{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:59:28Z","timestamp":1792789168012,"version":"4.5.0"},"reference-count":77,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2022,4,18]],"date-time":"2022-04-18T00:00:00Z","timestamp":1650240000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001862","name":"Swedish Research Council for Environment Agricultural Sciences and Spatial Planning","doi-asserted-by":"publisher","award":["Project 2017-00946 and 2019-00288"],"award-info":[{"award-number":["Project 2017-00946 and 2019-00288"]}],"id":[{"id":"10.13039\/501100001862","id-type":"DOI","asserted-by":"publisher"}]},{"name":"MCIN\/AEI \/10.13039\/501100011033 (Spain) and FEDER funds (EU).","award":["PID2019-108320RJ-I00 and IJCI-2015-24380"],"award-info":[{"award-number":["PID2019-108320RJ-I00 and IJCI-2015-24380"]}]},{"DOI":"10.13039\/501100003176","name":"Ministerio de Educaci\u00f3n Cultura y Deporte","doi-asserted-by":"publisher","award":["FPU15\/06029"],"award-info":[{"award-number":["FPU15\/06029"]}],"id":[{"id":"10.13039\/501100003176","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002809","name":"Generalitat de Catalunya","doi-asserted-by":"publisher","award":["2018 FI_B 00236"],"award-info":[{"award-number":["2018 FI_B 00236"]}],"id":[{"id":"10.13039\/501100002809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biology"],"abstract":"<jats:p>Uterine homeostasis is maintained after mating by eliminating pathogens, foreign cells, and proteins by a transient inflammation of the uterus. Such inflammation does not occur in the oviductal sperm reservoir (utero-tubal junction, UTJ), colonized by a population of potentially fertile spermatozoa before the inflammatory changes are triggered. Semen entry (spermatozoa and\/or seminal plasma) modifies the expression of regulatory genes, including cell proliferation and differentiation-related transcripts. Considering pigs display a fractionated ejaculation, this study aims to determine whether different ejaculate fractions differentially modulate cell proliferation and differentiation-related transcripts in the sow reproductive tract during the peri-ovulatory stage. Using species-specific microarray analyses, the differential expression of 144 cell proliferation and differentiation-related transcripts was studied in specific segments: cervix (Cvx), distal and proximal uterus (DistUt, ProxUt), UTJ, isthmus (Isth), ampulla (Amp), and infundibulum (Inf) of the peri-ovulatory sow reproductive tract in response to semen and\/or seminal plasma cervical deposition. Most mRNA expression changes were induced by mating. In addition, while mating upregulates the fibroblast growth factor 1 (FGF1, p-value DistUt = 0.0007; ProxUt = 0.0253) transcript in the endometrium, both its receptor, the fibroblast growth factor receptor 1 (FGFR1, p-value DistUt = 2.14 e\u221206; ProxUt = 0.0027; UTJ = 0.0458) transcript, and a potentiator of its biological effect, the fibroblast growth factor binding protein 1 (FGFBP1), were downregulated in the endometrium (p-value DistUt = 0.0068; ProxUt = 0.0011) and the UTJ (p-value UTJ = 0.0191). The FGFBP1 was downregulated in the whole oviduct after seminal depositions (p-value Isth = 0.0007; Amp = 0.0007; Inf = 6.87 e\u221205) and, interestingly, FGFR1 was downregulated in the endometrium in the absence of semen (p-value DistUt = 0.0097; ProxUt = 0.0456). In conclusion, the findings suggest that spermatozoa, seminal components, and the act of mating trigger, besides inflammation, differential mechanisms in the peri-ovulatory female reproductive tract, relevant for tissue repair.<\/jats:p>","DOI":"10.3390\/biology11040616","type":"journal-article","created":{"date-parts":[[2022,4,18]],"date-time":"2022-04-18T22:04:02Z","timestamp":1650319442000},"page":"616","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Semen Modulates Cell Proliferation and Differentiation-Related Transcripts in the Pig Peri-Ovulatory Endometrium"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7524-2088","authenticated-orcid":false,"given":"Jaume","family":"Gardela","sequence":"first","affiliation":[{"name":"Department of Biomedical & Clinical Sciences (BKV), BKH\/Obstetrics & Gynecology, Faculty of Medicine and Health Sciences, Link\u00f6ping University, 58185 Link\u00f6ping, Sweden"},{"name":"Department of Animal Health and Anatomy, Veterinary Faculty, Universitat Aut\u00f2noma de Barcelona, Bellaterra, 08193 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7092-7993","authenticated-orcid":false,"given":"Mateo","family":"Ruiz-Conca","sequence":"additional","affiliation":[{"name":"Department of Biomedical & Clinical Sciences (BKV), BKH\/Obstetrics & Gynecology, Faculty of Medicine and Health Sciences, Link\u00f6ping University, 58185 Link\u00f6ping, Sweden"},{"name":"Department of Animal Health and Anatomy, Veterinary Faculty, Universitat Aut\u00f2noma de Barcelona, Bellaterra, 08193 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2329-2635","authenticated-orcid":false,"given":"Dominic","family":"Wright","sequence":"additional","affiliation":[{"name":"Department of Physics, Chemistry and Biology, Faculty of Science and Engineering, Link\u00f6ping University, 58185 Link\u00f6ping, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9490-6126","authenticated-orcid":false,"given":"Manel","family":"L\u00f3pez-B\u00e9jar","sequence":"additional","affiliation":[{"name":"Department of Animal Health and Anatomy, Veterinary Faculty, Universitat Aut\u00f2noma de Barcelona, Bellaterra, 08193 Barcelona, Spain"},{"name":"College of Veterinary Medicine, Western University of Health Sciences, Pomona, CA 91766, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6811-0191","authenticated-orcid":false,"given":"Cristina A.","family":"Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Department of Biomedical & Clinical Sciences (BKV), BKH\/Obstetrics & Gynecology, Faculty of Medicine and Health Sciences, Link\u00f6ping University, 58185 Link\u00f6ping, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5194-2124","authenticated-orcid":false,"given":"Heriberto","family":"Rodr\u00edguez-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Department of Biomedical & Clinical Sciences (BKV), BKH\/Obstetrics & Gynecology, Faculty of Medicine and Health Sciences, Link\u00f6ping University, 58185 Link\u00f6ping, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0120-354X","authenticated-orcid":false,"given":"Manuel","family":"\u00c1lvarez-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Department of Biomedical & Clinical Sciences (BKV), BKH\/Obstetrics & Gynecology, Faculty of Medicine and Health Sciences, Link\u00f6ping University, 58185 Link\u00f6ping, Sweden"},{"name":"Department of Animal Health and Anatomy, Veterinary Faculty, Universitat Aut\u00f2noma de Barcelona, Bellaterra, 08193 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"881","DOI":"10.2471\/BLT.10.011210","article-title":"Mother or nothing: The agony of infertility","volume":"88","author":"Cui","year":"2010","journal-title":"Bull. 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