{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T13:36:54Z","timestamp":1785418614177,"version":"3.56.0"},"reference-count":141,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T00:00:00Z","timestamp":1779062400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271037"],"award-info":[{"award-number":["82271037"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"award":["82271037"],"award-info":[{"award-number":["82271037"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Shenyang Science and Technology Project","award":["23-408-3-04"],"award-info":[{"award-number":["23-408-3-04"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioengineering"],"abstract":"<jats:p>3D bioprinting technology has made great strides in the field of bone tissue engineering. It has been able to create personalized biological structures on a macroscopic scale. In terms of microstructure bionics, 3D printing technology has also made some progress in recent years. The use of nanotechnology and drug delivery technology has provided a microenvironment that is more compatible with cell growth. Finally, it is possible to bridge the gap between engineered organizational structures and natural tissues. In this work, we summarize the widely used 3D bioprinting methods and the preparation of bioinks. Next, the classification of bone tissue engineering scaffold materials and nanomaterials for loading is briefly introduced. Then the technical shortcomings of current nanotechnology-based 3D bioprinting are described, along with the corresponding improvements. Finally, we summarize the prospects of nano-based 3D bioprinting technology in bone tissue engineering.<\/jats:p>","DOI":"10.3390\/bioengineering13050569","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T14:12:54Z","timestamp":1779286374000},"page":"569","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Nano-Based 3D Printed Scaffold for Bone Tissue Engineering"],"prefix":"10.3390","volume":"13","author":[{"given":"Xiaoting","family":"Shi","sequence":"first","affiliation":[{"name":"Liaoning Provincial Key Laboratory of Oral Diseases, School and Hospital of Stomatology, China Medical University, Shenyang 110001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keda","family":"Liu","sequence":"additional","affiliation":[{"name":"Liaoning Provincial Key Laboratory of Oral Diseases, School and Hospital of Stomatology, China Medical University, Shenyang 110001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiqi","family":"Li","sequence":"additional","affiliation":[{"name":"Liaoning Provincial Key Laboratory of Oral Diseases, School and Hospital of Stomatology, China Medical University, Shenyang 110001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruobing","family":"Zhao","sequence":"additional","affiliation":[{"name":"Liaoning Provincial Key Laboratory of Oral Diseases, School and Hospital of Stomatology, China Medical University, Shenyang 110001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2798-0400","authenticated-orcid":false,"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Liaoning Provincial Key Laboratory of Oral Diseases, School and Hospital of Stomatology, China Medical University, Shenyang 110001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2744","DOI":"10.1002\/jbm.b.35125","article-title":"Laddec\u00ae versus Bio-Oss\u00ae: The effect on the healing of critical-sized defect\u2014Calvaria rabbit model","volume":"110","author":"Gil","year":"2022","journal-title":"J. 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