{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T02:27:06Z","timestamp":1760236026193,"version":"build-2065373602"},"reference-count":31,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T00:00:00Z","timestamp":1634774400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioengineering"],"abstract":"<jats:p>Intracranial aneurysms (IAs) are localized enlargements of cerebral blood vessels that cause substantial rates of mortality and morbidity in humans. The rupture possibility of these aneurysms is a critical medical challenge for physicians during treatment planning. This treatment planning while assessing the rupture potential of aneurysms becomes more complicated when they are constrained by an adjacent structure such as optic nerve tissues or bones, which is not widely studied yet. In this work, we considered and studied a constitutive model to investigate the bio-mechanical response of image-based patient-specific IA data using cardiovascular structural mechanics equations. We performed biomechanical modeling and simulations of four different patient-specific aneurysms\u2019 data (three middle cerebral arteries and one internal carotid artery) to assess the rupture potential of those aneurysms under a plane contact constraint. Our results suggest that aneurysms with plane contact constraints produce less or almost similar maximum wall effective stress compared to aneurysms with no contact constraints. In our research findings, we observed that a plane contact constraint on top of an internal carotid artery might work as a protective wall due to the 16.6% reduction in maximum wall effective stress than that for the case where there is no contact on top of the aneurysm.<\/jats:p>","DOI":"10.3390\/bioengineering8110149","type":"journal-article","created":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T14:37:48Z","timestamp":1634827068000},"page":"149","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Quantification of the Rupture Potential of Patient-Specific Intracranial Aneurysms under Contact Constraints"],"prefix":"10.3390","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1155-3909","authenticated-orcid":false,"given":"Manjurul","family":"Alam","sequence":"first","affiliation":[{"name":"Department of Bio-Engineering, George Mason University, Fairfax, VA 22030, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Mut","sequence":"additional","affiliation":[{"name":"Department of Bio-Engineering, George Mason University, Fairfax, VA 22030, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan R.","family":"Cebral","sequence":"additional","affiliation":[{"name":"Department of Bio-Engineering, George Mason University, Fairfax, VA 22030, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Padmanabhan","family":"Seshaiyer","sequence":"additional","affiliation":[{"name":"Department of Mathematical Sciences, George Mason University, Fairfax, VA 22030, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,10,21]]},"reference":[{"key":"ref_1","unstructured":"Stehbens, W.E. (1972). Pathology of the Cerebral Blood Vessels, C.V. Mosby."},{"key":"ref_2","first-page":"2550","article-title":"Characterization of cerebral aneurysms for assessing risk of rupture by using patient-specific computational hemodynamics models","volume":"26","author":"Cebral","year":"2005","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"ref_3","first-page":"1571","article-title":"Evaluation of the circle of Willis with three-dimensional CT angiography in patients with suspected intracranial aneurysms","volume":"16","author":"Alberico","year":"1995","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1161\/01.STR.15.5.846","article-title":"Cerebral aneurysms and variations in the circle of Willis","volume":"15","author":"Kayembe","year":"1984","journal-title":"Stroke"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.3174\/ajnr.A1600","article-title":"Quantitative Hemodynamic Analysis of Brain Aneurysms at Different Locations","volume":"30","author":"Chien","year":"2009","journal-title":"Am. J. Neuroradiol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"379","DOI":"10.3171\/jns.2000.93.3.0379","article-title":"Natural history of unruptured intracranial aneurysms: Probability of and risk factors for aneurysm rupture","volume":"93","author":"Juvela","year":"2000","journal-title":"J. Neurosurg."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"601","DOI":"10.3171\/jns.2005.102.4.0601","article-title":"Risk of rupture associated with intact cerebral aneurysms in the Japanese population: A systematic review of the literature from Japan","volume":"102","author":"Morita","year":"2005","journal-title":"J. Neurosurg."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1161\/01.STR.32.2.530","article-title":"Functional recovery after rehabilitation for cerebellar stroke","volume":"32","author":"Kelly","year":"2001","journal-title":"Stroke"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"909","DOI":"10.3171\/jns.1984.60.5.0909","article-title":"Outcome 1 year after SAH from cerebral aneurysm. Management morbidity, mortality, and functional status in 112 consecutive good-risk patients","volume":"60","author":"Ropper","year":"1984","journal-title":"J. Neurosurg."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"(1998). The International Study of Unruptured Intracranial Aneurysms Investigator, Unruptured intracranial aneurysms-risk of rupture and risks of surgical intervention. N. Engl. J. Med., 339, 1725\u20131733.","DOI":"10.1056\/NEJM199812103392401"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Wanderer, S., Andereggen, L., Mrosek, J., Kashefiolasl, S., Marbacher, S., and Konczalla, J. (2020). The Role of Losartan as a Potential Neuroregenerative Pharmacological Agent after Aneurysmal Subarachnoid Haemorrhage. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21186496"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Wanderer, S., Andereggen, L., Mrosek, J., Kashefiolasl, S., Schubert, G.A., Schubert, M., and Konczalla, J. (2021). Levosimendan as a therapeutic strategy to prevent neuroinflammation after aneurysmal subarachnoid hemorrhage?. J. NeuroInterventional Surg.","DOI":"10.1136\/neurintsurg-2021-017504"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.1161\/STROKEAHA.108.542571","article-title":"Greater rupture risk for familial as compared to sporadic unruptured intracranial aneurysms","volume":"40","author":"Broderick","year":"2009","journal-title":"Stroke"},{"key":"ref_14","first-page":"e2","article-title":"Unruptured intracranial aneurysms and the assessment of rupture risk based on anatomical and morphological factors: Sifting through the sands of data","volume":"26","author":"Lall","year":"2009","journal-title":"Neurosurg"},{"key":"ref_15","unstructured":"Wilkins, R.H., and Rengachary, S.S. (1985). Intracranial Aneurysms and Subarachnoid Hemorrhage: An Overview, Neurosurgery McGraw-Hill."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1007\/s10439-012-0723-0","article-title":"Suggested connections between risk factors of intracranial aneurysms: A review","volume":"41","author":"Cebral","year":"2013","journal-title":"Ann. Biomed. Eng."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/S0021-9290(01)00002-1","article-title":"On the potentially protective role of contact constraints on saccular aneurysms","volume":"34","author":"Seshaiyer","year":"2001","journal-title":"J. Biomech."},{"key":"ref_18","unstructured":"Alam, M., and Seshaiyer, P. (2018, January 5\u20139). Quantification of the Rupture Potential of Intracranial Saccular Aneurysms under Contact Constraints. Proceedings of the APS March Meeting, Los Angeles, CA, USA. Abstract: V46.00005."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Alam, M., and Seshaiyer, P. (2019). Impact of Contact Constraints on the Dynamics of Idealized Intracranial Saccular Aneurysms. Bioengineering, 6.","DOI":"10.3390\/bioengineering6030077"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1007\/s10439-015-1252-4","article-title":"Diversity in the Strength and Structure of Unruptured Cerebral Aneurysms","volume":"43","author":"Robertson","year":"2015","journal-title":"Ann. Biomed. Eng."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Maas, S.A., Ellis, B.J., Ateshian, G.A., and Weiss, J.A. (2012). FEBio: Finite elements for biomechanics. J. Biomech. Eng., 134.","DOI":"10.1115\/1.4005694"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1023\/A:1010989418250","article-title":"Structure, mechanical properties, and mechanics of intracranial saccular aneurysms","volume":"61","author":"Humphrey","year":"2000","journal-title":"J. Elast."},{"key":"ref_23","first-page":"43","article-title":"Hyper-elastic Mooney-Rivlin Model: Determination and Physical Interpretation of Material Constants","volume":"6","author":"Kumar","year":"2016","journal-title":"MIT Int. J. Mech. Eng."},{"key":"ref_24","first-page":"785","article-title":"Structural analysis of viscoelastic materials","volume":"5","author":"William","year":"1964","journal-title":"J. Am. Inst. Aero. Astro."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1063\/1.1712836","article-title":"A theory of large elastic deformation","volume":"11","author":"Mooney","year":"1940","journal-title":"J. Appl. Phys."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/0045-7825(91)90100-K","article-title":"Quasi-incompressible finite elasticity in principal stretches: Continuum basis and numerical algorithms","volume":"85","author":"Simo","year":"1991","journal-title":"Comput. Methods Appl. Mech. Eng."},{"key":"ref_27","unstructured":"Humphrey, J.D. (2013). Cardiovascular Solid Mechanics: Cells, Tissues, and Organs, Springer: Verlag New York Inc."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Voyiadjis, G.Z., and Kattan, P.I. (1999). Advance in Damage Mechanics: Metals and Metal Matrix Composites, Elsevier.","DOI":"10.1016\/B978-0-08-043601-2.50005-2"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"16-00678","DOI":"10.1299\/jbse.16-00678","article-title":"Researches on biomechanical properties and models of peripheral nerves-a review","volume":"12","author":"Chang","year":"2017","journal-title":"J. Biomech. Sc. Eng."},{"key":"ref_30","first-page":"2299","article-title":"Stress and strain analysis on the anastomosis site sutured with either epineurial or perineurial sutures after simulation of sciatic nerve injury","volume":"7","author":"Liu","year":"2012","journal-title":"Neural Regen. Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/S0006-3495(99)77181-X","article-title":"Three-Dimensional Imaging of Nerve Tissue by X-Ray Phase-Contrast Microtomography","volume":"76","author":"Beckmann","year":"1999","journal-title":"Biophys. J."}],"container-title":["Bioengineering"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2306-5354\/8\/11\/149\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:20:17Z","timestamp":1760167217000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2306-5354\/8\/11\/149"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,21]]},"references-count":31,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2021,11]]}},"alternative-id":["bioengineering8110149"],"URL":"https:\/\/doi.org\/10.3390\/bioengineering8110149","relation":{},"ISSN":["2306-5354"],"issn-type":[{"type":"electronic","value":"2306-5354"}],"subject":[],"published":{"date-parts":[[2021,10,21]]}}}