{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T11:41:08Z","timestamp":1778845268750,"version":"3.51.4"},"reference-count":44,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2021,12,7]],"date-time":"2021-12-07T00:00:00Z","timestamp":1638835200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biology"],"abstract":"<jats:p>\u201cCutaneous melanocytic tumor with CRTC1::TRIM11 fusion\u201d (CMTCT) is a recently described entity belonging to the family of superficial tumors displaying melanocytic differentiation. Thirteen cases have been reported so far, on the head and neck, extremities, and trunk of adults of all ages (12 cases) and one in an 11-year-old child. Histopathologically, it is a nodular or multilobulated tumor composed of spindle and epithelioid cells arranged in nests, fascicles, or bundles that are surrounded by thin collagenous septa. By immunohistochemistry, the tumor shows variable immunoreactivity for S100-protein, SOX10, and MITF, as well as specific melanocytic markers such as MelanA and HMB-45. The neoplasm\u2019s biologic behavior remains uncertain since the reported cases are limited and the follow-up is short (median 12 months). However, local recurrence and synchronous distant metastasis after 13 years of initial resection has been described in one case. Herein, we present a comprehensive literature review of CMTCT hoping to raise awareness among the dermatopathologists of this potentially novel entity.<\/jats:p>","DOI":"10.3390\/biology10121286","type":"journal-article","created":{"date-parts":[[2021,12,7]],"date-time":"2021-12-07T09:52:29Z","timestamp":1638870749000},"page":"1286","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Cutaneous Melanocytic Tumor with CRTC1::TRIM11 Fusion: Review of the Literature of a Potentially Novel Entity"],"prefix":"10.3390","volume":"10","author":[{"given":"Ourania","family":"Parra","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9462-652X","authenticated-orcid":false,"given":"Konstantinos","family":"Linos","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756, USA"},{"name":"Geisel School of Medicine, Dartmouth College, Hanover, NH 03755, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1097\/PAS.0000000000000996","article-title":"Cutaneous melanocytoma with CRTC1-TRIM11 fusion: Report of 5 cases resembling clear cell sarcoma","volume":"42","author":"Cellier","year":"2018","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1097\/PAS.0000000000001217","article-title":"CRTC1-TRIM11 fusion in a case of metastatic clear cell sarcoma: Are CRTC1-TRIM11 fusion-bearing tumors melanocytomas or clear cell sarcomas?","volume":"43","author":"Bontoux","year":"2019","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1111\/pin.12826","article-title":"A case report of cutaneous melanocytoma with CRTC1-TRIM11 fusion: Is CMCT distinct from clear cell sarcoma of soft tissue?","volume":"69","author":"Kashima","year":"2019","journal-title":"Pathol. Int."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1111\/cup.13533","article-title":"CRTC1-TRIM11 fusion defined melanocytic tumors: A series of four cases","volume":"46","author":"Ko","year":"2019","journal-title":"J. Cutan. Pathol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1111\/cup.13984","article-title":"Dermal melanocytic tumor with CRTC1-TRIM11 fusion: Report of two additional cases with review of the literature of an emerging entity","volume":"48","author":"Parra","year":"2021","journal-title":"J. Cutan. Pathol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.oraloncology.2008.03.012","article-title":"t(11;19) translocation and CRTC1-MAML2 fusion oncogene in mucoepidermoid carcinoma","volume":"45","year":"2009","journal-title":"Oral Oncol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2602","DOI":"10.1038\/onc.2015.283","article-title":"Dysregulated CRTC1 activity is a novel component of PGE2 signaling that contributes to colon cancer growth","volume":"35","author":"Schumacher","year":"2016","journal-title":"Oncogene"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1111\/jop.12970","article-title":"Prognostic value of CRTC1-MAML2 translocation in salivary mucoepidermoid carcinoma: Systematic review and meta-analysis","volume":"49","author":"Wagner","year":"2020","journal-title":"J. Oral. Pathol. Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1111\/his.13779","article-title":"CRTC1-MAML2fusion in mucoepidermoid carcinoma of the breast","volume":"74","author":"Bean","year":"2019","journal-title":"Histopathology"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/s13000-019-0863-8","article-title":"Primary mucoepidermoid carcinoma of the liver with CRTC1-MAML2 fusion: A case report","volume":"14","author":"Watanabe","year":"2019","journal-title":"Diagn Pathol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1002\/gcc.20440","article-title":"Frequent fusion of the CRTC1 and MAML2 genes in clear cell variants of cutaneous hidradenomas","volume":"46","author":"Winnes","year":"2007","journal-title":"Genes Chromosomes Cancer."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Chen, J., Li, J.-L., Chen, Z., Griffin, J.D., and Wu, L. (2015). Gene expression profiling analysis of CRTC1-MAML2 fusion oncogene-induced transcriptional program in human mucoepidermoid carcinoma cells. BMC Cancer, 15.","DOI":"10.1186\/s12885-015-1827-3"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1002\/path.5071","article-title":"Genetic analyses of undifferentiated small round cell sarcoma identifies a novel sarcoma subtype with a recurrent CRTC1-SS18 gene fusion","volume":"245","author":"Alholle","year":"2018","journal-title":"J. Pathol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1038\/s41379-020-0495-2","article-title":"NTRK3 overexpression in undifferentiated sarcomas with YWHAE and BCOR genetic alterations","volume":"33","author":"Kao","year":"2020","journal-title":"Mod. Pathol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1186\/s13046-016-0379-y","article-title":"TRIM11 overexpression promotes proliferation, migration and invasion of lung cancer cells","volume":"35","author":"Wang","year":"2016","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.clinre.2016.09.010","article-title":"High expression of TRIM11 correlates with poor prognosis in patients with hepatocellular carcinoma","volume":"41","author":"Chen","year":"2017","journal-title":"Clin. Res. Hepatol. Gastroenterol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"98","DOI":"10.12659\/MSM.911818","article-title":"Expression of Tripartite Motif-Containing Proteactiin 11 (TRIM11) is associated with the progression of human prostate cancer and is downregulated by microRNA-5193","volume":"25","author":"Pan","year":"2019","journal-title":"Med. Sci. Mon."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"86755","DOI":"10.18632\/oncotarget.13550","article-title":"TRIM11, a direct target of miR-24-3p, promotes cell proliferation and inhibits apoptosis in colon cancer","volume":"7","author":"Yin","year":"2016","journal-title":"Oncotarget"},{"key":"ref_19","first-page":"2097","article-title":"TRIM11 stimulates the proliferation of gastric cancer through targeting CPEB3\/EGFR axis","volume":"25","author":"Luo","year":"2020","journal-title":"J. BUON"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"111750","DOI":"10.1016\/j.yexcr.2019.111750","article-title":"TRIM11 promotes lymphomas by activating the \u03b2-catenin signaling and Axin1 ubiquitination degradation","volume":"387","author":"Hou","year":"2020","journal-title":"Exp. Cell Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.neo.2020.06.003","article-title":"TRIM11 promotes breast cancer cell proliferation by stabilizing estrogen receptor \u03b1","volume":"22","author":"Tang","year":"2020","journal-title":"Neoplasia"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"5038","DOI":"10.1038\/onc.2012.531","article-title":"TRIM11 is overexpressed in high-grade gliomas and promotes proliferation, invasion, migration and glial tumor growth","volume":"32","author":"Di","year":"2013","journal-title":"Oncogene"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.3892\/ol.2017.6432","article-title":"Proliferation and invasion of ovarian cancer cells are suppressed by knockdown of TRIM11","volume":"14","author":"Chen","year":"2017","journal-title":"Oncol. Lett."},{"key":"ref_24","first-page":"2019","article-title":"TRIM11 promotes tumor angiogenesis via activation of STAT3\/VEGFA signaling in lung adenocarcinoma","volume":"9","author":"Huang","year":"2019","journal-title":"Am. J. Cancer Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1097\/PAS.0b013e3181c7d8b2","article-title":"Cutaneous clear cell sarcoma: A clinicopathologic, immunohistochemical, and molecular analysis of 12 cases emphasizing its distinction from dermal melanoma","volume":"34","author":"Hantschke","year":"2010","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1111\/cup.13659","article-title":"A rare case of primary dermal clear cell sarcoma with focal epidermotropism: An entity difficult to distinguish from melanoma","volume":"47","author":"Nawrocki","year":"2020","journal-title":"J. Cutan. Pathol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1097\/PAS.0b013e31814b18fb","article-title":"Clear cell sarcoma of soft tissue: A clinicopathologic, immunohistochemical, and molecular analysis of 33 cases","volume":"32","author":"Hisaoka","year":"2008","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1097\/PAS.0000000000001331","article-title":"Expanding the phenotypic spectrum of mesenchymal tumors harboring the EWSR1-CREM fusion","volume":"43","author":"Yoshida","year":"2019","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1001\/archdermatol.2007.16","article-title":"Primary dermal melanoma: Distinct immunohistochemical findings and clinical outcome compared with nodular and metastatic melanoma","volume":"144","author":"Cassarino","year":"2008","journal-title":"Arch. Dermatol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/j.jaad.2014.07.051","article-title":"Primary dermal melanoma: A unique subtype of melanoma to be distinguished from cutaneous metastatic melanoma","volume":"71","author":"Sidiropoulos","year":"2014","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1016\/j.jaad.2016.08.028","article-title":"Mutational profile of primary dermal melanoma: A case series","volume":"75","author":"Sun","year":"2016","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cancergencyto.2004.06.004","article-title":"Genomic alterations in primary cutaneous melanomas detected by metaphase comparative genomic hybridization with laser capture or manual microdissection: 6p gains may predict poor outcome","volume":"157","author":"Namiki","year":"2005","journal-title":"Cancer Genet. Cytogenet."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1001\/archderm.140.1.99","article-title":"Primary dermal melanoma: A distinct subtype of melanoma","volume":"140","author":"Swetter","year":"2004","journal-title":"Arch Dermatol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1097\/PAS.0000000000001070","article-title":"Primary and metastatic melanoma with NTRK fusions","volume":"42","author":"Lezcano","year":"2018","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.cll.2017.05.003","article-title":"Toward a molecular-genetic classification of spitzoid neoplasms","volume":"37","author":"Tetzlaff","year":"2017","journal-title":"Clin. Lab. Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1111\/cup.13521","article-title":"The role of gene fusions in melanocytic neoplasms","volume":"46","author":"Quan","year":"2019","journal-title":"J. Cutan. Pathol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1097\/PAS.0000000000001235","article-title":"Filigree-like rete ridges, lobulated nests, rosette-like structures, and exaggerated naturation characterize Spitz Tumors with NTRK1 fusion","volume":"43","author":"Yeh","year":"2019","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1097\/PAS.0000000000000761","article-title":"A Comparison of morphologic and molecular features of BRAF, ALK, and NTRK1 fusion spitzoid neoplasms","volume":"41","author":"Amin","year":"2017","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_39","first-page":"962","article-title":"Clear Cell Tumor with melanocytic differentiation and ACTIN-MITF translocation: Report of 7 Cases of a novel entity","volume":"45","author":"Pissaloux","year":"2020","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_40","first-page":"1","article-title":"Clear cell tumor with melanocytic differentiation and MITF-CREM translocation: A novel entity similar to clear cell sarcoma [published online ahead of print, 2021 Jan 18]","volume":"479","author":"Pissaloux","year":"2021","journal-title":"Virchows Arch."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.path.2015.05.005","article-title":"Myoepithelial Tumors: An Update","volume":"8","author":"Jo","year":"2015","journal-title":"Surg. Pathol. Clin."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1097\/PAS.0000000000000589","article-title":"Epithelioid schwannomas","volume":"40","author":"Hart","year":"2016","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1097\/PAS.0000000000000379","article-title":"Epithelioid malignant peripheral nerve sheath tumor","volume":"39","author":"Jo","year":"2015","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1097\/00000478-200412000-00005","article-title":"Paraganglioma-like dermal melanocytic tumor: A unique entity distinct from cellular blue nevus, clear cell sarcoma, and cutaneous melanoma","volume":"28","author":"Deyrup","year":"2004","journal-title":"Am. J. Surg. Pathol."}],"container-title":["Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-7737\/10\/12\/1286\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:42:28Z","timestamp":1760168548000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-7737\/10\/12\/1286"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,7]]},"references-count":44,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2021,12]]}},"alternative-id":["biology10121286"],"URL":"https:\/\/doi.org\/10.3390\/biology10121286","relation":{},"ISSN":["2079-7737"],"issn-type":[{"value":"2079-7737","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,7]]}}}