{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T13:14:50Z","timestamp":1783430090970,"version":"3.54.6"},"reference-count":37,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:00:00Z","timestamp":1783382400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioengineering"],"abstract":"<jats:p>In this study, the impact of thrombus growth at the left coronary ostium\u2014resulting from a misplaced stent\u2014was investigated through numerical simulations. Blood flow from the aortic root into the coronary arteries was modeled for several potential thrombus sizes to assess changes in pressure and shear stress caused by thrombus development. The results showed that even in the most severe case examined (with the thrombus growing three times its original size), the obstruction to the coronary cross-sectional area was not sufficient to produce a significant pressure drop or wall shear stress increases. This outcome is primarily attributed to the thrombus\u2019s location at the tip of the stent; even with considerable elongation, it did not significantly narrow the coronary artery\u2019s lumen. While the specific configurations studied did not result in critical obstruction, it is important to note that other thrombus shapes or positions could potentially block flow more severely, leading to substantial pressure drops in the left coronary arteries.<\/jats:p>","DOI":"10.3390\/bioengineering13070779","type":"journal-article","created":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T09:53:46Z","timestamp":1783418026000},"page":"779","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Study of Coronary Stent Thrombosis Growth"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9541-311X","authenticated-orcid":false,"given":"Ivan Fernney","family":"Ibanez Aguilar","sequence":"first","affiliation":[{"name":"Department of Mechanical Engineering, Pontifical Catholic University of Rio de Janeiro, Rio de Janeiro 22451-900, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos","family":"Beltr\u00e3o Paraizo","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering, Pontifical Catholic University of Rio de Janeiro, Rio de Janeiro 22451-900, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5025-7531","authenticated-orcid":false,"given":"Pedro","family":"Soares Teixeira","sequence":"additional","affiliation":[{"name":"Fit Center\u2014Cl\u00ednica de Performance Humana, Niter\u00f3i 24220-331, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9717-8694","authenticated-orcid":false,"given":"Adriano","family":"Camargo Carneiro","sequence":"additional","affiliation":[{"name":"Hospital do Cora\u00e7\u00e3o\u2014HCor, S\u00e3o Paulo 04004-030, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4788-1496","authenticated-orcid":false,"given":"Bruno","family":"Alvares de Azevedo","sequence":"additional","affiliation":[{"name":"Hospital do Cora\u00e7\u00e3o\u2014HCor, S\u00e3o Paulo 04004-030, SP, Brazil"},{"name":"Department of Mechanical Engineering, Pontifical Catholic University of Rio de Janeiro, Rio de Janeiro 22451-900, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4836-8931","authenticated-orcid":false,"given":"Angela Ourivio","family":"Nieckele","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering, Pontifical Catholic University of Rio de Janeiro, Rio de Janeiro 22451-900, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4505-3344","authenticated-orcid":false,"given":"Carlos Eduardo","family":"Rochitte","sequence":"additional","affiliation":[{"name":"Hospital do Cora\u00e7\u00e3o\u2014HCor, S\u00e3o Paulo 04004-030, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1161\/CIRCULATIONAHA.106.666800","article-title":"A cause for concern","volume":"115","author":"Camenzind","year":"2007","journal-title":"Circulation"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1056\/NEJMoa1909406","article-title":"Five-year outcomes after PCI or CABG for left main coronary disease","volume":"381","author":"Stone","year":"2019","journal-title":"N. 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