{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T17:40:21Z","timestamp":1791567621173,"version":"4.3.4"},"reference-count":46,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2021,3,27]],"date-time":"2021-03-27T00:00:00Z","timestamp":1616803200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biology"],"abstract":"<jats:p>The aim of this study was to compare the efficacy of trabeculectomy (TE), single XEN microstent implantation (solo XEN) or combined XEN implantation and cataract surgery (combined XEN) in primary open-angle glaucoma cases, na\u00efve to prior surgical treatment, using a monocentric retrospective comparative cohort study. Intraocular pressure (IOP) and the number of IOP-lowering drugs (Meds) were monitored during the first 24 months after surgery. Further disease progression was monitored using peripapillary retinal nerve fiber layer (RNFL) thickness examinations using spectral domain optical coherence tomography (OCT) as well as visual acuity (VA) and visual field (VF) tests. In the TE group (52 eyes), the mean IOP decreased from 24.9 \u00b1 5.9 to 13.9 \u00b1 4.2 mmHg (p &lt; 0.001) and Meds decreased from 3.2 \u00b1 1.2 to 0.5 \u00b1 1.1 (p &lt; 0.001). In the solo XEN (38 eyes) and the combined XEN groups, the mean IOP decreased from 24.1 \u00b1 4.7 to 15.7 \u00b1 3.0 mmHg (p &lt; 0.001) and 25.4 \u00b1 5.6 to 14.7 \u00b1 3.2 mmHg (p &lt; 0.001), while Meds decreased from 3.3 \u00b1 0.8 to 0.8 \u00b1 1.2 (p &lt; 0.001) and 2.7 \u00b1 1.2 to 0.4 \u00b1 1.0 (p &lt; 0.001), respectively. The VF and VA indices showed no sign of further deterioration, the RNFL thickness further decreased in all treatment groups after surgery. TE and XEN led to comparable reductions in IOP and Meds. Although the VA and VF indices remained unaltered, the RNFL thickness continuously decreased in all treatment groups during the 24-month follow-up.<\/jats:p>","DOI":"10.3390\/biology10040273","type":"journal-article","created":{"date-parts":[[2021,3,28]],"date-time":"2021-03-28T22:09:01Z","timestamp":1616969341000},"page":"273","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Functional Monitoring after Trabeculectomy or XEN Microstent Implantation Using Spectral Domain Optical Coherence Tomography and Visual Field Indices\u2014A Retrospective Comparative Cohort Study"],"prefix":"10.3390","volume":"10","author":[{"given":"Marc","family":"Schargus","sequence":"first","affiliation":[{"name":"Universit\u00e4ts-Augenklinik D\u00fcsseldorf, Universit\u00e4tsklinikum D\u00fcsseldorf, Moorenstra\u00dfe 5, 40225 D\u00fcsseldorf, Germany"},{"name":"Department of Ophthalmology, Asklepios Klnik Nord-Heidberg, Tangstedter Landstrasse 400, 22417 Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catharina","family":"Busch","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Leipzig, Liebigstrasse 10-14, 04103 Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matus","family":"Rehak","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Leipzig, Liebigstrasse 10-14, 04103 Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Leipzig, Liebigstrasse 10-14, 04103 Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Leipzig, Liebigstrasse 10-14, 04103 Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Bormann","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Leipzig, Liebigstrasse 10-14, 04103 Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan Darius","family":"Unterlauft","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Leipzig, Liebigstrasse 10-14, 04103 Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,3,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1016\/j.ophtha.2014.05.013","article-title":"Global prevalence of glaucoma and projections of glaucoma burden through 2040: A systematic review and meta-analysis","volume":"121","author":"Tham","year":"2014","journal-title":"Ophthalmology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1136\/bjo.2005.081224","article-title":"The number of people with glaucoma worldwide in 2010 and 2020","volume":"90","author":"Quigley","year":"2006","journal-title":"Br. 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