{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T05:10:13Z","timestamp":1788930613051,"version":"build-2803163510"},"reference-count":93,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2021,12,7]],"date-time":"2021-12-07T00:00:00Z","timestamp":1638835200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007917","name":"Agricultural Research Service","doi-asserted-by":"publisher","award":["603441000-018-00-D"],"award-info":[{"award-number":["603441000-018-00-D"]}],"id":[{"id":"10.13039\/100007917","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biology"],"abstract":"<jats:p>Florida citrus production has declined 75% due to Huanglongbing (HLB), a disease caused by the pathogenic bacterium Candidatus Liberibacter asiaticus (CLas). Methods to combat CLas are costly and only partially effective. The cross-compatible species Poncirus trifoliata and some of its hybrids are known to be highly tolerant to CLas, and thus can potentially serve as an alternative feedstock for many citrus products. To further investigate the commercial potential of citrus hybrids, three citrus hybrids, US-802, US-897, and US-942, were studied for their potential as feedstocks for citrus co-products using steam explosion (STEX) followed by water extraction. Up to 93% of sugars were recovered. US-897 and US-942 have similar volatile profiles to that of the commercial citrus fruit types and as much as 85% of these volatiles could be recovered. Approximately 80% of the pectic hydrocolloids present in all three hybrids could be obtained in water washes of STEX material. Of the phenolics identified, the flavanone glycosides, i.e., naringin, neohesperidin, and poncirin were the most abundant quantitatively in these hybrids. The ability to extract a large percentage of these compounds, along with their inherent values, make US-802, US-897, and US-942 potentially viable feedstock sources for citrus co-products in the current HLB-blighted environment.<\/jats:p>","DOI":"10.3390\/biology10121285","type":"journal-article","created":{"date-parts":[[2021,12,7]],"date-time":"2021-12-07T09:52:29Z","timestamp":1638870749000},"page":"1285","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Steam Explosion (STEX) of Citrus \u00d7 Poncirus Hybrids with Exceptional Tolerance to Candidatus Liberibacter Asiaticus (CLas) as Useful Sources of Volatiles and Other Commercial Products"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4983-4693","authenticated-orcid":false,"given":"Christina","family":"Dorado","sequence":"first","affiliation":[{"name":"U.S. Horticultural Research Laboratory, United States Department of Agriculture, Agricultural Research Service, Fort Pierce, FL 34945, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5796-5626","authenticated-orcid":false,"given":"Kim D.","family":"Bowman","sequence":"additional","affiliation":[{"name":"U.S. Horticultural Research Laboratory, United States Department of Agriculture, Agricultural Research Service, Fort Pierce, FL 34945, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7812-6859","authenticated-orcid":false,"given":"Randall G.","family":"Cameron","sequence":"additional","affiliation":[{"name":"U.S. Horticultural Research Laboratory, United States Department of Agriculture, Agricultural Research Service, Fort Pierce, FL 34945, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A.","family":"Manthey","sequence":"additional","affiliation":[{"name":"U.S. Horticultural Research Laboratory, United States Department of Agriculture, Agricultural Research Service, Fort Pierce, FL 34945, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2006-8208","authenticated-orcid":false,"given":"Jinhe","family":"Bai","sequence":"additional","affiliation":[{"name":"U.S. Horticultural Research Laboratory, United States Department of Agriculture, Agricultural Research Service, Fort Pierce, FL 34945, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyle L.","family":"Ferguson","sequence":"additional","affiliation":[{"name":"U.S. Horticultural Research Laboratory, United States Department of Agriculture, Agricultural Research Service, Fort Pierce, FL 34945, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,7]]},"reference":[{"key":"ref_1","unstructured":"United States Department of Agriculture (2021, July 20). National Agricultural Statistics Service NASS, Florida Citrus Statistics 2019\u20132020, Available online: https:\/\/www.nass.usda.gov\/Statistics_by_State\/Florida\/Publications\/Citrus\/Citrus_Statistics\/."},{"key":"ref_2","first-page":"1655","article-title":"The profitability of new citrus plantings in Florida in the era of Huanglongbing","volume":"53","author":"Singerman","year":"2018","journal-title":"Hort. Sci."},{"key":"ref_3","first-page":"16","article-title":"Tolerance of the trifoliate citrus hybrid US-897 (Citrus reticulata Blanco \u00d7 Poncirus trifoliata L. Raf.) to huanglongbing","volume":"46","author":"Albrecht","year":"2011","journal-title":"Hort. Sci."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.scienta.2012.08.036","article-title":"Tolerance of trifoliate citrus rootstock hybrids to Candidatus Liberibacter asiaticus","volume":"147","author":"Albrecht","year":"2012","journal-title":"Sci. Hortic."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.scienta.2019.05.010","article-title":"Reciprocal influences of rootstock and scion citrus cultivars challenged with Ca. Liberibacter asiaticus","volume":"254","author":"Albrecht","year":"2019","journal-title":"Sci. Hortic."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Bowman, K.D., and Albrecht, U. (2015). Comparison of gene expression changes in susceptible, tolerant, and resistant hosts in response to infection with Citrus tristeza virus and huanglongbing. J. Cit. Pathol., 2.","DOI":"10.5070\/C421030450"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Bowman, K.D., and Albrecht, U. (2020). Rootstock influences on health and growth following Candidatus Liberibacter Asiaticus infection in young sweet orange trees. Agronomy, 10.","DOI":"10.3390\/agronomy10121907"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"109816","DOI":"10.1016\/j.scienta.2020.109816","article-title":"Effect of Poncirus trifoliata on the chemical composition of fruits in pedigrees of Citrus scion hybrids","volume":"277","author":"Deterre","year":"2021","journal-title":"Sci. Hortic."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1080\/87559129.2019.1695834","article-title":"Recent trends on the valorization strategies for the management of citrus by-products","volume":"37","author":"Panwar","year":"2021","journal-title":"Food Rev. Int."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Mahato, N., Sinha, M., Sharma, K., Koteswararao, R., and Cho, M.H. (2019). Modern extraction and purification techniques for obtaining high purity food-grade bioactive compounds and value-added co-products from citrus wastes. Foods, 8.","DOI":"10.3390\/foods8110523"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"e12895","DOI":"10.1111\/jfpe.12895","article-title":"Recent progress in the utilization of industrial waste and by-products of citrus fruits: A review","volume":"41","author":"Chavan","year":"2018","journal-title":"J. Food Process Eng."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.resconrec.2017.10.032","article-title":"Citrus processing wastes: Environmental impacts, recent advances, and future perspectives in total valorization","volume":"129","author":"Satari","year":"2018","journal-title":"Resour. Conserv. Recycl."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/j.biortech.2016.05.006","article-title":"Citrus waste as feedstock for bio-based products recovery: Review on limonene case study and energy valorization","volume":"214","author":"Negro","year":"2016","journal-title":"Bioresour. Technol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1016\/j.procbio.2007.09.006","article-title":"Simultaneous saccharification and fermentation of citrus peel waste by Saccharomyces cerevisiae to produce ethanol","volume":"42","author":"Wilkins","year":"2007","journal-title":"Process Biochem."},{"key":"ref_15","first-page":"307","article-title":"Developments in ethanol production from citrus peel waste","volume":"121","author":"Zhou","year":"2008","journal-title":"Proc. Fla. State Hortic. Soc."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"17","DOI":"10.13031\/2013.29174","article-title":"Simultaneous saccharification and fermentation of orange processing waste to ethanol using Kluyveromyces marxianus","volume":"2","author":"Widmer","year":"2009","journal-title":"Biol. Eng. Trans."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"5242","DOI":"10.1016\/j.biortech.2009.12.038","article-title":"Pretreatment effects on orange processing waste for making ethanol by simultaneous saccharification and fermentation","volume":"101","author":"Widmer","year":"2010","journal-title":"Bioresour. Technol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1002\/jctb.3859","article-title":"Extraction and recovery of pectic fragments from citrus processing waste for co-production with ethanol","volume":"88","author":"Grohman","year":"2013","journal-title":"J. Chem. Technol. Biotechnol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.bcab.2017.05.007","article-title":"Steam explosion and fermentation of sugar beets from Southern Florida and the Midwestern United States","volume":"11","author":"Dorado","year":"2017","journal-title":"Biocatal. Agric. Biotechnol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"100020","DOI":"10.1016\/j.fufo.2021.100020","article-title":"Bench scale batch steam explosion of Florida red and white grapefruit juice processing residues","volume":"3","author":"Dorado","year":"2021","journal-title":"Future Foods"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"691663","DOI":"10.3389\/fnut.2021.691663","article-title":"Analysis and potential value of compounds extracted from star ruby, rio red, and ruby red grapefruit, and grapefruit juice processing residues via steam explosion","volume":"8","author":"Dorado","year":"2021","journal-title":"Front. Nutr."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1007\/s11947-019-02300-3","article-title":"Study of static steam explosion of Citrus sinensis juice processing waste for the isolation of sugars, pectic hydrocolloids, flavonoids, and peel oil","volume":"12","author":"Dorado","year":"2019","journal-title":"Food Bioprocess Technol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.foodhyd.2017.05.025","article-title":"Release and recovery of pectic hydrocolloids and phenolics from culled citrus fruits","volume":"72","author":"Cameron","year":"2017","journal-title":"Food Hydrocoll."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"4467","DOI":"10.1002\/jsfa.8310","article-title":"Recovery of pectic hydrocolloids and phenolics from huanglongbing related dropped citrus fruit","volume":"97","author":"Cameron","year":"2017","journal-title":"J. Sci. Food Agric."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2597","DOI":"10.1002\/jctb.4854","article-title":"Continuous process for enhanced release and recovery of pectic hydrocolloids and phenolics from citrus biomass","volume":"91","author":"Cameron","year":"2016","journal-title":"J. Chem. Technol. Biotechnol."},{"key":"ref_26","first-page":"SL464","article-title":"Environmental Issues and Best Management Practices","volume":"Volume 2020","author":"Morgan","year":"2020","journal-title":"Nutrition of Florida Citrus Trees"},{"key":"ref_27","first-page":"SL462","article-title":"Recommended Fertilizer Rates and Timing","volume":"Volume 2020","author":"Morgan","year":"2020","journal-title":"Nutrition of Florida Citrus Trees"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Kimball, D. (1991). Citrus Processing Quality Control and Technology, AVI\/Van Nostrand Reinhold. [1st ed.].","DOI":"10.1007\/978-94-011-3700-3_24"},{"key":"ref_29","unstructured":"Kertesz, Z.I. (1951). The Pectic Substances, Interscience Publishers, Inc."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.foodchem.2008.01.042","article-title":"Combined enzymatic and colorimetric method for determining the uronic acid and methylester content of pectin: Application to tomato products","volume":"110","author":"Anthon","year":"2008","journal-title":"Food Chem."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/0003-2697(92)90204-K","article-title":"Assay of reducing end-groups in oligosaccharide homologues with 2,2\u2032-bicinchoninate","volume":"202","author":"Doner","year":"1992","journal-title":"Anal. Biochem."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1021\/bk-2003-0845.ch012","article-title":"Enzyme Processes for Pulp and Paper: A Review of Recent Developments","volume":"Volume 845","author":"Goodell","year":"2003","journal-title":"Wood Deterioration and Preservation"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"3749","DOI":"10.1021\/jf035284w","article-title":"Comparison of three colorimetric reagents in the determination of methanol with alcohol oxidase. application to the assay of pectin methylesterase","volume":"52","author":"Anthon","year":"2004","journal-title":"J. Agric. Food Chem."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1006\/abio.1996.0048","article-title":"A rapid formaldehyde assay using purpald reagent: Application under periodation conditions","volume":"234","author":"Quesenberry","year":"1996","journal-title":"Anal. Biochem."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0003-2670(97)00363-2","article-title":"Microplate photometric determination of aldehydes in disinfectant solutions","volume":"351","author":"Zurek","year":"1997","journal-title":"Anal. Chim. Acta"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1093\/aob\/mcu150","article-title":"Characterization of citrus pectin samples extracted under different conditions: Influence of acid type and pH of extraction","volume":"114","author":"Kaya","year":"2014","journal-title":"Ann. Bot."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"12","DOI":"10.3389\/fpls.2019.00012","article-title":"Volatile compounds in citrus essential oils: A comprehensive review","volume":"10","author":"Rambla","year":"2019","journal-title":"Front. Plant Sci."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1111\/j.1365-2621.1975.tb02236.x","article-title":"Total peel oil content of the major florida citrus cultivars","volume":"40","author":"Kesterson","year":"1975","journal-title":"J. Food Sci."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1111\/1541-4337.12006","article-title":"Stability of essential oils: A review","volume":"12","author":"Turek","year":"2013","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1017\/S174275840001345X","article-title":"Antiparasitic compounds from east african plants: Isolation and biological activity of anonaine, matricarianol, canthin-6-one and caryophyllene oxide","volume":"14","author":"Bettarini","year":"1993","journal-title":"Int. J. Trop. Insect Sci."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1007\/BF02059809","article-title":"Higher plant terpenoids: A phytocentric overview of their ecological roles","volume":"20","author":"Langenheim","year":"1994","journal-title":"J. Chem. Ecol."},{"key":"ref_42","unstructured":"Ultra International B.V. (2019, December 05). Essential Oils Market Report Autumn. Available online: http:\/\/ultranl.com\/market\/market-report-autumn_2019\/."},{"key":"ref_43","unstructured":"Ringbloom, U. (2004). The Orange Book, Tetra Pak Processing Systems AB. [1st ed.]."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2158","DOI":"10.1111\/1750-3841.13814","article-title":"Physicochemical and sensory properties of cold pressed oils from florida hamlin and valencia oranges affected by huanglongbing","volume":"82","author":"Xu","year":"2017","journal-title":"J. Food Sci."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1080\/10408398.2017.1384716","article-title":"Citrus essential oils: Extraction, authentication and application in food preservation","volume":"59","author":"Mahato","year":"2019","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1002\/1099-1026(200007\/08)15:4<240::AID-FFJ902>3.0.CO;2-F","article-title":"Volatile components of peel cold-pressed oils of two cultivars of sweet orange (Citrus sinensis (L.) Osbeck) from Ethiopia","volume":"15","author":"Mitiku","year":"2000","journal-title":"Flavour Fragr. J."},{"key":"ref_47","unstructured":"Braddock, R.J. (1999). Handbook of Citrus By-Products and Processing Technology, John Wiley & Sons."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"2370","DOI":"10.1021\/acs.jafc.7b00892","article-title":"Investigation on key molecules of Huanglongbing (HLB)-induced orange juice off-flavor","volume":"66","author":"Kiefl","year":"2018","journal-title":"J. Agric. Food Chem."},{"key":"ref_49","first-page":"13","article-title":"Tailoring Pectin with Specific Shape, Composition and Esterification Pattern","volume":"Volume 15","author":"Williams","year":"2010","journal-title":"Gums and Stabilisers for the Food Industry 15"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1016\/j.foodhyd.2006.01.002","article-title":"Microwave-assisted extraction of lime pectin","volume":"20","author":"Fishman","year":"2006","journal-title":"Food Hydrocoll."},{"key":"ref_51","unstructured":"The Food and Agriculture Organization of the United Nations (2007). Joint FAO\/WHO Expert Committee on Food Additives Monographs 4 (681h JECFA), FAO."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"106553","DOI":"10.1016\/j.foodhyd.2020.106553","article-title":"Impact of Huanglongbing (HLB) on grapefruit pectin yield and quality during grapefruit maturation","volume":"113","author":"Ferguson","year":"2021","journal-title":"Food Hydrocoll."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"109692","DOI":"10.1016\/j.lwt.2020.109692","article-title":"Huanglongbing disease and quality of pectin and fruit juice extracted from Valencia oranges","volume":"131","author":"Koh","year":"2020","journal-title":"LWT"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.foodhyd.2011.04.009","article-title":"Effect of debranching on the rheological properties of Ca2+\u2013pectin gels","volume":"26","author":"Kabuye","year":"2012","journal-title":"Food Hydrocoll."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.carbpol.2007.07.007","article-title":"Demethylation of a model homogalacturonan with a salt-independent pectin methylesterase from citrus: I. Effect of pH on demethylated block size, block number and enzyme mode of action","volume":"71","author":"Cameron","year":"2008","journal-title":"Carbohydr. Polym."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"19404","DOI":"10.1074\/jbc.M011242200","article-title":"Modulation of the degree and pattern of methyl-esterification of pectic homogalacturonan in plant cell walls. Implications for pectin methyl esterase action, matrix properties, and cell adhesion","volume":"276","author":"Willats","year":"2001","journal-title":"J. Biol. Chem."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1021\/acs.biomac.9b01332","article-title":"Pectin-GPTMS based biomaterial: Toward a sustainable Bioprinting of 3D scaffolds for Tissue Engineering application","volume":"21","author":"Lapomarda","year":"2019","journal-title":"Biomacromolecules"},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Mellinas, C., Ramos, M., Jim\u00e9nez, A., and Garrig\u00f3s, M.C. (2020). Recent trends in the use of pectin from agro-waste residues as a natural-based biopolymer for food packaging applications. Materials, 13.","DOI":"10.3390\/ma13030673"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1089\/ten.tea.2017.0299","article-title":"Functional mechanics of a pectin-based pleural sealant after lung injury","volume":"24","author":"Servais","year":"2018","journal-title":"Tissue Eng. Part A"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1002\/chem.200901879","article-title":"Pectin-derived porous materials","volume":"16","author":"White","year":"2010","journal-title":"Chem. Eur. J."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/0003-9861(61)90235-1","article-title":"Phenolic glycosides of grapefruit: A relation between bitterness and structure","volume":"92","author":"Horowitz","year":"1961","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/S0040-4020(01)99211-7","article-title":"Flavonoids of citrus\u2013VI. The structure of neohesperidose","volume":"19","author":"Horowitz","year":"1963","journal-title":"Tetrahedron"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0031-9422(00)85805-7","article-title":"Composition and inheritance of flavanones in citrus fruit","volume":"8","author":"Albach","year":"1969","journal-title":"Phytochemistry"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1021\/jf60164a049","article-title":"Taste and structure of phenolic glycosides","volume":"17","author":"Horowitz","year":"1969","journal-title":"J. Agric. Food Chem."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s00436-008-1145-7","article-title":"Bioactivity of flavonoid compounds from Poncirus trifoliata L. (Family: Rutaceae) against the dengue vector, Aedes aegypti L. (Diptera: Culicidae)","volume":"104","author":"Rajkumar","year":"2008","journal-title":"Parasitol. Res."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1002\/ptr.2840","article-title":"Protective effects of neohesperidin and poncirin isolated from the fruits of Poncirus trifoliata on potential gastric disease","volume":"23","author":"Lee","year":"2009","journal-title":"Phytother. Res."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1002\/ptr.6385","article-title":"Neohesperidin suppresses IgE-mediated anaphylactic reactions and mast cell activation via Lyn-PLC-Ca2+ pathway","volume":"33","author":"Zhao","year":"2019","journal-title":"Phytother. Res."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"12053","DOI":"10.1096\/fj.201903102RR","article-title":"Neohesperidin attenuates obesity by altering the composition of the gut microbiota in high-fat diet-fed mice","volume":"34","author":"Lu","year":"2020","journal-title":"FASEB J."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1002\/biof.1236","article-title":"Disease chemopreventive effects and molecular mechanisms of hydroxylated polymethoxyflavones","volume":"41","author":"Lai","year":"2015","journal-title":"BioFactors"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1007\/s40495-019-00170-z","article-title":"Polymethoxyflavones: Chemistry and molecular mechanisms for cancer prevention and treatment","volume":"5","author":"Tung","year":"2019","journal-title":"Curr. Pharmacol. Rep."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.jff.2017.11.036","article-title":"Chemical structures, bioactivities and molecular mechanisms of citrus polymethoxyflavones","volume":"40","author":"Zhao","year":"2018","journal-title":"J. Funct. Foods"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/B978-0-444-64179-3.00015-3","article-title":"Chapter 15\u2014Citrus polymethoxyflavones: Biofunctional molecules of therapeutic interest","volume":"59","author":"Owis","year":"2018","journal-title":"Stud. Nat. Prod. Chem."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.foodchem.2017.05.018","article-title":"Polymethoxyflavones in peel of Citrus reticulata \u2018Chachi\u2019 and their biological activities","volume":"234","author":"Duan","year":"2017","journal-title":"Food Chem."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"103699","DOI":"10.1016\/j.bioorg.2020.103699","article-title":"Bioactive prenylated coumarins as potential anti-inflammatory and anti-HIV agents from Clausena lenis","volume":"97","author":"Liu","year":"2020","journal-title":"Bioorg. Chem."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"112416","DOI":"10.1016\/j.phytochem.2020.112416","article-title":"Coumarin derivatives from the leaves and twigs of Murraya exotica L. and their anti-inflammatory activities","volume":"177","author":"Liang","year":"2020","journal-title":"Phytochemistry"},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Zhang, Z.-R., Leung, W.N., Cheung, H.Y., and Chan, C.W. (2015). Osthole: A review on its bioactivities, pharmacological properties, and potential as alternative medicine. Evid.-Based Complement. Altern. Med., 919616.","DOI":"10.1155\/2015\/919616"},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Chen, Y.-H., Guo, D.-S., Lu, M.-H., Yue, J.-Y., Liu, Y., Shang, C.-M., An, D.-R., and Zhao, M.M. (2019). Inhibitory effect of osthole from Cnidium monnieri on Tobacco mosaic virus (tmv) infection in Nicotiana glutinosa. Molecules, 25.","DOI":"10.3390\/molecules25010065"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"91","DOI":"10.3892\/or.2016.5245","article-title":"Marmesin-mediated suppression of VEGF\/VEGFR and integrin \u03b21 expression: Its implication in non-small cell lung cancer cell responses and tumor angiogenesis","volume":"37","author":"Kim","year":"2017","journal-title":"Oncol. Rep."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"16959","DOI":"10.3390\/molecules191016959","article-title":"Antioxidant, 5-lipoxygenase inhibitory and cytotoxic activities of compounds isolated from the Ferula lutea flowers","volume":"19","author":"Znati","year":"2014","journal-title":"Molecules"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"108893","DOI":"10.1016\/j.biopha.2019.108893","article-title":"Chaihu-Shugan-San and absorbed meranzin hydrate induce anti-atherosclerosis and behavioral improvements in high-fat diet ApoE\u2212\/\u2212 mice via anti-inflammatory and BDNF-TrkB pathway","volume":"115","author":"Li","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Werpy, T., and Petersen, G. (2004). Top Value Added Chemicals from Biomass Volume I-Results of Screening for Potential Candidates from Sugars and Synthesis Gas.","DOI":"10.2172\/15008859"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1039\/b922014c","article-title":"Technology development for the production of biobased products from biorefinery carbohydrates-the US Department of Energy\u2019s \u201cTop 10\u201d revisted","volume":"12","author":"Bozell","year":"2010","journal-title":"Green Chem."},{"key":"ref_83","unstructured":"De Jong, E., Higson, A., Walsh, P., and Wellisch, M. (2012). Bio-Based Chemicals: Value Added Products from Biorefineries, International Energy Agency, Bioenergy Task 42, Biorefinery."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1039\/C4GC01062K","article-title":"Chemical conversion pathways for carbohydrates","volume":"17","author":"Chatterjee","year":"2015","journal-title":"Green Chem."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1002\/bbb.1786","article-title":"Potential of commodity chemicals to become bio-based according to maximum yields and petrochemical prices","volume":"11","author":"Straathof","year":"2017","journal-title":"Biofuels Bioprod. Biorefin."},{"key":"ref_86","unstructured":"Pacific Pectin (2021, April 27). Pacific Pectin Products. Available online: https:\/\/pacificpectin.com\/products\/."},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Lara-Espinoza, C., Carvajal-Mill\u00e1n, E., Balandr\u00e1n-Quintana, R., L\u00f3pez-Franco, Y., and Rasc\u00f3n-Chu, A. (2018). Pectin and pectin-based composite materials: Beyond food texture. Molecules, 23.","DOI":"10.3390\/molecules23040942"},{"key":"ref_88","unstructured":"(2021, August 12). Wholesale Organic Grapefruit Seed Extract 98% Naringin from Coolflying. Available online: https:\/\/www.alibaba.com\/product-detail\/Wholesale-Organic-Grapefruit-Seed-Extract-98_1600083983518.html?spm=a2700.7724857.normal_offer.d_title.46009e8aiYQH6Y."},{"key":"ref_89","unstructured":"(2021, August 12). Natural Sweetener Citrus Aurantium Extract\/Bitter Orange Extract Powder Neohesperidin. Available online: https:\/\/www.alibaba.com\/product-detail\/Neohesperidin-Natural-Sweetener-Citrus-Aurantium-Extract_1600261028323.html?spm=a2700.7724857.normal_offer.d_title.542f7545aX1SlK&s=p>."},{"key":"ref_90","unstructured":"(2021, August 12). High Purity Poncirin CAS NO 14941-083. Available online: https:\/\/m.alibaba.com\/amp\/product\/1600276176419.html."},{"key":"ref_91","unstructured":"(2021). Global Flavonones Market-2027, Fior Markets."},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Singerman, A., Burani-Arouca, M., and Hutch, S.H. (2018). The Economics of Planting New Citrus Groves in Florida in the Era of HLB. Electronic Data Information Source of University of Florida, Institute of Food and Agricultural Sciences Extension. Available online: https:\/\/edis.ifas.ufl.edu\/publication\/FE1050.","DOI":"10.32473\/edis-fe1050-2018"},{"key":"ref_93","unstructured":"Singerman, A. (2021, October 20). The real cost of HLB in Florida, Citrus Industry Magazine, Available online: https:\/\/crec.ifas.ufl.edu\/media\/crecifasufledu\/economics\/cost_manuscript_20190801.pdf."}],"container-title":["Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-7737\/10\/12\/1285\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:42:28Z","timestamp":1760168548000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-7737\/10\/12\/1285"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,7]]},"references-count":93,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2021,12]]}},"alternative-id":["biology10121285"],"URL":"https:\/\/doi.org\/10.3390\/biology10121285","relation":{},"ISSN":["2079-7737"],"issn-type":[{"value":"2079-7737","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,7]]}}}