{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T20:39:25Z","timestamp":1790282365988,"version":"4.1.0"},"reference-count":33,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R33EY034343"],"award-info":[{"award-number":["R33EY034343"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K23EY0329"],"award-info":[{"award-number":["K23EY0329"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30EY001765"],"award-info":[{"award-number":["P30EY001765"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"award":["R33EY034343"],"award-info":[{"award-number":["R33EY034343"]}],"id":[{"id":"https:\/\/ror.org\/045p44t13","id-type":"ROR","asserted-by":"publisher"}]},{"award":["K23EY0329"],"award-info":[{"award-number":["K23EY0329"]}],"id":[{"id":"https:\/\/ror.org\/045p44t13","id-type":"ROR","asserted-by":"publisher"}]},{"award":["P30EY001765"],"award-info":[{"award-number":["P30EY001765"]}],"id":[{"id":"https:\/\/ror.org\/045p44t13","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Stephen F Raab and Mariellen Brickley-Raab Rising Professorship in Ophthalmology"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioengineering"],"abstract":"<jats:p>Purpose: To examine concordance in biometry, keratometry, and intraocular lens (IOL) calculation between the Heidelberg Anterion Cataract App and the Zeiss IOLMaster 700 in a US population presenting for cataract evaluation. Methods: In this retrospective cross-sectional study, 64 eyes of 40 patients presenting for cataract evaluation underwent imaging with both devices. Agreement was assessed for axial length (AL), anterior chamber depth (ACD), lens thickness (LT), white-to-white distance (WTW), central corneal thickness (CCT), pupil diameter (PD), and anterior, posterior, and total keratometry using Lin\u2019s concordance correlation coefficient (CCC), Bland\u2013Altman analysis and generalized estimating equations. Non-toric and toric IOL calculations were performed with the Barrett Universal II and Barrett True-K Toric formulas, respectively. Results: Concordance was excellent for AL, ACD, LT, and CCT (CCC &gt; 0.980), with no significant difference in AL. Compared with IOLMaster 700, Anterion measured larger PD (+0.56 mm), deeper ACD (+0.07 mm), thicker LT (+0.07 mm), thinner CCT (\u22123.19 \u03bcm), and smaller WTW (\u22120.22 mm; all p &lt; 0.01). Anterior keratometry showed excellent concordance (CCC \u2265 0.980) despite small flatter offsets in average K, K1, K2 and difference in (\u0394)K (\u22120.13, \u22120.08, \u22120.16 D, \u22120.10). Concordance was poor for posterior keratometry (average K: CCC = 0.529; Anterion steeper by 0.34 D), fairly good for total keratometry (average K: CCC = 0.891, Anterion flatter by 0.68 D), and these systematic inter-device offsets may be clinically relevant. For non-toric calculations, unrounded spherical IOL power agreed within 0.50 D in 88.88% (N = 56\/63) of eyes and predicted residual refractive error within 0.25 D in 95.24% (N = 60\/63). For toric calculations, predicted residual refractive error and residual astigmatism agreed within 0.25 D in 95.16% (N = 59\/62) and 85.48% (N = 53\/62) of eyes, respectively. Conclusions: Anterion and IOLMaster 700 showed strong agreement in core biometry, anterior keratometry, and predicted refractive outcomes, though posterior and total keratometry differed systematically. Postoperative refractive outcome studies are needed before the devices can be considered interchangeable in routine practice.<\/jats:p>","DOI":"10.3390\/bioengineering13080874","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T11:45:26Z","timestamp":1785239126000},"page":"874","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Concordance of Cataract Biometry Measurements Obtained via Swept-Source Optical Coherence Tomography Versus Optical Biometry"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-2824-6623","authenticated-orcid":false,"given":"Ramadhan","family":"Ahmed","sequence":"first","affiliation":[{"name":"School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamini Narendra","family":"Reddy","sequence":"additional","affiliation":[{"name":"Cornea Division, Wilmer Eye Institute, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Wilmer\/Woods 376, Baltimore, MD 21205, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2212-3906","authenticated-orcid":false,"given":"Matthew","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Biology, Krieger School of Arts and Sciences, Johns Hopkins University, Baltimore, MD 21218, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahad","family":"Mohamed","sequence":"additional","affiliation":[{"name":"School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4472-3852","authenticated-orcid":false,"given":"Nakul","family":"Shekhawat","sequence":"additional","affiliation":[{"name":"Cornea Division, Wilmer Eye Institute, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Wilmer\/Woods 376, Baltimore, MD 21205, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1097\/ICL.0000000000000552","article-title":"An Evaluation of the IOLMaster 700","volume":"45","author":"Bullimore","year":"2019","journal-title":"Eye Contact Lens Sci. Clin. Pract."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1167\/tvst.12.3.13","article-title":"Agreement of Total Keratometry and Posterior Keratometry Among IOLMaster 700, CASIA2, and Pentacam","volume":"12","author":"Jin","year":"2023","journal-title":"Trans. Vis. Sci. Tech."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1097\/j.jcrs.0000000000000327","article-title":"Posterior and total corneal astigmatism measured with optical coherence tomography-based biometer and dual Scheimpflug analyzer","volume":"46","author":"Wang","year":"2020","journal-title":"J. Cataract. Refract. Surg."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.21037\/atm-20-2290","article-title":"Recent developments in intraocular lens power calculation methods\u2014Update 2020","volume":"8","author":"Savini","year":"2020","journal-title":"Ann. Transl. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.preteyeres.2018.04.002","article-title":"Anterior segment optical coherence tomography","volume":"66","author":"Ang","year":"2018","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_6","unstructured":"Bille, J.F. (2025, February 04). Anterior Segment OCT, High Resolution Imaging in Microscopy and Ophthalmology: New Frontiers in Biomedical Optics, Available online: http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK554035\/."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"14853","DOI":"10.1038\/s41598-021-93999-8","article-title":"Comparison of two novel swept-source optical coherence tomography devices to a partial coherence interferometry-based biometer","volume":"11","author":"Chan","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1038\/s41598-020-79674-4","article-title":"Repeatability of automated measurements by a new anterior segment optical coherence tomographer and biometer and agreement with standard devices","volume":"11","author":"Hoffer","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1186\/s12886-024-03658-5","article-title":"Comparison of measurements and calculated lens power using three biometers: A Scheimpflug tomographer with partial coherence interferometry and two swept source optical coherence tomographers","volume":"24","author":"Ang","year":"2024","journal-title":"BMC Ophthalmol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.4103\/ijo.IJO_2433_21","article-title":"Comparison of ocular biometry and refractive outcome between ANTERION and IOL Master 700","volume":"70","author":"Panda","year":"2022","journal-title":"Indian J. Ophthalmol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1038\/eye.2010.187","article-title":"Ethnicity and ocular imaging","volume":"25","author":"Bourne","year":"2011","journal-title":"Eye"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"e489","DOI":"10.1016\/S2214-109X(20)30488-5","article-title":"The Lancet Global Health Commission on Global Eye Health: Vision beyond 2020","volume":"9","author":"Burton","year":"2021","journal-title":"Lancet Glob. Health Comm."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Wang, D., Amoozgar, B., Porco, T., Wang, Z., and Lin, S.C. (2017). Ethnic differences in lens parameters measured by ocular biometry in a cataract surgery population. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0179836"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s12886-021-01826-5","article-title":"Comparison of ocular biometric measurements in patients with cataract using three swept-source optical coherence tomography devices","volume":"21","author":"Oh","year":"2021","journal-title":"BMC Ophthalmol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1097\/j.jcrs.0000000000000788","article-title":"Agreement of intraocular lens power calculation between 2 SS-OCT\u2013based biometers","volume":"48","author":"Pfaeffli","year":"2022","journal-title":"J. Cataract Refract. Surg."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Aramberri, J., Hoffer, K.J., Olsen, T., Savini, G., and Shammas, H.J. (2024). Toric Calculations. Intraocular Lens Calculations, Springer International Publishing.","DOI":"10.1007\/978-3-031-50666-6"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.jbi.2008.08.010","article-title":"Research electronic data capture (REDCap)\u2014A metadata-driven methodology and workflow process for providing translational research informatics support","volume":"42","author":"Harris","year":"2009","journal-title":"J. Biomed. Inform."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"103208","DOI":"10.1016\/j.jbi.2019.103208","article-title":"The REDCap consortium: Building an international community of software platform partners","volume":"95","author":"Harris","year":"2019","journal-title":"J. Biomed. Inform."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"255","DOI":"10.2307\/2532051","article-title":"A concordance correlation coefficient to evaluate reproducibility","volume":"45","author":"Lin","year":"1989","journal-title":"Biometrics"},{"key":"ref_20","first-page":"614","article-title":"Biostatistics 104: Correlational Analysis","volume":"44","author":"Chan","year":"2003","journal-title":"Singap. Med. J."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1097\/00004424-200209000-00003","article-title":"3D versus 2D ultrasound: Accuracy of volume measurement in human cadaver kidneys","volume":"37","author":"Partik","year":"2002","journal-title":"Investig. Radiol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1177\/096228029900800204","article-title":"Measuring agreement in method comparison studies","volume":"8","author":"Bland","year":"1999","journal-title":"Stat. Methods Med. Res."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Dong, J., Yao, J., Chang, S., Kanclerz, P., Khoramnia, R., and Wang, X. (2022). Comparison Study of the Two Biometers Based on Swept-Source Optical Coherence Tomography Technology. Diagnostics, 12.","DOI":"10.3390\/diagnostics12030598"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1080\/17434440.2021.2008908","article-title":"Agreement of predicted intraocular lens power using swept-source optical coherence tomography and partial coherence interferometry","volume":"18","year":"2021","journal-title":"Expert Rev. Med. Devices"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1097\/j.jcrs.0000000000000494","article-title":"Repeatability of biometry measured by three devices and its impact on predicted intraocular lens power","volume":"47","author":"Shetty","year":"2021","journal-title":"J. Cataract Refract. Surg."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"23","DOI":"10.4103\/IJO.IJO_3122_24","article-title":"Comparison meta-analysis of two swept-source optical coherence biometers","volume":"74","author":"Romero","year":"2026","journal-title":"Indian J. Ophthalmol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"26560","DOI":"10.1038\/s41598-024-78266-w","article-title":"Accuracy of recent intraocular lens power calculation methods in post-myopic LASIK eyes","volume":"14","author":"Gettinger","year":"2024","journal-title":"Sci. Rep."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"e121","DOI":"10.1016\/j.ophtha.2020.06.054","article-title":"Intraocular Lens Power Calculations in Eyes with Previous Corneal Refractive Surgery","volume":"128","author":"Wang","year":"2021","journal-title":"Ophthalmology"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1097\/j.jcrs.0000000000000942","article-title":"Agreement between 2 SS-OCT biometry devices","volume":"48","author":"McLintock","year":"2022","journal-title":"J. Cataract Refract. Surg."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"497","DOI":"10.3341\/kjo.2018.0008","article-title":"Comparison of Intraocular Lens Power Calculation Methods Following Myopic Laser Refractive Surgery: New Options Using a Rotating Scheimpflug Camera","volume":"32","author":"Cho","year":"2018","journal-title":"Korean J. Ophthalmol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1111\/ceo.13760","article-title":"Total keratometry in intraocular lens power calculations in eyes with previous laser refractive surgery","volume":"48","author":"Lawless","year":"2020","journal-title":"Clin. Exp. Ophthalmol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.jcrs.2018.12.006","article-title":"ASCRS calculator formula accuracy in multifocal intraocular lens implantation in hyperopic corneal refractive laser surgery eyes","volume":"45","author":"Vrijman","year":"2019","journal-title":"J. Cataract Refract. Surg."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1097\/j.jcrs.0000000000000373","article-title":"Comparison of 2 swept-source optical coherence tomography\u2013based biometry devices","volume":"47","author":"Hirnschall","year":"2021","journal-title":"J. Cataract Refract. Surg."}],"container-title":["Bioengineering"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2306-5354\/13\/8\/874\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T12:18:51Z","timestamp":1785241131000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2306-5354\/13\/8\/874"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,28]]},"references-count":33,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2026,8]]}},"alternative-id":["bioengineering13080874"],"URL":"https:\/\/doi.org\/10.3390\/bioengineering13080874","relation":{},"ISSN":["2306-5354"],"issn-type":[{"value":"2306-5354","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,28]]}}}