{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T05:16:46Z","timestamp":1787894206197,"version":"build-2784847793"},"reference-count":40,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002770","name":"Cabinet Office","doi-asserted-by":"publisher","award":["BRIDGE"],"award-info":[{"award-number":["BRIDGE"]}],"id":[{"id":"10.13039\/501100002770","id-type":"DOI","asserted-by":"publisher"}]},{"award":["BRIDGE"],"award-info":[{"award-number":["BRIDGE"]}],"id":[{"id":"https:\/\/ror.org\/007f5s288","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP21K09456"],"award-info":[{"award-number":["JP21K09456"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP24K12634"],"award-info":[{"award-number":["JP24K12634"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP25K15973"],"award-info":[{"award-number":["JP25K15973"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"award":["JP21K09456"],"award-info":[{"award-number":["JP21K09456"]}],"id":[{"id":"https:\/\/ror.org\/00hhkn466","id-type":"ROR","asserted-by":"publisher"}]},{"award":["JP24K12634"],"award-info":[{"award-number":["JP24K12634"]}],"id":[{"id":"https:\/\/ror.org\/00hhkn466","id-type":"ROR","asserted-by":"publisher"}]},{"award":["JP25K15973"],"award-info":[{"award-number":["JP25K15973"]}],"id":[{"id":"https:\/\/ror.org\/00hhkn466","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioengineering"],"abstract":"<jats:p>Fetal cardiac ultrasound screening is vital for the prenatal diagnosis of congenital heart disease (CHD). However, understanding complex cardiovascular structures and continuity from two-dimensional (2D) ultrasound images remains challenging. Therefore, this study developed and evaluated an artificial intelligence (AI)-based three-dimensional (3D) visualization approach that reconstructs fetal cardiovascular structures from 2D ultrasound sweep video. To this end, information from the adjacent frames was used. Instead of interpreting each ultrasound frame independently, this method incorporates neighboring frames, enabling the continuous visualization of the right- and left-sided functional circulatory pathways. Our method achieved a mean Dice coefficient of 0.785 on an independent test dataset, demonstrating that the adjacent frame information can provide stable 3D segmentation. Diffusion-based anatomical plausibility analysis trained exclusively on normal anatomies showed exploratory discrimination between normal fetuses and fetuses with CHD (AUC, 0.861; 95% CI, 0.695\u20130.980). In a clinical comparison study involving 12 obstetricians, the introduction of this AI-driven 3D cardiovascular visualization slightly improved the screening accuracy from 0.779 to 0.808 and significantly improved the confidence-weighted accuracy score (p = 0.002). Our approach can potentially support examiners and facilitate fetal cardiac ultrasound screenings.<\/jats:p>","DOI":"10.3390\/bioengineering13090986","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:04:32Z","timestamp":1787756672000},"page":"986","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["AI-Driven Three-Dimensional Reconstruction of Fetal Cardiovascular Pathways from Ultrasound Sweep Videos for Congenital Heart Disease Screening"],"prefix":"10.3390","volume":"13","author":[{"given":"Naoaki","family":"Harada","sequence":"first","affiliation":[{"name":"Department of NCC Cancer Science, Biomedical Science and Engineering Track, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan"},{"name":"Division of Medical AI Research and Development, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan"},{"name":"Digital Health Platform Development Office, Healthcare Business Unit, Fujitsu Japan Ltd., 1-5 Omiya-cho, Saiwai-ku, Kawasaki 212-0014, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0421-8085","authenticated-orcid":false,"given":"Masaaki","family":"Komatsu","sequence":"additional","affiliation":[{"name":"Division of Medical AI Research and Development, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan"},{"name":"AI Medical Engineering Team, RIKEN Center for Advanced Intelligence Project, 1-4-1 Nihonbashi, Chuo-ku, Tokyo 103-0027, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1296-8152","authenticated-orcid":false,"given":"Naoki","family":"Teraya","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Showa Medical University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8666, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shohei","family":"Wakisaka","sequence":"additional","affiliation":[{"name":"Division of Medical AI Research and Development, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan"},{"name":"Department of Obstetrics and Gynecology, Showa Medical University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8666, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8053-8098","authenticated-orcid":false,"given":"Katsuji","family":"Takeda","sequence":"additional","affiliation":[{"name":"Department of NCC Cancer Science, Biomedical Science and Engineering Track, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan"},{"name":"Division of Medical AI Research and Development, National Cancer Center Research Institute, 5-1-1 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