{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T10:02:51Z","timestamp":1790071371212,"version":"4.0.1"},"reference-count":32,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T00:00:00Z","timestamp":1789776000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008102","name":"University of Cincinnati","doi-asserted-by":"publisher","award":["ODSA Tech 15-0160-1012977"],"award-info":[{"award-number":["ODSA Tech 15-0160-1012977"]}],"id":[{"id":"10.13039\/100008102","id-type":"DOI","asserted-by":"publisher"}]},{"award":["ODSA Tech 15-0160-1012977"],"award-info":[{"award-number":["ODSA Tech 15-0160-1012977"]}],"id":[{"id":"https:\/\/ror.org\/01e3m7079","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioengineering"],"abstract":"<jats:p>The arteriovenous fistula (AVF) is the preferred method of vascular access for hemodialysis; however, 30\u201350% of AVFs undergo primary maturation failure and are unsuitable for clinical use. As disturbed hemodynamics initiate endothelial injury and intimal hyperplasia, we designed an endovascular flow-conditioning anastomotic device (FCAD) to directly improve AVF hemodynamics and protect the anastomotic region. Using computational fluid dynamics, we characterized the flow field and wall shear stress (WSS) profiles in idealized AVF models with and without the FCAD. Incorporation of the FCAD into a brachiocephalic AVF model reduced regions of oscillatory WSS and generated a symmetrical flow profile in the draining vein compared to a reference AVF. Parametric studies identified an FCAD geometry with a tab angle, height, and aspect ratio of 30\u00b0, 0.1 diameters, and 1.0 that increased time-averaged WSS along the inner venous wall and achieved a physiological WSS (1\u20133 Pa) without inducing regions of oscillatory flow throughout the cardiac cycle. Similar findings were observed with an in vitro model using particle image velocimetry. This study demonstrates the feasibility of the FCAD to normalize venous flow and WSS while imposing minimal resistance to blood flow. Restoring physiological WSS levels on the venous wall may help preserve endothelial function and improve AVF maturation.<\/jats:p>","DOI":"10.3390\/bioengineering13091089","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T08:03:47Z","timestamp":1789977827000},"page":"1089","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Computational and Experimental Evaluation of a Flow-Conditioning Anastomotic Device for Arteriovenous Fistula Maturation"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3851-1039","authenticated-orcid":false,"given":"Keith","family":"Saum","sequence":"first","affiliation":[{"name":"Division of Nephrology and Hypertension, College of Medicine, University of Cincinnati, Cincinnati, OH 45221, USA"},{"name":"Division of Nephrology, Department of Internal Medicine, University of Michigan, 5313 Brehm Center, 1000 Wall St, Ann Arbor, MI 48105, USA"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"project-administration","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"funding-acquisition","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"given":"Bego\u00f1a","family":"Campos","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, College of Medicine, University of Cincinnati, Cincinnati, OH 45221, USA"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"project-administration","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"resources","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2006-2407","authenticated-orcid":false,"given":"Diego","family":"Celdran Bonafonte","sequence":"additional","affiliation":[{"name":"Division of Nephrology, College of Medicine, University of Arizona, Tucson, AZ 85714, USA"},{"name":"University Animal Care Department, University of Arizona, Tucson, AZ 85714, USA"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"investigation","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3232-6799","authenticated-orcid":false,"given":"Liran","family":"Oren","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, College of Medicine, University of Cincinnati, Cincinnati, OH 45221, USA"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"validation","vocabulary":"credit"},{"role":"resources","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"software","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"suffix":"III","given":"Albert Phillip","family":"Owens","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Health and Disease, College of Medicine, University of Cincinnati, Cincinnati, OH 45221, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prabir","family":"Roy-Chaudhury","sequence":"additional","affiliation":[{"name":"Division of Nephrology, College of Medicine, University of Arizona, Tucson, AZ 85714, USA"},{"name":"Division of Nephrology and Hypertension, Department of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"supervision","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"funding-acquisition","vocabulary":"credit"},{"role":"resources","vocabulary":"credit"},{"role":"conceptualization","vocabulary":"credit"},{"role":"validation","vocabulary":"credit"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3005","DOI":"10.1681\/ASN.2016121355","article-title":"Intimal Hyperplasia, Stenosis, and Arteriovenous Fistula Maturation Failure in the Hemodialysis Fistula Maturation Study","volume":"28","author":"Cheung","year":"2017","journal-title":"J. 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