{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:55:47Z","timestamp":1791248147873,"version":"4.1.0"},"reference-count":146,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2021,6,22]],"date-time":"2021-06-22T00:00:00Z","timestamp":1624320000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["CONACYT-000000000257155"],"award-info":[{"award-number":["CONACYT-000000000257155"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biology"],"abstract":"<jats:p>Diatoms are the most abundant group of phytoplankton, and their success lies in their significant adaptation ability to stress conditions, such as nutrient limitation. Phosphorus (P) is a key nutrient involved in the transfer of energy and the synthesis of several cellular components. Molecular and biochemical mechanisms related to how diatoms cope with P deficiency are not clear, and research into this has been limited to a few species. Among the molecular responses that have been reported in diatoms cultured under P deficient conditions is the upregulation of genes encoding enzymes related to the transport, assimilation, remobilization and recycling of this nutrient. Regarding biochemical responses, due to the reduction of the requirements for carbon structures for the synthesis of proteins and phospholipids, more CO2 is fixed than is consumed by the Calvin cycle. To deal with this excess, diatoms redirect the carbon flow toward the synthesis of storage compounds such as triacylglycerides and carbohydrates, which are excreted as extracellular polymeric substances. This review aimed to gather all current knowledge regarding the biochemical and molecular mechanisms of diatoms related to managing P deficiency in order to provide a wider insight into and understanding of their responses, as well as the metabolic pathways affected by the limitation of this nutrient.<\/jats:p>","DOI":"10.3390\/biology10070565","type":"journal-article","created":{"date-parts":[[2021,6,22]],"date-time":"2021-06-22T13:02:10Z","timestamp":1624366930000},"page":"565","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Biochemical and Molecular Aspects of Phosphorus Limitation in Diatoms and Their Relationship with Biomolecule Accumulation"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5970-8554","authenticated-orcid":false,"given":"Jos\u00e9 Pablo","family":"Lovio-Fragoso","sequence":"first","affiliation":[{"name":"Departamento de Investigaciones Cient\u00edficas y Tecnol\u00f3gicas, Universidad de Sonora, Blvd. Colosio y Sahuaripa, Colonia Centro, Hermosillo, Sonora CP 83000, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damaristelma","family":"de Jes\u00fas-Campos","sequence":"additional","affiliation":[{"name":"Departamento de Investigaciones Cient\u00edficas y Tecnol\u00f3gicas, Universidad de Sonora, Blvd. Colosio y Sahuaripa, Colonia Centro, Hermosillo, Sonora CP 83000, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Antonio","family":"L\u00f3pez-El\u00edas","sequence":"additional","affiliation":[{"name":"Departamento de Investigaciones Cient\u00edficas y Tecnol\u00f3gicas, Universidad de Sonora, Blvd. Colosio y Sahuaripa, Colonia Centro, Hermosillo, Sonora CP 83000, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9188-8185","authenticated-orcid":false,"given":"Luis \u00c1ngel","family":"Medina-Ju\u00e1rez","sequence":"additional","affiliation":[{"name":"Departamento de Investigaciones Cient\u00edficas y Tecnol\u00f3gicas, Universidad de Sonora, Blvd. Colosio y Sahuaripa, Colonia Centro, Hermosillo, Sonora CP 83000, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Fimbres-Olivarr\u00eda","sequence":"additional","affiliation":[{"name":"Departamento de Investigaciones Cient\u00edficas y Tecnol\u00f3gicas, Universidad de Sonora, Blvd. Colosio y Sahuaripa, Colonia Centro, Hermosillo, Sonora CP 83000, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7846-6124","authenticated-orcid":false,"given":"Corina","family":"Hayano-Kanashiro","sequence":"additional","affiliation":[{"name":"Departamento de Investigaciones Cient\u00edficas y Tecnol\u00f3gicas, Universidad de Sonora, Blvd. Colosio y Sahuaripa, Colonia Centro, Hermosillo, Sonora CP 83000, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,6,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Dyhrman, S.T., Jenkins, B.D., Rynearson, T.A., Saito, M.A., Mercier, M.L., Alexander, H., Whitney, L.A.P., Drzewianowski, A., Bulygin, V.V., and Bertrand, E.M. (2012). The Transcriptome and Proteome of the Diatom Thalassiosira pseudonana Reveal a Diverse Phosphorus Stress Response. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0033768"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1007\/s00299-018-2334-1","article-title":"Genome editing in diatoms: Achievements and goals","volume":"37","author":"Kroth","year":"2018","journal-title":"Plant Cell Rep."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1089\/ees.2017.0521","article-title":"Factors Affecting Growth of Various Microalgal Species","volume":"35","author":"Gatamaneni","year":"2018","journal-title":"Environ. Eng. Sci."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1111\/jpy.12365","article-title":"Phosphorus physiological ecology and molecular mechanisms in marine phytoplankton","volume":"52","author":"Lin","year":"2016","journal-title":"J. Phycol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"4607","DOI":"10.3390\/en6094607","article-title":"Effects of Environmental Factors and Nutrient Availability on the Biochemical Composition of Algae for Biofuels Production: A Review","volume":"6","author":"Juneja","year":"2013","journal-title":"Energies"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1139\/m62-029","article-title":"Studies of marine planktonic diatoms: I. Cyclotella nana hustedt, and detonula Confervacea (cleve) Gran","volume":"8","author":"Guillard","year":"1962","journal-title":"Can. J. Microbiol."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Seckbach, J., and Gordon, R. (2019). Diatoms: Fundamentals and Applications, Wiley Online Library. [1st ed.].","DOI":"10.1002\/9781119370741"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"695","DOI":"10.5194\/bg-7-695-2010","article-title":"Sargasso Sea phosphorus biogeochemistry: An important role for dissolved organic phosphorus (DOP)","volume":"7","author":"Lomas","year":"2010","journal-title":"Biogeosciences"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1021\/cr0503613","article-title":"The Oceanic Phosphorus Cycle","volume":"107","author":"Paytan","year":"2007","journal-title":"Chem. Rev."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2755","DOI":"10.1007\/s10811-019-01831-8","article-title":"Luxury phosphorus uptake in microalgae","volume":"31","author":"Solovchenko","year":"2019","journal-title":"J. Appl. Phycol."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Solovchenko, A., Khozin-Goldberg, I., Selyakh, I., Semenova, L., Ismagulova, T., Lukyanov, A., Mamedov, I., Vinogradova, E., Karpova, O., and Konyukhov, I. (2019). Phosphorus starvation and luxury uptake in green microalgae revisited. Algal Res., 43.","DOI":"10.1016\/j.algal.2019.101651"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2827","DOI":"10.1007\/s10811-018-1390-9","article-title":"Evaluating potential of green alga Chlorella vulgaris to accumulate phosphorus and to fertilise nutrient-poor soil substrates for crop plants","volume":"30","author":"Schreiber","year":"2018","journal-title":"J. Appl. Phycol."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Borowitzka, M., Beardall, J., and Raven, J. (2016). Nutrients and their acquisition: Phosphorus physiology in microalgae. The Physiology of Microalgae, Springer.","DOI":"10.1007\/978-3-319-24945-2"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Grobbelaar, J.U. (2013). Inorganic algal nutrition. Handbook of Microalgal Culture, John Wiley & Sons, Ltd.","DOI":"10.1002\/9781118567166.ch8"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"4207","DOI":"10.1016\/j.watres.2009.06.011","article-title":"Towards a luxury uptake process via microalgae Defining the polyphosphate dynamics","volume":"43","author":"Powell","year":"2009","journal-title":"Water Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"5958","DOI":"10.1021\/es703118s","article-title":"Factors Influencing Luxury Uptake of Phosphorus by Microalgae in Waste Stabilization Ponds","volume":"42","author":"Powell","year":"2008","journal-title":"Environ. Sci. Technol."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Richmond, A. (2004). Algal niutrition. Mineral nutrition. Handbook of Microalgal Culture: Biotechnology and Applied Phycology, Blackwell Publishing Ltd.","DOI":"10.1002\/9780470995280"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/mbo3.694","article-title":"Selective chemoattraction of the benthic diatomSeminavis robustato phosphate but not to inorganic nitrogen sources contributes to biofilm structuring","volume":"8","author":"Bondoc","year":"2019","journal-title":"MicrobiologyOpen"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Brembu, T., M\u00fchlroth, A., Alipanah, L., and Bones, A.M. (2017). The effects of phosphorus limitation on carbon metabolism in diatoms. Philos. Trans. R. Soc. B Biol. Sci., 372.","DOI":"10.1098\/rstb.2016.0406"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fmars.2018.00380","article-title":"Dissolved Organic Phosphorus Utilization by Phytoplankton Reveals Preferential Degradation of Polyphosphates over Phosphomonoesters","volume":"5","author":"Diaz","year":"2018","journal-title":"Front. Mar. Sci."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.scitotenv.2005.09.026","article-title":"Extracellular carbohydrates released by the marine diatoms Cylindrotheca closterium, Thalassiosira pseudonana and Skeletonema costatum: Effect of P-depletion and growth status","volume":"353","author":"Urbani","year":"2005","journal-title":"Sci. Total Environ."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"275","DOI":"10.3856\/vol44-issue2-fulltext-9","article-title":"Growth, nutrient uptake and chemical composition of Chlorella sp. and Nannochloropsis oculata under nitrogen starvation","volume":"44","author":"Paes","year":"2016","journal-title":"Lat. Am. J. Aquat. Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"247","DOI":"10.3354\/ame015247","article-title":"Bacterial-algal interactions in polysaccharide production","volume":"15","author":"Guerrini","year":"1998","journal-title":"Aquat. Microb. Ecol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1046\/j.1529-8817.2000.99193.x","article-title":"Production of mucilage by the adriatic epipelic diatom","volume":"36","author":"Alcoverro","year":"2000","journal-title":"J. Phycol."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Lauritano, C., Ferrante, M.I., and Rogato, A. (2019). Marine Natural Products from Microalgae: An-Omics Overview. Mar. Drugs, 17.","DOI":"10.3390\/md17050269"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.algal.2018.08.012","article-title":"Orchestration of transcriptome, proteome and metabolome in the diatom Phaeodactylum tricornutum during nitrogen limitation","volume":"35","author":"Remmers","year":"2018","journal-title":"Algal Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"42","DOI":"10.2174\/1876390101103010042","article-title":"Dying for Something to Eat: How Cells Respond to Starvation","volume":"3","year":"2011","journal-title":"Open Cell Signal. J."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0924-7963(97)00113-9","article-title":"Are diatoms poor competitors at low phosphate concentrations?","volume":"16","author":"Egge","year":"1998","journal-title":"J. Mar. Syst."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/BF00389251","article-title":"Effect of inorganic phosphorus on the growth rate of diatoms","volume":"26","author":"Finenko","year":"1974","journal-title":"Mar. Biol."},{"key":"ref_30","unstructured":"Kabanova, Y.G. (1958). Organic Phosphorus as a Food Source for Phytoplankton. [Ph.D. Thesis, Institute of Oceanology, USSR Academy of Sciences]. (In Russian)."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1111\/1462-2920.12411","article-title":"Systems-level analysis of the metabolic responses of the diatom P haeodactylum tricornutum to phosphorus stress","volume":"16","author":"Yang","year":"2014","journal-title":"Environ. Microbiol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1111\/nph.13787","article-title":"Noncoding and coding transcriptome responses of a marine diatom to phosphate fluctuations","volume":"210","author":"Sun","year":"2016","journal-title":"New Phytol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1128\/aem.57.2.419-425.1991","article-title":"Growth of and \u03c9-3-Fatty-Acid production by Phaeodactylum tricornutum under different culture conditions","volume":"57","author":"Yongmanitchai","year":"1991","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s40415-019-00515-4","article-title":"Effect of phosphorus and growth phases on the transcription levels of EPA biosynthesis genes in the diatom Phaeodactylum tricornutum","volume":"42","author":"Lopes","year":"2019","journal-title":"Braz. J. Bot."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"361","DOI":"10.3856\/vol47-issue2-fulltext-17","article-title":"Effect of different phosphorus concentrations on growth and biochemical composition of Chaetoceros muelleri","volume":"47","year":"2019","journal-title":"Lat. Am. J. Aquat. Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"554","DOI":"10.4319\/lo.2012.57.2.0554","article-title":"Allometric scaling and taxonomic variation in nutrient utilization traits and maximum growth rate of phytoplankton","volume":"57","author":"Edwards","year":"2012","journal-title":"Limnol. Oceanogr."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1111\/j.0022-3646.1989.00070.x","article-title":"Photoadaptation and the \u201cpackage\u201d effectin Dunaliella tertiolecta (chlorophycae)","volume":"25","author":"Berner","year":"1989","journal-title":"J. Phycol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1007\/s00343-011-0224-2","article-title":"Photosynthetic efficiency, cell volume, and elemental stoichiometric ratios in Thalassirosira weissflogii under phosphorus limitation","volume":"29","author":"Liu","year":"2011","journal-title":"Chin. J. Oceanol. Limnol."},{"key":"ref_39","unstructured":"Likens, G.E. (1972). Characterization of phosphorus-limited plankton algae. Nutrients and Eutrophication: The Limiting Nutrient Controversy, Allen Press."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1046\/j.1529-8817.2003.01019.x","article-title":"Influence of phosphorus limitation on toxicity and photosynthesis of Alexandrium minutum (Dinophyceae) monitored by in-line detection of variable chlorophyll fluorescence","volume":"39","author":"Lippemeier","year":"2003","journal-title":"J. Phycol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1023\/A:1020547616096","article-title":"The Pho Regulons of Bacteria","volume":"71","author":"Vershinina","year":"2002","journal-title":"Microbiology"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Santos-Beneit, F. (2015). The Pho regulon: A huge regulatory network in bacteria. Front. Microbiol., 6.","DOI":"10.3389\/fmicb.2015.00402"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"3512","DOI":"10.1128\/JB.00258-10","article-title":"Functional Characterization of Synechocystis sp. Strain PCC 6803 pst1 and pst2 Gene Clusters Reveals a Novel Strategy for Phosphate Uptake in a Freshwater Cyanobacterium","volume":"192","author":"Pitt","year":"2010","journal-title":"J. Bacteriol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.1152\/physrev.00022.2017","article-title":"Phosphate as a Signaling Molecule and Its Sensing Mechanism","volume":"98","author":"Michigami","year":"2018","journal-title":"Physiol. Rev."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1042\/BST20160026","article-title":"Pi sensing and signalling: From prokaryotic to eukaryotic cells","volume":"44","author":"Qi","year":"2016","journal-title":"Biochem. Soc. Trans."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/nchembio.2007.52","article-title":"Molecular basis of cyclin-CDK-CKI regulation by reversible binding of an inositol pyrophosphate","volume":"4","author":"Lee","year":"2008","journal-title":"Nat. Chem. Biol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1126\/science.8108735","article-title":"Phosphorylation of the transcription factor PHO4 by a cyclin-CDK complex, PHO80-PHO85","volume":"263","author":"Kaffman","year":"1994","journal-title":"Science"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/0968-0004(96)10048-7","article-title":"Signaling phosphate starvation","volume":"21","author":"Lenburg","year":"1996","journal-title":"Trends Biochem. Sci."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"4438","DOI":"10.1091\/mbc.e07-05-0457","article-title":"Pho91 Is a Vacuolar Phosphate Transporter That Regulates Phosphate and Polyphosphate Metabolism in Saccharomyces cerevisiae","volume":"18","author":"Werner","year":"2007","journal-title":"Mol. Biol. Cell"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1038\/ng2041","article-title":"Root tip contact with low-phosphate media reprograms plant root architecture","volume":"39","author":"Svistoonoff","year":"2007","journal-title":"Nat. Genet."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Balzergue, C., Dartevelle, T., Godon, C., Laugier, E., Meisrimler, C., Teulon, J.-M., Creff, A., Bissler, M., Brouchoud, C., and Hag\u00e8ge, A. (2017). Low phosphate activates STOP1-ALMT1 to rapidly inhibit root cell elongation. Nat. Commun., 8.","DOI":"10.1038\/ncomms15300"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"14174","DOI":"10.1073\/pnas.0901778106","article-title":"ER-resident proteins PDR2 and LPR1 mediate the developmental response of root meristems to phosphate availability","volume":"106","author":"Ticconi","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1111\/j.1365-313X.2010.04375.x","article-title":"Dissection of local and systemic transcriptional responses to phosphate starvation in Arabidopsis","volume":"64","author":"Thibaud","year":"2010","journal-title":"Plant J."},{"key":"ref_54","first-page":"889","article-title":"Identification and Characterization of the Arabidopsis PHO1 Gene Involved in Phosphate Loading to the Xylem","volume":"14","author":"Hamburger","year":"2002","journal-title":"Society"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"3554","DOI":"10.1105\/tpc.108.064980","article-title":"The WRKY6 Transcription Factor Modulates PHOSPHATE1 Expression in Response to Low Pi Stress in Arabidopsis","volume":"21","author":"Chen","year":"2009","journal-title":"Plant Cell"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Alipanah, L., Winge, P., Rohloff, J., Najafi, J., Brembu, T., and Bones, A.M. (2018). Molecular adaptations to phosphorus deprivation and comparison with nitrogen deprivation responses in the diatom Phaeodactylum tricornutum. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0193335"},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Feng, T.Y., Yang, Z.K., Zheng, J.W., Xie, Y., Li, D.W., Murugan, S.B., Yang, W.D., Liu, J.S., and Li, H.Y. (2015). Examination of metabolic responses to phosphorus limitation via proteomic analyses in the marine diatom Phaeodactylum tricornutum. Sci. Rep., 5.","DOI":"10.1038\/srep10373"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1007\/s10126-013-9494-3","article-title":"Identification and Characterization of an Extracellular Alkaline Phosphatase in the Marine Diatom Phaeodactylum tricornutum","volume":"15","author":"Lin","year":"2013","journal-title":"Mar. Biotechnol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"492","DOI":"10.4319\/lo.2010.55.2.0492","article-title":"Variations in Synechococcus cell quotas of phosphorus, sulfur, manganese, iron, nickel, and zinc within mesoscale eddies in the Sargasso Sea","volume":"55","author":"Twining","year":"2010","journal-title":"Limnol. Oceanogr."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Zhang, S.F., Yuan, C.J., Chen, Y., Chen, X.H., Li, D.X., Liu, J.L., Lin, L., and Wang, D.Z. (2016). Comparative Transcriptomic Analysis Reveals Novel Insights into the Adaptive Response of Skeletonema costatum to Changing Ambient Phosphorus. Front. Aquat. Microbiol., 7.","DOI":"10.3389\/fmicb.2016.01476"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jembe.2015.05.001","article-title":"Transcriptional responses to phosphorus stress in the marine diatom, Chaetoceros affinis, reveal characteristic genes and expression patterns in phosphorus uptake and intracellular recycling","volume":"470","author":"Shih","year":"2015","journal-title":"J. Exp. Mar. Biol. Ecol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.mam.2012.07.007","article-title":"Phosphate transporters of the SLC20 and SLC34 families","volume":"34","author":"Forster","year":"2013","journal-title":"Mol. Asp. Med."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.semcdb.2017.06.013","article-title":"Molecular mechanism of phosphate signaling in plants","volume":"74","author":"Wang","year":"2018","journal-title":"Semin. Cell Dev. Biol."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Fu, M., Song, X., Yu, Z., and Liu, Y. (2013). Responses of Phosphate Transporter Gene and Alkaline Phosphatase in Thalassiosira pseudonana to Phosphine. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0059770"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.talanta.2004.10.004","article-title":"Reduced inorganic phosphorus in the natural environment: Significance, speciation and determination","volume":"66","author":"Hanrahan","year":"2005","journal-title":"Talanta"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fpls.2013.00536","article-title":"RNA function and phosphorus use by photosynthetic organisms","volume":"4","author":"Raven","year":"2013","journal-title":"Front. Plant Sci."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.tree.2009.08.004","article-title":"Genome streamlining and the elemental costs of growth","volume":"25","author":"Hessen","year":"2010","journal-title":"Trends Ecol. Evol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1073\/pnas.0707946105","article-title":"Whole-genome expression profiling of the marine diatom Thalassiosira pseudonana identifies genes involved in silicon bioprocesses","volume":"105","author":"Mock","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1080\/15216540310001603093","article-title":"The PUF Family of RNA-binding Proteins: Does Evolutionarily Conserved Structure Equal Conserved Function?","volume":"55","author":"Spassov","year":"2003","journal-title":"IUBMB Life"},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Pandey, G.K. (2015). The role of long non-coding RNAs in abiotic stress tolerance in plants. Elucidation of Abiotic Stress Signaling in Plants, Springer.","DOI":"10.1007\/978-1-4939-2540-7"},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Akalin, A. (2020). Computational Genomics with R, Chapman and Hall\/CRC. [1st ed.].","DOI":"10.1201\/9780429084317"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"3523","DOI":"10.1093\/jxb\/ers100","article-title":"The interaction of plant biotic and abiotic stresses: From genes to the field","volume":"63","author":"Atkinson","year":"2012","journal-title":"J. Exp. Bot."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1093\/femsre\/fuz001","article-title":"Diversity, versatility and complexity of bacterial gene regulation mechanisms: Opportunities and drawbacks for applications in synthetic biology","volume":"43","author":"Bervoets","year":"2019","journal-title":"FEMS Microbiol. Rev."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.semcdb.2017.11.026","article-title":"Posttranscriptional regulation of lipid metabolism by non-coding RNAs and RNA binding proteins","volume":"81","author":"Singh","year":"2018","journal-title":"Semin. Cell Dev. Biol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.gpb.2017.01.007","article-title":"Non-coding RNAs and Their Roles in Stress Response in Plants","volume":"15","author":"Wang","year":"2017","journal-title":"Genom. Proteom. Bioinform."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1534\/genetics.107.086090","article-title":"Green Transcription Factors: A Chlamydomonas Overview","volume":"179","year":"2008","journal-title":"Genetics"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1105\/tpc.106.045427","article-title":"Integration of Chloroplast Nucleic Acid Metabolism into the Phosphate Deprivation Response in Chlamydomonas reinhardtii","volume":"19","author":"Zimmer","year":"2007","journal-title":"Plant Cell"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1128\/EC.5.1.26-44.2006","article-title":"Genome-Based Approaches to Understanding Phosphorus Deprivation Responses and PSR1 Control in Chlamydomonas reinhardtii","volume":"5","author":"Moseley","year":"2006","journal-title":"Eukaryot. Cell"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1104\/pp.120.3.685","article-title":"Chlamydomonas reinhardtii Mutants Abnormal in Their Responses to Phosphorus Deprivation","volume":"120","author":"Shimogawara","year":"1999","journal-title":"Plant Physiol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"2380","DOI":"10.1111\/nph.16248","article-title":"The Myb-like transcription factor phosphorus starvation response (PtPSR) controls conditional P acquisition and remodelling in marine microalgae","volume":"225","author":"Sharma","year":"2019","journal-title":"New Phytol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1104\/pp.17.00621","article-title":"Mechanisms of Phosphorus Acquisition and Lipid Class Remodeling under P Limitation in a Marine Microalga","volume":"175","author":"Winge","year":"2017","journal-title":"Plant Physiol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.tig.2013.03.002","article-title":"Long noncoding RNAs in development and disease of the central nervous system","volume":"29","author":"Ng","year":"2013","journal-title":"Trends Genet."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.tplants.2011.10.008","article-title":"Long noncoding RNA: Unveiling hidden layer of gene regulatory networks","volume":"17","author":"Kim","year":"2012","journal-title":"Trends Plant Sci."},{"key":"ref_84","unstructured":"Barsanti, L., and Gualtieri, P. (2014). Algae: Anatomy, Biochemistry, and Biotechnology, CRC Press. [2nd ed.]."},{"key":"ref_85","first-page":"120","article-title":"Effects of different nitrogen and phosphorus concentrations on the growth and chlorophyll fluorescence parameters of Pavloca viridis","volume":"1","author":"Liang","year":"2008","journal-title":"Trans. Oceanol. Limnol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/S1360-1385(02)02312-9","article-title":"Oxidative stress, antioxidants and stress tolerance","volume":"7","author":"Mittler","year":"2002","journal-title":"Trends Plant Sci."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1126\/science.1090165","article-title":"Structure of the Cytochrome b6f Complex of Oxygenic Photosynthesis: Tuning the Cavity","volume":"302","author":"Kurisu","year":"2003","journal-title":"Science"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"2200","DOI":"10.1128\/JB.182.8.2200-2206.2000","article-title":"Evidence for the Presence of an F-Type ATP Synthase Involved in Sulfate Respiration in Desulfovibrio vulgaris","volume":"182","author":"Ozawa","year":"2000","journal-title":"J. Bacteriol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1134\/S1021443716050058","article-title":"Variable chlorophyll fluorescence and its use for assessing physiological condition of plant photosynthetic apparatus","volume":"63","author":"Goltsev","year":"2016","journal-title":"Russ. J. Plant Physiol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1023\/A:1009900124650","article-title":"Estimation of phytoplankton photosynthesis and nutrient limitation in the Eastern Scheldt estuary using variable fluorescence","volume":"33","author":"Kromkamp","year":"1999","journal-title":"Aquat. Ecol."},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Nymark, M., Valle, K.C., Hancke, K., Winge, P., Andresen, K., Johnsen, G., Bones, A.M., and Brembu, T. (2013). Molecular and Photosynthetic Responses to Prolonged Darkness and Subsequent Acclimation to Re-Illumination in the Diatom Phaeodactylum tricornutum. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0058722"},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Athanasakoglou, A., and Kampranis, S.C. (2019). Diatom isoprenoids: Advances and biotechnological potential. Biotechnol. Adv., 37.","DOI":"10.1016\/j.biotechadv.2019.107417"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.jff.2011.07.001","article-title":"Biological activities and health benefit effects of natural pigments derived from marine algae","volume":"3","author":"Pangestuti","year":"2011","journal-title":"J. Funct. Foods"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"2667","DOI":"10.3390\/md11072667","article-title":"Production, Characterization, and Antioxidant Activity of Fucoxanthin from the Marine Diatom Odontella aurita","volume":"11","author":"Xia","year":"2013","journal-title":"Mar. Drugs"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.etap.2006.01.004","article-title":"Cultivated microalgae and the carotenoid fucoxanthin from Odontella aurita as potent anti-proliferative agents in bronchopulmonary and epithelial cell lines","volume":"22","author":"Moreau","year":"2006","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.algal.2015.08.004","article-title":"Production of fucoxanthin-rich fraction (FxRF) from a diatom, Chaetoceros calcitrans (Paulsen) Takano 1968","volume":"12","author":"Foo","year":"2015","journal-title":"Algal Res."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.aquaculture.2012.09.016","article-title":"Greening effect on oysters and biological activities of the blue pigments produced by the diatom Haslea karadagensis (Naviculaceae)","volume":"368","author":"Gastineau","year":"2012","journal-title":"Aquaculture"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"6278","DOI":"10.1021\/jf073187n","article-title":"Antioxidant and Free Radical Scavenging Properties of Marennine, a Blue-Green Polyphenolic Pigment from the DiatomHaslea ostrearia (Gaillon\/Bory) Simonsen Responsible for the Natural Greening of Cultured Oysters","volume":"56","author":"Pouvreau","year":"2008","journal-title":"J. Agric. Food Chem."},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Lauritano, C., Helland, K., Riccio, G., Andersen, J.H., Ianora, A., and Hansen, E.H. (2020). Lysophosphatidylcholines and Chlorophyll-Derived Molecules from the Diatom Cylindrotheca closterium with Anti-Inflammatory Activity. Mar. Drugs, 18.","DOI":"10.3390\/md18030166"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"33","DOI":"10.3354\/meps193033","article-title":"Intra-class variability in the carbon, pigment and biomineral content of prymnesiophytes and diatoms","volume":"193","author":"Llewellyn","year":"2000","journal-title":"Mar. Ecol. Prog. Ser."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1046\/j.1529-8817.2000.99070.x","article-title":"Metabolic responses of the diatom Achnanthes brevipes (Bacillariophyceae) to nutrient limitation","volume":"36","author":"Guerrini","year":"2000","journal-title":"J. Phycol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.biortech.2014.01.092","article-title":"Phosphorus limitation and starvation effects on cell growth and lipid accumulation in Isochrysis galbana U4 for biodiesel production","volume":"156","author":"Roopnarain","year":"2014","journal-title":"Bioresour. Technol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.algal.2012.04.003","article-title":"Comparative analysis of diatom genomes reveals substantial differences in the organization of carbon partitioning pathways","volume":"1","author":"Smith","year":"2012","journal-title":"Algal Res."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1146\/annurev-marine-120709-142720","article-title":"Carbon Concentrating Mechanisms in Eukaryotic Marine Phytoplankton","volume":"3","author":"Reinfelder","year":"2011","journal-title":"Annu. Rev. Mar. Sci."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj3400001","article-title":"Structure, function and regulation of pyruvate carboxylase","volume":"340","author":"Jitrapakdee","year":"1999","journal-title":"Biochem. J."},{"key":"ref_106","first-page":"53","article-title":"Phosphofructokinase: Structure and control","volume":"293","author":"Evans","year":"1981","journal-title":"Philos. Trans. R. Soc. B"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.foodhyd.2017.08.002","article-title":"Chemical characterization and antioxidant activity of sulfated polysaccharides from Navicula sp.","volume":"75","year":"2018","journal-title":"Food Hydrocoll."},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Boh\u00f3rquez, J., McGenity, T.J., Papaspyrou, S., Garcia-Robledo, E., Corzo, A., and Underwood, G.J.C. (2017). Different Types of Diatom-Derived Extracellular Polymeric Substances Drive Changes in Heterotrophic Bacterial Communities from Intertidal Sediments. Front. Microbiol., 8.","DOI":"10.3389\/fmicb.2017.00245"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"4791","DOI":"10.1073\/pnas.1719274115","article-title":"Reduced vacuolar \u03b2-1,3-glucan synthesis affects carbohydrate metabolism as well as plastid homeostasis and structure in Phaeodactylum tricornutum","volume":"115","author":"Huang","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"5993","DOI":"10.3390\/md13095993","article-title":"Diatom-Specific Oligosaccharide and Polysaccharide Structures Help to Unravel Biosynthetic Capabilities in Diatoms","volume":"13","author":"Burel","year":"2015","journal-title":"Mar. Drugs"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1615\/InterJAlgae.v17.i1.50","article-title":"Diatom Exopolysaccharides: A Review","volume":"17","author":"Shniukova","year":"2015","journal-title":"Int. J. Algae"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"4883","DOI":"10.3390\/md12094883","article-title":"Preliminary Characterization, Antioxidant Properties and Production of Chrysolaminarin from Marine Diatom Odontella aurita","volume":"12","author":"Xia","year":"2014","journal-title":"Mar. Drugs"},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Kroth, P.G., Chiovitti, A., Gruber, A., Martin-Jezequel, V., Mock, T., Parker, M.S., Stanley, M.S., Kaplan, A., Caron, L., and Weber, T. (2008). A Model for Carbohydrate Metabolism in the Diatom Phaeodactylum tricornutum Deduced from Comparative Whole Genome Analysis. PLoS ONE, 3.","DOI":"10.1371\/journal.pone.0001426"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"233","DOI":"10.3390\/md11010233","article-title":"Bioactivity and Applications of Sulphated Polysaccharides from Marine Microalgae","volume":"11","author":"Raposo","year":"2013","journal-title":"Mar. Drugs"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"16292","DOI":"10.1021\/bi0516226","article-title":"Structural Determinants for Plant Annexin\u2212Membrane Interactions","volume":"44","author":"Dabitz","year":"2005","journal-title":"Biochemistry"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/0014-5793(94)80566-0","article-title":"Annexin-I inhibits phospholipase A2by specific interaction, not by substrate depletion","volume":"343","author":"Kim","year":"1994","journal-title":"FEBS Lett."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.plipres.2019.01.003","article-title":"The lipid biochemistry of eukaryotic algae","volume":"74","author":"Thelen","year":"2019","journal-title":"Prog. Lipid Res."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1016\/j.biotechadv.2014.10.003","article-title":"Microalgal lipids biochemistry and biotechnological perspectives","volume":"32","author":"Bellou","year":"2014","journal-title":"Biotechnol. Adv."},{"key":"ref_119","doi-asserted-by":"crossref","unstructured":"Kainz, M., Brett, M., and Arts, M. (2009). Algal lipids and effect of the environment on their biochemistry. Lipids in Aquatic Ecosystems, Springer.","DOI":"10.1007\/978-0-387-89366-2"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1007\/s00425-012-1718-7","article-title":"Stearoyl-acyl carrier protein desaturase gene from the oleaginous microalga Chlorella zofingiensis: Cloning, characterization and transcriptional analysis","volume":"236","author":"Liu","year":"2012","journal-title":"Planta"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"6487","DOI":"10.1073\/pnas.120067297","article-title":"Phospholipid:diacylglycerol acyltransferase: An enzyme that catalyzes the acyl-CoA-independent formation of triacylglycerol in yeast and plants","volume":"97","author":"Dahlqvist","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1002\/lipd.12081","article-title":"Properties and Biotechnological Applications of Acyl-CoA:diacylglycerol Acyltransferase and Phospholipid:diacylglycerol Acyltransferase from Terrestrial Plants and Microalgae","volume":"53","author":"Xu","year":"2018","journal-title":"Lipids"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.bbalip.2017.12.010","article-title":"Using lipidomics to reveal details of lipid accumulation in developing seeds from oilseed rape (Brassica napus L.)","volume":"1863","author":"Woodfield","year":"2018","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/1754-6834-5-74","article-title":"Transcriptomic analysis of the oleaginous microalga Neochloris oleoabundans reveals metabolic insights into triacylglyceride accumulation","volume":"5","author":"Haznedaroglu","year":"2012","journal-title":"Biotechnol. Biofuels"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1007\/s11105-015-0954-y","article-title":"Overexpression of SsDGAT2 from Sapium sebiferum (L.) Roxb Increases Seed Oleic Acid Level in Arabidopsis","volume":"34","author":"Wang","year":"2016","journal-title":"Plant Mol. Biol. Rep."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1111\/pbi.12278","article-title":"Altered lipid composition and enhanced lipid production in green microalga by introduction of brassica diacylglycerol acyltransferase 2","volume":"13","author":"Ahmad","year":"2015","journal-title":"Plant Biotechnol. J."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"4558","DOI":"10.3390\/md11114558","article-title":"Improvement of Neutral Lipid and Polyunsaturated Fatty Acid Biosynthesis by Overexpressing a Type 2 Diacylglycerol Acyltransferase in Marine Diatom Phaeodactylum tricornutum","volume":"11","author":"Niu","year":"2013","journal-title":"Mar. Drugs"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"24173","DOI":"10.1074\/jbc.M113.475699","article-title":"Identification of a Pair of Phospholipid: Diacylglycerol Acyltransferases from Developing Flax (Linum usitatissimum L.) Seed Catalyzing the Selective Production of Trilinolenin","volume":"288","author":"Pan","year":"2013","journal-title":"J. Biol. Chem."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.plaphy.2012.09.008","article-title":"A unique caleosin serving as the major integral protein in oil bodies isolated from Chlorella sp. cells cultured with limited nitrogen","volume":"61","author":"Lin","year":"2012","journal-title":"Plant Physiol. Biochem."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"4266","DOI":"10.1002\/pmic.201100114","article-title":"Proteomic profiling of oil bodies isolated from the unicellular green microalga Chlamydomonas reinhardtii: With focus on proteins involved in lipid metabolism","volume":"11","author":"Nguyen","year":"2011","journal-title":"Proteomics"},{"key":"ref_131","doi-asserted-by":"crossref","unstructured":"Levine, I.A., and Fleurence, J. (2018). Lipids from microalgae. Microalgae in Health and Disease Prevention, Academic Press.","DOI":"10.1016\/B978-0-12-811405-6.00001-3"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.plipres.2018.03.001","article-title":"Current trends to comprehend lipid metabolism in diatoms","volume":"70","author":"Zulu","year":"2018","journal-title":"Prog. Lipid Res."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s13068-017-0699-y","article-title":"Prospects for commercial production of diatoms","volume":"10","author":"Wang","year":"2017","journal-title":"Biotechnol. Biofuels"},{"key":"ref_134","first-page":"1","article-title":"A look back at the US Department of Energy\u2019s aquatic species program: Biodiesel from algae","volume":"328","author":"Sheehan","year":"1998","journal-title":"Natl. Renew. Energy Lab."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1104\/pp.114.252395","article-title":"Membrane Glycerolipid Remodeling Triggered by Nitrogen and Phosphorus Starvation inPhaeodactylum tricornutum","volume":"167","author":"Abida","year":"2015","journal-title":"Plant Physiol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/nature07659","article-title":"Phytoplankton in the ocean use non-phosphorus lipids in response to phosphorus scarcity","volume":"458","author":"Fredricks","year":"2009","journal-title":"Nature"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1038\/ismej.2010.192","article-title":"Phosphorus supply drives rapid turnover of membrane phospholipids in the diatom Thalassiosira pseudonana","volume":"5","author":"Martin","year":"2011","journal-title":"ISME J."},{"key":"ref_138","doi-asserted-by":"crossref","unstructured":"J\u00f3nasd\u00f3ttir, S.H. (2019). Fatty Acid Profiles and Production in Marine Phytoplankton. Mar. Drugs, 17.","DOI":"10.3390\/md17030151"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1002\/bbb.1864","article-title":"Microalgae cultivation and metabolites production: A comprehensive review","volume":"12","author":"Vuppaladadiyam","year":"2018","journal-title":"Biofuels Bioprod. Biorefining"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1007\/s00449-018-1950-z","article-title":"Effects of fundamental nutrient stresses on the lipid accumulation profiles in two diatom species Thalass. Weissflogii Chaetoceros Muelleri","volume":"41","author":"Lin","year":"2018","journal-title":"Bioprocess Biosyst. Eng."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1007\/s00253-017-8728-0","article-title":"Effect of different CO2 concentrations on biomass, pigment content, and lipid production of the marine diatom Thalassiosira pseudonana","volume":"102","author":"Sabia","year":"2018","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.1007\/s10811-014-0252-3","article-title":"Fatty acids profile and temperature in the cultured marine diatom Odontella aurita","volume":"26","author":"Pasquet","year":"2014","journal-title":"J. Appl. Phycol."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1111\/j.0022-3646.1994.00972.x","article-title":"Effect of nutrient limitation on fatty acid and lipid content of marine microalgae","volume":"30","author":"Reitan","year":"1994","journal-title":"J. Phycol."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"95","DOI":"10.3354\/meps055095","article-title":"Changes in the fatty acid composition of Phaeodactylum tricornutum and Dunaliella tertiolecta during growth and under phosphorus deficiency","volume":"55","author":"Siron","year":"1989","journal-title":"Mar. Ecol. Prog. Ser."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1017\/S0025315400017239","article-title":"Comparative evaluation of certain organic and inorganic sources of nitrogen for phototrophic growth of marine microalgae","volume":"55","author":"Antia","year":"1975","journal-title":"J. Mar. Biol. Assoc. UK"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1007\/s00248-017-0983-1","article-title":"Common and Species-Specific Effects of Phosphate on Marine Microalgae Fatty Acids Shape Their Function in Phytoplankton Trophic Ecology","volume":"74","author":"Armada","year":"2017","journal-title":"Microb. Ecol."}],"container-title":["Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-7737\/10\/7\/565\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:20:48Z","timestamp":1760163648000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-7737\/10\/7\/565"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,22]]},"references-count":146,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2021,7]]}},"alternative-id":["biology10070565"],"URL":"https:\/\/doi.org\/10.3390\/biology10070565","relation":{},"ISSN":["2079-7737"],"issn-type":[{"value":"2079-7737","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,22]]}}}