{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T02:11:48Z","timestamp":1760235108377,"version":"build-2065373602"},"reference-count":49,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2021,7,16]],"date-time":"2021-07-16T00:00:00Z","timestamp":1626393600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["16GRNT31090009"],"award-info":[{"award-number":["16GRNT31090009"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Florida Heart Research Foundation","award":["Florida Heart Research Foundation"],"award-info":[{"award-number":["Florida Heart Research Foundation"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioengineering"],"abstract":"<jats:p>The utility of implanting a bioscaffold mitral valve consisting of porcine small intestinal submucosa (PSIS) in a juvenile baboon model (12 to 14 months old at the time of implant; n = 3) to assess their in vivo tissue remodeling responses was investigated. Our findings demonstrated that the PSIS mitral valve exhibited the robust presence of de novo extracellular matrix (ECM) at all explantation time points (at 3-, 11-, and 20-months). Apart from a significantly lower level of proteoglycans in the implanted valve\u2019s annulus region (p &lt; 0.05) at 3 months compared to the 11- and 20-month explants, there were no other significant differences (p &gt; 0.05) found between any of the other principal valve ECM components (collagen and elastin) at the leaflet, annulus, or chordae tendinea locations, across these time points. In particular, neochordae tissue had formed, which seamlessly integrated with the native papillary muscles. However, additional processing will be required to trigger accelerated, uniform and complete valve ECM formation in the recipient. Regardless of the specific processing done to the bioscaffold valve, in this proof-of-concept study, we estimate that a 3-month window following bioscaffold valve replacement is the timeline in which complete regeneration of the valve and integration with the host needs to occur.<\/jats:p>","DOI":"10.3390\/bioengineering8070100","type":"journal-article","created":{"date-parts":[[2021,7,18]],"date-time":"2021-07-18T21:16:48Z","timestamp":1626643008000},"page":"100","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["De Novo Valve Tissue Morphology Following Bioscaffold Mitral Valve Replacement in a Juvenile Non-Human Primate Model"],"prefix":"10.3390","volume":"8","author":[{"given":"Brittany A.","family":"Gonzalez","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering, Florida International University, Miami, FL 33174, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcos","family":"Perez Gonzalez","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Florida International University, Miami, FL 33174, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3084-3012","authenticated-orcid":false,"given":"Frank","family":"Scholl","sequence":"additional","affiliation":[{"name":"Memorial Healthcare System, Joe DiMaggio Children\u2019s Hospital, Hollywood, FL 33021, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven","family":"Bibevski","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Florida International University, Miami, FL 33174, USA"},{"name":"Memorial Healthcare System, Joe DiMaggio Children\u2019s Hospital, Hollywood, FL 33021, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Ladich","sequence":"additional","affiliation":[{"name":"Memorial Healthcare System, Joe DiMaggio Children\u2019s Hospital, Hollywood, FL 33021, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Bibevski","sequence":"additional","affiliation":[{"name":"COR Veterinary Surgery Services, Hollywood, FL 33301, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablo","family":"Morales","sequence":"additional","affiliation":[{"name":"The Mannheimer Foundation, Inc., Homestead, FL 33034, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jesus","family":"Lopez","sequence":"additional","affiliation":[{"name":"The Mannheimer Foundation, Inc., Homestead, FL 33034, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mike","family":"Casares","sequence":"additional","affiliation":[{"name":"Memorial Healthcare System, Joe DiMaggio Children\u2019s Hospital, Hollywood, FL 33021, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent","family":"Brehier","sequence":"additional","affiliation":[{"name":"Memorial Healthcare System, Joe DiMaggio Children\u2019s Hospital, Hollywood, FL 33021, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lazaro","family":"Hernandez","sequence":"additional","affiliation":[{"name":"Memorial Healthcare System, Joe DiMaggio Children\u2019s Hospital, Hollywood, FL 33021, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4108-7141","authenticated-orcid":false,"given":"Sharan","family":"Ramaswamy","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Florida International University, Miami, FL 33174, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,7,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1053\/j.jvca.2020.10.031","article-title":"The Year in Cardiothoracic and Vascular Anesthesia: Selected Highlights from 2020","volume":"35","author":"Martin","year":"2021","journal-title":"J. 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