{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T02:08:14Z","timestamp":1760234894619,"version":"build-2065373602"},"reference-count":27,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2021,6,22]],"date-time":"2021-06-22T00:00:00Z","timestamp":1624320000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioengineering"],"abstract":"<jats:p>A new surgical procedure for the treatment of primary bladder neck obstruction with maintenance of anterograde ejaculation is proposed. In place of monolateral or bilateral bladder neck incision, associated with a loss of ejaculation rate of up to 30%, the new surgical procedure consists of laser drilling the bladder neck with a number of holes and without muscle fiber disruption. The effect of this novel procedure has been studied numerically, with a simplified two-dimensional numerical model of the internal urethral sphincter, varying the position and the number of holes in the fibrotic region of the urethral tissue. Results show an improvement of the urethral sphincter opening by increasing the number of holes, ranging from about 6% to 16% of recovery. Moreover, a non-aligned position of holes positively influences the opening recovery. The concentrations of maximum principal strain and stress have been registered in the proximity of the interface between the physiologic and diseased sphincter, and in those regions where the radial thickness is significantly thinner. The effects on the first five patients have been included in the study, showing improvement in micturition, lower urinary tract symptoms, sustained ejaculatory function, and quality of life.<\/jats:p>","DOI":"10.3390\/bioengineering8070087","type":"journal-article","created":{"date-parts":[[2021,6,22]],"date-time":"2021-06-22T13:02:10Z","timestamp":1624366930000},"page":"87","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["A Preliminary Validation of a New Surgical Procedure for the Treatment of Primary Bladder Neck Obstruction Using a Computational Modeling Approach"],"prefix":"10.3390","volume":"8","author":[{"given":"Michele","family":"Serpilli","sequence":"first","affiliation":[{"name":"Department of Civil and Building Engineering, and Architecture, Universit\u00e0 Politecnica delle Marche, Via Brecce Biance, 60131 Ancona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4223-3772","authenticated-orcid":false,"given":"Gianluca","family":"Zitti","sequence":"additional","affiliation":[{"name":"Department of Civil and Building Engineering, and Architecture, Universit\u00e0 Politecnica delle Marche, Via Brecce Biance, 60131 Ancona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Dellabella","sequence":"additional","affiliation":[{"name":"Department of Urology, IRCCS INRCA, 60124 Ancona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7354-9190","authenticated-orcid":false,"given":"Daniele","family":"Castellani","sequence":"additional","affiliation":[{"name":"Department of Urology, IRCCS INRCA, 60124 Ancona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2414-3773","authenticated-orcid":false,"given":"Elvira","family":"Maranesi","sequence":"additional","affiliation":[{"name":"Department of Urology, IRCCS INRCA, 60124 Ancona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8327-8379","authenticated-orcid":false,"given":"Micaela","family":"Morettini","sequence":"additional","affiliation":[{"name":"Department of Information Engineering, Universit\u00e0 Politecnica delle Marche, 60131 Ancona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3154-7896","authenticated-orcid":false,"given":"Stefano","family":"Lenci","sequence":"additional","affiliation":[{"name":"Department of Civil and Building Engineering, and Architecture, Universit\u00e0 Politecnica delle Marche, Via Brecce Biance, 60131 Ancona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9474-7046","authenticated-orcid":false,"given":"Laura","family":"Burattini","sequence":"additional","affiliation":[{"name":"Department of Information Engineering, Universit\u00e0 Politecnica delle Marche, 60131 Ancona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,6,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1001\/archfami.2.7.729","article-title":"A population-based study of health care-seeking behavior for treatment of urinary symptoms: The Olmsted County Study of Urinary Symptoms and Health Status Among Men","volume":"2","author":"Jacobsen","year":"1993","journal-title":"Arch. 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