{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T16:21:50Z","timestamp":1783441310222,"version":"3.54.6"},"reference-count":33,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T00:00:00Z","timestamp":1782259200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioengineering"],"abstract":"<jats:p>Background: Biodegradable Temporizing Matrix (BTM) is a synthetic, biodegradable polyurethane dermal substitute that promotes neodermis formation and supports re-epithelialization by secondary intention. However, published experience with BTM in facial reconstruction is limited to small case series with narrow anatomic indications, and its performance across multiple distinct facial subunits has not been systematically characterized. Methods: A retrospective case series was conducted of all patients who underwent nasal, periocular, or scalp reconstruction with BTM following Mohs micrographic surgery (MMS) at a single tertiary academic center. Patient demographics, defect characteristics, healing times, complications, and secondary procedures were recorded. Results: A total of 135 patients were included: 67 nasal, 40 periocular, and 28 scalp. Overall complication rates were 7.5%, 20.0%, and 17.9%, respectively. The majority of patients across all sites achieved definitive coverage by secondary intention without skin grafting. Lower eyelid involvement was the strongest independent predictor of ocular complications in the periocular cohort, and prior radiation was the dominant predictor of scalp complications. Conclusions: In this retrospective series, BTM demonstrated favorable outcomes for facial reconstruction following MMS across nasal, periocular, and scalp subunits, reliably supporting secondary re-epithelialization and functioning as definitive reconstruction, a temporizing agent, and a lining adjunct for staged forehead flap reconstruction. Prospective comparative studies are needed to confirm these findings.<\/jats:p>","DOI":"10.3390\/bioengineering13070732","type":"journal-article","created":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T15:02:56Z","timestamp":1783436576000},"page":"732","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Biodegradable Temporizing Matrix for Facial Reconstruction Following Mohs Micrographic Surgery: A Multi-Subunit Analysis"],"prefix":"10.3390","volume":"13","author":[{"given":"Alexandra L.","family":"Martinez","sequence":"first","affiliation":[{"name":"Department of Plastic Surgery, UT Southwestern Medical Center, Dallas, TX 75390, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James F.","family":"Thornton","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, UT Southwestern Medical Center, Dallas, TX 75390, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"166","DOI":"10.5999\/aps.2012.39.2.166","article-title":"Basal cell carcinoma","volume":"39","author":"Chung","year":"2012","journal-title":"Arch. Plast. Surg."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.12968\/hmed.2021.0126","article-title":"Non-melanoma skin cancer of the head and neck","volume":"84","author":"Roland","year":"2023","journal-title":"Br. J. Hosp. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1097\/MOO.0000000000000960","article-title":"Head and neck nonmelanoma skin cancers: Surgical management and debated issues","volume":"32","author":"Rampinelli","year":"2024","journal-title":"Curr. Opin. Otolaryngol. Head Neck Surg."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Thornton, J., and Carboy, J.A. (2017). Facial Reconstruction After Mohs Surgery, Thieme.","DOI":"10.1055\/b-0038-162368"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1097\/PRS.0000000000007884","article-title":"Scalp Reconstruction after Mohs Cancer Excision: Lessons Learned from More Than 900 Consecutive Cases","volume":"147","author":"Harirah","year":"2021","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1097\/PRS.0000000000008098","article-title":"Nasal Reconstruction after Mohs Cancer Resection: Lessons Learned from 2553 Consecutive Cases","volume":"148","author":"Halani","year":"2021","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_7","unstructured":"PolyNovo (2025, November 18). NovoSorb BTM. Available online: https:\/\/polynovo.com\/novosorb-btm\/."},{"key":"ref_8","first-page":"e13","article-title":"A biodegradable polyurethane dermal matrix in reconstruction of free flap donor sites: A pilot study","volume":"15","author":"Wagstaff","year":"2015","journal-title":"Eplasty"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1097\/BCR.0b013e318233fac1","article-title":"Comparison of a sealed, polymer foam biodegradable temporizing matrix against Integra\u00ae dermal regeneration template in a porcine wound model","volume":"33","author":"Greenwood","year":"2012","journal-title":"J. Burn Care Res."},{"key":"ref_10","first-page":"e27","article-title":"Free Flap Donor Site Reconstruction: A Prospective Case Series Using an Optimized Polyurethane Biodegradable Temporizing Matrix","volume":"15","author":"Wagstaff","year":"2015","journal-title":"Eplasty"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.burnso.2017.08.001","article-title":"Experience with a synthetic bilayer Biodegradable temporising Matrix in significant burn injury","volume":"2","author":"Greenwood","year":"2018","journal-title":"Burns Open"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1055\/s-0042-1742749","article-title":"Technical Refinements with the Use of Biologic Healing Agents","volume":"36","author":"Dibbs","year":"2022","journal-title":"Semin. Plast. Surg."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1055\/s-0042-1742750","article-title":"Use of Biologic Agents in Nasal and Scalp Reconstruction","volume":"36","author":"Depani","year":"2022","journal-title":"Semin. Plast. Surg."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"e6492","DOI":"10.1097\/GOX.0000000000006492","article-title":"Secondary Healing Over NovoSorb BTM in the Management of Complex Nasal Defects","volume":"13","author":"McMahon","year":"2025","journal-title":"Plast. Reconstr. Surg. Glob. Open"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"e6702","DOI":"10.1097\/GOX.0000000000006702","article-title":"The Use of Novosorb Biodegradable Temporizing Matrix for Reconstruction in Head and Neck Cancer","volume":"13","author":"Conway","year":"2025","journal-title":"Plast. Reconstr. Surg. Glob. Open"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"e6497","DOI":"10.1097\/GOX.0000000000006497","article-title":"Biodegradable Temporizing Matrix in Postoncological Scalp Reconstruction: A Case Series","volume":"13","author":"Calderbank","year":"2025","journal-title":"Plast. Reconstr. Surg. Glob. Open"},{"key":"ref_17","first-page":"e20","article-title":"Case Series of Reconstruction Applying NovoSorb Biodegradable Temporising Matrix","volume":"25","author":"Tam","year":"2025","journal-title":"Eplasty"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"D\u2019Urso, M., and Kurniawan, N.A. (2020). Mechanical and Physical Regulation of Fibroblast-Myofibroblast Transition. Front. Bioeng. Biotechnol., 8.","DOI":"10.3389\/fbioe.2020.609653"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Rajaram, R., Zhang, M., Premaratne, G., and Ng, S. (2024). Novosorb\u00ae BTM\u2014History, production and application in challenging wounds. Front. Bioeng. Biotechnol., 12.","DOI":"10.3389\/fbioe.2024.1450973"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.jpra.2025.07.007","article-title":"Biodegradable Temporizing Matrix (BTM) resilience to wound infection: A consecutive case series","volume":"48","author":"Wilson","year":"2025","journal-title":"JPRAS Open"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.fsc.2010.10.001","article-title":"Anatomy, physiology, and general concepts in nasal reconstruction","volume":"19","author":"Bloom","year":"2011","journal-title":"Facial Plast. Surg. Clin. North Am."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1097\/00006534-198508000-00010","article-title":"The subunit principle in nasal reconstruction","volume":"76","author":"Burget","year":"1985","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"138e","DOI":"10.1097\/PRS.0b013e3181d0ae2b","article-title":"Nasal reconstruction","volume":"125","author":"Menick","year":"2010","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.fsc.2010.10.013","article-title":"Bilobed flaps in nasal reconstruction","volume":"19","author":"Steiger","year":"2011","journal-title":"Facial Plast. Surg. Clin. North Am."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1046\/j.1524-4725.2000.99160.x","article-title":"A review of the bilobed flap\u2019s design with particular emphasis on the minimization of alar displacement","volume":"26","author":"Cook","year":"2000","journal-title":"Dermatol. Surg."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.jhsg.2024.05.006","article-title":"Novosorb Biodegradable Temporizing Matrix for Reconstruction of Complex Upper-Extremity Wounds","volume":"6","author":"Jou","year":"2024","journal-title":"J. Hand Surg. Glob. Online"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1111\/dsu.12254","article-title":"Efficacy and complication rates of full-thickness skin graft repair after Mohs micrographic surgery","volume":"39","author":"Oganesyan","year":"2013","journal-title":"Dermatol. Surg."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.jss.2023.12.043","article-title":"Current Approaches to Wound Repair in Burns","volume":"296","year":"2024","journal-title":"J. Surg. Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1055\/s-0032-1312691","article-title":"Successes, revisions, and postoperative complications in 446 Mohs defect repairs","volume":"28","author":"Sclafani","year":"2012","journal-title":"Facial Plast. Surg."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1097\/IOP.0000000000003042","article-title":"Periocular Reconstruction Utilizing the Integra Dermal Regeneration Template","volume":"42","author":"Dallalzadeh","year":"2026","journal-title":"Ophthalmic Plast. Reconstr. Surg."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1089\/ten.teb.2011.0064","article-title":"Hair follicle regeneration in skin grafts: Current concepts and future perspectives","volume":"18","author":"Mahjour","year":"2012","journal-title":"Tissue Eng. Part B Rev."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1097\/01.sap.0000263323.65563.e7","article-title":"Hair-bearing scalp reconstruction using a dermal regeneration template and micrograft hair transplantation","volume":"59","author":"Spector","year":"2007","journal-title":"Ann. Plast. Surg."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"e7537","DOI":"10.1097\/GOX.0000000000007537","article-title":"Scalp Reconstruction with a Synthetic Dermal Substitute After Cylindroma Excision in Brooke-Spiegler Syndrome","volume":"14","author":"Martinez","year":"2026","journal-title":"Plast. Reconstr. Surg. Glob. 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