{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T22:46:31Z","timestamp":1790635591904,"version":"4.1.0"},"reference-count":111,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2022,6,28]],"date-time":"2022-06-28T00:00:00Z","timestamp":1656374400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biology"],"abstract":"<jats:p>Cystitis is a bladder disease with a high rate of prevalence in the world population. This report focuses on Interstitial Cystitis (IC), Hemorrhagic Cystitis (HC) and Chronic Radiation Cystitis. These pathologies have different etiologies, but they share common symptoms, for instance, pain, bleeding, and a contracted bladder. Overall, treatments are quite similar for abacterial cystitis, and include bladder epithelium protective or anti-inflammatory agents, alleviating pain and reducing bleeding. This review summarizes the mechanisms that the pathologies have in common, for instance, bladder dysfunction and inflammation. Conversely, some mechanisms have been described as present in only one pathology, such as neural regulation. Based on these specificities, we propose identifying a mechanism that could be common to all the above-mentioned pathologies.<\/jats:p>","DOI":"10.3390\/biology11070972","type":"journal-article","created":{"date-parts":[[2022,6,28]],"date-time":"2022-06-28T03:16:06Z","timestamp":1656386166000},"page":"972","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Molecular Mechanisms and Key Processes in Interstitial, Hemorrhagic and Radiation Cystitis"],"prefix":"10.3390","volume":"11","author":[{"given":"Cl\u00e9ment","family":"Brossard","sequence":"first","affiliation":[{"name":"Laboratoire de Radiobiologie des Expositions M\u00e9dicales (LRMED), Service de Recherche en Radiobiologie et en M\u00e9decine R\u00e9g\u00e9n\u00e9rative (SERAMED), Institut de Radioprotection et de S\u00fbret\u00e9 Nucl\u00e9aire (IRSN), 92260 Fontenay-aux-Roses, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Charlotte","family":"Lefranc","sequence":"additional","affiliation":[{"name":"Laboratoire de Radiobiologie des Expositions M\u00e9dicales (LRMED), Service de Recherche en Radiobiologie et en M\u00e9decine R\u00e9g\u00e9n\u00e9rative (SERAMED), Institut de Radioprotection et de S\u00fbret\u00e9 Nucl\u00e9aire (IRSN), 92260 Fontenay-aux-Roses, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Laure","family":"Pouliet","sequence":"additional","affiliation":[{"name":"Laboratoire de Radiobiologie des Expositions M\u00e9dicales (LRMED), Service de Recherche en Radiobiologie et en M\u00e9decine R\u00e9g\u00e9n\u00e9rative (SERAMED), Institut de Radioprotection et de S\u00fbret\u00e9 Nucl\u00e9aire (IRSN), 92260 Fontenay-aux-Roses, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Marc","family":"Simon","sequence":"additional","affiliation":[{"name":"Radiotherapy Oncology Department, H\u00f4pital Universitaire Piti\u00e9-Salp\u00eatri\u00e8re, 47-83 Boulevard de l\u2019H\u00f4pital, CEDEX 13, 75651 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Benderitter","sequence":"additional","affiliation":[{"name":"Laboratoire de Radiobiologie des Expositions M\u00e9dicales (LRMED), Service de Recherche en Radiobiologie et en M\u00e9decine R\u00e9g\u00e9n\u00e9rative (SERAMED), Institut de Radioprotection et de S\u00fbret\u00e9 Nucl\u00e9aire (IRSN), 92260 Fontenay-aux-Roses, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabien","family":"Milliat","sequence":"additional","affiliation":[{"name":"Laboratoire de Radiobiologie des Expositions M\u00e9dicales (LRMED), Service de Recherche en Radiobiologie et en M\u00e9decine R\u00e9g\u00e9n\u00e9rative (SERAMED), Institut de Radioprotection et de S\u00fbret\u00e9 Nucl\u00e9aire (IRSN), 92260 Fontenay-aux-Roses, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4687-4120","authenticated-orcid":false,"given":"Alain","family":"Chapel","sequence":"additional","affiliation":[{"name":"Laboratoire de Radiobiologie des Expositions M\u00e9dicales (LRMED), Service de Recherche en Radiobiologie et en M\u00e9decine R\u00e9g\u00e9n\u00e9rative (SERAMED), Institut de Radioprotection et de S\u00fbret\u00e9 Nucl\u00e9aire (IRSN), 92260 Fontenay-aux-Roses, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.juro.2012.09.022","article-title":"The distribution and function of chondroitin sulfate and other sulfated glycosaminoglycans in the human bladder and their contribution to the protective bladder barrier","volume":"189","author":"Janssen","year":"2013","journal-title":"J. Urol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/nature09851","article-title":"Hedgehog\/Wnt feedback supports regenerative proliferation of epithelial stem cells in bladder","volume":"472","author":"Shin","year":"2011","journal-title":"Nature"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Lang, R., Liu, G., Shi, Y., Bharadwaj, S., Leng, X., Zhou, X., Liu, H., Atala, A., and Zhang, Y. (2013). Self-renewal and differentiation capacity of urine-derived stem cells after urine preservation for 24 hours. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0053980"},{"key":"ref_4","first-page":"S3","article-title":"Interstitial cystitis-epidemiology, diagnostic criteria, clinical markers","volume":"4","author":"Hanno","year":"2002","journal-title":"Rev. Urol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/S0090-4295(99)80327-6","article-title":"Epidemiology of interstitial cystitis","volume":"49","author":"Jones","year":"1997","journal-title":"Urology"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/S0022-5347(17)36120-7","article-title":"The natural history of interstitial cystitis: A survey of 374 patients","volume":"149","author":"Koziol","year":"1993","journal-title":"J. Urol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/S0090-4295(99)80332-X","article-title":"Interstitial cystitis: Unexplained associations with other chronic disease and pain syndromes","volume":"49","author":"Alagiri","year":"1997","journal-title":"Urology"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2118","DOI":"10.1016\/S0022-5347(05)65517-6","article-title":"How do patients with interstitial cystitis present?","volume":"166","author":"Driscoll","year":"2001","journal-title":"J. Urol."},{"key":"ref_9","first-page":"1068","article-title":"Recent trends in patient characteristics and therapeutic choices for interstitial cystitis: Analysis of 282 Japanese patients","volume":"14","author":"Ito","year":"2007","journal-title":"Int. J. Urol. Off. J. Jpn. Urol. Assoc."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.urology.2011.04.030","article-title":"Are ulcerative and nonulcerative interstitial cystitis\/painful bladder syndrome 2 distinct diseases? A study of coexisting conditions","volume":"78","author":"Peters","year":"2011","journal-title":"Urology"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1055\/s-0038-1676089","article-title":"Interstitial Cystitis\/Bladder Pain Syndrome","volume":"36","author":"Marcu","year":"2018","journal-title":"Semin. Reprod. Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1111\/bju.12291","article-title":"Chemical- and radiation-induced haemorrhagic cystitis: Current treatments and challenges","volume":"112","author":"Payne","year":"2013","journal-title":"BJU Int."},{"key":"ref_13","first-page":"568","article-title":"Management of radiation cystitis","volume":"14","author":"Rigaud","year":"2004","journal-title":"Prog. Urol. J. L\u2019Assoc. Fr. D\u2019Urol. Soc. Fr. D\u2019Urol."},{"key":"ref_14","first-page":"591","article-title":"Hemorrhagic cystitis: Etiology and treatment","volume":"11","author":"Traxer","year":"2001","journal-title":"Prog. Urol. J. L\u2019Assoc. Fr. D\u2019Urol. Soc. Fr. D\u2019Urol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1182\/blood-2004-12-4988","article-title":"BK DNA viral load in plasma: Evidence for an association with hemorrhagic cystitis in allogeneic hematopoietic cell transplant recipients","volume":"106","author":"Erard","year":"2005","journal-title":"Blood"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"159","DOI":"10.4103\/0970-1591.65380","article-title":"Hemorrhagic cystitis: A challenge to the urologist","volume":"26","author":"Manikandan","year":"2010","journal-title":"Indian J. Urol. IJU J. Urol. Soc. India"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0022-5347(17)39848-8","article-title":"Hemorrhagic cystitis: A review","volume":"143","author":"Freiha","year":"1990","journal-title":"J. Urol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1200\/JCO.1989.7.2.194","article-title":"Hemorrhagic cystitis following high-dose chemotherapy and bone marrow transplantation in children with malignancies: Incidence, clinical course, and outcome","volume":"7","author":"Brugieres","year":"1989","journal-title":"J. Clin. Oncol. Off. J. Am. Soc. Clin. Oncol."},{"key":"ref_19","first-page":"385","article-title":"Preparative regimens for marrow transplantation containing busulphan are associated with haemorrhagic cystitis and hepatic veno-occlusive disease but a short duration of leucopenia and little oro-pharyngeal mucositis","volume":"2","author":"Atkinson","year":"1987","journal-title":"Bone Marrow Transpl."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1159\/000049760","article-title":"Radiation-induced haemorrhagic cystitis","volume":"40","author":"Crew","year":"2001","journal-title":"Eur. Urol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1097\/01.ju.0000148361.82074.77","article-title":"Abnormal urinary potassium metabolism in patients with interstitial cystitis","volume":"173","author":"Parsons","year":"2005","journal-title":"J. Urol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1007\/s00404-017-4364-2","article-title":"Etiology, pathophysiology and biomarkers of interstitial cystitis\/painful bladder syndrome","volume":"295","author":"Patnaik","year":"2017","journal-title":"Arch. Gynecol. Obstet."},{"key":"ref_23","first-page":"542","article-title":"Clinical guidelines for interstitial cystitis and hypersensitive bladder updated in 2015","volume":"23","author":"Homma","year":"2016","journal-title":"Int. J. Urol. Off. J. Jpn. Urol. Assoc."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1016\/S0022-5347(05)68345-0","article-title":"Antiproliferative activity is present in bladder but not renal pelvic urine from interstitial cystitis patients","volume":"162","author":"Keay","year":"1999","journal-title":"J. Urol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2382","DOI":"10.1097\/01.ju.0000180417.11976.99","article-title":"Regulation of tight junction proteins and bladder epithelial paracellular permeability by an antiproliferative factor from patients with interstitial cystitis","volume":"174","author":"Zhang","year":"2005","journal-title":"J. Urol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1159\/000282832","article-title":"Distinctive ultrastructural pathology of nonulcerative interstitial cystitis: New observations and their potential significance in pathogenesis","volume":"56","author":"Elbadawi","year":"1996","journal-title":"Urol. Int."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0090-4295(01)01166-9","article-title":"Biopsy features are associated with primary symptoms in interstitial cystitis: Results from the interstitial cystitis database study","volume":"57","author":"Tomaszewski","year":"2001","journal-title":"Urology"},{"key":"ref_28","first-page":"203","article-title":"Intravesical hyaluronic acid for interstitial cystitis\/painful bladder syndrome: A comparative randomized assessment of different regimens","volume":"20","author":"Lai","year":"2013","journal-title":"Int. J. Urol. Off. J. Jpn. Urol. Assoc."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"865463","DOI":"10.1155\/2014\/865463","article-title":"Evidence for bladder urothelial pathophysiology in functional bladder disorders","volume":"2014","author":"Keay","year":"2014","journal-title":"BioMed Res. Int."},{"key":"ref_30","first-page":"563","article-title":"Increased bladder permeability in interstitial cystitis\/painful bladder syndrome","volume":"4","author":"Hurst","year":"2015","journal-title":"Transl. Androl. Urol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"225.e13","DOI":"10.1016\/j.urology.2012.01.047","article-title":"Differences in mast cell infiltration, E-cadherin, and zonula occludens-1 expression between patients with overactive bladder and interstitial cystitis\/bladder pain syndrome","volume":"80","author":"Liu","year":"2012","journal-title":"Urology"},{"key":"ref_32","first-page":"473536","article-title":"Cystitis: From urothelial cell biology to clinical applications","volume":"2014","author":"Lee","year":"2014","journal-title":"BioMed Res. Int."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1016\/0006-2952(79)90222-3","article-title":"Cyclophosphamide cystitis--identification of acrolein as the causative agent","volume":"28","author":"Cox","year":"1979","journal-title":"Biochem. Pharmacol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.radonc.2006.07.015","article-title":"Radiation-induced damage to mouse urothelial barrier","volume":"80","author":"Jaal","year":"2006","journal-title":"Radiother. Oncol. J. Eur. Soc. Ther. Radiol. Oncol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.adro.2016.07.004","article-title":"Modeling of chronic radiation-induced cystitis in mice","volume":"1","author":"Zwaans","year":"2016","journal-title":"Adv. Radiat. Oncol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"673","DOI":"10.3109\/02841869209083852","article-title":"Urination frequency and cystic pressure resistance after fractionated whole or partial irradiation of the rabbit urinary bladder","volume":"31","author":"Kohler","year":"1992","journal-title":"Acta Oncol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.juro.2015.03.108","article-title":"Intravesical Liposomal Tacrolimus Protects against Radiation Cystitis Induced by 3-Beam Targeted Bladder Radiation","volume":"194","author":"Rajaganapathy","year":"2015","journal-title":"J. Urol."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Jiang, Y.H., Peng, C.H., Liu, H.T., and Kuo, H.C. (2013). Increased pro-inflammatory cytokines, C-reactive protein and nerve growth factor expressions in serum of patients with interstitial cystitis\/bladder pain syndrome. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0076779"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Wang, Q., Wu, Q., Wang, J., Chen, Y., Zhang, G., Chen, J., Zhao, J., and Wu, P. (2017). Ketamine Analog Methoxetamine Induced Inflammation and Dysfunction of Bladder in Rats. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18010117"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1111\/jcmm.12624","article-title":"The secretome of myocardial telocytes modulates the activity of cardiac stem cells","volume":"19","author":"Albulescu","year":"2015","journal-title":"J. Cell. Mol. Med."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.1111\/j.1582-4934.2011.01449.x","article-title":"Experimental acute myocardial infarction: Telocytes involvement in neo-angiogenesis","volume":"15","author":"Manole","year":"2011","journal-title":"J. Cell. Mol. Med."},{"key":"ref_42","first-page":"1067","article-title":"Telocytes, a distinct type of cell among the stromal cells present in the lamina propria of jejunum","volume":"27","author":"Cretoiu","year":"2012","journal-title":"Histol. Histopathol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/S0090-4295(00)01110-9","article-title":"Intravesical potassium sensitivity in patients with interstitial cystitis and urethral syndrome","volume":"57","author":"Parsons","year":"2001","journal-title":"Urology"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.urology.2006.08.1109","article-title":"The mast cell in interstitial cystitis: Role in pathophysiology and pathogenesis","volume":"69","author":"Sant","year":"2007","journal-title":"Urology"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0090-4295(01)01129-3","article-title":"Mast cell involvement in interstitial cystitis: A review of human and experimental evidence","volume":"57","author":"Theoharides","year":"2001","journal-title":"Urology"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/S0022-5347(05)67873-1","article-title":"Recruitment, distribution and phenotypes of mast cells in interstitial cystitis","volume":"163","author":"Peeker","year":"2000","journal-title":"J. Urol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0014-2999(97)83033-6","article-title":"Human mast cell tryptase: A stimulus of microvascular leakage and mast cell activation","volume":"328","author":"He","year":"1997","journal-title":"Eur. J. Pharmacol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/s00441-002-0638-4","article-title":"Kit-negative fibroblast-like cells expressing SK3, a Ca2+-activated K+ channel, in the gut musculature in health and disease","volume":"310","author":"Vanderwinden","year":"2002","journal-title":"Cell Tissue Res."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"2586","DOI":"10.1111\/j.1582-4934.2011.01262.x","article-title":"Characterization of upper lamina propria interstitial cells in bladders from patients with neurogenic detrusor overactivity and bladder pain syndrome","volume":"15","author":"Gevaert","year":"2011","journal-title":"J. Cell. Mol. Med."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Gevaert, T., Moles Lopez, X., Sagaert, X., Libbrecht, L., Roskams, T., Rorive, S., Decaestecker, C., Salmon, I., and De Ridder, D. (2015). Morphometric and quantitative immunohistochemical analysis of disease-related changes in the upper (suburothelial) lamina propria of the human bladder dome. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0127020"},{"key":"ref_51","first-page":"118","article-title":"The telocytes\/myofibroblasts 3-D network forms a stretch receptor in the human bladder mucosa. Is this structure involved in the detrusor overactive diseases?","volume":"218","author":"Vannucchi","year":"2018","journal-title":"Ann. Anat. = Anat. Anz. Off. Organ Anat. Ges."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1111\/jcmm.13308","article-title":"Adaptive changes of telocytes in the urinary bladder of patients affected by neurogenic detrusor overactivity","volume":"22","author":"Traini","year":"2018","journal-title":"J. Cell. Mol. Med."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/bcpt.12626","article-title":"The Role of the Mucosa in Normal and Abnormal Bladder Function","volume":"119","author":"Fry","year":"2016","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1002\/nau.20938","article-title":"Elevation of serum c-reactive protein in patients with OAB and IC\/BPS implies chronic inflammation in the urinary bladder","volume":"30","author":"Chung","year":"2011","journal-title":"Neurourol. Urodyn."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1590\/S0102-86502010000100011","article-title":"Protective effect of simvastatin in the cyclophosphamide-induced hemorrhagic cystitis in rats","volume":"25","author":"Dantas","year":"2010","journal-title":"Acta Cir. Bras."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"R574","DOI":"10.1152\/ajpregu.00465.2002","article-title":"COX-2 and prostanoid expression in micturition pathways after cyclophosphamide-induced cystitis in the rat","volume":"284","author":"Hu","year":"2003","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/s10565-006-0078-0","article-title":"Pathophysiological aspects of cyclophosphamide and ifosfamide induced hemorrhagic cystitis; implication of reactive oxygen and nitrogen species as well as PARP activation","volume":"23","author":"Korkmaz","year":"2007","journal-title":"Cell Biol. Toxicol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0378-4274(02)00508-8","article-title":"Peroxynitrite-induced cytotoxicity: Mechanism and opportunities for intervention","volume":"140\u2013141","author":"Virag","year":"2003","journal-title":"Toxicol. Lett."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1002\/jbt.21494","article-title":"Uroprotective effect of pentoxifylline in cyclophosphamide-induced hemorrhagic cystitis in rats","volume":"27","year":"2013","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.intimp.2018.06.031","article-title":"Neutrophils contribute to the pathogenesis of hemorrhagic cystitis induced by ifosfamide","volume":"62","author":"Pereira","year":"2018","journal-title":"Int. Immunopharmacol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"199","DOI":"10.3109\/02841869509093956","article-title":"Histological changes after fractionated whole or partial irradiation of the rabbit urinary bladder","volume":"34","author":"Kohler","year":"1995","journal-title":"Acta Oncol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1016\/S0022-5347(05)00658-0","article-title":"Radiation induced inflammatory changes in the mouse bladder: The role of cyclooxygenase-2","volume":"175","author":"Jaal","year":"2006","journal-title":"J. Urol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1097\/01.ju.0000135009.55905.cb","article-title":"Possible mechanisms inducing glomerulations in interstitial cystitis: Relationship between endoscopic findings and expression of angiogenic growth factors","volume":"172","author":"Tamaki","year":"2004","journal-title":"J. Urol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1111\/j.1464-410X.2009.08467.x","article-title":"Increased vascular endothelial growth factor expression in patients with bladder pain syndrome\/interstitial cystitis: Its association with pain severity and glomerulations","volume":"104","author":"Kiuchi","year":"2009","journal-title":"BJU Int."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"971.e11","DOI":"10.1016\/j.urology.2011.05.050","article-title":"Increased expression of hypoxia-inducible factor-1alpha and vascular endothelial growth factor associated with glomerulation formation in patients with interstitial cystitis","volume":"78","author":"Lee","year":"2011","journal-title":"Urology"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/s00345-012-0852-y","article-title":"Mapping the cytokine profile of painful bladder syndrome\/interstitial cystitis in human bladder and urine specimens","volume":"31","author":"Corcoran","year":"2013","journal-title":"World J. Urol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.biocel.2016.02.012","article-title":"Uroprotective effect of oleuropein in a rat model of hemorrhagic cystitis","volume":"74","author":"Sherif","year":"2016","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.ejphar.2013.03.008","article-title":"Relevance of the cyclophosphamide-induced cystitis model for pharmacological studies targeting inflammation and pain of the bladder","volume":"707","author":"Auge","year":"2013","journal-title":"Eur. J. Pharmacol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1002\/nau.21002","article-title":"Vascular therapy for radiation cystitis","volume":"30","author":"Soler","year":"2011","journal-title":"Neurourol. Urodyn."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"2696","DOI":"10.1016\/j.juro.2006.07.138","article-title":"Radiation induced late damage to the barrier function of small blood vessels in mouse bladder","volume":"176","author":"Jaal","year":"2006","journal-title":"J. Urol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"e14377","DOI":"10.14814\/phy2.14377","article-title":"Radiation cystitis modeling: A comparative study of bladder fibrosis radio-sensitivity in C57BL\/6, C3H, and BALB\/c mice","volume":"8","author":"Zwaans","year":"2020","journal-title":"Physiol. Rep."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.12688\/f1000research.16096.1","article-title":"Recent advances in imaging and understanding interstitial cystitis","volume":"7","author":"Tyagi","year":"2018","journal-title":"F1000Research"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.3892\/mmr.2016.5482","article-title":"Evaluation of urinary bladder fibrogenesis in a mouse model of long-term ketamine injection","volume":"14","author":"Shen","year":"2016","journal-title":"Mol. Med. Rep."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"9782","DOI":"10.1038\/s41598-018-28093-7","article-title":"Downregulation of WNT11 is associated with bladder tissue fibrosis in patients with interstitial cystitis\/bladder pain syndrome without Hunner lesion","volume":"8","author":"Choi","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/1476-9255-6-23","article-title":"Gender-based reciprocal expression of transforming growth factor-beta1 and the inducible nitric oxide synthase in a rat model of cyclophosphamide-induced cystitis","volume":"6","author":"Tyagi","year":"2009","journal-title":"J. Inflamm."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1097\/00042307-200307000-00007","article-title":"Recent developments in the management of interstitial cystitis","volume":"13","author":"Bouchelouche","year":"2003","journal-title":"Curr. Opin. Urol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/S0090-4295(01)01112-8","article-title":"Clinical highlights of the National Institute of Diabetes and Digestive and Kidney Diseases\/Interstitial Cystitis Association scientific conference on interstitial cystitis","volume":"57","author":"Hanno","year":"2001","journal-title":"Urology"},{"key":"ref_78","first-page":"167","article-title":"From interstitial cystitis to chronic pelvic pain","volume":"3","author":"Persu","year":"2010","journal-title":"J. Med. Life"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"619","DOI":"10.2307\/3579377","article-title":"Radiation-induced changes in transforming growth factor beta and collagen expression in the murine bladder wall and its correlation with bladder function","volume":"146","author":"Kraft","year":"1996","journal-title":"Radiat. Res."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"2441","DOI":"10.1002\/nau.23721","article-title":"Relaxin-2 therapy reverses radiation-induced fibrosis and restores bladder function in mice","volume":"37","author":"Ikeda","year":"2018","journal-title":"Neurourol. Urodyn."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"649","DOI":"10.2307\/3574851","article-title":"Late radiation damage in the mouse bladder as measured by increased urination frequency","volume":"75","author":"Stewart","year":"1978","journal-title":"Radiat. Res."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0167-8140(84)80049-3","article-title":"Multifraction irradiation of mouse bladders","volume":"2","author":"Stewart","year":"1984","journal-title":"Radiother. Oncol. J. Eur. Soc. Ther. Radiol. Oncol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/S0167-8140(85)80123-7","article-title":"The proliferative and functional response of mouse bladder to treatment with radiation and cyclophosphamide","volume":"4","author":"Stewart","year":"1985","journal-title":"Radiother. Oncol. J. Eur. Soc. Ther. Radiol. Oncol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1259\/0007-1285-54-645-799","article-title":"Repair during fractionated irradiation of the mouse bladder","volume":"54","author":"Stewart","year":"1981","journal-title":"Br. J. Radiol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1038\/nrurol.2010.23","article-title":"Management of radiation cystitis","volume":"7","author":"Smit","year":"2010","journal-title":"Nat. Rev. Urol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1016\/S0022-5347(05)66981-9","article-title":"Pentosanpolysulfate inhibits mast cell histamine secretion and intracellular calcium ion levels: An alternative explanation of its beneficial effect in interstitial cystitis","volume":"164","author":"Chiang","year":"2000","journal-title":"J. Urol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1590\/1806-9282.65.4.535","article-title":"Interstitial cystitis-intravesical treatment","volume":"65","author":"Almeida","year":"2019","journal-title":"Rev. Assoc. Med. Bras. (1992)"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1111\/bju.14516","article-title":"Current management of radiation cystitis: A review and practical guide to clinical management","volume":"123","author":"Pascoe","year":"2019","journal-title":"BJU Int."},{"key":"ref_89","first-page":"S21","article-title":"The role of pentosan polysulfate in treatment approaches for interstitial cystitis","volume":"4","author":"Teichman","year":"2002","journal-title":"Rev. Urol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1016\/S0022-5347(17)38437-9","article-title":"Epithelial dysfunction in nonbacterial cystitis (interstitial cystitis)","volume":"145","author":"Parsons","year":"1991","journal-title":"J. Urol."},{"key":"ref_91","first-page":"331","article-title":"Clinical Management of Bladder Pain Syndrome\/Interstitial Cystitis: A Review on Current Recommendations and Emerging Treatment Options","volume":"12","author":"Colemeadow","year":"2020","journal-title":"Res. Rep. Urol."},{"key":"ref_92","first-page":"677","article-title":"Current guidelines in the management of interstitial cystitis","volume":"4","author":"Colaco","year":"2015","journal-title":"Transl. Androl. Urol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.1016\/S0022-5347(05)65134-8","article-title":"Tumor necrosis factor-alpha and interleukin-1beta mediate the production of nitric oxide involved in the pathogenesis of ifosfamide induced hemorrhagic cystitis in mice","volume":"167","author":"Ribeiro","year":"2002","journal-title":"J. Urol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1560363","DOI":"10.1155\/2017\/1560363","article-title":"Treatment of Severe Refractory Hematuria due to Radiation-Induced Hemorrhagic Cystitis with Dexamethasone","volume":"2017","author":"Nascimento","year":"2017","journal-title":"Case Rep. Med."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/S0022-5347(17)37356-1","article-title":"Aluminum toxicity and death following intravesical alum irrigation in a patient with renal impairment","volume":"147","author":"Shoskes","year":"1992","journal-title":"J. Urol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/S0022-5347(17)45009-9","article-title":"Encephalopathy and an elevated serum aluminum level in a patient receiving intravesical alum irrigation for severe urinary hemorrhage","volume":"136","author":"Kavoussi","year":"1986","journal-title":"J. Urol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1097\/SPC.0000000000000375","article-title":"A contemporary review about the management of radiation-induced hemorrhagic cystitis","volume":"12","author":"Dautruche","year":"2018","journal-title":"Curr. Opin. Supportive Palliat. Care"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1007\/s11934-018-0790-3","article-title":"Scoping Review and Meta-analysis of Hyperbaric Oxygen Therapy for Radiation-Induced Hemorrhagic Cystitis","volume":"19","author":"Cardinal","year":"2018","journal-title":"Curr. Urol. Rep."},{"key":"ref_99","first-page":"98","article-title":"Hyperbaric oxygen therapy for radiation cystitis after pelvic radiotherapy: Systematic review of the recent literature","volume":"27","author":"Villeirs","year":"2020","journal-title":"Int. J. Urol. Off. J. Jpn. Urol. Assoc."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1016\/S1470-2045(19)30494-2","article-title":"Radiation-induced cystitis treated with hyperbaric oxygen therapy (RICH-ART): A randomised, controlled, phase 2\u20133 trial","volume":"20","author":"Oscarsson","year":"2019","journal-title":"Lancet Oncol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"8134","DOI":"10.1038\/s41598-019-44631-3","article-title":"N-acetylcysteine prevents bladder tissue fibrosis in a lipopolysaccharide-induced cystitis rat model","volume":"9","author":"Ryu","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1111\/j.1464-410X.2006.06274.x","article-title":"MN-001, a novel oral anti-inflammatory agent, suppresses bladder hyperactivity in a rat model","volume":"98","author":"Rajasekaran","year":"2006","journal-title":"BJU Int."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1002\/nau.23204","article-title":"Dimethyl sulfoxide (DMSO) as intravesical therapy for interstitial cystitis\/bladder pain syndrome: A review","volume":"36","author":"Rawls","year":"2017","journal-title":"Neurourol. Urodyn."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.urology.2006.08.1108","article-title":"Neural upregulation in interstitial cystitis","volume":"69","author":"Nazif","year":"2007","journal-title":"Urology"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1046\/j.1464-410X.2002.02912.x","article-title":"Effects of dimethyl sulphoxide and heparin on stretch-activated ATP release by bladder urothelial cells from patients with interstitial cystitis","volume":"90","author":"Sun","year":"2002","journal-title":"BJU Int."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1310\/hpj4909-809","article-title":"Amitriptyline: Interstitial cystitis (painful bladder syndrome)","volume":"49","author":"Generali","year":"2014","journal-title":"Hosp. Pharm."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.urology.2005.04.011","article-title":"What is the value of cystoscopy with hydrodistension for interstitial cystitis?","volume":"66","author":"Ottem","year":"2005","journal-title":"Urology"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s00192-017-3355-y","article-title":"A systematic review of the literature on cystodistension in bladder pain syndrome","volume":"29","author":"Olson","year":"2018","journal-title":"Int. Urogynecol. J."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1159\/000485735","article-title":"Placenta-Derived Decidua Stromal Cells for Hemorrhagic Cystitis after Stem Cell Transplantation","volume":"139","author":"Baygan","year":"2018","journal-title":"Acta Haematol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1038\/sj.leu.2404833","article-title":"Tissue repair using allogeneic mesenchymal stem cells for hemorrhagic cystitis, pneumomediastinum and perforated colon","volume":"21","author":"Ringden","year":"2007","journal-title":"Leukemia"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1007\/s12016-012-8347-6","article-title":"Use of mesenchymal stem cells (MSC) in chronic inflammatory fistulizing and fibrotic diseases: A comprehensive review","volume":"45","author":"Voswinkel","year":"2013","journal-title":"Clin. Rev. Allergy Immunol."}],"container-title":["Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-7737\/11\/7\/972\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:39:23Z","timestamp":1760139563000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-7737\/11\/7\/972"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,28]]},"references-count":111,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2022,7]]}},"alternative-id":["biology11070972"],"URL":"https:\/\/doi.org\/10.3390\/biology11070972","relation":{},"ISSN":["2079-7737"],"issn-type":[{"value":"2079-7737","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,28]]}}}