{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T02:05:33Z","timestamp":1760234733588,"version":"build-2065373602"},"reference-count":24,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2021,6,19]],"date-time":"2021-06-19T00:00:00Z","timestamp":1624060800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biology"],"abstract":"<jats:p>Background: Allogeneic stem cell transplantation (aSCT) is a common treatment for a variety of hematological diseases. Advances in transplantation practices have led to an increasing number of long-term aSCT survivors, but data about health status and late complications are sparse. This analysis focusses on kidney function and urological complications in this population. Methods: This study is a prospective unicentric non-interventional trial. Before starting the study, we obtained the approval of the local ethics review board. Furthermore, the study was registered at WHO Clinical Trial Registry. The study protocol is available via UTN. Results: We were able to include 33 patients with a mean age of 60.5 years (SD 11.1). The median survival time following allogeneic stem cell transplantation was 9.0 years (IQR 8.5\u201313.0). Five patients (15.2%) had BKPyV viruria with mean 218.3 (SD 674.2) copies\/mL. BKPyV viruria was significantly linked to pre-existing chronic kidney failure (p = 0.019), creatine &gt; 100 \u00b5mol\/L (p &lt; 0.001), and cystatin c &gt; 1.11 mg\/L (p = 0.021), respectively. We were not able to identify a single risk factor for BKPyV viruria in univariate or multivariate Cox regression. Conclusions: BKPyV-associated nephropathy might be one reason for impaired kidney function in long-term survivors of aSCT.<\/jats:p>","DOI":"10.3390\/biology10060553","type":"journal-article","created":{"date-parts":[[2021,6,20]],"date-time":"2021-06-20T22:00:02Z","timestamp":1624226402000},"page":"553","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Significance of BK Polyomavirus in Long-Term Survivors after Adult Allogeneic Stem Cell Transplantation"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1160-1277","authenticated-orcid":false,"given":"Thomas","family":"Neumann","sequence":"first","affiliation":[{"name":"Department of Hematology\/Oncology, University Medical Center Greifswald, 17475 Greifswald, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadette","family":"Peters","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology, University Medical Center Greifswald, 17475 Greifswald, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Kranz","sequence":"additional","affiliation":[{"name":"Department of Urology and Kidney Transplantation, Martin-Luther-University, 06120 Halle\/Saale, Germany"},{"name":"Department of Urology, St. Antonius Hospital gGmbH, 52249 Eschweiler, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Desiree","family":"Dr\u00e4ger","sequence":"additional","affiliation":[{"name":"Department of Urology, University Medical Center Rostock, 18055 Rostock, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2438-1955","authenticated-orcid":false,"given":"Florian","family":"Heidel","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology, University Medical Center Greifswald, 17475 Greifswald, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3427-3632","authenticated-orcid":false,"given":"William","family":"Kr\u00fcger","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology, University Medical Center Greifswald, 17475 Greifswald, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3409-8654","authenticated-orcid":false,"given":"Laila","family":"Schneidewind","sequence":"additional","affiliation":[{"name":"Department of Urology, University Medical Center Rostock, 18055 Rostock, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,6,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2230","DOI":"10.1200\/JCO.2010.33.7212","article-title":"Long-Term Survival and Late Deaths After Allogeneic Hematopoietic Cell Transplantation","volume":"29","author":"Wingard","year":"2011","journal-title":"J. Clin. Oncol."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Torrent, A., Ferr\u00e1, C., Batlle, M., Hidalgo, F., Jim\u00e9nez-Lorenzo, M.-J., and Ribera, J.-M. (2020). Estudio prospectivo del seguimiento de pacientes largos supervivientes a un trasplante alog\u00e9nico de progenitores hematopoy\u00e9ticos. Med. Cl\u00edn.","DOI":"10.1016\/j.medcli.2020.07.038"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1016\/j.bbmt.2017.08.016","article-title":"Chronic kidney disease in long-term survivors after allogeneic hematopoitic stem cell transplantation: Retrospective analysis at a single institution","volume":"23","author":"Jo","year":"2017","journal-title":"Biol. Blood Marrow Transplant."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.bbmt.2008.10.011","article-title":"Study of Kidney Function Impairment after Reduced-Intensity Conditioning Allogeneic Hematopoietic Stem Cell Transplantation. A Single-Center Experience","volume":"15","author":"Martino","year":"2009","journal-title":"Biol. Blood Marrow Transplant."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/bmt.2009.99","article-title":"A multicenter, retrospective study of acute kidney injury in adult patients with nonmyeloablative hematopoietic SCT","volume":"45","author":"Liu","year":"2010","journal-title":"Bone Marrow Transplant."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.bbmt.2010.07.010","article-title":"Pretransplant Predictors and Posttransplant Sequels of Acute Kidney Injury after Allogeneic Stem Cell Transplantation","volume":"17","author":"Kagoya","year":"2011","journal-title":"Biol. Blood Marrow Transplant."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1038\/bmt.2012.85","article-title":"The significant impact of acute kidney injury on CKD in patients who survived over 10 years after myeloablative allogeneic SCT","volume":"48","author":"Shimoi","year":"2012","journal-title":"Bone Marrow Transplant."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2256","DOI":"10.1056\/NEJMra1404711","article-title":"Renal Complications of Hematopoietic-Cell Transplantation","volume":"374","author":"Hingorani","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1038\/bmt.2013.55","article-title":"GVHD-associated chronic kidney disease after allogeneic haematopoietic cell transplantation","volume":"48","author":"Sakellari","year":"2013","journal-title":"Bone Marrow Transplant."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1159\/000445124","article-title":"Urological Complications and BK Virus-Associated Diseases Under Allogenic Stem Cell Transplantation","volume":"97","author":"Schneidewind","year":"2016","journal-title":"Urol. Int."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1086\/344060","article-title":"Pathogenesis and Management of Polyomavirus Infection in Transplant Recipients","volume":"35","author":"Kwak","year":"2002","journal-title":"Clin. Infect. Dis."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.medmal.2012.04.011","article-title":"BK-virus infections: A literature review","volume":"42","author":"Siguier","year":"2012","journal-title":"M\u00e9decine Mal. Infect."},{"key":"ref_13","first-page":"E3","article-title":"Urological complications associated with adult allogeneic stem cell transplantation","volume":"93","author":"Schneidewind","year":"2017","journal-title":"Am. J. Hematol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1007\/s00277-017-2935-8","article-title":"Nationwide survey of BK polyomavirus associated hemorrhagic cystitis in adult allogeneic stem cell transplantation among haematologists and urologists","volume":"96","author":"Schneidewind","year":"2017","journal-title":"Ann. Hematol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.bbmt.2005.06.007","article-title":"Incidence, Clinical Outcome, and Management of Virus-Induced Hemorrhagic Cystitis in Children and Adolescents after Allogeneic Hematopoietic Cell Transplantation","volume":"11","author":"Gorczynska","year":"2005","journal-title":"Biol. Blood Marrow Transplant."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1097\/01.TP.0000165110.78397.93","article-title":"Co-infection of Polyomavirus-BK and Cytomegalovirus in Renal Transplant Recipients","volume":"80","author":"Toyoda","year":"2005","journal-title":"Transplantation"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1002\/ajh.1108","article-title":"Detection of human herpesvirus 6 and JC virus in progressive multifocal leukoencephalopathy complicating follicular lymphoma","volume":"67","author":"Daibata","year":"2001","journal-title":"Am. J. Hematol."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Tong, A., Flemming, K., McInnes, E., Oliver, S., and Craig, J. (2012). Enhancing transparency in reporting the synthesis of qualitative research: ENTREQ. BMC Med. Res. Methodol., 12.","DOI":"10.1186\/1471-2288-12-181"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"e01102","DOI":"10.1002\/cti2.1102","article-title":"Proteome-wide analysis of T-cell response to BK polyomavirus in healthy virus carriers and kidney transplant recipients reveals a unique transcriptional and functional profile","volume":"9","author":"Ambalathingal","year":"2020","journal-title":"Clin. Transl. Immunol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1097\/TP.0b013e31823328c0","article-title":"BK virus-specific T cells for use in cellular therapy show specificity to multiple antigens and polyfunctional cytokine responses","volume":"92","author":"Blyth","year":"2011","journal-title":"Transplantation"},{"key":"ref_21","first-page":"2443","article-title":"BK Virus-Specific Immunity Kinetics: A Predictor of Recovery from Polyomavirus BK-Associated Nephropathy","volume":"11","author":"Schachtner","year":"2011","journal-title":"Arab. Archaeol. Epigr."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2393","DOI":"10.1097\/TP.0000000000003133","article-title":"BK Polyomavirus-specific T Cells as a Diagnostic and Prognostic Marker for BK Polyomavirus Infections After Pediatric Kidney Transplantation","volume":"104","author":"Sester","year":"2020","journal-title":"Transplantation"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"e12914","DOI":"10.1111\/tid.12914","article-title":"Comparison of intravenous or intravesical cidofovir in the treatment of BK polyomavirus-associated hemorrhagic cystitis following adult allogeneic stem cell transplantation\u2014A systematic review","volume":"20","author":"Schneidewind","year":"2018","journal-title":"Transpl. Infect. Dis."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"9097","DOI":"10.1111\/jcmm.15546","article-title":"Targeting IL-11 in the treatment of BK virus-associated haemorrhagic cystitis\u2014A promising new approach","volume":"24","author":"Schneidewind","year":"2020","journal-title":"J. Cell. Mol. Med."}],"container-title":["Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-7737\/10\/6\/553\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:19:17Z","timestamp":1760163557000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-7737\/10\/6\/553"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,19]]},"references-count":24,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2021,6]]}},"alternative-id":["biology10060553"],"URL":"https:\/\/doi.org\/10.3390\/biology10060553","relation":{},"ISSN":["2079-7737"],"issn-type":[{"type":"electronic","value":"2079-7737"}],"subject":[],"published":{"date-parts":[[2021,6,19]]}}}