{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:42:50Z","timestamp":1790707370823,"version":"4.1.0"},"reference-count":40,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2021,4,6]],"date-time":"2021-04-06T00:00:00Z","timestamp":1617667200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biology"],"abstract":"<jats:p>The use of a loop ileostomy as the defunctioning procedure of choice to protect a distal colonic anastomosis causes histological and endoscopic changes in the intestinal mucosal architecture, which have been related to chronic inflammation and changes in the microflora that consequently impact the intestinal structure and function following fecal stream diversion. The aim of this study was to evaluate the histological and endoscopic changes on the colonic mucosa in patients with diversion colitis after stimulation of the efferent loop with probiotics prior to closure of the protective ileostomy. A prospective, randomized, double-blind, controlled study was designed. All patients who underwent surgery for colorectal carcinoma with protective ileostomy between January 2017 and December 2018 were included. These patients were pending reconstructive surgery and were diagnosed with endoscopic and histological diversion colitis. Divided into two groups, a group stimulated with probiotics (SG) and a control group (CG). 34 cases and 35 controls were included in the study. Histological and endoscopic changes were evaluated after stimulation, after restorative surgery and during the short-term follow-up after surgery. A decrease in endoscopic pathological findings (mucosal friability, mucous erosions, polyps, edema, erythema and stenosis) and in histological findings (follicular hyperplasia, eosinophils, cryptic abscesses, lymphocyte infiltration, plasma cell infiltration and architecture distortion) was observed in SG. These results were statistically significant with a p &lt; 0.001. The stimulation of the efferent loop of the ileostomy in patients with diversion colitis produced a decrease of the endoscopic and histological severity of colitis in the short term.<\/jats:p>","DOI":"10.3390\/biology10040303","type":"journal-article","created":{"date-parts":[[2021,4,6]],"date-time":"2021-04-06T10:34:12Z","timestamp":1617705252000},"page":"303","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Diversion Colitis: Macro and Microscopic Findings after Probiotics Stimulation"],"prefix":"10.3390","volume":"10","author":[{"given":"\u00c1ngela","family":"Rodr\u00edguez-Padilla","sequence":"first","affiliation":[{"name":"Department of General Surgery, Infanta Elena University Clinical Hospital, 21080 Huelva, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Germ\u00e1n","family":"Morales-Mart\u00edn","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Infanta Elena University Clinical Hospital, 21080 Huelva, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roc\u00edo","family":"P\u00e9rez-Quintero","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Juan Ram\u00f3n Jim\u00e9nez University Clinical Hospital, 21005 Huelva, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9053-7730","authenticated-orcid":false,"given":"Juan","family":"G\u00f3mez-Salgado","sequence":"additional","affiliation":[{"name":"Department of Sociology, Social Work and Public Health, Faculty of Labour Sciences, University of Huelva, 21007 Huelva, Spain"},{"name":"Safety and Health Postgraduate Programme, Universidad Esp\u00edritu Santo, Guayaquil 092301, Ecuador"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Rada-Morgades","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Juan Ram\u00f3n Jim\u00e9nez University Clinical Hospital, 21005 Huelva, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3715-1382","authenticated-orcid":false,"given":"Carlos","family":"Ruiz-Frutos","sequence":"additional","affiliation":[{"name":"Department of Sociology, Social Work and Public Health, Faculty of Labour Sciences, University of Huelva, 21007 Huelva, Spain"},{"name":"Safety and Health Postgraduate Programme, Universidad Esp\u00edritu Santo, Guayaquil 092301, Ecuador"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,4,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Biagioli, M., Capobianco, D., Carino, A., Marchian\u00f2, S., Fiorucci, C., Ricci, P., Distrutti, E., and Fiorucci, S. 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Bras."}],"container-title":["Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-7737\/10\/4\/303\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T13:34:07Z","timestamp":1760362447000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-7737\/10\/4\/303"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,6]]},"references-count":40,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2021,4]]}},"alternative-id":["biology10040303"],"URL":"https:\/\/doi.org\/10.3390\/biology10040303","relation":{},"ISSN":["2079-7737"],"issn-type":[{"value":"2079-7737","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,6]]}}}