{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T04:38:06Z","timestamp":1789792686666,"version":"4.0.1"},"reference-count":120,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:00:00Z","timestamp":1786320000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81973261"],"award-info":[{"award-number":["81973261"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"award":["81973261"],"award-info":[{"award-number":["81973261"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioengineering"],"abstract":"<jats:p>Functional nanomaterials, such as functionalized nanoparticles, nanofibers, nanocrystals, MXene and liposomes, have emerged as game-changers in tissue engineering, enabling precise modulation of cellular behaviors and dynamic biomimetic microenvironments. This review comprehensively summarizes and discusses the cutting-edge applications of nanomaterials in tissue regeneration (including bone, skin, neural and cardiac tissue regeneration), with a focus on their unique physicochemical properties (e.g., stimuli-responsiveness, nano-topography) and hybrid system design. Recent breakthroughs include 4D-printed shape-memory nanocomposites for irregular bone defects and \u201csmart\u201d wound dressings integrating antibacterial nanoparticles with real-time biosensing. However, clinical adoption remains constrained by unresolved challenges in biocompatibility, scalability of nanomanufacturing, and regulatory ambiguities. We critically analyze these barriers and propose a translational roadmap leveraging AI-driven material design and multi-omics validation platforms to accelerate commercialization.<\/jats:p>","DOI":"10.3390\/bioengineering13080902","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T11:38:09Z","timestamp":1786361889000},"page":"902","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Advances and Clinical Translation Potentials of Functional Nanomaterials in Tissue Engineering"],"prefix":"10.3390","volume":"13","author":[{"given":"Yuhan","family":"He","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2268-3178","authenticated-orcid":false,"given":"Qiang","family":"Peng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Makarevich, P.I., and Tkachuk, V.A. 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