{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T23:20:40Z","timestamp":1785280840845,"version":"3.55.0"},"reference-count":63,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2021,9,15]],"date-time":"2021-09-15T00:00:00Z","timestamp":1631664000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006255","name":"Universidad de Concepci\u00f3n","doi-asserted-by":"publisher","award":["VRID-Enlace 218.036.047-1.0"],"award-info":[{"award-number":["VRID-Enlace 218.036.047-1.0"]}],"id":[{"id":"10.13039\/501100006255","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biology"],"abstract":"<jats:p>Helicobacter pylori is capable of entering into yeast, but the factors driving this endosymbiosis remain unknown. This work aimed to determine if temperatures outside the optimal range for H. pylori increase its harboring within Candida. H. pylori strains were co-cultured with Candida strains in Brucella broth supplemented with 5% fetal bovine serum and incubated at 4, 25, 37 or 40 \u00b0C. After co-culturing, yeasts containing bacteria-like bodies (Y-BLBs) were observed by optical microscopy, and the bacterium were identified as H. pylori by FISH. The H. pylori 16S rRNA gene was amplified from the total DNA of Y-BLBs. The viability of intra-yeast H. pylori cells was confirmed using a viability assay. All H. pylori strains were capable of entering into all Candida strains assayed. The higher percentages of Y-BLBs are obtained at 40 \u00b0C with any of the Candida strains. H pylori also increased its harboring within yeast in co-cultures incubated at 25 \u00b0C when compared to those incubated at 37 \u00b0C. In conclusion, although H. pylori grew significantly at 40 \u00b0C, this temperature increased its harboring within Candida. The endosymbiosis between both microorganisms is strain-dependent and permits bacterial cells to remain viable under the stressing environmental conditions assayed.<\/jats:p>","DOI":"10.3390\/biology10090915","type":"journal-article","created":{"date-parts":[[2021,9,14]],"date-time":"2021-09-14T23:34:11Z","timestamp":1631662451000},"page":"915","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Temperatures Outside the Optimal Range for Helicobacter pylori Increase Its Harboring within Candida Yeast Cells"],"prefix":"10.3390","volume":"10","author":[{"given":"Kimberly","family":"S\u00e1nchez-Alonzo","sequence":"first","affiliation":[{"name":"Laboratory of Bacterial Pathogenicity, Department of Microbiology, Faculty of Biological Sciences, Universidad de Concepcion, Concepci\u00f3n 4070386, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciano","family":"Arellano-Arriagada","sequence":"additional","affiliation":[{"name":"Laboratory of Bacterial Pathogenicity, Department of Microbiology, Faculty of Biological Sciences, Universidad de Concepcion, Concepci\u00f3n 4070386, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6964-3264","authenticated-orcid":false,"given":"Susana","family":"Castro-Seriche","sequence":"additional","affiliation":[{"name":"Laboratory of Bacterial Pathogenicity, Department of Microbiology, Faculty of Biological Sciences, Universidad de Concepcion, Concepci\u00f3n 4070386, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9836-8107","authenticated-orcid":false,"given":"Cristian","family":"Parra-Sep\u00falveda","sequence":"additional","affiliation":[{"name":"Laboratory of Bacterial Pathogenicity, Department of Microbiology, Faculty of Biological Sciences, Universidad de Concepcion, Concepci\u00f3n 4070386, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Humberto","family":"Bernasconi","sequence":"additional","affiliation":[{"name":"Laboratorio Pasteur, Research and Development Area, Concepci\u00f3n 4030000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9ctor","family":"Benavidez-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Laboratory of Bacterial Pathogenicity, Department of Microbiology, Faculty of Biological Sciences, Universidad de Concepcion, Concepci\u00f3n 4070386, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1167-5241","authenticated-orcid":false,"given":"V\u00edctor L.","family":"Campos","sequence":"additional","affiliation":[{"name":"Laboratory of Environmental Microbiology, Department of Microbiology, Faculty of Biological Sciences, Universidad de Concepci\u00f3n, Concepci\u00f3n 4070386, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katia","family":"S\u00e1ez","sequence":"additional","affiliation":[{"name":"Department of Statistics, Faculty of Physical and Mathematical Sciences, Universidad de Concepci\u00f3n, Concepci\u00f3n 4070386, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3802-7236","authenticated-orcid":false,"given":"Carlos T.","family":"Smith","sequence":"additional","affiliation":[{"name":"Laboratory of Bacterial Pathogenicity, Department of Microbiology, Faculty of Biological Sciences, Universidad de Concepcion, Concepci\u00f3n 4070386, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3909-9733","authenticated-orcid":false,"given":"Apolinaria","family":"Garc\u00eda-Cancino","sequence":"additional","affiliation":[{"name":"Laboratory of Bacterial Pathogenicity, Department of Microbiology, Faculty of Biological Sciences, Universidad de Concepcion, Concepci\u00f3n 4070386, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,9,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"00001","DOI":"10.1128\/MMBR.00001-18","article-title":"Helicobacter pylori Biofilm Formation and Its Potential Role in Pathogenesis","volume":"82","author":"Hathroubi","year":"2018","journal-title":"Microbiol. 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