{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T06:03:17Z","timestamp":1785477797127,"version":"3.56.0"},"reference-count":264,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2021,10,14]],"date-time":"2021-10-14T00:00:00Z","timestamp":1634169600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["436605\/2018-0"],"award-info":[{"award-number":["436605\/2018-0"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["Finance Code 001"],"award-info":[{"award-number":["Finance Code 001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biology"],"abstract":"<jats:p>Cardiovascular diseases include all types of disorders related to the heart or blood vessels. High blood pressure is an important risk factor for cardiac complications and pathological disorders. An increase in circulating angiotensin-II is a potent stimulus for the expression of reactive oxygen species and pro-inflammatory cytokines that activate oxidative stress, perpetuating a deleterious effect in hypertension. Studies demonstrate the capacity of NO to prevent platelet or leukocyte activation and adhesion and inhibition of proliferation, as well as to modulate inflammatory or anti-inflammatory reactions and migration of vascular smooth muscle cells. However, in conditions of low availability of NO, such as during hypertension, these processes are impaired. Currently, there is great interest in the development of compounds capable of releasing NO in a modulated and stable way. Accordingly, compounds containing metal ions coupled to NO are being investigated and are widely recognized as having great relevance in the treatment of different diseases. Therefore, the exogenous administration of NO is an attractive and pharmacological alternative in the study and treatment of hypertension. The present review summarizes the role of nitric oxide in hypertension, focusing on the role of new NO donors, particularly the metal-based drugs and their protagonist activity in vascular function.<\/jats:p>","DOI":"10.3390\/biology10101041","type":"journal-article","created":{"date-parts":[[2021,10,14]],"date-time":"2021-10-14T09:10:49Z","timestamp":1634202649000},"page":"1041","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":81,"title":["Nitric Oxide as a Central Molecule in Hypertension: Focus on the Vasorelaxant Activity of New Nitric Oxide Donors"],"prefix":"10.3390","volume":"10","author":[{"given":"Gabriela","family":"da Silva","sequence":"first","affiliation":[{"name":"Laboratory of Nutrition, Physical Activity and Phenotypic Plasticity, Federal University of Pernambuco, Vit\u00f3ria de Santo Ant\u00e3o 55.608-680, PE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8026-4943","authenticated-orcid":false,"given":"Mirelly","family":"da Silva","sequence":"additional","affiliation":[{"name":"Laboratory of Nutrition, Physical Activity and Phenotypic Plasticity, Federal University of Pernambuco, Vit\u00f3ria de Santo Ant\u00e3o 55.608-680, PE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00e9borah","family":"Nascimento","sequence":"additional","affiliation":[{"name":"Laboratory of Nutrition, Physical Activity and Phenotypic Plasticity, Federal University of Pernambuco, Vit\u00f3ria de Santo Ant\u00e3o 55.608-680, PE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6645-5716","authenticated-orcid":false,"given":"Ellen","family":"Lima Silva","sequence":"additional","affiliation":[{"name":"Laboratory of Nutrition, Physical Activity and Phenotypic Plasticity, Federal University of Pernambuco, Vit\u00f3ria de Santo Ant\u00e3o 55.608-680, PE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fab\u00edola","family":"Gouv\u00eaa","sequence":"additional","affiliation":[{"name":"School of Technical Health, Health Sciences Center, Federal University of Para\u00edba, Jo\u00e3o Pessoa 58.051-900, PB, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3641-1835","authenticated-orcid":false,"given":"Luiz","family":"de Fran\u00e7a Lopes","sequence":"additional","affiliation":[{"name":"Laboratory of Bioinorganic Chemistry, Department of Organic and Inorganic Chemistry, Federal University of Cear\u00e1, Fortaleza 60.020-181, CE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9728-8033","authenticated-orcid":false,"given":"Alice","family":"Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Laboratory of Nutrition, Physical Activity and Phenotypic Plasticity, Federal University of Pernambuco, Vit\u00f3ria de Santo Ant\u00e3o 55.608-680, PE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelli","family":"Ferraz Pereira","sequence":"additional","affiliation":[{"name":"Laboratory of Nutrition, Physical Activity and Phenotypic Plasticity, Federal University of Pernambuco, Vit\u00f3ria de Santo Ant\u00e3o 55.608-680, PE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4183-7328","authenticated-orcid":false,"given":"Thyago","family":"de Queiroz","sequence":"additional","affiliation":[{"name":"Laboratory of Nutrition, Physical Activity and Phenotypic Plasticity, Federal University of Pernambuco, Vit\u00f3ria de Santo Ant\u00e3o 55.608-680, PE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,10,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.exphem.2019.12.006","article-title":"Clonal hematopoiesis, aging, and cardiovascular diseases","volume":"83","author":"Pardali","year":"2020","journal-title":"Exp. 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