{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:34:08Z","timestamp":1787027648133,"version":"build-2736575974"},"reference-count":37,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2021,11,3]],"date-time":"2021-11-03T00:00:00Z","timestamp":1635897600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005297","name":"Uniwersytet Medyczny w Bialymstoku","doi-asserted-by":"publisher","award":["SUB\/1\/DN\/19\/001\/1149"],"award-info":[{"award-number":["SUB\/1\/DN\/19\/001\/1149"]}],"id":[{"id":"10.13039\/501100005297","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biology"],"abstract":"<jats:p>Plaque psoriasis (PSO) and lichen planus (LP) are skin diseases with some similarities in pathogenesis, comorbidities, and clinical presentation. Mucosal addressin cell adhesion molecule-1 (MAdCAM-1) and its ligand, \u03b14\u03b27 integrin, are involved in inflammatory bowel diseases and liver dysfunctions, which occur more frequently in PSO and LP. Serum MAdCAM-1 and ITGB7 levels in patients with plaque PSO and eruptive LP have never been studied before. The study included 42 patients with PSO, 13 with LP, and 23 controls. Serum molecules levels were evaluated using the immune\u2013enzymatic method. ITGB7 concentration was not statistically different, both in patients with PSO and LP, compared to controls (both p &gt; 0.05). MAdCAM-1 level was significantly lower in PSO subjects than in controls (p = 0.041), whereas in the LP group, a downward trend was observed (p = 0.088) with p = 0.0455 in ANOVA. Multiple linear regression revealed independent associations between ITGB7 and HDL and BMI and RBC in the LP group. In psoriatic patients with elevated CRP, there was an upward trend for MAdCAM-1, and also a positive correlation between MAdCAM-1 and WBC. ITGB7 and MAdCAM-1 cannot serve as markers of disease activity or liver pathology neither in patients with PSO nor LP. MAdCAM-1 might play a role as an inflammation indicator in PSO and a beneficial influence on the lipid profile in LP.<\/jats:p>","DOI":"10.3390\/biology10111129","type":"journal-article","created":{"date-parts":[[2021,11,3]],"date-time":"2021-11-03T17:59:38Z","timestamp":1635962378000},"page":"1129","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Circulating MAdCAM-1 and ITGB7 in Patients with Plaque Psoriasis and Eruptive Lichen Planus\u2014Preliminary Data"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8018-9960","authenticated-orcid":false,"given":"Anna","family":"Baran","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology, Medical University of Bialystok, Zurawia 14 St., 15-540 Bialystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6870-1167","authenticated-orcid":false,"given":"Julia","family":"Nowowiejska","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, Medical University of Bialystok, Zurawia 14 St., 15-540 Bialystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8688-4171","authenticated-orcid":false,"given":"Tomasz W.","family":"Kami\u0144ski","sequence":"additional","affiliation":[{"name":"Pittsburgh Heart, Lung and Blood Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA 15260, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julita A.","family":"Krahel","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, Medical University of Bialystok, Zurawia 14 St., 15-540 Bialystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iwona","family":"Flisiak","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, Medical University of Bialystok, Zurawia 14 St., 15-540 Bialystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,11,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1001\/jama.2020.4006","article-title":"Pathophysiology, Clinical Presentation, and Treatment of Psoriasis: A Review","volume":"323","author":"Armstrong","year":"2020","journal-title":"JAMA"},{"key":"ref_2","first-page":"6","article-title":"Update on the pathophysiology of psoriasis","volume":"102","author":"Hugh","year":"2018","journal-title":"Cutis"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Rendon, A., and Sch\u00e4kel, K. (2019). Psoriasis Pathogenesis and Treatment. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20061475"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.cpm.2016.02.004","article-title":"Psoriasis: Pathogenesis, Assessment, and Therapeutic Update","volume":"33","author":"Schleicher","year":"2016","journal-title":"Clin. Podiatr. Med. Surg."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1111\/ijd.14864","article-title":"Global burden of psoriasis\u2014Comparison of regional and global epidemiology, 1990 to 2017","volume":"59","author":"AlQassimi","year":"2020","journal-title":"Int. J. Dermatol."},{"key":"ref_6","first-page":"508","article-title":"Psoriasis and cardiometabolic disorders","volume":"107","author":"Nowowiejska","year":"2020","journal-title":"Derm. Rev."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1590\/abd1806-4841.20153038","article-title":"Psoriasis: Classical and emerging comorbidities","volume":"90","author":"Duarte","year":"2015","journal-title":"Bras. Dermatol."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Nowowiejska, J., Baran, A., and Flisiak, I. (2021). Aberrations in Lipid Expression and Metabolism in Psoriasis. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22126561"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Baran, A., Nowowiejska, J., Krahel, J.A., Kaminski, T.W., Maciaszek, M., and Flisiak, I. (2020). Higher Serum Selenoprotein P Level as a Novel Inductor of Metabolic Complications in Psoriasis. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21134594"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Krahel, J.A., Baran, A., Kaminski, T.W., Maciaszek, M., and Flisiak, I. (2020). Methotrexate Decreases the Level of PCSK9-A Novel Indicator of the Risk of Proatherogenic Lipid Profile in Psoriasis. The Preliminary Data. J. Clin. Med., 9.","DOI":"10.3390\/jcm9040910"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Nowowiejska, J., Baran, A., Lewoc, M., Grabowska, P., Kaminski, T.W., and Flisiak, I. (2021). The Assessment of Risk and Predictors of Sleep Disorders in Patients with Psoriasis\u2014A Questionnaire-Based Cross-Sectional Analysis. J. Clin. Med., 10.","DOI":"10.3390\/jcm10040664"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"674460","DOI":"10.3389\/fpsyt.2021.674460","article-title":"Mutual Relationship between Sleep Disorders, Quality of Life and Psychosocial Aspects in Patients with Psoriasis","volume":"12","author":"Nowowiejska","year":"2021","journal-title":"Front. Psychiatry"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Amoruso, G.F., Nistic\u00f2, S.P., Iannone, L., Russo, E., Rago, G., Patruno, C., and Bennardo, L. (2021). Ixekizumab May Improve Renal Function in Psoriasis. Healthcare, 9.","DOI":"10.3390\/healthcare9050543"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"e14504","DOI":"10.1111\/dth.14504","article-title":"Emerging role of anti-IL23 in the treatment of psoriasis: When humanized is very promising","volume":"33","author":"Dattola","year":"2020","journal-title":"Derm. Ther."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.jaad.2018.02.010","article-title":"Lichen planus and lichenoid dermatoses: Clinical overview and molecular basis","volume":"79","author":"Tziotzios","year":"2018","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_16","first-page":"463","article-title":"Immunophenotyping as a diagnostic tool to differentiate lichen planus from chronic graft-versus-host disease: Diagnostic observations on two patients","volume":"45","author":"Hitchins","year":"1997","journal-title":"J. Investig. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1056\/NEJMcp1103641","article-title":"Lichen Planus","volume":"366","author":"Chosidow","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"ref_18","first-page":"17","article-title":"Lichen planus: An update and review","volume":"90","author":"Sharma","year":"2012","journal-title":"Cutis"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Ying, J., Xiang, W., Qiu, Y., and Zeng, X. (2020). Risk of metabolic syndrome in patients with lichen planus: A systematic review and meta-analysis. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0238005"},{"key":"ref_20","first-page":"273","article-title":"Sleep disorders in psoriasis","volume":"107","author":"Nowowiejska","year":"2020","journal-title":"Derm. Rev."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1002\/jcph.1590","article-title":"Population Pharmacokinetics and Pharmacodynamics of Ontamalimab (SHP647), a Fully Human Monoclonal Antibody Against Mucosal Addressin Cell Adhesion Molecule-1 (MAdCAM-1), in Patients with Ulcerative Colitis or Crohn\u2019s Disease","volume":"60","author":"Wang","year":"2020","journal-title":"J. Clin. Pharmacol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"S669","DOI":"10.1093\/ecco-jcc\/jjy059","article-title":"Targeting Endothelial Ligands: ICAM-1\/alicaforsen, MAdCAM-1","volume":"12","author":"Reinisch","year":"2018","journal-title":"J. Crohns Colitis"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1016\/j.jhep.2017.02.001","article-title":"\u03b27-Integrin and MAdCAM-1 play opposing roles during the development of non-alcoholic steatohepatitis","volume":"66","author":"Drescher","year":"2017","journal-title":"J. Hepatol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/BF02786396","article-title":"Mucosal addressin cell adhesion molecule-1 (MAdCAM-1). Its binding motif for alpha 4 beta 7 and role in experimental colitis","volume":"16","author":"Fong","year":"1997","journal-title":"Immunol. Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1046\/j.1440-1711.2003.t01-1-01175.x","article-title":"Mucosal vascular addressin cell adhesion molecule-1 is expressed outside the endothelial lineage on fibroblasts and melanoma cells","volume":"81","author":"Leung","year":"2003","journal-title":"Immunol. Cell Biol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1159\/000500116","article-title":"Psoriasis and Inflammatory Bowel Disease","volume":"37","author":"Cottone","year":"2019","journal-title":"Dig. Dis."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1007\/s00403-017-1775-7","article-title":"Digestive system in psoriasis: An update","volume":"309","author":"Pietrzak","year":"2017","journal-title":"Arch. Derm. Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1111\/1346-8138.14647","article-title":"Intestinal barrier integrity in patients with plaque psoriasis","volume":"45","author":"Sikora","year":"2018","journal-title":"J. Dermatol."},{"key":"ref_29","first-page":"142","article-title":"Coexistence of lichen planus and ulcerative colitis\u2014A case report","volume":"28","author":"Szponar","year":"2011","journal-title":"Adv. Derm. Allergol."},{"key":"ref_30","first-page":"580","article-title":"Vedolizumab-associated psoriasis: Until where does gut selectivity go?","volume":"112","author":"Pedroto","year":"2020","journal-title":"Rev. Esp. Enferm. Dig."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"E9","DOI":"10.1097\/MIB.0000000000001011","article-title":"Psoriasis Induced by Vedolizumab","volume":"23","author":"Sody","year":"2017","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1111\/j.0818-9641.2004.01247.x","article-title":"Bioassay detects soluble MAdCAM-1 in body fluids","volume":"82","author":"Leung","year":"2004","journal-title":"Immunol. Cell Biol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/nature05485","article-title":"Inflammation and metabolic disorders","volume":"444","author":"Hotamisligil","year":"2006","journal-title":"Nature"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"817","DOI":"10.17116\/klinderma202019061817","article-title":"Study of the level of integrins ITGA4 and ITGB7 in blood serum in children with atopic dermatitis","volume":"19","author":"Zainullina","year":"2020","journal-title":"Klin. Dermatol. I Venerol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.freeradbiomed.2018.04.578","article-title":"The intricate role of selenium and selenoproteins in erythropoiesis","volume":"127","author":"Liao","year":"2018","journal-title":"Free Radic. Biol. Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1080\/17461391.2019.1571114","article-title":"Mechanisms of beneficial effects of exercise training on non-alcoholic fatty liver disease (NAFLD): Roles of oxidative stress and inflammation","volume":"19","author":"Farzanegi","year":"2019","journal-title":"Eur. J. Sport Sci."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1093\/ecco-jcc\/jjx158","article-title":"Expression Patterns of TNF\u03b1, MAdCAM1, and STAT3 in Intestinal and Skin Manifestations of Inflammatory Bowel Disease","volume":"12","author":"Vavricka","year":"2018","journal-title":"J. Crohns Colitis"}],"container-title":["Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-7737\/10\/11\/1129\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:25:17Z","timestamp":1760167517000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-7737\/10\/11\/1129"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,3]]},"references-count":37,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2021,11]]}},"alternative-id":["biology10111129"],"URL":"https:\/\/doi.org\/10.3390\/biology10111129","relation":{},"ISSN":["2079-7737"],"issn-type":[{"value":"2079-7737","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,3]]}}}