{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T07:33:20Z","timestamp":1792481600803,"version":"4.5.0"},"reference-count":95,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2022,2,16]],"date-time":"2022-02-16T00:00:00Z","timestamp":1644969600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001778","name":"Deakin University","doi-asserted-by":"publisher","award":["School of Life and Environmental Sciences"],"award-info":[{"award-number":["School of Life and Environmental Sciences"]}],"id":[{"id":"10.13039\/501100001778","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001778","name":"Deakin University","doi-asserted-by":"publisher","award":["Institute for Mental and Physical Health and Clinical Translation (IMPACT)"],"award-info":[{"award-number":["Institute for Mental and Physical Health and Clinical Translation (IMPACT)"]}],"id":[{"id":"10.13039\/501100001778","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biology"],"abstract":"<jats:p>Ocular allergy is an immunoglobulin E-mediated Type I hypersensitivity reaction localised to the ocular surface and surrounding tissues. Primary signs and symptoms of ocular allergy include itching, redness, irritation and inflammation. Eye-rubbing caused by itching has been shown to alter ocular surface protein concentrations in conditions linked to ocular allergy such as keratoconus. In keratoconus, the cornea begins to thin and sag over time, leading to progressive vision loss and blindness in severe conditions. Due to the high incidence of ocular allergy sufferers rubbing their eyes in response to symptoms of itching, the protein landscape of the ocular surface may be significantly altered. Differential protein expression caused by long-term inflammation and eye-rubbing may lead to subsequent changes in ocular surface structure and function over time. This review aims to summarise and explore the findings of current ocular allergy proteome research conducted using techniques such as gel electrophoresis, mass spectrometry and lab-on-a-chip proteomics. Proteins of interest for this review include differentially expressed immunoglobulins, mucins, functional proteins, enzymes and proteins with previously uncharacterised roles in ocular allergy. Additionally, potential applications of this research are addressed in terms of diagnostics, drug development and future research prospects.<\/jats:p>","DOI":"10.3390\/biology11020312","type":"journal-article","created":{"date-parts":[[2022,2,16]],"date-time":"2022-02-16T20:26:41Z","timestamp":1645043201000},"page":"312","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["A Review of Emerging Tear Proteomics Research on the Ocular Surface in Ocular Allergy"],"prefix":"10.3390","volume":"11","author":[{"given":"Esrin","family":"Aydin","sequence":"first","affiliation":[{"name":"School of Life and Environmental Sciences, Deakin University, Waurn Ponds, VIC 3216, Australia"},{"name":"Deakin Optometry, Deakin University, Waurn Ponds, VIC 3216, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poshmaal","family":"Dhar","sequence":"additional","affiliation":[{"name":"School of Medicine, Deakin University, Waurn Ponds, VIC 3216, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moneisha","family":"Gokhale","sequence":"additional","affiliation":[{"name":"Deakin Optometry, Deakin University, Waurn Ponds, VIC 3216, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5694-4500","authenticated-orcid":false,"given":"Luke","family":"Chong","sequence":"additional","affiliation":[{"name":"Deakin Optometry, Deakin University, Waurn Ponds, VIC 3216, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serap","family":"Azizoglu","sequence":"additional","affiliation":[{"name":"Deakin Optometry, Deakin University, Waurn Ponds, VIC 3216, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0101-0668","authenticated-orcid":false,"given":"Cenk","family":"Suphioglu","sequence":"additional","affiliation":[{"name":"School of Life and Environmental Sciences, Deakin University, Waurn Ponds, VIC 3216, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,2,16]]},"reference":[{"key":"ref_1","first-page":"653","article-title":"Outdoor Allergens","volume":"108","author":"Burge","year":"2000","journal-title":"Environ. 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