{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T16:37:50Z","timestamp":1780591070701,"version":"3.54.1"},"reference-count":49,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2022,2,7]],"date-time":"2022-02-07T00:00:00Z","timestamp":1644192000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Science and High Education of the Russian Federation","award":["FSRG-2020-0016"],"award-info":[{"award-number":["FSRG-2020-0016"]}]},{"name":"Project of the YSC CMP &quot;Study of the genetic structure and burden of hereditary pathology in the populations of the Republic of Sakha (Yakutia)&quot;","award":["no"],"award-info":[{"award-number":["no"]}]},{"name":"Russian State Budget program","award":["0259-2021-0014."],"award-info":[{"award-number":["0259-2021-0014."]}]},{"DOI":"10.13039\/501100002261","name":"RFBR","doi-asserted-by":"publisher","award":["18-05-60035_Arctika"],"award-info":[{"award-number":["18-05-60035_Arctika"]}],"id":[{"id":"10.13039\/501100002261","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002261","name":"RFBR","doi-asserted-by":"publisher","award":["20-015-00328_A"],"award-info":[{"award-number":["20-015-00328_A"]}],"id":[{"id":"10.13039\/501100002261","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biology"],"abstract":"<jats:p>An increase in the prevalence of autosomal recessive deafness 1A (DFNB1A) in populations of European descent was shown to be promoted by assortative marriages among deaf people. Assortative marriages became possible with the widespread introduction of sign language, resulting in increased genetic fitness of deaf individuals and, thereby, relaxing selection against deafness. However, the effect of this phenomenon was not previously studied in populations with different genetic structures. We developed an agent-based computer model for the analysis of the spread of DFNB1A. Using this model, we tested the impact of different intensities of selection pressure against deafness in an isolated human population over 400 years. Modeling of the \u201cpurifying\u201d selection pressure on deafness (\u201cNo deaf mating\u201d scenario) resulted in a decrease in the proportion of deaf individuals and the pathogenic allele frequency. Modeling of the \u201crelaxed\u201d selection (\u201cAssortative mating\u201d scenario) resulted in an increase in the proportion of deaf individuals in the first four generations, which then quickly plateaued with a subsequent decline and a decrease in the pathogenic allele frequency. The results of neutral selection pressure modeling (\u201cRandom mating\u201d scenario) showed no significant changes in the proportion of deaf individuals or the pathogenic allele frequency after 400 years.<\/jats:p>","DOI":"10.3390\/biology11020257","type":"journal-article","created":{"date-parts":[[2022,2,7]],"date-time":"2022-02-07T20:36:42Z","timestamp":1644266202000},"page":"257","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Agent-Based Modeling of Autosomal Recessive Deafness 1A (DFNB1A) Prevalence with Regard to Intensity of Selection Pressure in Isolated Human Population"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2936-5818","authenticated-orcid":false,"given":"Georgii P.","family":"Romanov","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Biology, M. K. Ammosov North-Eastern Federal University, Kulakovskogo 46, 677010 Yakutsk, Russia"},{"name":"Laboratory of Molecular Genetics, Yakut Science Centre of Complex Medical Problems, Yaroslavskogo 6\/3, 677000 Yakutsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna A.","family":"Smirnova","sequence":"additional","affiliation":[{"name":"Sector for Computer Analysis and Modeling of Biological Systems, Federal Research Center Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Lavrentyeva 10, 630090 Novosibirsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir I.","family":"Zamyatin","sequence":"additional","affiliation":[{"name":"Sector for Computer Analysis and Modeling of Biological Systems, Federal Research Center Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Lavrentyeva 10, 630090 Novosibirsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1102-0934","authenticated-orcid":false,"given":"Aleksey M.","family":"Mukhin","sequence":"additional","affiliation":[{"name":"Sector for Computer Analysis and Modeling of Biological Systems, Federal Research Center Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Lavrentyeva 10, 630090 Novosibirsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5711-7539","authenticated-orcid":false,"given":"Fedor V.","family":"Kazantsev","sequence":"additional","affiliation":[{"name":"Sector for Computer Analysis and Modeling of Biological Systems, Federal Research Center Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Lavrentyeva 10, 630090 Novosibirsk, Russia"},{"name":"Novosibirsk State University, Pirogova 1, 630090 Novosibirsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera G.","family":"Pshennikova","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Genetics, Yakut Science Centre of Complex Medical Problems, Yaroslavskogo 6\/3, 677000 Yakutsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fedor M.","family":"Teryutin","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Biology, M. K. Ammosov North-Eastern Federal University, Kulakovskogo 46, 677010 Yakutsk, Russia"},{"name":"Laboratory of Molecular Genetics, Yakut Science Centre of Complex Medical Problems, Yaroslavskogo 6\/3, 677000 Yakutsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aisen V.","family":"Solovyev","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Biology, M. K. Ammosov North-Eastern Federal University, Kulakovskogo 46, 677010 Yakutsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6952-3868","authenticated-orcid":false,"given":"Sardana A.","family":"Fedorova","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Biology, M. K. Ammosov North-Eastern Federal University, Kulakovskogo 46, 677010 Yakutsk, Russia"},{"name":"Laboratory of Molecular Genetics, Yakut Science Centre of Complex Medical Problems, Yaroslavskogo 6\/3, 677000 Yakutsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1352-3591","authenticated-orcid":false,"given":"Olga L.","family":"Posukh","sequence":"additional","affiliation":[{"name":"Novosibirsk State University, Pirogova 1, 630090 Novosibirsk, Russia"},{"name":"Laboratory of Human Molecular Genetics, Federal Research Center Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Lavrentyeva 10, 630090 Novosibirsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3138-381X","authenticated-orcid":false,"given":"Sergey A.","family":"Lashin","sequence":"additional","affiliation":[{"name":"Sector for Computer Analysis and Modeling of Biological Systems, Federal Research Center Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Lavrentyeva 10, 630090 Novosibirsk, Russia"},{"name":"Novosibirsk State University, Pirogova 1, 630090 Novosibirsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6984-7934","authenticated-orcid":false,"given":"Nikolay A.","family":"Barashkov","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Biology, M. K. Ammosov North-Eastern Federal University, Kulakovskogo 46, 677010 Yakutsk, Russia"},{"name":"Laboratory of Molecular Genetics, Yakut Science Centre of Complex Medical Problems, Yaroslavskogo 6\/3, 677000 Yakutsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,2,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"16094","DOI":"10.1038\/nrdp.2016.94","article-title":"Congenital hearing loss","volume":"3","author":"Korver","year":"2017","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.1056\/NEJMra050700","article-title":"Newborn Hearing Screening\u2014A Silent Revolution","volume":"354","author":"Morton","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"ref_3","unstructured":"Toriello, H., and Smith, S. (2013). Hereditary Hearing Loss and Its Syndromes, Oxford University Press. 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