{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:02:36Z","timestamp":1792803756620,"version":"4.5.0"},"reference-count":144,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2022,3,16]],"date-time":"2022-03-16T00:00:00Z","timestamp":1647388800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["R01-EY028125"],"award-info":[{"award-number":["R01-EY028125"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006312","name":"BrightFocus Foundation","doi-asserted-by":"publisher","award":["G2013077, G2016030, and G2019103"],"award-info":[{"award-number":["G2013077, G2016030, and G2019103"]}],"id":[{"id":"10.13039\/100006312","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Feldstein Medical Foundation","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}],"id":[{"id":"https:\/\/ror.org\/03nrefn76","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/100001818","name":"Research to Prevent Blindness","doi-asserted-by":"publisher","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}],"id":[{"id":"10.13039\/100001818","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biology"],"abstract":"<jats:p>Glaucoma is a group of ophthalmologic conditions characterized by progressive retinal ganglion cell death, optic nerve degeneration, and irreversible vision loss. While intraocular pressure is the only clinically modifiable risk factor, glaucoma may continue to progress at controlled intraocular pressure, indicating other major factors in contributing to the disease mechanisms. Recent studies demonstrated the feasibility of advanced diffusion magnetic resonance imaging (dMRI) in visualizing the microstructural integrity of the visual system, opening new possibilities for non-invasive characterization of glaucomatous brain changes for guiding earlier and targeted intervention besides intraocular pressure lowering. In this review, we discuss dMRI methods currently used in visual system investigations, focusing on the eye, optic nerve, optic tract, subcortical visual brain nuclei, optic radiations, and visual cortex. We evaluate how conventional diffusion tensor imaging, higher-order diffusion kurtosis imaging, and other extended dMRI techniques can assess the neuronal and glial integrity of the visual system in both humans and experimental animal models of glaucoma, among other optic neuropathies or neurodegenerative diseases. We also compare the pros and cons of these methods against other imaging modalities. A growing body of dMRI research indicates that this modality holds promise in characterizing early glaucomatous changes in the visual system, determining the disease severity, and identifying potential neurotherapeutic targets, offering more options to slow glaucoma progression and to reduce the prevalence of this world\u2019s leading cause of irreversible but preventable blindness.<\/jats:p>","DOI":"10.3390\/biology11030454","type":"journal-article","created":{"date-parts":[[2022,3,16]],"date-time":"2022-03-16T22:09:58Z","timestamp":1647468598000},"page":"454","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Advanced Diffusion MRI of the Visual System in Glaucoma: From Experimental Animal Models to Humans"],"prefix":"10.3390","volume":"11","author":[{"given":"Monica","family":"Mendoza","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering, Tandon School of Engineering, New York University, New York, NY 11201, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5139-2217","authenticated-orcid":false,"given":"Max","family":"Shotbolt","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Tandon School of Engineering, New York University, New York, NY 11201, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muneeb A.","family":"Faiq","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, NYU Grossman School of Medicine, NYU Langone Health, New York University, New York, NY 10017, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Parra","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, NYU Grossman School of Medicine, NYU Langone Health, New York University, New York, NY 10017, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4012-7084","authenticated-orcid":false,"given":"Kevin C.","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Tandon School of Engineering, New York University, New York, NY 11201, USA"},{"name":"Department of Ophthalmology, NYU Grossman School of Medicine, NYU Langone Health, New York University, New York, NY 10017, USA"},{"name":"Department of Radiology, Neuroscience Institute, NYU Grossman School of Medicine, NYU Langone Health, New York University, New York, NY 10016, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1016\/j.ophtha.2014.05.013","article-title":"Global Prevalence of Glaucoma and Projections of Glaucoma Burden through 2040: A systematic review and meta-analysis","volume":"121","author":"Tham","year":"2014","journal-title":"Ophthalmology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1097\/ICU.0b013e32833651d8","article-title":"Intracranial pressure and glaucoma","volume":"21","author":"Berdahl","year":"2010","journal-title":"Curr. Opin. Ophthalmol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1136\/bjophthalmol-2015-307223","article-title":"Global variations and time trends in the prevalence of primary open angle glaucoma (POAG): A systematic review and meta-analysis","volume":"100","author":"Kapetanakis","year":"2015","journal-title":"Br. J. Ophthalmol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1016\/S0140-6736(10)61423-7","article-title":"Glaucoma","volume":"377","author":"Quigley","year":"2011","journal-title":"Lancet"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1001\/jama.2014.3192","article-title":"The Pathophysiology and Treatment of Glaucoma: A review","volume":"311","author":"Weinreb","year":"2014","journal-title":"JAMA\u2014J. Am. Med. Assoc."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.survophthal.2015.01.004","article-title":"The interactions of genes, age, and environment in glaucoma pathogenesis","volume":"60","author":"Doucette","year":"2015","journal-title":"Surv. Ophthalmol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.mehy.2019.04.008","article-title":"Glaucoma as a dangerous interplay between ocular fluid and cerebrospinal fluid","volume":"127","author":"Wostyn","year":"2019","journal-title":"Med. Hypotheses"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0161-6420(98)92665-3","article-title":"Prevalence of glaucoma and intraocular pressure distribution in a defined population: The Egna-Neumarkt study","volume":"105","author":"Bonomi","year":"1998","journal-title":"Ophthalmology"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1016\/S0161-6420(92)31774-9","article-title":"Prevalence of Glaucoma: The Beaver Dam Eye Study","volume":"99","author":"Klein","year":"1992","journal-title":"Ophthalmology"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1007\/s13311-021-01033-6","article-title":"Citicoline Modulates Glaucomatous Neurodegeneration Through Intraocular Pressure-Independent Control","volume":"18","author":"Murphy","year":"2021","journal-title":"Neurotherapeutics"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"4254","DOI":"10.1167\/iovs.06-0299","article-title":"Variations in Primary Open-Angle Glaucoma Prevalence by Age, Gender, and Race: A Bayesian Meta-Analysis","volume":"47","author":"Rudnicka","year":"2006","journal-title":"Investig. Opthalmol. Vis. Sci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"4643","DOI":"10.1038\/s41598-018-22850-4","article-title":"Age-related Changes in Eye, Brain and Visuomotor Behavior in the DBA\/2J Mouse Model of Chronic Glaucoma","volume":"8","author":"Yang","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1126\/science.1066901","article-title":"Adult-Onset Primary Open-Angle Glaucoma Caused by Mutations in Optineurin","volume":"295","author":"Rezaie","year":"2002","journal-title":"Science"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1001\/archopht.116.12.1640","article-title":"Genetic Risk of Primary Open-angle Glaucoma","volume":"116","author":"Wolfs","year":"1998","journal-title":"Arch. Ophthalmol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000081775","article-title":"Diabetes mellitus as a Risk Factor for Glaucomatous Optic Neuropathy","volume":"219","author":"Nakamura","year":"2005","journal-title":"Ophthalmologica"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.1016\/S0161-6420(99)90416-5","article-title":"The relationship between glaucoma and myopia: The blue mountains eye study","volume":"106","author":"Mitchell","year":"1999","journal-title":"Ophthalmology"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1136\/bjo.2005.081224","article-title":"The number of people with glaucoma worldwide in 2010 and 2020","volume":"90","author":"Quigley","year":"2006","journal-title":"Br. J. Ophthalmol."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Kami\u0144ska, A., Romano, G., Rejdak, R., Zweifel, S., Fiedorowicz, M., Rejdak, M., Bajka, A., Amato, R., Bucolo, C., and Avitabile, T. (2021). Influence of trace elements on neurodegenerative diseases of the eye\u2014The glaucoma model. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22094323"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.mri.2021.03.014","article-title":"Recent advances on optic nerve magnetic resonance imaging and post-processing","volume":"79","author":"Chow","year":"2021","journal-title":"Magn. Reson. Imaging"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"9890831","DOI":"10.1155\/2019\/9890831","article-title":"Twenty-Four-Hour Contact Lens Sensor Monitoring of Aqueous Humor Dynamics in Surgically or Medically Treated Glaucoma Patients","volume":"2019","author":"Posarelli","year":"2019","journal-title":"J. Ophthalmol."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Schacknow, P.N., and Samples, J.R. (2010). The Glaucoma Book: A Practical, Evidence-Based Approach to Patient Care, Springer.","DOI":"10.1007\/978-0-387-76700-0"},{"key":"ref_22","first-page":"736","article-title":"Histomorphometry of the human optic nerve","volume":"31","author":"Jonas","year":"1990","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1016\/j.ophtha.2018.03.052","article-title":"Patterns of Progressive Ganglion Cell\u2013Inner Plexiform Layer Thinning in Glaucoma Detected by OCT","volume":"125","author":"Shin","year":"2018","journal-title":"Ophthalmology"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1167\/iovs.04-1107","article-title":"Analysis of Retinal Nerve Fiber Layer and Optic Nerve Head in Glaucoma with Different Reference Plane Offsets, Using Optical Coherence Tomography","volume":"46","author":"Leung","year":"2005","journal-title":"Investig. Opthalmol. Vis. Sci."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.ajo.2020.09.026","article-title":"Detection of Glaucoma Deterioration in the Macular Region with Optical Coherence Tomography: Challenges and Solutions","volume":"222","author":"Weiss","year":"2021","journal-title":"Am. J. Ophthalmol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1007\/s12035-013-8416-8","article-title":"Glaucoma: An Extension of Various Chronic Neurodegenerative Disorders","volume":"48","author":"Jindal","year":"2013","journal-title":"Mol. Neurobiol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/j.1442-9071.2012.02832.x","article-title":"Diffusion tensor magnetic resonance imaging reveals visual pathway damage that correlates with clinical severity in glaucoma","volume":"41","author":"Chen","year":"2013","journal-title":"Clin. Exp. Ophthalmol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.survophthal.2017.09.010","article-title":"Glaucoma and the brain: Trans-synaptic degeneration, structural change, and implications for neuroprotection","volume":"63","author":"Lawlor","year":"2018","journal-title":"Surv. Ophthalmol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1167\/tvst.3.3.1","article-title":"Refined Data Analysis Provides Clinical Evidence for Central Nervous System Control of Chronic Glaucomatous Neurodegeneration","volume":"3","author":"Sponsel","year":"2014","journal-title":"Transl. Vis. Sci. Technol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1097\/IJG.0000000000000783","article-title":"Relationship Between Optic Nerve Head Drusen Volume and Structural and Functional Optic Nerve Damage","volume":"26","author":"Skaat","year":"2017","journal-title":"J. Glaucoma"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"e295","DOI":"10.1111\/j.1755-3768.2011.02346.x","article-title":"Anterior visual pathway assessment by magnetic resonance imaging in normal-pressure glaucoma","volume":"90","author":"Zhang","year":"2012","journal-title":"Acta Ophthalmol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1111\/opo.12293","article-title":"Using magnetic resonance imaging to assess visual deficits: A review","volume":"36","author":"Brown","year":"2016","journal-title":"Ophthalmic Physiol. Opt."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"17525","DOI":"10.1073\/pnas.0605790103","article-title":"Structural and functional MRI reveals multiple retinal layers","volume":"103","author":"Cheng","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.exer.2012.06.006","article-title":"Layer-specific blood-flow MRI of retinitis pigmentosa in RCS rats","volume":"101","author":"Li","year":"2012","journal-title":"Exp. Eye Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1038\/nature03495","article-title":"Lack of long-term cortical reorganization after macaque retinal lesions","volume":"435","author":"Smirnakis","year":"2005","journal-title":"Nature"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"35","DOI":"10.3389\/fncir.2019.00035","article-title":"Applications of Manganese-Enhanced Magnetic Resonance Imaging in Ophthalmology and Visual Neuroscience","volume":"13","author":"Deng","year":"2019","journal-title":"Front. Neural Circuits"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"3887","DOI":"10.1002\/hbm.25472","article-title":"Comparison of multiple tractography methods for reconstruction of the retinogeniculate visual pathway using diffusion MRI","volume":"42","author":"He","year":"2021","journal-title":"Hum. Brain Mapp."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1016\/j.neuroimage.2010.03.035","article-title":"Comparative mouse brain tractography of diffusion magnetic resonance imaging","volume":"51","author":"Moldrich","year":"2010","journal-title":"NeuroImage"},{"key":"ref_39","first-page":"264","article-title":"Primary congenital glaucoma in infants with abnormal brain MRI findings","volume":"27","author":"Dai","year":"2007","journal-title":"Ann. Saudi Med."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"5880","DOI":"10.1167\/iovs.13-11776","article-title":"Evidence for Widespread Structural Brain Changes in Glaucoma: A Preliminary Voxel-Based MRI Study","volume":"54","author":"Williams","year":"2013","journal-title":"Investig. Opthalmol. Vis. Sci."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"144","DOI":"10.5507\/bp.2013.038","article-title":"Glaucoma and CNS. Comparison of fMRI results in high tension and normal tension glaucoma","volume":"158","author":"Lestak","year":"2014","journal-title":"Biomed. Pap."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"3468","DOI":"10.1167\/iovs.14-13902","article-title":"An Investigation of Lateral Geniculate Nucleus Volume in Patients With Primary Open-Angle Glaucoma Using 7 Tesla Magnetic Resonance Imaging","volume":"55","author":"Lee","year":"2014","journal-title":"Investig. Opthalmol. Vis. Sci."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Fukuda, M., Omodaka, K., Tatewaki, Y., Himori, N., Matsudaira, I., Nishiguchi, K.M., Murata, T., Taki, Y., and Nakazawa, T. (2018). Quantitative MRI evaluation of glaucomatous changes in the visual pathway. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0197027"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"4114","DOI":"10.1167\/iovs.17-22093","article-title":"Magnetic Resonance Imaging of Optic Nerve Traction During Adduction in Primary Open-Angle Glaucoma With Normal Intraocular Pressure","volume":"58","author":"Demer","year":"2017","journal-title":"Investig. Opthalmol. Vis. Sci."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"18969","DOI":"10.1038\/srep18969","article-title":"Structural brain alterations in primary open angle glaucoma: A 3T MRI study","volume":"6","author":"Wang","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.neuroimage.2014.12.009","article-title":"One diffusion acquisition and different white matter models: How does microstructure change in human early development based on WMTI and NODDI?","volume":"107","author":"Jelescu","year":"2015","journal-title":"NeuroImage"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1002\/nbm.1307","article-title":"Assessing optic nerve pathology with diffusion MRI: From mouse to human","volume":"21","author":"Xu","year":"2008","journal-title":"NMR Biomed."},{"key":"ref_48","first-page":"407","article-title":"Diffusion weighted magnetic resonance imaging and its recent trend\u2014A survey","volume":"5","author":"Chilla","year":"2015","journal-title":"Quant. Imaging Med. Surg."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1148\/radiology.188.3.8351339","article-title":"Human brain: Proton diffusion MR spectroscopy","volume":"188","author":"Posse","year":"1993","journal-title":"Radiology"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1113\/JP277008","article-title":"Baroreflex functionality in the eye of diffusion tensor imaging","volume":"597","author":"Tsai","year":"2018","journal-title":"J. Physiol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"446","DOI":"10.4103\/1673-5374.243712","article-title":"In vivo imaging of structural, metabolic and functional brain changes in glaucoma","volume":"14","author":"Kasi","year":"2019","journal-title":"Neural Regen. Res."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.3389\/fphar.2020.573238","article-title":"Changes of Ocular Dimensions as a Marker of Disease Progression in a Murine Model of Pigmentary Glaucoma","volume":"11","author":"Fiedorowicz","year":"2020","journal-title":"Front. Pharmacol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1097\/00061198-200406000-00003","article-title":"Association of Magnetic Resonance Imaging of Anterior Optic Pathway with Glaucomatous Visual Field Damage and Optic Disc Cupping","volume":"13","author":"Kashiwagi","year":"2004","journal-title":"J. Glaucoma"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.3174\/ajnr.A2486","article-title":"Assessment of Lateral Geniculate Nucleus Atrophy with 3T MR Imaging and Correlation with Clinical Stage of Glaucoma","volume":"32","author":"Dai","year":"2011","journal-title":"Am. J. Neuroradiol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1136\/bjo.2008.138172","article-title":"Atrophy of the lateral geniculate nucleus in human glaucoma detected by magnetic resonance imaging","volume":"93","author":"Gupta","year":"2008","journal-title":"Br. J. Ophthalmol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1136\/bjo.2005.086769","article-title":"Human glaucoma and neural degeneration in intracranial optic nerve, lateral geniculate nucleus, and visual cortex","volume":"90","author":"Gupta","year":"2006","journal-title":"Br. J. Ophthalmol."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Yu, L., Xie, B., Yin, X., Liang, M., Evans, A.C., Wang, J., and Dai, C. (2013). Reduced Cortical Thickness in Primary Open-Angle Glaucoma and Its Relationship to the Retinal Nerve Fiber Layer Thickness. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0073208"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1001\/archopht.118.3.378","article-title":"Loss of Neurons in Magnocellular and Parvocellular Layers of the Lateral Geniculate Nucleus in Glaucoma","volume":"118","author":"Zhang","year":"2000","journal-title":"Arch. Ophthalmol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1186\/s40478-019-0768-5","article-title":"Retinal pathology in experimental optic neuritis is characterized by retrograde degeneration and gliosis","volume":"7","author":"Manogaran","year":"2019","journal-title":"Acta Neuropathol. Commun."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1212\/01.wnl.0000335766.22758.cd","article-title":"Disability in optic neuritis correlates with diffusion tensor-derived directional diffusivities","volume":"72","author":"Naismith","year":"2009","journal-title":"Neurology"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.neuron.2006.08.012","article-title":"Principles of Diffusion Tensor Imaging and Its Applications to Basic Neuroscience Research","volume":"51","author":"Mori","year":"2006","journal-title":"Neuron"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.neuroimage.2011.06.006","article-title":"White matter characterization with diffusional kurtosis imaging","volume":"58","author":"Fieremans","year":"2011","journal-title":"NeuroImage"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.3174\/ajnr.A2543","article-title":"Diffusion Changes in the Vitreous Humor of the Eye during Aging","volume":"32","author":"Meral","year":"2011","journal-title":"Am. J. Neuroradiol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1002\/nbm.1609","article-title":"In vivo diffusion tensor MRI of the mouse retina: A noninvasive visualization of tissue organization","volume":"24","author":"Chen","year":"2010","journal-title":"NMR Biomed."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"235","DOI":"10.3389\/fnins.2017.00235","article-title":"Shared and Differential Retinal Responses against Optic Nerve Injury and Ocular Hypertension","volume":"11","author":"Rovere","year":"2017","journal-title":"Front. Neurosci."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"S205","DOI":"10.1148\/rg.26si065510","article-title":"Understanding Diffusion MR Imaging Techniques: From Scalar Diffusion-weighted Imaging to Diffusion Tensor Imaging and Beyond","volume":"26","author":"Hagmann","year":"2006","journal-title":"RadioGraphics"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.neuroimage.2013.05.028","article-title":"Weighted linear least squares estimation of diffusion MRI parameters: Strengths, limitations, and pitfalls","volume":"81","author":"Veraart","year":"2013","journal-title":"NeuroImage"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"31","DOI":"10.3389\/fnins.2013.00031","article-title":"A hitchhiker\u2019s guide to diffusion tensor imaging","volume":"7","author":"Soares","year":"2013","journal-title":"Front. Neurosci."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.jmr.2011.09.022","article-title":"Microstructural and physiological features of tissues elucidated by quantitative-diffusion-tensor MRI","volume":"213","author":"Basser","year":"2011","journal-title":"J. Magn. Reson."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.nurt.2007.05.011","article-title":"Diffusion tensor imaging of the brain","volume":"4","author":"Alexander","year":"2007","journal-title":"Neurotherapeutics"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"128","DOI":"10.3174\/ajnr.A2714","article-title":"Voxel-Based Morphometry and Diffusion Tensor Imaging of the Optic Pathway in Primary Open-Angle Glaucoma: A Preliminary Study","volume":"33","author":"Zikou","year":"2011","journal-title":"Am. J. Neuroradiol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"6539","DOI":"10.1167\/iovs.16-19838","article-title":"Optic radiations microstructural changes in glaucoma and association with severity: A study using 3tesla-magnetic resonance diffusion tensor imaging","volume":"57","author":"Tellouck","year":"2016","journal-title":"Investig. Opthalmol. Vis. Sci."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"3788","DOI":"10.1167\/iovs.14-15552","article-title":"In Vivo Evaluation of White Matter Integrity and Anterograde Transport in Visual System After Excitotoxic Retinal Injury with Multimodal MRI and OCT","volume":"56","author":"Ho","year":"2015","journal-title":"Investig. Opthalmol. Vis. Sci."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.acra.2011.12.005","article-title":"A New Approach to Assess Intracranial White Matter Abnormalities in Glaucoma Patients: Changes of Fractional Anisotropy Detected by 3T Diffusion Tensor Imaging","volume":"19","author":"Engelhorn","year":"2012","journal-title":"Acad. Radiol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1148\/radiol.2522081240","article-title":"Optic Nerve and Optic Radiation Neurodegeneration in Patients with Glaucoma: In Vivo Analysis with 3-T Diffusion-Tensor MR Imaging","volume":"252","author":"Garaci","year":"2009","journal-title":"Radiology"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1167\/iovs.62.10.21","article-title":"Diffusion Tensor Imaging of Visual Pathway Abnormalities in Five Glaucoma Animal Models","volume":"62","author":"Colbert","year":"2021","journal-title":"Investig. Opthalmol. Vis. Sci."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1002\/hbm.23862","article-title":"Diffuse brain damage in normal tension glaucoma","volume":"39","author":"Giorgio","year":"2018","journal-title":"Hum. Brain Mapp."},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Frezzotti, P., Giorgio, A., Motolese, I., De Leucio, A., Iester, M., Motolese, E., Federico, A., and De Stefano, N. (2014). Structural and Functional Brain Changes beyond Visual System in Patients with Advanced Glaucoma. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0105931"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.brainres.2019.05.006","article-title":"Combined machine learning and diffusion tensor imaging reveals altered anatomic fiber connectivity of the brain in primary open-angle glaucoma","volume":"1718","author":"Qu","year":"2019","journal-title":"Brain Res."},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Sun, Z., Parra, C., Bang, J.W., Fieremans, E., Wollstein, G., Schuman, J.S., and Chan, K.C. (2020, January 20\u201324). Diffusion Kurtosis Imaging Reveals Optic Tract Damage That Correlates with Clinical Severity in Glaucoma. Proceedings of the 2020 42nd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC), Montreal, QC, Canada.","DOI":"10.1109\/EMBC44109.2020.9176192"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1167\/iovs.17-23597","article-title":"White matter abnormalities and correlation with severity in normal tension glaucoma: A whole brain atlas-based diffusion tensor study","volume":"59","author":"Wang","year":"2018","journal-title":"Investig. Opthalmol. Vis. Sci."},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Miller, N., Liu, Y., Krivochenitser, R., and Rokers, B. (2019). Linking neural and clinical measures of glaucoma with diffusion magnetic resonance imaging (dMRI). PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0217011"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1097\/IJG.0b013e318294861d","article-title":"Optic nerve diffusion tensor imaging parameters and their correlation with optic disc topography and disease severity in adult glaucoma patients and controls","volume":"23","author":"Chang","year":"2014","journal-title":"J. Glaucoma"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/bs.pmbts.2015.06.010","article-title":"Neuroinflammation in Glaucoma and Optic Nerve Damage","volume":"134","author":"Nickells","year":"2015","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.neurad.2012.04.001","article-title":"Reduced white matter integrity in primary open-angle glaucoma: A DTI study using tract-based spatial statistics","volume":"40","author":"Lu","year":"2013","journal-title":"J. Neuroradiol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/s41526-017-0023-y","article-title":"MRI-derived diffusion parameters in the human optic nerve and its surrounding sheath during head-down tilt","volume":"3","author":"Gerlach","year":"2017","journal-title":"NPJ Microgravity"},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Schmidt, M.A., Knott, M., Heidemann, R., Michelson, G., Kober, T., D\u00f6rfler, A., and Engelhorn, T. (2018). Investigation of lateral geniculate nucleus volume and diffusion tensor imaging in patients with normal tension glaucoma using 7 tesla magnetic resonance imaging. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0198830"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s00417-011-1887-2","article-title":"DTI parameters of axonal integrity and demyelination of the optic radiation correlate with glaucoma indices","volume":"251","author":"Michelson","year":"2013","journal-title":"Graefe\u2019s Arch. Clin. Exp. Ophthalmol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1016\/j.ejrad.2014.05.014","article-title":"Glaucoma severity affects diffusion tensor imaging (DTI) parameters of the optic nerve and optic radiation","volume":"83","author":"Sidek","year":"2014","journal-title":"Eur. J. Radiol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/s00234-012-1122-9","article-title":"Whole-brain voxel-based analysis of diffusion tensor MRI parameters in patients with primary open angle glaucoma and correlation with clinical glaucoma stage","volume":"55","author":"Dai","year":"2012","journal-title":"Neuroradiology"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"591.e9","DOI":"10.1016\/j.crad.2018.01.010","article-title":"Microstructural visual pathway abnormalities in patients with primary glaucoma: 3 T diffusion kurtosis imaging study","volume":"73","author":"Xu","year":"2018","journal-title":"Clin. Radiol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"426","DOI":"10.3389\/fnhum.2018.00426","article-title":"Diffusion Tensor Imaging Detects Microstructural Differences of Visual Pathway in Patients with Primary Open-Angle Glaucoma and Ocular Hypertension","volume":"12","author":"Song","year":"2018","journal-title":"Front. Hum. Neurosci."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.exer.2017.02.005","article-title":"Biomechanical aspects of axonal damage in glaucoma: A brief review","volume":"157","author":"Stowell","year":"2017","journal-title":"Exp. Eye Res."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"31464","DOI":"10.1038\/srep31464","article-title":"Retinal Structures and Visual Cortex Activity are Impaired Prior to Clinical Vision Loss in Glaucoma","volume":"6","author":"Murphy","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"W26","DOI":"10.2214\/AJR.13.11365","article-title":"Diffusion Kurtosis Imaging: An Emerging Technique for Evaluating the Microstructural Environment of the Brain","volume":"202","author":"Steven","year":"2014","journal-title":"Am. J. Roentgenol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1002\/mrm.20508","article-title":"Diffusional kurtosis imaging: The quantification of non-gaussian water diffusion by means of magnetic resonance imaging","volume":"53","author":"Jensen","year":"2005","journal-title":"Magn. Reson. Med."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1007\/s00062-018-0728-7","article-title":"Magnetic Resonance Spectroscopy Features of the Visual Pathways in Patients with Glaucoma","volume":"29","author":"Aksoy","year":"2019","journal-title":"Clin. Neuroradiol."},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Nucci, C., Garaci, F., Altobelli, S., Di Ci\u00f2, F., Martucci, A., Aiello, F., Lanzafame, S., Di Giuliano, F., Picchi, E., and Minosse, S. (2020). Diffusional Kurtosis Imaging of White Matter Degeneration in Glaucoma. J. Clin. Med., 9.","DOI":"10.3390\/jcm9103122"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1007\/s10792-017-0658-4","article-title":"Cognitive evaluation of patients with glaucoma and its comparison with individuals with Alzheimer\u2019s disease","volume":"38","author":"Maurano","year":"2017","journal-title":"Int. Ophthalmol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"146874","DOI":"10.1016\/j.brainres.2020.146874","article-title":"Altered information flow and microstructure abnormalities of visual cortex in normal-tension glaucoma: Evidence from resting-state fMRI and DKI","volume":"1741","author":"Li","year":"2020","journal-title":"Brain Res."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.neuroimage.2016.01.047","article-title":"Including diffusion time dependence in the extra-axonal space improves in vivo estimates of axonal diameter and density in human white matter","volume":"130","author":"Jones","year":"2016","journal-title":"NeuroImage"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.neurobiolaging.2018.07.006","article-title":"Modeling white matter tract integrity in aging with diffusional kurtosis imaging","volume":"70","author":"Benitez","year":"2018","journal-title":"Neurobiol. Aging"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1089\/neu.2017.5320","article-title":"White Matter Tract Integrity: An Indicator of Axonal Pathology after Mild Traumatic Brain Injury","volume":"35","author":"Chung","year":"2018","journal-title":"J. Neurotrauma"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.3174\/ajnr.A3553","article-title":"Novel White Matter Tract Integrity Metrics Sensitive to Alzheimer Disease Progression","volume":"34","author":"Fieremans","year":"2013","journal-title":"Am. J. Neuroradiol."},{"key":"ref_105","unstructured":"Jones, D.K. (2010). Diffusion MRI Theory, Methods, and Applications, Oxford University Press."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1093\/brain\/awy338","article-title":"Demyelination precedes axonal loss in the transneuronal spread of human neurodegenerative disease","volume":"142","author":"You","year":"2019","journal-title":"Brain"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"6866","DOI":"10.1038\/s41598-021-85602-x","article-title":"White matter alterations in glaucoma and monocular blindness differ outside the visual system","volume":"11","author":"Hanekamp","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1167\/iovs.63.2.12","article-title":"Consensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms","volume":"63","author":"McDowell","year":"2022","journal-title":"Investig. Opthalmol. Vis. Sci."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.neuroimage.2012.06.081","article-title":"White matter integrity, fiber count, and other fallacies: The do\u2019s and don\u2019ts of diffusion MRI","volume":"73","author":"Jones","year":"2013","journal-title":"NeuroImage"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/j.mri.2012.02.012","article-title":"Effect of cerebrovascular changes on brain DTI quantitation: A hypercapnia study","volume":"30","author":"Ding","year":"2012","journal-title":"Magn. Reson. Imaging"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1006\/nimg.2002.1132","article-title":"Improved Optimization for the Robust and Accurate Linear Registration and Motion Correction of Brain Images","volume":"17","author":"Jenkinson","year":"2002","journal-title":"NeuroImage"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1148\/radiol.2493072141","article-title":"Diffusion-tensor neuronal fiber tractography and manganese-enhanced mr imaging of primate visual pathway in the common marmoset: Preliminary results","volume":"249","author":"Yamada","year":"2008","journal-title":"Radiology"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.clinimag.2019.11.012","article-title":"Demonstration of acute retinal ischemia on diffusion weighted magnetic resonance imaging","volume":"59","author":"Pottabatula","year":"2020","journal-title":"Clin. Imaging"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1002\/mrm.20279","article-title":"Q-ball imaging","volume":"52","author":"Tuch","year":"2004","journal-title":"Magn. Reson. Med."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"2796","DOI":"10.1523\/JNEUROSCI.1770-15.2016","article-title":"Application ofq-Space Diffusion MRI for the Visualization of White Matter","volume":"36","author":"Fujiyoshi","year":"2016","journal-title":"J. Neurosci."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1227\/NEU.0b013e3182592faa","article-title":"High-definition fiber tractography of the human brain","volume":"71","author":"Pathak","year":"2012","journal-title":"Neurosurgery"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1002\/mrm.22073","article-title":"Theory of Q-ball imaging redux: Implications for fiber tracking","volume":"62","author":"Barnett","year":"2009","journal-title":"Magn. Reson. Med."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"2366","DOI":"10.1016\/j.neuroimage.2009.10.022","article-title":"B-value dependence of DTI quantitation and sensitivity in detecting neural tissue changes","volume":"49","author":"Hui","year":"2010","journal-title":"NeuroImage"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"14168","DOI":"10.1038\/s41598-019-50793-x","article-title":"Widespread brain reorganization perturbs visuomotor coordination in early glaucoma","volume":"9","author":"Trivedi","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1001\/jamaneurol.2018.4882","article-title":"Spaceflight-Associated Brain White Matter Microstructural Changes and Intracranial Fluid Redistribution","volume":"76","author":"Lee","year":"2019","journal-title":"JAMA Neurol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1148\/radiol.11102277","article-title":"Parkinson Disease: Diagnostic Utility of Diffusion Kurtosis Imaging","volume":"261","author":"Wang","year":"2011","journal-title":"Radiology"},{"key":"ref_122","doi-asserted-by":"crossref","unstructured":"Surova, Y., Lampinen, B., Nilsson, M., L\u00e4tt, J., Hall, S., Widner, H., van Westen, D., Hansson, O., Swedish BioFINDER study, and van Westen, D. (2016). Alterations of Diffusion Kurtosis and Neurite Density Measures in Deep Grey Matter and White Matter in Parkinson\u2019s Disease. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0157755"},{"key":"ref_123","doi-asserted-by":"crossref","unstructured":"Drouyer, E., Dkhissi-Benyahya, O., Chiquet, C., WoldeMussie, E., Ruiz, G., Wheeler, L.A., Denis, P., and Cooper, H.M. (2008). Glaucoma Alters the Circadian Timing System. PLoS ONE, 3.","DOI":"10.1371\/journal.pone.0003931"},{"key":"ref_124","first-page":"2347","article-title":"Sleep-regulating systems are impaired in glaucoma","volume":"62","author":"Bang","year":"2021","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.cortex.2019.01.011","article-title":"Circadian circuits in humans: White matter microstructure predicts daytime sleepiness","volume":"122","author":"Koller","year":"2019","journal-title":"Cortex"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.nicl.2014.07.010","article-title":"Multi-modal MRI of mild traumatic brain injury","volume":"7","author":"Narayana","year":"2015","journal-title":"NeuroImage Clin."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.expneurol.2014.11.004","article-title":"Repetitive mild traumatic brain injury with impact acceleration in the mouse: Multifocal axonopathy, neuroinflammation, and neurodegeneration in the visual system","volume":"275","author":"Xu","year":"2016","journal-title":"Exp. Neurol."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"e3872","DOI":"10.1002\/nbm.3872","article-title":"Multiband diffusion-weighted MRI of the eye and orbit free of geometric distortions using a RARE-EPI hybrid","volume":"31","author":"Paul","year":"2018","journal-title":"NMR Biomed."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1002\/mrm.24395","article-title":"Noninvasive mapping of water diffusional exchange in the human brain using filter-exchange imaging","volume":"69","author":"Nilsson","year":"2013","journal-title":"Magn. Reson. Med."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"e3711","DOI":"10.1002\/nbm.3711","article-title":"Resolution limit of cylinder diameter estimation by diffusion MRI: The impact of gradient waveform and orientation dispersion","volume":"30","author":"Nilsson","year":"2017","journal-title":"NMR Biomed."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1002\/jmri.27367","article-title":"Role of Structural, Metabolic, and Functional MRI in Monitoring Visual System Impairment and Recovery","volume":"54","author":"Sims","year":"2021","journal-title":"J. Magn. Reson. Imaging"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"32080","DOI":"10.1038\/srep32080","article-title":"Non-invasive MRI Assessments of Tissue Microstructures and Macromolecules in the Eye upon Biomechanical or Biochemical Modulation","volume":"6","author":"Ho","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1002\/hbm.23049","article-title":"Selective reduction of fMRI responses to transient achromatic stimuli in the magnocellular layers of the LGN and the superficial layer of the SC of early glaucoma patients","volume":"37","author":"Zhang","year":"2016","journal-title":"Hum. Brain Mapp."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"4404","DOI":"10.1007\/s00330-016-4279-5","article-title":"In vivo proton magnetic resonance spectroscopy (1H-MRS) evaluation of the metabolite concentration of optic radiation in primary open angle glaucoma","volume":"26","author":"Sidek","year":"2016","journal-title":"Eur. Radiol."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1038\/eye.2012.84","article-title":"Evaluation of corpus geniculatum laterale and vitreous fluid by magnetic resonance spectroscopy in patients with glaucoma; a preliminary study","volume":"26","author":"Doganay","year":"2012","journal-title":"Eye"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.exer.2008.10.002","article-title":"Proton magnetic resonance spectroscopy revealed choline reduction in the visual cortex in an experimental model of chronic glaucoma","volume":"88","author":"Chan","year":"2009","journal-title":"Exp. Eye Res."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1007\/s11604-017-0617-z","article-title":"Evaluation of glymphatic system activity with the diffusion MR technique: Diffusion tensor image analysis along the perivascular space (DTI-ALPS) in Alzheimer\u2019s disease cases","volume":"35","author":"Taoka","year":"2017","journal-title":"Jpn. J. Radiol."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"1","DOI":"10.21037\/qims.2019.11.18","article-title":"Quantitative imaging of the clearance systems in the eye and the brain","volume":"10","author":"Deng","year":"2020","journal-title":"Quant. Imaging Med. Surg."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"3747","DOI":"10.1167\/iovs.14-14263","article-title":"In Vivo Assessment of Aqueous Humor Dynamics Upon Chronic Ocular Hypertension and Hypotensive Drug Treatment Using Gadolinium-Enhanced MRI","volume":"55","author":"Ho","year":"2014","journal-title":"Investig. Opthalmol. Vis. Sci."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1016\/j.neuroimage.2008.01.002","article-title":"Evaluation of the retina and optic nerve in a rat model of chronic glaucoma using in vivo manganese-enhanced magnetic resonance imaging","volume":"40","author":"Chan","year":"2008","journal-title":"NeuroImage"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.exer.2008.06.015","article-title":"GD-DTPA enhanced MRI of ocular transport in a rat model of chronic glaucoma","volume":"87","author":"Chan","year":"2008","journal-title":"Exp. Eye Res."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"S290","DOI":"10.1016\/S0039-6257(01)00206-5","article-title":"Role of Alpha-2 Adrenergic Receptors in Neuroprotection and Glaucoma","volume":"45","author":"Wheeler","year":"2001","journal-title":"Surv. Ophthalmol."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"e06701","DOI":"10.1016\/j.heliyon.2021.e06701","article-title":"A longitudinal comparison in cynomolgus macaques of the effect of brimonidine on optic nerve neuropathy using diffusion tensor imaging magnetic resonance imaging and spectral domain optical coherence tomography","volume":"7","author":"Takahashi","year":"2021","journal-title":"Heliyon"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/s13311-015-0348-8","article-title":"Gaps Between Aims and Achievements in Therapeutic Modification of Neuronal Damage (\u201cNeuroprotection\u201d)","volume":"12","author":"Wiendl","year":"2015","journal-title":"Neurotherapeutics"}],"container-title":["Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-7737\/11\/3\/454\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:37:50Z","timestamp":1760135870000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-7737\/11\/3\/454"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,16]]},"references-count":144,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2022,3]]}},"alternative-id":["biology11030454"],"URL":"https:\/\/doi.org\/10.3390\/biology11030454","relation":{},"ISSN":["2079-7737"],"issn-type":[{"value":"2079-7737","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,16]]}}}