{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T17:09:56Z","timestamp":1779210596259,"version":"3.51.4"},"reference-count":133,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T00:00:00Z","timestamp":1778457600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioengineering"],"abstract":"<jats:p>Corneal diseases affect a significant proportion of the global population, with younger age groups being particularly vulnerable. In severe cases involving vision loss, standard techniques such as keratoplasty often fail. These cases require more invasive treatment through the implantation of artificial cornea or keratoprostheses. Since the development of the oldest technique for creating and implanting the first keratoprostheses by Strampelli, these devices have experienced major modifications to improve their biocompatibility, function, and long-term viability. As a result, there is currently a wide range of implants and procedures that are available and can be applied according to patient indications and clinical settings. This narrative review attempts to cover the literature on this topic by focusing on (1) recent advances in rigid (Boston Type I and II, osteo-odonto-keratoprosthesis, modified osteo-odonto-keratoprosthesis, and LV Prasad Eye Institute keratoprosthesis) and soft (AlphaCor, CorNeat, and EndoArt) keratoprosthesis designs and (2) more recent studies on innovative biomaterials and techniques that could lead to the fabrication of fully functional biosynthetic corneas with optimal properties. In our review of these materials, we cover the current clinical applications and limitations, as well as future prospects of less invasive and more efficient prostheses that could improve patient outcomes and quality of life.<\/jats:p>","DOI":"10.3390\/bioengineering13050548","type":"journal-article","created":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T16:07:26Z","timestamp":1779206846000},"page":"548","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prosthetic Corneal Surgery: A Narrative Review of Current Keratoprostheses and the Future Prospects of New Biomaterials"],"prefix":"10.3390","volume":"13","author":[{"given":"\u0141ukasz","family":"Drzyzga","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Prof. K. Gibi\u0144ski University Clinical Center, Medical University of Silesia, 40-514 Katowice, Poland"},{"name":"Clinical Ophthalmology Center Okolux, 40-754 Katowice, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3596-7970","authenticated-orcid":false,"given":"Dorota","family":"\u015apiewak","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Prof. K. Gibi\u0144ski University Clinical Center, Medical University of Silesia, 40-514 Katowice, Poland"},{"name":"Clinical Ophthalmology Center Okolux, 40-754 Katowice, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1768-9628","authenticated-orcid":false,"given":"Mariola","family":"Dorecka","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Prof. K. Gibi\u0144ski University Clinical Center, Medical University of Silesia, 40-514 Katowice, Poland"},{"name":"Department of Ophthalmology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, 40-287 Katowice, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorota","family":"Wygl\u0119dowska-Promie\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Prof. K. Gibi\u0144ski University Clinical Center, Medical University of Silesia, 40-514 Katowice, Poland"},{"name":"Department of Ophthalmology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, 40-287 Katowice, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Holland, G., Pandit, A., Sanchez-Abella, L., Haiek, A., Loinaz, I., Dupin, D., Gonzalez, M., Larra, E., Bidaguren, A., and Lagali, N. (2021). Artificial Cornea: Past, Current, and Future Directions. Front. Med., 8.","DOI":"10.3389\/fmed.2021.770780"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1136\/bjophthalmol-2011-300539","article-title":"Global estimates of visual impairment: 2010","volume":"96","author":"Pascolini","year":"2012","journal-title":"Br. J. Ophthalmol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"753","DOI":"10.3928\/1081597X-20121011-01","article-title":"Progression of keratoconus and efficacy of corneal collagen cross-linking in children and adolescents","volume":"28","author":"Chatzis","year":"2012","journal-title":"J. Refract. Surg."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1097\/ICO.0000000000002957","article-title":"Pediatric Microbial Keratitis: Identification of Clinical Biomarkers for Prognosis and Outcome of 218 Cases From 2009 to 2019","volume":"41","author":"Rajan","year":"2022","journal-title":"Cornea"},{"key":"ref_5","first-page":"1","article-title":"From Tooth to Vision: A Decade of Breakthroughs in Osteo-Odonto-Keratoprosthesis (OOKP) and Modified OOKP-Global Insights into Surgical Techniques, Outcomes, and Pioneering Research","volume":"40","author":"France","year":"2025","journal-title":"Semin. Ophthalmol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1001\/archopht.123.10.1319","article-title":"Modified osteo-odonto-keratoprosthesis for treatment of corneal blindness: Long-term anatomical and functional outcomes in 181 cases","volume":"123","author":"Falcinelli","year":"2005","journal-title":"Arch. Ophthalmol."},{"key":"ref_7","unstructured":"(2026, January 14). AJL Opththalmic. Available online: https:\/\/ajlsa.com\/en\/product\/ajl-ookp-en\/."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1136\/bjo-2025-327222","article-title":"Lifelong experience of modified osteo-odonto-keratoprosthesis implantation over 50 years","volume":"109","author":"Taloni","year":"2025","journal-title":"Br. J. Ophthalmol."},{"key":"ref_9","unstructured":"(2017, May 20). Modified Osteo-Odonto-Keratoprosthesis (MOOKP): Indications, Contraindications, and Surgical Technique. Fastest Otolaryngology & Ophthalmology Insight Engine. Endo Key, Available online: https:\/\/entokey.com\/modified-osteo-odonto-keratoprosthesis-mookp-indications-contraindications-and-surgical-technique\/."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"620","DOI":"10.4103\/ijo.IJO_22_18","article-title":"Keratoprosthesis: Current global scenario and a broad Indian perspective","volume":"66","author":"Iyer","year":"2018","journal-title":"Indian J. Ophthalmol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1097\/ICU.0000000000000373","article-title":"The Boston keratoprosthesis","volume":"28","author":"Saeed","year":"2017","journal-title":"Curr. Opin. Ophthalmol."},{"key":"ref_12","first-page":"8","article-title":"Anesthesia Considerations in Modified Osteo-odonto-keratoprosthesis","volume":"8","author":"Raman","year":"2019","journal-title":"Asia Pac. J. Ophthalmol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1097\/ICU.0000000000000388","article-title":"The osteo-odonto-keratoprosthesis","volume":"28","author":"Avadhanam","year":"2017","journal-title":"Curr. Opin. Ophthalmol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.jtos.2016.07.002","article-title":"Osteokeratoprosthesis Using Tibial Bone: Surgical Technique and Outcomes","volume":"14","author":"Charoenrook","year":"2016","journal-title":"Ocul. Surf."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.jtos.2018.08.006","article-title":"When there is no tooth\u2014Looking beyond the Falcinelli MOOKP","volume":"17","author":"Avadhanam","year":"2019","journal-title":"Ocul. Surf."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1097\/ICO.0000000000002207","article-title":"Design and Outcomes of a Novel Keratoprosthesis. Addressing Unmet Needs in End-Stage Cicatricial Corneal Blindness","volume":"39","author":"Bakshi","year":"2020","journal-title":"Cornea"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.jtos.2019.04.006","article-title":"Osteo-odonto-, Tibial bone and Boston keratoprosthesis in clinically comparable cases of chemical injury and autoimmune disease","volume":"17","author":"Charoenrook","year":"2019","journal-title":"Ocul. Surf."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"697","DOI":"10.2147\/OPTH.S27083","article-title":"Keratoprostheses for corneal blindness: A review of contemporary devices","volume":"9","author":"Avadhanam","year":"2015","journal-title":"Clin. Ophthalmol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.jtos.2022.03.005","article-title":"The evolution of the modified osteo-odonto-keratoprosthesis, its reliability, and long-term visual rehabilitation prognosis: An analytical review","volume":"24","author":"Soifer","year":"2022","journal-title":"Ocul. Surf."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.2147\/OPTH.S219270","article-title":"Boston Type 1 Keratoprosthesis: Updated Perspectives","volume":"14","author":"Nonpassopon","year":"2020","journal-title":"Clin. Ophthalmol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"8","DOI":"10.21037\/aes-22-67","article-title":"Boston type I keratoprosthesis","volume":"9","author":"Hu","year":"2024","journal-title":"Annals of Eye Sci."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1097\/ICO.0b013e31823e6110","article-title":"Boston keratoprosthesis type 1 surgery: Use of frozen versus fresh corneal donor carriers","volume":"31","author":"Robert","year":"2012","journal-title":"Cornea"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.ophtha.2016.07.019","article-title":"Boston Keratoprosthesis Type 1: A Randomized Controlled Trial of Fresh versus Frozen Corneal Donor Carriers with Long-Term Follow-up","volume":"124","author":"Muzychuk","year":"2017","journal-title":"Ophthalmology"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.ajo.2019.03.016","article-title":"The Aurolab Keratoprosthesis (KPro) versus the Boston Type I Kpro: 5-year Clinical Outcomes in 134 Cases of Bilateral Corneal Blindness","volume":"205","author":"Basu","year":"2019","journal-title":"Am. J. Ophthalmol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1001\/jamaophthalmol.2015.4776","article-title":"Global Survey of Corneal Transplantation and Eye Banking","volume":"134","author":"Gain","year":"2016","journal-title":"JAMA Ophthalmol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1007\/s00417-011-1684-y","article-title":"Titanium back plate for a PMMA keratoprosthesis: Clinical outcomes","volume":"249","author":"Todani","year":"2011","journal-title":"Graefe\u2019s Arch. Clin. Exp. Ophthalmol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1097\/ICO.0b013e3181a186dc","article-title":"Boston keratoprosthesis outcomes and complications","volume":"28","author":"Chew","year":"2009","journal-title":"Cornea"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"3863","DOI":"10.1167\/iovs.13-11714","article-title":"In vitro and in vivo assessment of titanium surface modification for coloring the backplate of the Boston keratoprosthesis","volume":"54","author":"Paschalis","year":"2013","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1097\/ICO.0000000000001462","article-title":"Retroprosthetic Membrane Formation in Boston Keratoprosthesis: A Case-Control-Matched Comparison of Titanium Versus PMMA Backplate","volume":"37","author":"Talati","year":"2018","journal-title":"Cornea"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1097\/00003226-200101000-00003","article-title":"Keratoprosthesis: Preoperative prognostic categories","volume":"20","author":"Yaghouti","year":"2001","journal-title":"Cornea"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"e13","DOI":"10.1097\/ICO.0000000000001154","article-title":"Boston Type 1 Keratoprosthesis: Visual Outcomes, Device Retention, and Complications","volume":"36","author":"Parker","year":"2017","journal-title":"Cornea"},{"key":"ref_32","unstructured":"Goel, P., and Hemmati, H.D. (2017). Boston Type I Keratoprosthesis EyeNet Magazine, Cornea Ophthalmic Pearls."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1136\/bjophthalmol-2017-311649","article-title":"LVP keratoprosthesis: Anatomical and functional outcomes in bilateral end-stage corneal blindness","volume":"103","author":"Basu","year":"2018","journal-title":"Br. J. Ophthalmol."},{"key":"ref_34","first-page":"bcr2013202756","article-title":"Boston type 1 based keratoprosthesis (Auro Kpro) and its modification (LVP Kpro) in chronic Stevens Johnson syndrome","volume":"2014","author":"Basu","year":"2014","journal-title":"Case Rep."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"3311","DOI":"10.1016\/S0142-9612(01)00168-5","article-title":"An overview of the development of artificial corneas with porous skirts and the use of PHEMA for such an application","volume":"22","author":"Chirila","year":"2001","journal-title":"Biomaterials"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.msec.2015.01.089","article-title":"T-style keratoprosthesis based on surface-modified poly (2-hydroxyethyl methacrylate) hydrogel for cornea repairs","volume":"50","author":"Xiang","year":"2015","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1038\/eye.2011.122","article-title":"AlphaCor artificial cornea: Clinical outcome","volume":"25","author":"Jiraskova","year":"2011","journal-title":"Eye"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1038\/s41433-022-02105-3","article-title":"The first-in-human implantation of the CorNeat keratoprosthesis","volume":"37","author":"Bahar","year":"2023","journal-title":"Eye"},{"key":"ref_39","first-page":"14","article-title":"Providing Hope for the Corneally Blind","volume":"28","author":"Litvin","year":"2024","journal-title":"Corneal Physician"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1097\/ICO.0000000000002798","article-title":"CorNeat KPro: Ocular Implantation Study in Rabbits","volume":"40","author":"Litvin","year":"2021","journal-title":"Cornea"},{"key":"ref_41","unstructured":"Ni Dhubhghaill, S. (2017, May 20). EndoArt Under PKP. Cataract & Refractive Surgery Today. Available online: https:\/\/crstoday.com\/wp-content\/uploads\/sites\/4\/2023\/03\/0323CRST_AECOS-Update_Ni-Dhubhghaill.pdf."},{"key":"ref_42","first-page":"e100619","article-title":"EndoArt in Corneal Endothelial Disease: Systematic Review and Meta-Analysis of Clinical Outcomes and Complications","volume":"18","author":"Khan","year":"2026","journal-title":"Cureus"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s40123-025-01286-w","article-title":"Current Landscape and Future Prospects of Corneal Regenerative Medicine","volume":"15","author":"Giannaccare","year":"2026","journal-title":"Ophthalmol. Ther."},{"key":"ref_44","first-page":"559","article-title":"Corneal Endothelial Keratoprosthesis EndoArt in Patients with Glaucoma at High Risk of Graft Failure After Keratoplasty","volume":"44","author":"Wiedemann","year":"2024","journal-title":"Cornea"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Romano, D., Ventura, M., Vaccaro, S., Forbice, E., Hau, S., Semeraro, F., and Romano, V. (2024). Corneal Artificial Endothelial Layer (EndoArt): Literature Review and Our Experience. J. Clin. Med., 13.","DOI":"10.3390\/jcm13216520"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1097\/ICO.0000000000003433","article-title":"Early Outcomes of an Artificial Endothelial Replacement Membrane Implantation After Failed Repeat Endothelial Keratoplasty","volume":"43","author":"Fontana","year":"2024","journal-title":"Cornea"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1016\/j.survophthal.2022.01.005","article-title":"The historical development and an overview of contemporary keratoprostheses","volume":"67","author":"Moshirfar","year":"2022","journal-title":"Surv. Ophthalmol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/j.ophtha.2023.05.010","article-title":"Follow-up Extension Up to 43 Years of Modified Osteo-Odonto-Keratoprosthesis","volume":"130","author":"Colliardo","year":"2023","journal-title":"Ophthalmology"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"e426","DOI":"10.1016\/j.jcms.2012.02.020","article-title":"Osteo-odonto-keratoprosthesis\u2014A maxillofacial perspective","volume":"40","author":"Narayanan","year":"2012","journal-title":"J. Cranio-Maxillofac. Surg."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.xjec.2020.01.001","article-title":"Mucosal complications in osteo-odonto keratoprosthesis (OOKP) surgery","volume":"6","author":"Avadhanam","year":"2020","journal-title":"J. EuCornea"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.bjoms.2019.07.001","article-title":"Contribution to oral and maxillary surgery and surgical technique of osteo-odontokeratoprosthesis in Japan","volume":"57","author":"Enomoto","year":"2019","journal-title":"Br. J. Oral Maxillofac. Surg."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1007\/s44445-025-00102-2","article-title":"Osteo-odonto-keratoprosthesis: A surgical procedure for treating advanced corneal diseases","volume":"38","author":"Morawiec","year":"2026","journal-title":"Saudi Dent. J."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.ajo.2022.05.015","article-title":"Osteo-odonto-keratoprosthesis According to Strampelli Original Technique. A Retrospective Study with Up to 30 Years of Follow-up","volume":"242","author":"Iannetti","year":"2022","journal-title":"Am. J. Ophthalmol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1097\/ICO.0000000000003495","article-title":"Long-Term Outcomes of Keratoprosthesis with Biological Haptic: A Review of 25 Years of Single-Center Surgeries","volume":"43","author":"Angerer","year":"2024","journal-title":"Cornea"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.ajo.2014.11.030","article-title":"Glaucoma in modified osteo-odonto-keratoprosthesis eyes: Role of additional stage 1A and Ahmed glaucoma drainage device-technique and timing","volume":"159","author":"Iyer","year":"2015","journal-title":"Am. J. Ophthalmol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1097\/IJG.0b013e31818456a4","article-title":"Glaucoma Management in Patients with Osteo-odonto-keratoprosthesis (OOKP)","volume":"18","author":"Sasikumar","year":"2009","journal-title":"J. Glaucoma"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1016\/j.ophtha.2017.12.003","article-title":"Vitreoretinal Complications and Outcomes in 92 Eyes Undergoing Surgery for Modified Osteo-Odonto-Keratoprosthesis. A 10-Year Review","volume":"125","author":"Rishi","year":"2018","journal-title":"Ophthalmology"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1111\/1469-0691.12118","article-title":"Endophthalmitis","volume":"19","author":"Durand","year":"2013","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/j.jtos.2020.07.010","article-title":"Clinical study of laminar resorption: Part 1\u2014Factors affecting laminar resorption","volume":"18","author":"Avadhanam","year":"2020","journal-title":"Ocul. Surf."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.jtos.2021.08.001","article-title":"Clinical study of laminar resorption: Part 2- outcomes, review and proposal for classification","volume":"22","author":"Avadhanam","year":"2021","journal-title":"Ocul. Surf."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.jtos.2012.01.003","article-title":"Osteo-odonto keratoprosthesis: Systematic review of surgical outcomes and complication rates","volume":"10","author":"Tan","year":"2012","journal-title":"Ocul. Surf."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"89","DOI":"10.4103\/jips.jips_283_17","article-title":"Osteo-odonto keratoprosthesis: Innovative dental and ophthalmic blending","volume":"18","author":"Kaur","year":"2018","journal-title":"J. Indian Prosthodont. Soc."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"22","DOI":"10.4103\/KSDJ.KSDJ_8_24","article-title":"Osteo-Odonto-Keratoprosthesis","volume":"47","author":"Thomas","year":"2024","journal-title":"Kerala Dent. J."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1111\/j.1442-9071.2004.00781.x","article-title":"Deposits in artificial corneas: Risk factors and prevention","volume":"32","author":"Hicks","year":"2004","journal-title":"Clin. Exp. Ophthalmol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1136\/bjo-2024-326211","article-title":"Feature developments in artificial corneal devices: A review","volume":"109","author":"Li","year":"2025","journal-title":"Br. J. Ophthalmol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1097\/ICO.0b013e31813e0bd8","article-title":"Complications of AlphaCor keratoprosthesis: A clinicopathologic report","volume":"26","author":"Chalam","year":"2007","journal-title":"Cornea"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1097\/ICO.0000000000003835","article-title":"Long-Term Clinical Outcomes and Anterior Segment Optical Coherence Tomography Findings After Artificial Endothelial Replacement Membrane Implantation","volume":"45","author":"Fontana","year":"2026","journal-title":"Cornea"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1097\/ICO.0000000000002806","article-title":"Implantation of an Artificial Endothelial Layer for Treatment of Chronic Corneal Edema","volume":"40","author":"Auffarth","year":"2021","journal-title":"Cornea"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"369","DOI":"10.2147\/OPTH.S349719","article-title":"Challenges of Glaucoma Management in Patients with Type I Boston Keratoprosthesis","volume":"16","author":"AlHilali","year":"2022","journal-title":"Clin. Ophthalmol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"022006","DOI":"10.1088\/2516-1091\/ae4d91","article-title":"Engineered surfaces for biomedical implants: Advances in coatings, materials, and techniques","volume":"8","author":"Zaheer","year":"2026","journal-title":"Prog. Biomed. Eng."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"130018","DOI":"10.1016\/j.colsurfa.2022.130018","article-title":"Optical and thermal properties of polymethyl methacrylate (PMMA) bearing phenyl and adamantyl substituents","volume":"653","author":"Wu","year":"2022","journal-title":"Colloids Surf. A Physicochem. Eng. Asp."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1002\/term.3173","article-title":"Bioinspired Hydrogel Surfaces to Augment Corneal Endothelial Cell Monolayer Formation","volume":"15","author":"Ozgun","year":"2021","journal-title":"J. Tissue Eng. Regen. Med."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Wu, K.Y., Qian, S.Y., Faucher, A., and Tran, S.D. (2024). Advancements in Hydrogels for Corneal Healing and Tissue Engineering. Gels, 10.","DOI":"10.3390\/gels10100662"},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Chi, M., Yuan, B., Xie, Z., and Hong, J. (2023). The Innovative Biomaterials and Technologies for Developing Corneal Endothelium Tissue Engineering Scaffolds: A Review and Prospect. Bioengineering, 10.","DOI":"10.3390\/bioengineering10111284"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"e304\u2013309","DOI":"10.11607\/jomi.te12","article-title":"Biointegration of the osteo-odonto lamina in the modified osteo-odonto keratoprosthesis: Engineering of tissue to restore lost vision","volume":"28","author":"Sawatari","year":"2013","journal-title":"Int. J. Oral Maxillofac. Implants"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.actbio.2020.01.023","article-title":"Surface modification of corneal prosthesis with nano-hydroxyapatite to enhance in vivo biointegration","volume":"107","author":"Riau","year":"2020","journal-title":"Acta Biomater."},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Boraldi, F., Lofaro, F.D., Bonacorsi, S., Mazzilli, A., Garcia-Fernandez, M., and Quaglino, D. (2024). The Role of Fibroblasts in Skin Homeostasis and Repair. Biomedicines, 12.","DOI":"10.3390\/biomedicines12071586"},{"key":"ref_78","first-page":"07","article-title":"Protein Adsorption on Biomaterial Surfaces: Subsequent Conformational and Biological Consequences\u2014A Review","volume":"36","author":"Mitra","year":"2020","journal-title":"J. Surf. Sci. Technol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/ten.2005.11.1","article-title":"Mediation of Biomaterial\u2013Cell Interactions by Adsorbed Proteins: A Review","volume":"11","author":"Wilson","year":"2005","journal-title":"Tissue Eng."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1038\/s41580-024-00777-1","article-title":"The role and regulation of integrins in cell migration and invasion","volume":"26","author":"Chastney","year":"2024","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"25405","DOI":"10.1038\/s41598-025-08415-2","article-title":"Hierarchical micro-nano topographies to control Bacteria and mesenchymal stem cells biological responses","volume":"15","author":"Alameda","year":"2025","journal-title":"Sci. Rep."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"025001","DOI":"10.1088\/2631-7990\/acbd6c","article-title":"Embedding aligned nanofibrous architectures within 3D-printed polycaprolactone scaffolds for directed cellular infiltration and tissue regeneration","volume":"5","author":"Meng","year":"2023","journal-title":"Int. J. Extrem. Manuf."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1902069","DOI":"10.1002\/admi.201902069","article-title":"Covalent Mucin Coatings Form Stable Anti-Biofouling Layers on a Broad Range of Medical Polymer Materials","volume":"7","author":"Winkeljann","year":"2020","journal-title":"Adv. Mater. Interfaces"},{"key":"ref_84","first-page":"12","article-title":"The impact of biomaterial characteristics on macrophage phenotypes in tissue engineering: A review","volume":"12","author":"Jackson","year":"2025","journal-title":"Plast. Aesthetic Res."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1007\/s00018-025-06041-9","article-title":"Macrophage polarization in inflammatory regulation: Molecular mechanisms, therapeutic targets, and translational challenges","volume":"83","author":"He","year":"2026","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"P\u00e9rez, S., and Rius-P\u00e9rez, S. (2022). Macrophage Polarization and Reprogramming in Acute Inflammation: A Redox Perspective. Antioxidants, 11.","DOI":"10.3390\/antiox11071394"},{"key":"ref_87","first-page":"25158414211058249","article-title":"Use of biomaterials in corneal endothelial repair","volume":"13","author":"Hussain","year":"2021","journal-title":"Ther. Adv. Ophthalmol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.actbio.2005.03.002","article-title":"Heparin functionalized PEG gels that modulate protein adsorption for hMSC adhesion and differentiation","volume":"1","author":"Benoit","year":"2005","journal-title":"Acta Biomater."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"114","DOI":"10.3390\/jfb4030114","article-title":"Keeping an eye on decellularized corneas: A review of methods, characterization and applications","volume":"4","author":"Wilson","year":"2013","journal-title":"J. Funct. Biomater."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"102940","DOI":"10.1016\/j.mtbio.2026.102940","article-title":"Multifunctional implantable hydrogels: Smart platforms at the forefront of biomedical innovation","volume":"37","author":"Nagay","year":"2026","journal-title":"Mater. Today Bio"},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Zeppieri, M., Gagliano, C., D\u2019Esposito, F., Musa, M., Russo, A., Longo, A., Giglio, R., Tognetto, D., Scollo, D., and Visalli, F. (2026). Progress in Bioengineering: An Extensive Examination of State-of-the-Art Innovations in the Development of Artificial Corneas. Front. Biosci. Elite, 18.","DOI":"10.31083\/FBE38592"},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Lynch, C.R., Kondiah, P.P.D., Choonara, Y.E., du Toit, L.C., Ally, N., and Pillay, V. (2020). Hydrogel Biomaterials for Application in Ocular Drug Delivery. Front. Bioeng. Biotechnol., 8.","DOI":"10.3389\/fbioe.2020.00228"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1002\/adhm.201400045","article-title":"Biodegradable and biocompatible poly(ethylene glycol)-based hydrogel films for the regeneration of corneal endothelium","volume":"3","author":"Ozcelik","year":"2014","journal-title":"Adv. Healthc. Mater."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"e2408021","DOI":"10.1002\/advs.202408021","article-title":"Biomaterials for Corneal Regeneration","volume":"12","author":"Li","year":"2025","journal-title":"Adv. Sci."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"eaba2187","DOI":"10.1126\/sciadv.aba2187","article-title":"LiQD Cornea: Pro-regeneration collagen mimetics as patches and alternatives to corneal transplantation","volume":"6","author":"McTiernan","year":"2020","journal-title":"Sci. Adv."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/j.biomaterials.2007.11.011","article-title":"Recombinant human collagen for tissue engineered corneal substitutes","volume":"29","author":"Liu","year":"2008","journal-title":"Biomaterials"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"2420","DOI":"10.1016\/j.biomaterials.2013.11.079","article-title":"Stable corneal regeneration four years after implantation of a cell-free recombinant human collagen scaffold","volume":"35","author":"Fagerholm","year":"2014","journal-title":"Biomaterials"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"46ra61","DOI":"10.1126\/scitranslmed.3001022","article-title":"A biosynthetic alternative to human donor tissue for inducing corneal regeneration: 24-month follow-up of a phase 1 clinical study","volume":"2","author":"Fagerholm","year":"2010","journal-title":"Sci. Transl. Med."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1167\/iovs.10-5224","article-title":"Biosynthetic corneal implants for replacement of pathologic corneal tissue: Performance in a controlled rabbit alkali burn model","volume":"52","author":"Hackett","year":"2011","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1111\/cts.12293","article-title":"Bioengineered Corneas Grafted as Alternatives to Human Donor Corneas in Three High-Risk Patients","volume":"8","author":"Buznyk","year":"2015","journal-title":"Clin. Transl. Sci."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"e05105","DOI":"10.1016\/j.heliyon.2020.e05105","article-title":"Collagen-based scaffolds with infused anti-VEGF release system as potential cornea substitute for high-risk keratoplasty: A preliminary in vitro evaluation","volume":"6","author":"Buznyk","year":"2020","journal-title":"Heliyon"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1038\/s41536-017-0038-8","article-title":"Biomaterials-enabled cornea regeneration in patients at high risk for rejection of donor tissue transplantation","volume":"3","author":"Islam","year":"2018","journal-title":"NPJ Regen. Med."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.3727\/096368914X685744","article-title":"Stem Cell Therapy for Corneal Regeneration Medicine and Contemporary Nanomedicine for Corneal Disorders","volume":"24","author":"Hsu","year":"2015","journal-title":"Cell Transplant."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s40824-023-00348-z","article-title":"Immunogenicity of decellularized extracellular matrix scaffolds: A bottleneck in tissue engineering and regenerative medicine","volume":"27","author":"Kasravi","year":"2023","journal-title":"Biomater. Res."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s13770-021-00393-6","article-title":"Preparation and In Vitro Characterization of Gelatin Methacrylate for Corneal Tissue Engineering","volume":"19","author":"Yan","year":"2022","journal-title":"Tissue Eng. Regen. Med."},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Visalli, F., Fava, F., Capobianco, M., Musa, M., D\u2019Esposito, F., Russo, A., Scollo, D., Longo, A., Gagliano, C., and Zeppieri, M. (2024). Innovative Bioscaffolds in Stem Cell and Regenerative Therapies for Corneal Pathologies. Bioengineering, 11.","DOI":"10.3390\/bioengineering11090859"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"rbae033","DOI":"10.1093\/rb\/rbae033","article-title":"Advances in 3D bioprinting for regenerative medicine applications","volume":"11","author":"Loukelis","year":"2024","journal-title":"Regen. Biomater."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.medengphy.2019.05.002","article-title":"3D bioprinting for artificial cornea: Challenges and perspectives","volume":"71","author":"Zhang","year":"2019","journal-title":"Med. Eng. Phys."},{"key":"ref_109","doi-asserted-by":"crossref","unstructured":"Xie, Z.J., Yuan, B.W., Chi, M.M., and Hong, J. (2024). Focus on seed cells: Stem cells in 3D bioprinting of corneal grafts. Front. Bioeng. Biotechnol., 12.","DOI":"10.3389\/fbioe.2024.1423864"},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Patroklou, G., Triantafyllopoulou, E., Goula, P.E., Karali, V., Chountoulesi, M., Valsami, G., Pispas, S., and Pippa, N. (2025). pH-Responsive Hydrogels: Recent Advances in Pharmaceutical Applications. Polymers, 17.","DOI":"10.3390\/polym17111451"},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Bordbar-Khiabani, A., and Gasik, M. (2022). Smart Hydrogels for Advanced Drug Delivery Systems. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23073665"},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Mijanovic, O., Pylaev, T., Nikitkina, A., Artyukhova, M., Brankovic, A., Peshkova, M., Bikmulina, P., Turk, B., Bolevich, S., and Avetisov, S. (2021). Tissue Engineering Meets Nanotechnology: Molecular Mechanism Modulations in Cornea Regeneration. Micromachines, 12.","DOI":"10.3390\/mi12111336"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1177\/08853282251393784","article-title":"Corneal bioengineering via electrospun nanofibers and nanoparticles","volume":"40","author":"Salehi","year":"2026","journal-title":"J. Biomater. Appl."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"rbad107","DOI":"10.1093\/rb\/rbad107","article-title":"Decellularized extracellular matrix-based composite scaffolds for tissue engineering and regenerative medicine","volume":"11","author":"Xu","year":"2024","journal-title":"Regen. Biomater."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"20417314231197793","DOI":"10.1177\/20417314231197793","article-title":"3D bioprinting of corneal models: A review of the current state and future outlook","volume":"14","author":"Balters","year":"2023","journal-title":"J. Tissue Eng."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1089\/ten.tec.2015.0008","article-title":"Early Observation of Extracellular Matrix-Derived Hydrogels for Corneal Stroma Regeneration","volume":"21","author":"Ahearne","year":"2015","journal-title":"Tissue Eng. Part C Methods"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"116636","DOI":"10.1016\/j.lfs.2019.116636","article-title":"CRISPR-Cas9 system: A new-fangled dawn in gene editing","volume":"232","author":"Gupta","year":"2019","journal-title":"Life Sci."},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Sarkar, S., Panikker, P., D\u2019Souza, S., Shetty, R., Mohan, R.R., and Ghosh, A. (2023). Corneal Regeneration Using Gene Therapy Approaches. Cells, 12.","DOI":"10.3390\/cells12091280"},{"key":"ref_119","first-page":"100180","article-title":"Emerging Technologies in Corneal Transplantation: Innovations, Challenges, and Global Implications","volume":"39","author":"Almurabi","year":"2025","journal-title":"Transplant. Rep."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"3499","DOI":"10.2147\/OPTH.S438127","article-title":"Artificial Intelligence in Ophthalmic Surgery: Current Applications and Expectations","volume":"17","author":"Nuliqiman","year":"2023","journal-title":"Clin. Ophthalmol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"e301","DOI":"10.1016\/j.jcjo.2023.07.016","article-title":"Artificial intelligence chatbot performance in triage of ophthalmic conditions","volume":"59","author":"Lyons","year":"2024","journal-title":"Can. J. Ophthalmol. J. Can. D\u2019ophtalmologie"},{"key":"ref_122","doi-asserted-by":"crossref","unstructured":"Tafti, M.F., Khorrami-Nejad, M., Arabfard, M., Ghiasi, M., Afkhamizadeh, F., Jadidi, K., and Aghamollaei, H. (2025). AI-driven strategies for advancing corneal cell therapy: A promising frontier. Front. Med., 12.","DOI":"10.3389\/fmed.2025.1563891"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"e194","DOI":"10.1002\/mco2.194","article-title":"3D bioprinting and its innovative approach for biomedical applications","volume":"4","author":"Tripathi","year":"2023","journal-title":"MedComm"},{"key":"ref_124","doi-asserted-by":"crossref","unstructured":"Hern\u00e1ndez, J., Santos, N., and Ahumada, M. (2025). Advances in 3D Bioprinting for Corneal Regeneration. Gels, 11.","DOI":"10.3390\/gels11060422"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"988","DOI":"10.4103\/ijo.IJO_1131_18","article-title":"Robotics and ophthalmology: Are we there yet?","volume":"67","author":"Pandey","year":"2019","journal-title":"Indian J. Ophthalmol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"124510","DOI":"10.1016\/j.ijpharm.2024.124510","article-title":"Comprehensive review of the state-of-the-art in corneal 3D bioprinting, including regulatory aspects","volume":"662","author":"Diaz","year":"2024","journal-title":"Int. J. Pharm."},{"key":"ref_127","first-page":"522","article-title":"Next-generation smart ophthalmic biomaterials: From passive response to active interaction and closed-loop control","volume":"56","author":"Zhang","year":"2026","journal-title":"Bioact. Mater."},{"key":"ref_128","doi-asserted-by":"crossref","unstructured":"Guerin, L.P., Le-Bel, G., Desjardins, P., Couture, C., Gillard, E., Boisselier, E., Bazin, R., Germain, L., and Guerin, S.L. (2021). The Human Tissue-Engineered Cornea (hTEC): Recent Progress. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22031291"},{"key":"ref_129","doi-asserted-by":"crossref","unstructured":"Lopez-Paniagua, M., de la Mata, A., Galindo, S., Blazquez, F., Calonge, M., and Nieto-Miguel, T. (2021). Advanced Therapy Medicinal Products for the Eye: Definitions and Regulatory Framework. Pharmaceutics, 13.","DOI":"10.3390\/pharmaceutics13030347"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1089\/ten.teb.2020.0319","article-title":"Translational and Regulatory Challenges of Corneal Endothelial Cell Therapy: A Global Perspective","volume":"28","author":"Ting","year":"2022","journal-title":"Tissue Eng. Part B Rev."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1089\/ten.teb.2014.0397","article-title":"Corneal tissue engineering: Recent advances and future perspectives","volume":"21","author":"Ghezzi","year":"2015","journal-title":"Tissue Eng. Part B Rev."},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"Kumar, V.B., Tiwari, O.S., Finkelstein-Zuta, G., Rencus-Lazar, S., and Gazit, E. (2023). Design of Functional RGD Peptide-Based Biomaterials for Tissue Engineering. Pharmaceutics, 15.","DOI":"10.3390\/pharmaceutics15020345"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.preteyeres.2015.07.001","article-title":"Corneal structure and transparency","volume":"49","author":"Meek","year":"2015","journal-title":"Prog. Retin. 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