signaling and Their Emerging Role as Noninvasive Biomarkers. Biology, 12.","DOI":"10.3390\/biology12050710"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"5240","DOI":"10.1021\/acsami.7b17620","article-title":"Tissue-Engineered Bone Immobilized with Human Adipose Stem Cells-Derived Exosomes Promotes Bone Regeneration","volume":"10","author":"Li","year":"2018","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1186\/s10020-024-00904-w","article-title":"BMSC-derived exosomes promote osteoporosis alleviation via M2 macrophage polarization","volume":"30","author":"Zhang","year":"2024","journal-title":"Mol. Med."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Koniusz, S., Andrzejewska, A., Muraca, M., Srivastava, A.K., Janowski, M., and Lukomska, B. (2016). Extracellular Vesicles in Physiology, Pathology, and Therapy of the Immune and Central Nervous System, with Focus on Extracellular Vesicles Derived from Mesenchymal Stem Cells as Therapeutic Tools. Front. Cell Neurosci., 10.","DOI":"10.3389\/fncel.2016.00109"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"237","DOI":"10.7150\/thno.21945","article-title":"Exosome Theranostics: Biology and Translational Medicine","volume":"8","author":"He","year":"2018","journal-title":"Theranostics"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"eaau6977","DOI":"10.1126\/science.aau6977","article-title":"The biology, function, and biomedical applications of exosomes","volume":"367","author":"Kalluri","year":"2020","journal-title":"Science"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Harrell, C.R., Jovicic, N., Djonov, V., Arsenijevic, N., and Volarevic, V. (2019). Mesenchymal Stem Cell-Derived Exosomes and Other Extracellular Vesicles as New Remedies in the Therapy of Inflammatory Diseases. Cells, 8.","DOI":"10.3390\/cells8121605"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"114068","DOI":"10.1016\/j.jconrel.2025.114068","article-title":"Molecular engineering of extracellular vesicles for drug delivery: Strategies, challenges, and perspectives","volume":"386","author":"Dave","year":"2025","journal-title":"J. Control Release"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1186\/s12967-025-06578-0","article-title":"Precision exosome engineering for enhanced wound healing and scar revision","volume":"23","author":"Liu","year":"2025","journal-title":"J. Transl. Med."},{"key":"ref_22","first-page":"383","article-title":"Pretreated exosomes by electrical stimulation accelerate bone regeneration","volume":"51","author":"Chen","year":"2025","journal-title":"Bioact. Mater."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"6306","DOI":"10.1039\/C4CS00322E","article-title":"Emerging translational research on magnetic nanoparticles for regenerative medicine","volume":"44","author":"Gao","year":"2015","journal-title":"Chem. Soc. Rev."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"174657","DOI":"10.1016\/j.ejphar.2021.174657","article-title":"Mesenchymal stem cell-based nanoparticles and scaffolds in regenerative medicine","volume":"918","author":"Raghav","year":"2022","journal-title":"Eur. J. Pharmacol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1186\/s40001-025-02696-z","article-title":"Promising biomedical applications using superparamagnetic nanoparticles","volume":"30","author":"Fahim","year":"2025","journal-title":"Eur. J. Med. Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"e2405641","DOI":"10.1002\/adma.202405641","article-title":"A Superparamagnetic Composite Hydrogel Scaffold as In Vivo Dynamic Monitorable Theranostic Platform for Osteoarthritis Regeneration","volume":"36","author":"Rong","year":"2024","journal-title":"Adv. Mater."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.pbiomolbio.2022.11.006","article-title":"Evidence of the static magnetic field effects on bone-related diseases and bone cells","volume":"177","author":"Yang","year":"2023","journal-title":"Prog. Biophys. Mol. Biol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1385\/CBB:39:2:163","article-title":"Mechanism of action of moderate-intensity static magnetic fields on biological systems","volume":"39","author":"Rosen","year":"2003","journal-title":"Cell Biochem. Biophys."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1186\/s12951-021-00958-6","article-title":"Bone mesenchymal stem cells stimulation by magnetic nanoparticles and a static magnetic field: Release of exosomal miR-1260a improves osteogenesis and angiogenesis","volume":"19","author":"Wu","year":"2021","journal-title":"J. Nanobiotechnol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"7979","DOI":"10.2147\/IJN.S275650","article-title":"Exosomes Derived from Bone Mesenchymal Stem Cells with the Stimulation of Fe3O4 Nanoparticles and Static Magnetic Field Enhance Wound Healing Through Upregulated miR-21-5p","volume":"15","author":"Wu","year":"2020","journal-title":"Int. J. Nanomed."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.bbrc.2017.04.111","article-title":"PP2A catalytic subunit silence by microRNA-429 activates AMPK and protects osteoblastic cells from dexamethasone","volume":"487","author":"Guo","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1039\/D3NA00851G","article-title":"Recent advances of nanoparticles on bone tissue engineering and bone cells","volume":"6","author":"Zhang","year":"2024","journal-title":"Nanoscale Adv."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1039\/D4NA00797B","article-title":"Bone-derived nanoparticles (BNPs) enhance osteogenic differentiation via Notch signaling","volume":"7","author":"Stellpflug","year":"2025","journal-title":"Nanoscale Adv."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"3633","DOI":"10.1039\/D4BM00391H","article-title":"From bone to nanoparticles: Development of a novel generation of bone derived nanoparticles for image guided orthopedic regeneration","volume":"12","author":"Stellpflug","year":"2024","journal-title":"Biomater. Sci."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1007\/s11010-023-04775-3","article-title":"M2 macrophage-derived exosomes carry miR-142-3p to restore the differentiation balance of irradiated BMMSCs by targeting TGF-\u03b21","volume":"479","author":"Huang","year":"2024","journal-title":"Mol. Cell Biochem."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.biomaterials.2016.01.035","article-title":"Magnetic nanocomposite scaffolds combined with static magnetic field in the stimulation of osteoblastic differentiation and bone formation","volume":"85","author":"Yun","year":"2016","journal-title":"Biomaterials"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"14190","DOI":"10.1039\/D3RA00306J","article-title":"\u03b2-FeOOH\/TiO(2)\/cellulose nanocomposite aerogel as a novel heterogeneous photocatalyst for highly efficient photo-Fenton degradation","volume":"13","author":"Jing","year":"2023","journal-title":"RSC Adv."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"6165","DOI":"10.1021\/acsnano.4c14311","article-title":"Responsive Magnetic Polymer Nanocomposites through Thermal-Induced Structural Reorganization","volume":"19","author":"Chen","year":"2025","journal-title":"ACS Nano"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Popescu, R.C., Vasile, B., Savu, D.I., Mogo\u015fanu, G.D., Bejenaru, L.E., Andronescu, E., Grumezescu, A.M., and Mogoant\u0103, L. (2022). Influence of Polymer Shell Molecular Weight on Functionalized Iron Oxide Nanoparticles Morphology and In Vivo Biodistribution. Pharmaceutics, 14.","DOI":"10.3390\/pharmaceutics14091877"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Zhang, Y., Chen, C., Udenigwe, C.C., Zheng, Z., and Liu, Y. (2026). Tetrapeptides derived from black bean enhance osteogenesis and alleviate ovariectomy-induced bone loss via activation of BMP-2\/Smad signaling. J. Adv. Res.","DOI":"10.1016\/j.jare.2026.01.012"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Goto, S., Zhang, Y., Vyas, S.A., Zhu, Q., and Wildsoet, C.F. (2023). Changes in Expression in BMP2 and Two Closely Related Genes in Guinea Pig Retinal Pigment Epithelium during Induction and Recovery from Myopia. Biomolecules, 13.","DOI":"10.3390\/biom13091373"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"e70122","DOI":"10.1002\/jcp.70122","article-title":"MiR-101-3p Promotes Cardiac Senescence and Inflammation via Targeting Tbx20 and Bmp2 to Perturb Cardiac Homeostasis","volume":"240","author":"Das","year":"2025","journal-title":"J. Cell Physiol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"120094","DOI":"10.1016\/j.biomaterials.2020.120094","article-title":"CRISPR interference-mediated noggin knockdown promotes BMP2-induced osteogenesis and calvarial bone healing","volume":"252","author":"Hsu","year":"2020","journal-title":"Biomaterials"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"5660927","DOI":"10.1155\/2021\/5660927","article-title":"Treatment of Radiation Bone Injury with Transplanted hUCB-MSCs via Wnt\/\u03b2-Catenin","volume":"2021","author":"Zhang","year":"2021","journal-title":"Stem Cells Int."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Huang, C., Li, H., Zhang, Z., Mou, T., Wang, D., Li, C., Tian, L., and Zong, C. (2025). From Mechanism to Therapy: The Role of MSC-EVs in Alleviating Radiation-Induced Injuries. Pharmaceutics, 17.","DOI":"10.3390\/pharmaceutics17050652"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"tkab043","DOI":"10.1093\/burnst\/tkab043","article-title":"Therapeutic implications of exosomes in the treatment of radiation injury","volume":"10","author":"Dai","year":"2022","journal-title":"Burn. Trauma."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"114709","DOI":"10.1016\/j.colsurfb.2025.114709","article-title":"Immunomodulatory peptide DP7-C mediates macrophage-derived exosomal miR-21b to promote bone regeneration via the SOCS1\/JAK2\/STAT3 axis","volume":"253","author":"Lai","year":"2025","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1089\/ten.tea.2025.0013","article-title":"\u03b23GALT2 Gene Promotes Osteogenic Differentiation of BMSCs on n-HA\/PA66 Via Exosomes","volume":"32","author":"Peng","year":"2025","journal-title":"Tissue Eng. Part. A"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1007\/s43630-025-00810-y","article-title":"Effects of hypoxic and photobiomodulation preconditioning on mesenchymal stem cell-derived exosomes: An in vitro study with an osteogenic potential approach","volume":"24","author":"Khosravipour","year":"2025","journal-title":"Photochem. Photobiol. Sci."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.joen.2025.03.004","article-title":"CBCT-Assessed Outcomes and Prognostic Factors of Primary Endodontic Treatment and Retreatment: A Systematic Review and Meta-Analysis","volume":"51","author":"Georgiou","year":"2025","journal-title":"J. Endod."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s13287-018-1121-9","article-title":"BM-MSC-derived exosomes alleviate radiation-induced bone loss by restoring the function of recipient BM-MSCs and activating Wnt\/\u03b2-catenin signaling","volume":"10","author":"Zuo","year":"2019","journal-title":"Stem Cell Res. Ther."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.actbio.2019.12.020","article-title":"Hypoxic mesenchymal stem cell-derived exosomes promote bone fracture healing by the transfer of miR-126","volume":"103","author":"Liu","year":"2020","journal-title":"Acta Biomater."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"652","DOI":"10.20892\/j.issn.2095-3941.2020.0063","article-title":"Serum miR-339-3p as a potential diagnostic marker for non-small cell lung cancer","volume":"17","author":"Trakunram","year":"2020","journal-title":"Cancer Biol. Med."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1186\/s13046-017-0568-3","article-title":"miR-500a-3p promotes cancer stem cells properties via STAT3 pathway in human hepatocellular carcinoma","volume":"36","author":"Jiang","year":"2017","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"147006","DOI":"10.1016\/j.ijbiomac.2025.147006","article-title":"Let-7i-3p inhibits the progression of gastric cancer by targeting CCND1 and suppressing the NF-\u03baB signaling pathway","volume":"322","author":"Tu","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"e1322","DOI":"10.1002\/iid3.1322","article-title":"Quantitative proteomic analysis of circulating exosomes reveals the mechanism by which Triptolide protects against collagen-induced arthritis","volume":"12","author":"Liu","year":"2024","journal-title":"Immun. Inflamm. Dis."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Farris, M.K., Helis, C.A., Hughes, R.T., LeCompte, M.C., Borg, A.M., Nieto, K., Munley, M.T., and Willey, J.S. (2020). Bench to Bedside: Animal Models of Radiation Induced Musculoskeletal Toxicity. Cancers, 12.","DOI":"10.3390\/cancers12020427"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1016\/j.identj.2025.03.006","article-title":"Establishment of an Osteoradionecrosis Model and its Mechanism Via Single Ionizing Radiation Exposure","volume":"75","author":"Wang","year":"2025","journal-title":"Int. Dent. J."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1038\/nprot.2012.113","article-title":"Evaluation of bone regeneration using the rat critical size calvarial defect","volume":"7","author":"Spicer","year":"2012","journal-title":"Nat. Protoc."},{"key":"ref_60","first-page":"3226","article-title":"Guided bone regeneration in a small animal model of critical size craniofacial bone defects","volume":"25","author":"He","year":"2021","journal-title":"Chin. J. Tissue Eng. Res."}],"container-title":["Bioengineering"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2306-5354\/13\/4\/402\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T16:20:40Z","timestamp":1775060440000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2306-5354\/13\/4\/402"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,30]]},"references-count":60,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2026,4]]}},"alternative-id":["bioengineering13040402"],"URL":"https:\/\/doi.org\/10.3390\/bioengineering13040402","relation":{},"ISSN":["2306-5354"],"issn-type":[{"value":"2306-5354","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,30]]}}}