{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T23:52:40Z","timestamp":1784245960173,"version":"3.55.0"},"reference-count":87,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2022,11,30]],"date-time":"2022-11-30T00:00:00Z","timestamp":1669766400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioengineering"],"abstract":"<jats:p>Muscle tissue is formed by elongated and contractile cells with specific morphofunctional characteristics. Thus, it is divided into three basic types: smooth muscle tissue, cardiac striated muscle tissue and skeletal striated muscle tissue. The striated skeletal muscle tissue presents high plasticity, regeneration and growth capacity due to the presence of satellite cells, quiescent myoblasts that are activated in case of injury to the tissue and originate new muscle fibers when they differentiate. In more severe deficiencies or injuries there is a loss of their regenerative capacity, thus compromising the body\u2019s functionality at different levels. Tissue engineering studies the development of biomaterials capable of stimulating the recovery of cellular activity in injured body tissues, as well as the activity of cells with muscle differentiation potential in injury repair. However, the need for three-dimensional re-assembly in a complex organization makes it difficult to mimic this tissue and fully regenerate it for the sake of precise and effective movements. Thus, this article aims to provide a narrative review of tissue engineering strategies applied to the regeneration of skeletal muscle, in a critical evaluation of research, whether aimed at injury or atrophies such as spinal muscular atrophy.<\/jats:p>","DOI":"10.3390\/bioengineering9120744","type":"journal-article","created":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T02:24:46Z","timestamp":1669861486000},"page":"744","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Tissue Engineering Applied to Skeletal Muscle: Strategies and Perspectives"],"prefix":"10.3390","volume":"9","author":[{"given":"Ana Luisa Lopes","family":"Martins","sequence":"first","affiliation":[{"name":"Centro de Engenharia, Modelagem e Ci\u00eancias Sociais Aplicadas (CECS), Universidade Federal do ABC, S\u00e3o Bernardo do Campo 09606-070, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7105-6261","authenticated-orcid":false,"given":"Luciana Pastena","family":"Giorno","sequence":"additional","affiliation":[{"name":"Centro de Ci\u00eancias Naturais e Humanas (CCNH), Universidade Federal do ABC, Bloco Delta, Sala 204, Alameda da Universidade, s\/n, Anchieta, S\u00e3o Bernardo do Campo 09606-070, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0535-0088","authenticated-orcid":false,"suffix":"Jr.","given":"Arnaldo Rodrigues","family":"Santos","sequence":"additional","affiliation":[{"name":"Centro de Ci\u00eancias Naturais e Humanas (CCNH), Universidade Federal do ABC, Bloco Delta, Sala 204, Alameda da Universidade, s\/n, Anchieta, S\u00e3o Bernardo do Campo 09606-070, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,30]]},"reference":[{"key":"ref_1","unstructured":"Junqueira, L.C.U., and Carneiro, J. (2017). Histologia B\u00e1sica, Guanabara Koogan. [13rd ed.]."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"289","DOI":"10.3390\/jfmk1030289","article-title":"Morphological and functional aspects of human skeletal muscle","volume":"1","author":"Trovato","year":"2016","journal-title":"J. Funct. Morphol. Kinesiol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/bs.ctdb.2017.08.007","article-title":"Cellular biomechanics in skeletal muscle regeneration","volume":"126","author":"Li","year":"2018","journal-title":"Curr. Top. Dev. Biol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1002\/cphy.c140068","article-title":"Satellite cells and skeletal muscle regeneration","volume":"5","author":"Dumont","year":"2015","journal-title":"Compr. Physiol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1089\/ten.teb.2017.0451","article-title":"Stem cells for skeletal muscle tissue engineering","volume":"24","author":"Pantelic","year":"2018","journal-title":"Tissue Eng. Part B Rev."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1006\/dbio.1996.0097","article-title":"Satellite cell proliferative compartments in growing skeletal muscles","volume":"175","author":"Schultz","year":"1996","journal-title":"Dev. Biol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1152\/physrev.00043.2011","article-title":"Satellite cells and the muscle stem cell niche","volume":"93","author":"Yin","year":"2013","journal-title":"Physiol Rev."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s00223-014-9915-y","article-title":"Skeletal muscle: A brief review of structure and function","volume":"96","author":"Frontera","year":"2015","journal-title":"Calcif. Tissue Int."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"329e","DOI":"10.1097\/PRS.0000000000005273","article-title":"Muscle-derived stem cell-enriched scaffolds are capable of enhanced healing of a murine volumetric muscle loss defect","volume":"143","author":"Wang","year":"2019","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_10","first-page":"121","article-title":"Tissue engineering applied to skeletal muscle injuries: An overview of therapeutic perspectives","volume":"2","author":"Martins","year":"2021","journal-title":"J. Bio. Med. Open Access"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2945","DOI":"10.1242\/jcs.03029","article-title":"Myogenic potential of adipose-tissue-derived cells","volume":"119","author":"Iachininoto","year":"2006","journal-title":"J. Cell Sci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1111\/vsu.12787","article-title":"Extracellular matrix scaffolds for treatment of large volume muscle injuries: A review","volume":"47","author":"Sarrafian","year":"2018","journal-title":"Vet. Surg."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1111\/dmcn.14365","article-title":"Congenital myopathies: An update","volume":"62","author":"Claeys","year":"2020","journal-title":"Dev. Med. Child Neurol."},{"key":"ref_14","first-page":"261","article-title":"Spinal muscular atrophy: Diagnosis, treatment and future prospects","volume":"86","author":"Baioni","year":"2010","journal-title":"J. Pediatr."},{"key":"ref_15","unstructured":"Hashmi, S. (2016). Tissue Engineering Concepts. Reference Module in Materials Science and Materials Engineering, Elsevier."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.copbio.2017.05.003","article-title":"Biomaterials for skeletal muscle tissue engineering","volume":"47","author":"Kwee","year":"2017","journal-title":"Curr. Opi. Biotechnol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"3287","DOI":"10.1073\/pnas.0903875106","article-title":"Functional muscle regeneration with combined delivery of angiogenesis and myogenesis factors","volume":"107","author":"Borselli","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.biomaterials.2016.05.009","article-title":"Synthetic niche to modulate regenerative potential of MSCs and enhance skeletal muscle regeneration","volume":"99","author":"Pumberger","year":"2016","journal-title":"Biomaterials"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"e04885","DOI":"10.7554\/eLife.04885","article-title":"Bioengineered human myobundles mimic clinical responses of skeletal muscle to drugs","volume":"4","author":"Madden","year":"2015","journal-title":"eLife"},{"key":"ref_20","first-page":"2","article-title":"Isolation and purification of satellite cells for skeletal muscle tissue engineering","volume":"3","author":"Syverud","year":"2014","journal-title":"J. Regen. Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1006\/excr.2001.5191","article-title":"Purification of mouse primary myoblasts based on \u03b17 integrin expression","volume":"265","author":"Yao","year":"2001","journal-title":"Exp. Cell Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"179","DOI":"10.3349\/ymj.2006.47.2.179","article-title":"Comparative study of magnetic-activated cell sorting, cytotoxicity and preplating for the purification of human myoblasts","volume":"47","author":"Park","year":"2006","journal-title":"Yonsei Med. J."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1002\/stem.2450","article-title":"Concise Review: Human embryonic stem cells\u2014What have we done? What are we doing? Where are we going?","volume":"35","author":"Ilic","year":"2016","journal-title":"Stem Cells"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Nuge, T., Liu, Z., Liu, X., Ang, B.C., Andriyana, A., Metselaar, H.S.C., and Hoque, M.E. (2021). Recent advances in scaffolding from natural-based polymers for volumetric muscle injury. Molecules, 26.","DOI":"10.3390\/molecules26030699"},{"key":"ref_25","unstructured":"(2021, October 10). Brasil. Lei n\u00ba 11.105, de 24 de Mar\u00e7o de 2005. Disp\u00f5e Sobre a Pol\u00edtica Nacional de Biosseguran\u00e7a. Di\u00e1rio Oficial da Uni\u00e3o, Bras\u00edlia, DF, Available online: http:\/\/www.planalto.gov.br\/ccivil_03\/_ato2004-2006\/2005\/lei\/l11105.htm."},{"key":"ref_26","unstructured":"(2021, October 10). Brasil. Resolu\u00e7\u00e3o RDC No. 505, de 27 de Maio de 2021. Disp\u00f5e Sobre o Registro de Produto de Terapia Avan\u00e7ada e d\u00e1 Outras Provid\u00eancias. Edi\u00e7\u00e3o: 101. Se\u00e7\u00e3o: 1, Available online: https:\/\/www.in.gov.br\/en\/web\/dou\/-\/resolucao-rdc-n-505-de-27-de-maio-de-2021-323002775."},{"key":"ref_27","unstructured":"(2021, October 10). Brasil. Resolu\u00e7\u00e3o RDC No. 506, de 27 de Maio de 2021. Disp\u00f5e Sobre as Regras para a Realiza\u00e7\u00e3o de Ensaios Cl\u00ednicos com Produto de Terapia Avan\u00e7ada Investigacional no Brasil, e d\u00e1 Outras Provid\u00eancias. Edi\u00e7\u00e3o: 101. Se\u00e7\u00e3o: 1, Available online: https:\/\/www.in.gov.br\/en\/web\/dou\/-\/resolucao-rdc-n-506-de-27-de-maio-de-2021-323008725."},{"key":"ref_28","unstructured":"(2021, October 10). Brasil. Resolu\u00e7\u00e3o RDC No. 508, de 27 de Maio de 2021. Disp\u00f5e Sobre as Boas Pr\u00e1ticas em C\u00e9lulas Humanas para Uso Terap\u00eautico e Pesquisa Cl\u00ednica, e d\u00e1 Outras Provid\u00eancias. Edi\u00e7\u00e3o: 101. Se\u00e7\u00e3o: 1, Available online: https:\/\/www.in.gov.br\/en\/web\/dou\/-\/resolucao-rdc-n-508-de-27-de-maio-de-2021-323013606#:~:text=Disp%C3%B5e%20sobre%20as%20Boas%20Pr%C3%A1ticas,que%20lhe%20conferem%20os%20arts."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"252","DOI":"10.2174\/1574888X13666180115093800","article-title":"Stem cells derived from amniotic fluid: A potential pluripotent-like cell source for cellular therapy?","volume":"13","author":"Ramasamy","year":"2018","journal-title":"Curr. Stem Cell Res. Ther."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.cell.2006.07.024","article-title":"Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors","volume":"126","author":"Takahashi","year":"2006","journal-title":"Cell"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"36","DOI":"10.7150\/ijms.21666","article-title":"Ethical and safety issues of stem cell-based therapy","volume":"15","author":"Volarevic","year":"2018","journal-title":"Int. J. Med. Sci."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1002\/stem.1681","article-title":"Concise review: The surface markers and identity of human mesenchymal stem cells","volume":"32","author":"Lv","year":"2014","journal-title":"Stem Cells"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1186\/ar2116","article-title":"Mesenchymal stromal cells. Biology of adult mesenchymal stem cells. Regulation of niche, self-renewal and differentiation","volume":"9","author":"Kolf","year":"2007","journal-title":"Arthritis Res. Ther."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1590\/S1516-84842009005000038","article-title":"Caracter\u00edsticas biol\u00f3gicas das c\u00e9lulas-tronco mesenquimais","volume":"31","author":"Bydlowski","year":"2009","journal-title":"R. Bras. Hematol. Hemoter."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1002\/stem.1661","article-title":"Concise review: Evidence for CD34 as a common marker for diverse progenitors","volume":"32","author":"Sidney","year":"2014","journal-title":"Stem Cells"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.scr.2011.06.004","article-title":"Fetal muscle contains different CD34+ cell subsets that distinctly differentiate into adipogenic, angiogenic and myogenic lineages","volume":"7","author":"Dupas","year":"2011","journal-title":"Stem Cell Res."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1080\/14653240500319234","article-title":"Clarification of the nomenclature for MSC: The international society for cellular therapy position statement","volume":"7","author":"Horwitz","year":"2005","journal-title":"Cytotherapy"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/nyas.13102","article-title":"Isolation and characterization of primary bone marrow mesenchymal stromal cells","volume":"1370","author":"Li","year":"2016","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_39","first-page":"1109","article-title":"Commonly used mesenchymal stem cell markers and tracking labels: Limitations and challenges","volume":"28","author":"Lin","year":"2013","journal-title":"Histol. Histopathol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1002\/jcp.20636","article-title":"Characterization of freshly isolated and cultured cells derived from the fatty and fluid portions of liposuction aspirates","volume":"208","author":"Yoshimura","year":"2006","journal-title":"J. Cel. Physiol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1089\/107632701300062859","article-title":"Multilineage cells from human adipose tissue: Implications for cell-based therapies","volume":"7","author":"Zuk","year":"2001","journal-title":"Tis. Eng."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"2770","DOI":"10.1089\/scd.2012.0176","article-title":"Allogeneic and xenogeneic transplantation of adipose-derived stem cells in immunocompetent recipients without immunosuppressants","volume":"21","author":"Lin","year":"2012","journal-title":"Stem Cells Dev."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"2739","DOI":"10.1634\/stemcells.2007-0197","article-title":"Concise review: Mesenchymal stem cells: Their phenotype, differentiation capacity, immunological features, and potential for homing","volume":"25","author":"Chamberlain","year":"2007","journal-title":"Stem Cells"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.exphem.2004.02.004","article-title":"Mesenchymal stem cells: Paradoxes of passaging","volume":"32","author":"Javazon","year":"2004","journal-title":"Exp. Hematol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"683","DOI":"10.4236\/jbise.2013.66083","article-title":"Stem cells and cell therapy: From basic sciences to clinical perspectives","volume":"6","author":"Machado","year":"2013","journal-title":"J. Biomed. Sci. Eng."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.bbrc.2013.07.049","article-title":"Biophysical cues enhance myogenesis of human adipose derived stem\/stromal cells","volume":"438","author":"Cook","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.2147\/IJN.S101955","article-title":"Evaluation of adipose-derived stem cells for tissue-engineered muscle repair construct-mediated repair of a murine model of volumetric muscle loss injury","volume":"11","author":"Kesireddy","year":"2016","journal-title":"Int. J. Nanomed."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Kulesza, A., Burdzinska, A., Szczepanska, I., Zarychta-Wisniewska, W., Pajak, B., Bojarczuk, K., Dybowski, B., and Paczek, L. (2016). The mutual interactions between mesenchymal stem cells and myoblasts in an autologous co-culture model. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0161693"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Witt, R., Weigand, A., Boos, A.M., Cai, A., Dippold, D., Boccaccini, A.R., Schubert, D.W., Hardt, M., Lange, C., and Arkudas, A. (2017). Mesenchymal stem cells and myoblast differentiation under HGF and IGF-1 stimulation for 3D skeletal muscle tissue engineering. BMC Cell Biology, 18.","DOI":"10.1186\/s12860-017-0131-2"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1083\/jcb.201603111","article-title":"A human in vitro model of Duchenne muscular dystrophy muscle formation and contractility","volume":"215","author":"Nesmith","year":"2016","journal-title":"J. Cell Biol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"S53","DOI":"10.1002\/mds.20540","article-title":"In vitro models of multiple system atrophy","volume":"20","author":"Stefanova","year":"2005","journal-title":"Mov. Disord."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"2491","DOI":"10.1038\/s41598-020-59268-w","article-title":"In vitro modeling of dendritic atrophy in Rett syndrome: Determinants for phenotypic drug screening in neurodevelopmental disorders","volume":"10","author":"Nerli","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13018-016-0421-y","article-title":"Matrix scaffolding for stem cell guidance toward skeletal muscle tissue engineering","volume":"11","author":"Fuoco","year":"2016","journal-title":"J. Orthop. Surg. Res."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Kang, M.S., Lee, S.H., Park, W.J., Lee, J.E., Kim, B., and Han, D.-W. (2020). Advanced techniques for skeletal muscle tissue engineering and regeneration. Bioengineering, 7.","DOI":"10.3390\/bioengineering7030099"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"7777","DOI":"10.1016\/j.jmrt.2020.04.049","article-title":"Low-cost hybrid scaffolds based on polyurethane and gelatin","volume":"9","author":"Rodrigues","year":"2020","journal-title":"J. Mater. Res. Technol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"3188","DOI":"10.1016\/j.biomaterials.2013.12.072","article-title":"Engineering hybrid polymer-protein super-aligned nanofibers via rotary jet spinning","volume":"35","author":"Badrossamay","year":"2014","journal-title":"Biomaterials"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/s41538-019-0054-8","article-title":"Muscle tissue engineering in fibrous gelatin: Implications for meat analogs","volume":"3","author":"MacQqueen","year":"2019","journal-title":"NPJ Sci. Food"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"2740","DOI":"10.1039\/C5CS00714C","article-title":"3D-Printing technologies for electrochemical applications","volume":"45","author":"Ambrosi","year":"2016","journal-title":"Chem. Soc. Rev."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1601118","DOI":"10.1002\/adhm.201601118","article-title":"3D Bioprinting for organ regeneration","volume":"6","author":"Cui","year":"2017","journal-title":"Adv. Healthc. Mater."},{"key":"ref_60","first-page":"49","article-title":"Bioprinting and stem cells: The new frontier of tissue engineering and regenerative medicine","volume":"4","author":"Souza","year":"2018","journal-title":"J. Stem Cell Res. Ther."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"12307","DOI":"10.1038\/s41598-018-29968-5","article-title":"3D Bioprinted human skeletal muscle constructs for muscle function restoration","volume":"8","author":"Kim","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"lb449","DOI":"10.1096\/fasebj.2019.33.1_supplement.lb449","article-title":"Using bioprinting to tissue engineer microvascularized constructs for skeletal muscle repair","volume":"33","author":"Bour","year":"2019","journal-title":"FASEB J."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Ayres, C. (2021). Substitutos tissulares aplicado ao tecido \u00f3sseo. Cole\u00e7\u00e3o Desafios das Engenharias: Engenharia Biom\u00e9dica, Atena Editora. [1st ed.].","DOI":"10.22533\/at.ed.569211607"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1002\/bip.22120","article-title":"Fabrication of gelatin nanofibrous scaffolds using ethanol\/phosphate buffer saline as a benign solvent","volume":"97","author":"Zha","year":"2012","journal-title":"Biopolymers"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"2622","DOI":"10.1111\/j.1582-4934.2010.01183.x","article-title":"Engineering skeletal muscle tissue\u2014New perspectives in vitro and in vivo","volume":"14","author":"Klumpp","year":"2010","journal-title":"J. Cell. Mol. Med."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1177\/0963689718805370","article-title":"Adipose-derived stem\/stromal cells on electrospun fibrin microfiber bundles enable moderate muscle reconstruction in a volumetric muscle loss model","volume":"27","author":"Ginn","year":"2018","journal-title":"Cell Transplant."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Reddy, M.S.B., Ponnamma, D., Choudhary, R., and Sadasivuni, K.K. (2021). A Comparative Review of Natural and Synthetic Biopolymer Composite Scaffolds. Polymers, 13.","DOI":"10.3390\/polym13071105"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"6932","DOI":"10.1039\/C4RA12486C","article-title":"A novel polyurethane\/cellulose fibrous scaffold for cardiac tissue engineering","volume":"5","author":"Chen","year":"2015","journal-title":"RSC Adv."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"331","DOI":"10.2217\/rme-2017-0120","article-title":"Adipose-derived stem-cell-implanted poly(\u03f5-caprolactone)\/chitosan scaffold improves bladder regeneration in a rat model","volume":"13","author":"Zhou","year":"2018","journal-title":"Regen. Med."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Abatangelo, C., Vindigni, V., Avruscio, G., Pandis, L., and Brun, P. (2020). Hyaluronic acid: Redefining its role. Cells, 9.","DOI":"10.3390\/cells9071743"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"20170380","DOI":"10.1098\/rsif.2017.0380","article-title":"Hydrogel biomaterials and their therapeutic potential for muscle injuries and muscular dystrophies","volume":"15","author":"Lev","year":"2018","journal-title":"J. R. Soc. Interface"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1002\/jbm.b.33859","article-title":"Natural polymeric hydrogel evaluation for skeletal muscle tissue engineering","volume":"106","author":"Pollot","year":"2017","journal-title":"J. Biomed. Mater. Res. Part B Appl. Biomat."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.biomaterials.2017.07.003","article-title":"Laminin-111 enriched fibrin hydrogels for skeletal muscle regeneration","volume":"141","author":"Marcinczyk","year":"2017","journal-title":"Biomaterials"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.scr.2018.01.008","article-title":"Volumetric muscle loss injury repair using in situ fibrin gel cast seeded with muscle-derived stem cells (MDSCs)","volume":"27","author":"Matthias","year":"2018","journal-title":"Stem Cell Res."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"2763","DOI":"10.1002\/jbm.b.34057","article-title":"Gelatin-genipin-based biomaterials for skeletal muscle tissue engineering","volume":"106","author":"Gattazzo","year":"2018","journal-title":"J. Biomed. Mater. Res. Part B Appl. Biomat."},{"key":"ref_76","first-page":"15","article-title":"Decellularized extracellular matrix scaffolds: Recent trends and emerging strategies in tissue engineering","volume":"10","author":"Zhang","year":"2022","journal-title":"Bioact. Mater."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1006\/jsre.1996.0018","article-title":"Intestine submucosa and polypropylene mesh for abdominal wall repair in dogs","volume":"60","author":"Clarke","year":"1996","journal-title":"J. Surg. Res."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"7870","DOI":"10.1016\/j.biomaterials.2011.07.016","article-title":"The pro-myogenic environment provided by whole organ scale acellular scaffolds from skeletal muscle","volume":"32","author":"Perniconi","year":"2011","journal-title":"Biomaterials"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.biomaterials.2015.07.040","article-title":"An acellular biologic scaffold does not regenerate appreciable de novo muscle tissue in rat models of volumetric muscle loss injury","volume":"67","author":"Aurora","year":"2015","journal-title":"Biomaterials"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1007\/s00441-018-2955-2","article-title":"Skeletal muscle fibrosis: An overview","volume":"375","author":"Mahdy","year":"2019","journal-title":"Cell Tissue Res."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"2234","DOI":"10.1089\/ten.tea.2013.0730","article-title":"Bladder acellular matrix conjugated with basic fibroblast growth factor for bladder regeneration","volume":"20","author":"Chen","year":"2014","journal-title":"Tissue Eng. Part A"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"e1801168","DOI":"10.1002\/adhm.201801168","article-title":"Engineering Biomimetic Materials for Skeletal Muscle Repair and Regeneration","volume":"8","author":"Nakayama","year":"2019","journal-title":"Adv. Healthc. Mater."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"2511","DOI":"10.1042\/BCJ20180283","article-title":"Glycans and glycosaminoglycans in neurobiology: Key regulators of neuronal cell function and fate","volume":"475","author":"Hayes","year":"2018","journal-title":"Biochem. J."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"6010","DOI":"10.1073\/pnas.1402679111","article-title":"An engineered muscle flap for reconstruction of large soft tissue defects","volume":"111","author":"Shandalov","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"577","DOI":"10.3727\/096368908785095980","article-title":"Efficient delivery of human single fiber-derived muscle precursor cells via biocompatible scaffold","volume":"17","author":"Boldrin","year":"2008","journal-title":"Cell Transplant."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.1089\/ten.tea.2012.0597","article-title":"Skeletal muscle atrophy in bioengineered skeletal muscle: A new model system","volume":"19","author":"Lee","year":"2013","journal-title":"Tissue Eng. Part A"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1089\/ten.2006.12.1833","article-title":"Paracrine release of insulin-like growth factor 1 from a bioengineered tissue stimulates skeletal muscle growth in vitro","volume":"12","author":"Shansky","year":"2006","journal-title":"Tissue Eng."}],"container-title":["Bioengineering"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2306-5354\/9\/12\/744\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:30:49Z","timestamp":1760146249000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2306-5354\/9\/12\/744"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,30]]},"references-count":87,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2022,12]]}},"alternative-id":["bioengineering9120744"],"URL":"https:\/\/doi.org\/10.3390\/bioengineering9120744","relation":{},"ISSN":["2306-5354"],"issn-type":[{"value":"2306-5354","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,30]]}}}