{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T13:11:15Z","timestamp":1782393075986,"version":"3.54.5"},"reference-count":136,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2022,7,18]],"date-time":"2022-07-18T00:00:00Z","timestamp":1658102400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biology"],"abstract":"<jats:p>Biological clocks set the timing for a large number of essential processes in the living human organism. After death, scientific evidence is required in forensic investigations in order to collect as much information as possible on the death circumstances and personal identifiers of the deceased victim. We summarize the associations between the molecular mechanisms of biological rhythms and forensically relevant aspects, including post-mortem interval and cause of death, entomological findings, sex, age, ethnicity and development. Given their importance during lifetime, biological rhythms could be potential tools to draw conclusions on the death circumstances and the identity of a deceased person by mechanistic investigations of the different biological clocks in a forensic context. This review puts the known effects of biological rhythms on the functions of the human organism in context with potential applications in forensic fields of interest, such as personal identification, entomology as well as the determination of the post-mortem interval and cause of death.<\/jats:p>","DOI":"10.3390\/biology11071071","type":"journal-article","created":{"date-parts":[[2022,7,18]],"date-time":"2022-07-18T11:32:23Z","timestamp":1658143943000},"page":"1071","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Common Ground between Biological Rhythms and Forensics"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8057-3567","authenticated-orcid":false,"given":"Klara","family":"Janji\u0107","sequence":"first","affiliation":[{"name":"University Clinic of Dentistry, Medical University of Vienna, 1090 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Reisinger","sequence":"additional","affiliation":[{"name":"Center for Forensic Medicine, Medical University of Vienna, 1090 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6720-6781","authenticated-orcid":false,"given":"Fabian","family":"Kanz","sequence":"additional","affiliation":[{"name":"Center for Forensic Medicine, Medical University of Vienna, 1090 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"E3911","DOI":"10.1073\/pnas.1420753112","article-title":"Distinct roles for GABA across multiple timescales in mammalian circadian timekeeping","volume":"112","author":"DeWoskin","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/nrg.2015.8","article-title":"Bayesian molecular clock dating of species divergences in the genomics era","volume":"17","author":"Donoghue","year":"2016","journal-title":"Nat. Rev. Genet."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Satoh, A., Takasu, M., Yano, K., and Terai, Y. (2021). De novo assembly and annotation of the mangrove cricket genome. BMC Res. Notes, 14.","DOI":"10.1186\/s13104-021-05798-z"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"R432","DOI":"10.1016\/j.cub.2016.04.011","article-title":"The circadian clock and human health","volume":"26","author":"Roenneberg","year":"2016","journal-title":"Curr. Biol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1111\/jsr.12312","article-title":"Effects of lunar phase on sleep in men and women in Surrey","volume":"24","author":"Atzori","year":"2015","journal-title":"J. Sleep Res."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1081\/CBI-100107521","article-title":"Seasonal variation in the effect of a fixed dose of heparin on activated clotting time in patients prepared for open-heart surgery","volume":"18","author":"Hodoglugil","year":"2001","journal-title":"Chronobiol. Int."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"3525","DOI":"10.1016\/j.jmb.2020.03.009","article-title":"The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks","volume":"432","author":"Andreatta","year":"2020","journal-title":"J. Mol. Biol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.jsmc.2015.08.003","article-title":"Neurobiology of circadian rhythm regulation","volume":"10","author":"Rosenwasser","year":"2015","journal-title":"Sleep Med. Clin."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1038\/s41581-018-0048-9","article-title":"Circadian rhythms and the kidney","volume":"14","author":"Firsov","year":"2018","journal-title":"Nat. Rev. Nephrol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.jhep.2019.03.020","article-title":"The circadian clock and liver function in health and disease","volume":"71","author":"Mukherji","year":"2019","journal-title":"J. Hepatol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1177\/0748730414563537","article-title":"The circadian clock in skin: Implications for adult stem cells, tissue regeneration, cancer, aging, and immunity","volume":"30","author":"Plikus","year":"2015","journal-title":"J. Biol. Rhythm."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"114045","DOI":"10.1016\/j.bcp.2020.114045","article-title":"Circadian rhythm in pharmacokinetics and its relevance to chronotherapy","volume":"178","author":"Dong","year":"2020","journal-title":"Biochem. Pharmacol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.tem.2019.05.001","article-title":"Circadian clocks and cancer: Timekeeping governs cellular metabolism","volume":"30","author":"Verlande","year":"2019","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"682","DOI":"10.3389\/fphys.2019.00682","article-title":"New insights into the circadian rhythm and its related diseases","volume":"10","author":"Xie","year":"2019","journal-title":"Front. Physiol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/bs.irn.2016.07.002","article-title":"Circadian rhythm and the gut microbiome","volume":"131","author":"Voigt","year":"2016","journal-title":"Int. Rev. Neurobiol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1159\/000500071","article-title":"Effect of circadian rhythm on metabolic processes and the regulation of energy balance","volume":"74","author":"Serin","year":"2019","journal-title":"Ann. Nutr. Metab."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"3700","DOI":"10.1016\/j.jmb.2019.12.044","article-title":"Molecular interactions between components of the circadian clock and the immune system","volume":"432","author":"Hergenhan","year":"2020","journal-title":"J. Mol. Biol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"3661","DOI":"10.1016\/j.jmb.2019.12.036","article-title":"Molecular connections between circadian clocks and aging","volume":"432","author":"Welz","year":"2020","journal-title":"J. Mol. Biol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/s13073-019-0704-0","article-title":"Genomics of circadian rhythms in health and disease","volume":"11","author":"Takahashi","year":"2019","journal-title":"Genome Med."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"3565","DOI":"10.1016\/j.jmb.2019.12.004","article-title":"Proteomics in circadian biology","volume":"432","author":"Mauvoisin","year":"2020","journal-title":"J. Mol. Biol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s10528-019-09938-w","article-title":"Disruption of the molecular circadian clock and cancer: An epigenetic link","volume":"58","year":"2020","journal-title":"Biochem. Genet."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.sleep.2017.04.008","article-title":"Evolution of circadian rhythms: From bacteria to human","volume":"35","author":"Bhadra","year":"2017","journal-title":"Sleep Med."},{"key":"ref_23","first-page":"540","article-title":"Challenges of DNA profiling in mass disaster investigations","volume":"46","author":"Alonso","year":"2005","journal-title":"Croat. Med. J."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1007\/s00414-019-02186-y","article-title":"Identification of human remains using Rapid DNA analysis","volume":"134","author":"Turingan","year":"2020","journal-title":"Int. J. Leg. Med."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"5150","DOI":"10.1039\/D0AY01634A","article-title":"Soil as a tool of revelation in forensic science: A review","volume":"12","author":"Sangwan","year":"2020","journal-title":"Anal. Methods"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/s12024-010-9209-2","article-title":"Forensic entomology: Applications and limitations","volume":"7","author":"Amendt","year":"2011","journal-title":"Forensic Sci. Med. Pathol."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Barrea, L., Vetrani, C., Altieri, B., Verde, L., Savastano, S., Colao, A., and Muscogiuri, G. (2021). The Importance of Being a \u201cLark\u201d in Post-Menopausal Women with Obesity: A Ploy to Prevent Type 2 Diabetes Mellitus?. Nutrients, 13.","DOI":"10.3390\/nu13113762"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1080\/07420528.2021.1992419","article-title":"Evaluating chronotypically tailored light therapy for breast cancer survivors: Preliminary findings on fatigue and disrupted sleep","volume":"39","author":"Wu","year":"2022","journal-title":"Chronobiol. Int."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1080\/07420528.2021.2016795","article-title":"Snacking behavior differs between evening and morning chronotype individuals but no differences are observed in overall energy intake, diet quality, or food cravings","volume":"39","author":"Yang","year":"2022","journal-title":"Chronobiol. Int."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Gohar, A.A., Knauert, M., Kalot, M.A., Khan, A., Sider, D., Javed, M.A., Wooldridge, D., Eck, L., Buckhold, F., and Colaco, B. (2021). Influence of medical trainee sleep pattern (chronotype) on burn-out and satisfaction with work schedules: A multicentre observational study. Postgrad. Med. J.","DOI":"10.1136\/postgradmedj-2021-140975"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1080\/15402002.2021.2019035","article-title":"Sleeping through a Lockdown: How Adolescents and Young Adults Struggle with Lifestyle and Sleep Habits Upheaval during a Pandemic","volume":"20","author":"Potvin","year":"2022","journal-title":"Behav. Sleep Med."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"550597","DOI":"10.3389\/fpsyt.2020.550597","article-title":"Time of day matters: An exploratory assessment of chronotype in a forensic psychiatric hospital","volume":"11","author":"Belfry","year":"2020","journal-title":"Front. Psychiatry"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0304-4165(97)00094-9","article-title":"Postmortem stability of total RNA isolated from rabbit ligament, tendon and cartilage","volume":"1379","author":"Marchuk","year":"1998","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1002\/jnr.490160123","article-title":"Extensive postmortem stability of RNA from rat and human brain","volume":"16","author":"Johnson","year":"1986","journal-title":"J. Neurosci. Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1007\/s00414-006-0131-9","article-title":"Successful RNA extraction from various human postmortem tissues","volume":"121","author":"Heinrich","year":"2007","journal-title":"Int. J. Leg. Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0959-437X(03)00055-8","article-title":"The mammalian circadian clock","volume":"13","author":"Albrecht","year":"2003","journal-title":"Curr. Opin. Genet. Dev."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0092-8674(02)00825-5","article-title":"The orphan nuclear receptor REV-ERBalpha controls circadian transcription within the positive limb of the mammalian circadian oscillator","volume":"110","author":"Preitner","year":"2002","journal-title":"Cell"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/s00414-010-0527-4","article-title":"Estimating time of death based on the biological clock","volume":"125","author":"Kimura","year":"2011","journal-title":"Int. J. Leg. Med."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1177\/0748730413478552","article-title":"Sex difference in daily rhythms of clock gene expression in the aged human cerebral cortex","volume":"28","author":"Lim","year":"2013","journal-title":"J. Biol. Rhythm."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1111\/j.1600-079X.2007.00461.x","article-title":"Day-night expression patterns of clock genes in the human pineal gland","volume":"43","author":"Ackermann","year":"2007","journal-title":"J. Pineal Res."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.fsigen.2015.12.008","article-title":"Evaluation of mRNA markers for estimating blood deposition time: Towards alibi testing from human forensic stains with rhythmic biomarkers","volume":"21","author":"Lech","year":"2016","journal-title":"Forensic Sci. Int. Genet."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"638","DOI":"10.3858\/emm.2009.41.9.070","article-title":"Comprehensive analysis of microRNA-mRNA co-expression in circadian rhythm","volume":"41","author":"Na","year":"2009","journal-title":"Exp. Mol. Med."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1007\/s00414-012-0811-6","article-title":"miRNA analysis in vitreous humor to determine the time of death: A proof-of-concept pilot study","volume":"127","author":"Odriozola","year":"2013","journal-title":"Int. J. Leg. Med."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Maiese, A., Scatena, A., Costantino, A., Di Paolo, M., La Russa, R., Turillazzi, E., Frati, P., and Fineschi, V. (2021). Micrornas as useful tools to estimate time since death. A systematic review of current literature. Diagnostics, 11.","DOI":"10.3390\/diagnostics11010064"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Manetti, A.C., Maiese, A., Baronti, A., Mezzetti, E., Frati, P., Fineschi, V., and Turillazzi, E. (2021). Mirnas as new tools in lesion vitality evaluation: A systematic review and their forensic applications. Biomedicines, 9.","DOI":"10.3390\/biomedicines9111731"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"9950","DOI":"10.1073\/pnas.1305814110","article-title":"Circadian patterns of gene expression in the human brain and disruption in major depressive disorder","volume":"110","author":"Li","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1073\/pnas.1508249112","article-title":"Effects of aging on circadian patterns of gene expression in the human prefrontal cortex","volume":"113","author":"Chen","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_48","first-page":"608","article-title":"Time of death in diseases with lethal outcomes in a pediatric surgery department and a pediatric hospital","volume":"132","author":"Angerpointner","year":"1984","journal-title":"Mon. Kinderheilkd"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"713","DOI":"10.5665\/sleep.1838","article-title":"Diurnal fluctuation in histidine decarboxylase expression, the rate limiting enzyme for histamine production, and its disorder in neurodegenerative diseases","volume":"35","author":"Shan","year":"2012","journal-title":"Sleep"},{"key":"ref_50","first-page":"97","article-title":"A self-assessment questionnaire to determine morningness-eveningness in human circadian rhythms","volume":"4","author":"Horne","year":"1976","journal-title":"Int. J. Chronobiol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1002\/ana.23636","article-title":"A common polymorphism near PER1 and the timing of human behavioral rhythms","volume":"72","author":"Lim","year":"2012","journal-title":"Ann. Neurol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.fsigen.2017.06.008","article-title":"Integrating the microbiome as a resource in the forensics toolkit","volume":"30","author":"Clarke","year":"2017","journal-title":"Forensic Sci. Int. Genet."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.forsciint.2017.04.024","article-title":"A comparative in situ decomposition study using still born piglets and leaf litter from a deciduous forest","volume":"276","author":"Olakanye","year":"2017","journal-title":"Forensic Sci. Int."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1007\/s12024-015-9667-7","article-title":"Seasonal variation of postmortem microbial communities","volume":"11","author":"Carter","year":"2015","journal-title":"Forensic Sci. Med. Pathol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.freeradbiomed.2017.11.024","article-title":"Circadian clock-mediated regulation of blood pressure","volume":"119","author":"Douma","year":"2018","journal-title":"Free Radic. Biol. Med."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1111\/j.1475-097X.1993.tb00379.x","article-title":"Circadian variation of cardiac autonomic regulation during 24-h bed rest","volume":"13","author":"Hartikainen","year":"1993","journal-title":"Clin. Physiol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1182\/blood-2013-07-517060","article-title":"Human circadian system causes a morning peak in prothrombotic plasminogen activator inhibitor-1 (PAI-1) independent of the sleep\/wake cycle","volume":"123","author":"Scheer","year":"2014","journal-title":"Blood"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1056\/NEJM198511213132103","article-title":"Circadian variation in the frequency of onset of acute myocardial infarction","volume":"313","author":"Muller","year":"1985","journal-title":"N. Engl. J. Med."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1080\/00015385.2020.1834248","article-title":"Biological rhythms of fatal myocardial infarction in Greece: An autopsy study","volume":"76","author":"Sakelliadis","year":"2021","journal-title":"Acta Cardiol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1111\/apa.15695","article-title":"Circadian variation in sudden unexpected infant death in the United States","volume":"110","author":"Anderson","year":"2021","journal-title":"Acta Paediatr."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.trecan.2019.07.002","article-title":"Interplay between Circadian Clock and Cancer: New Frontiers for Cancer Treatment","volume":"5","author":"Sulli","year":"2019","journal-title":"Trends Cancer"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.cell.2008.07.002","article-title":"The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control","volume":"134","author":"Nakahata","year":"2008","journal-title":"Cell"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1165\/rcmb.2014-0474OC","article-title":"Disruption of Sirtuin 1-Mediated Control of Circadian Molecular Clock and Inflammation in Chronic Obstructive Pulmonary Disease","volume":"53","author":"Yao","year":"2015","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1007\/s00414-006-0086-x","article-title":"Best practice in forensic entomology--standards and guidelines","volume":"121","author":"Amendt","year":"2007","journal-title":"Int. J. Leg. Med."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Cascallares, G., Riva, S., Franco, D.L., Risau-Gusman, S., and Gleiser, P.M. (2018). Role of the circadian clock in the statistics of locomotor activity in Drosophila. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0202505"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/s41586-021-03934-0","article-title":"Circadian autophagy drives iTRF-mediated longevity","volume":"598","author":"Ulgherait","year":"2021","journal-title":"Nature"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/j.jinsphys.2011.04.006","article-title":"Circadian clock genes period and cycle regulate photoperiodic diapause in the bean bug Riptortus pedestris males","volume":"57","author":"Ikeno","year":"2011","journal-title":"J. Insect Physiol."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Ikeno, T., Tanaka, S.I., Numata, H., and Goto, S.G. (2010). Photoperiodic diapause under the control of circadian clock genes in an insect. BMC Biol., 8.","DOI":"10.1186\/1741-7007-8-116"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1038\/343536a0","article-title":"Feedback of the Drosophila period gene product on circadian cycling of its messenger RNA levels","volume":"343","author":"Hardin","year":"1990","journal-title":"Nature"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1126\/science.8128247","article-title":"Block in nuclear localization of period protein by a second clock mutation, timeless","volume":"263","author":"Vosshall","year":"1994","journal-title":"Science"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s40851-014-0003-y","article-title":"Common features in diverse insect clocks","volume":"1","author":"Numata","year":"2015","journal-title":"Zool. Lett."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"776826","DOI":"10.3389\/fphys.2021.776826","article-title":"The circadian clock in lepidoptera","volume":"12","author":"Brady","year":"2021","journal-title":"Front. Physiol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1007\/s00414-016-1495-0","article-title":"Muscidae (Diptera) of forensic importance-an identification key to third instar larvae of the western Palaearctic region and a catalogue of the muscid carrion community","volume":"131","author":"Grzywacz","year":"2017","journal-title":"Int. J. Leg. Med."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/s00414-015-1289-9","article-title":"The distribution of blow fly (Diptera: Calliphoridae) larval lengths and its implications for estimating post mortem intervals","volume":"130","author":"Moffatt","year":"2016","journal-title":"Int. J. Leg. Med."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1177\/07487304211054419","article-title":"A comparative study of circadian rhythmicity and photoperiodism in closely related species of blow flies: External coincidence, maternal induction, and diapause at northern latitudes","volume":"36","author":"Saunders","year":"2021","journal-title":"J. Biol. Rhythm."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1177\/074873049100600303","article-title":"Adult locomotor rhythmicity as \u201chands\u201d of the maternal photoperiodic clock regulating larval diapause in the blowfly, Calliphora vicina","volume":"6","author":"Kenny","year":"1991","journal-title":"J. Biol. Rhythm."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/S0022-1910(03)00114-8","article-title":"Selection for high diapause incidence in blow flies (Calliphora vicina) maintained under long days increases the maternal critical daylength: Some consequences for the photoperiodic clock","volume":"49","author":"Saunders","year":"2003","journal-title":"J. Insect Physiol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1673\/031.003.1401","article-title":"Effects of 5,7-dihydroxytriptamine (5,7-DHT) on circadian locomotor activity of the blow fly, Calliphora vicina","volume":"3","author":"Cymborowski","year":"2003","journal-title":"J. Insect Sci."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.forsciint.2017.03.002","article-title":"Chronobiological studies on body search, oviposition and emergence of Megaselia scalaris (Diptera, Phoridae) in controlled conditions","volume":"275","author":"Bostock","year":"2017","journal-title":"Forensic Sci. Int."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.jinsphys.2016.08.003","article-title":"Entrainment of eclosion and preliminary ontogeny of circadian clock gene expression in the flesh fly, Sarcophaga crassipalpis","volume":"93\u201394","author":"Short","year":"2016","journal-title":"J. Insect Physiol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1016\/j.jinsphys.2011.05.006","article-title":"Thermoperiodic regulation of the circadian eclosion rhythm in the flesh fly, Sarcophaga crassipalpis","volume":"57","author":"Miyazaki","year":"2011","journal-title":"J. Insect Physiol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"151","DOI":"10.2108\/zs160153","article-title":"Clock and Hormonal Controls of an Eclosion Gate in the Flesh Fly Sarcophaga crassipalpis","volume":"34","author":"Yamamoto","year":"2017","journal-title":"Zool. Sci."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.jinsphys.2017.11.007","article-title":"Effects of gender, age, and nutrition on circadian locomotor activity rhythms in the flesh fly Sarcophaga crassipalpis","volume":"107","author":"Prohaska","year":"2018","journal-title":"J. Insect Physiol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1177\/0748730419841931","article-title":"Distinct physiological mechanisms induce latitudinal and sexual differences in the photoperiodic induction of diapause in a fly","volume":"34","author":"Yamaguchi","year":"2019","journal-title":"J. Biol. Rhythm."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/j.toxrep.2020.07.011","article-title":"The toxic influence and biodegradation of carbon nanofibers in freshwater invertebrates of the families Gammaridae, Ephemerellidae, and Chironomidae","volume":"7","author":"Chaika","year":"2020","journal-title":"Toxicol. Rep."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1111\/1556-4029.12707","article-title":"The Use of the Developmental Rate of the Aquatic Midge Chironomus riparius (Diptera, Chironomidae) in the Assessment of the Postsubmersion Interval","volume":"60","year":"2015","journal-title":"J. Forensic Sci."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"102023","DOI":"10.1016\/j.jflm.2020.102023","article-title":"Seasonal study of the decomposition pattern and insects on a submerged pig cadaver","volume":"74","author":"Dalal","year":"2020","journal-title":"J. Forensic Leg. Med."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.jinsphys.2015.07.008","article-title":"Continuous activity and no cycling of clock genes in the Antarctic midge during the polar summer","volume":"81","author":"Kobelkova","year":"2015","journal-title":"J. Insect Physiol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/nature20151","article-title":"The genomic basis of circadian and circalunar timing adaptations in a midge","volume":"540","author":"Kaiser","year":"2016","journal-title":"Nature"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"2845","DOI":"10.1111\/j.1365-294X.2010.04706.x","article-title":"Strong genetic differentiation and postglacial origin of populations in the marine midge Clunio marinus (Chironomidae, Diptera)","volume":"19","author":"Kaiser","year":"2010","journal-title":"Mol. Ecol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"601676","DOI":"10.3389\/fnbeh.2020.601676","article-title":"Model and Non-model Insects in Chronobiology","volume":"14","author":"Beer","year":"2020","journal-title":"Front. Behav. Neurosci."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1673\/031.013.3201","article-title":"The community of Hymenoptera parasitizing necrophagous Diptera in an urban biotope","volume":"13","author":"Frederickx","year":"2013","journal-title":"J. Insect Sci."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1007\/s00427-017-0597-0","article-title":"The effect of Wolbachia on diapause, fecundity, and clock gene expression in Trichogramma brassicae (Hymenoptera: Trichogrammatidae)","volume":"227","author":"Ashouri","year":"2017","journal-title":"Dev. Genes Evol."},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Ingram, K.K., Kutowoi, A., Wurm, Y., Shoemaker, D., Meier, R., and Bloch, G. (2012). The molecular clockwork of the fire ant Solenopsis invicta. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0045715"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.smrv.2007.07.005","article-title":"Epidemiology of the human circadian clock","volume":"11","author":"Roenneberg","year":"2007","journal-title":"Sleep Med. Rev."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"R1038","DOI":"10.1016\/j.cub.2004.11.039","article-title":"A marker for the end of adolescence","volume":"14","author":"Roenneberg","year":"2004","journal-title":"Curr. Biol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1081\/CBI-120005390","article-title":"Gender differences in morningness-eveningness preference","volume":"19","author":"Adan","year":"2002","journal-title":"Chronobiol. Int."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"14215","DOI":"10.1038\/s41598-017-13973-1","article-title":"Sex differences in light sensitivity impact on brightness perception, vigilant attention and sleep in humans","volume":"7","author":"Chellappa","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1080\/07420520802387773","article-title":"Diurnal variation of plasma brain-derived neurotrophic factor (BDNF) in humans: An analysis of sex differences","volume":"25","author":"Piccinni","year":"2008","journal-title":"Chronobiol. Int."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1177\/0748730417693124","article-title":"Circadian Rhythms in Plasma Brain-derived Neurotrophic Factor Differ in Men and Women","volume":"32","author":"Cain","year":"2017","journal-title":"J. Biol. Rhythm."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1177\/0748730410374943","article-title":"Sex differences in phase angle of entrainment and melatonin amplitude in humans","volume":"25","author":"Cain","year":"2010","journal-title":"J. Biol. Rhythm."},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"\u0160krlec, I., Talapko, J., Juzba\u0161i\u0107, M., and Steiner, R. (2021). Sex differences in circadian clock genes and myocardial infarction susceptibility. J. Cardiovasc. Dev. Dis., 8.","DOI":"10.3390\/jcdd8050053"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1002\/ajmg.b.32507","article-title":"Sex-specific linkage scans in opioid dependence","volume":"174","author":"Yang","year":"2017","journal-title":"Am. J. Med. Genet. B Neuropsychiatr. Genet."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/S0031-3955(05)70486-7","article-title":"Developing circadian rhythmicity. Basic and clinical aspects","volume":"44","author":"Rivkees","year":"1997","journal-title":"Pediatr. Clin. N. Am."},{"key":"ref_105","first-page":"594","article-title":"Circadian rhythms during pregnancy","volume":"14","author":"Ducsay","year":"1993","journal-title":"Endocr. Rev."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"109353","DOI":"10.1016\/j.mehy.2019.109353","article-title":"Reduced melatonin synthesis in pregnant night workers: Metabolic implications for offspring","volume":"132","author":"Nehme","year":"2019","journal-title":"Med. Hypotheses"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"2862","DOI":"10.1038\/s41467-021-22922-6","article-title":"Importance of circadian timing for aging and longevity","volume":"12","author":"Green","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1034\/j.1600-079X.2001.310311.x","article-title":"Circadian abnormalities in older adults","volume":"31","author":"Youngstedt","year":"2001","journal-title":"J. Pineal Res."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1080\/07420520500180439","article-title":"Circadian phase in adults of contrasting ages","volume":"22","author":"Kripke","year":"2005","journal-title":"Chronobiol. Int."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s004140050283","article-title":"Age estimation: The state of the art in relation to the specific demands of forensic practise","volume":"113","author":"Cattaneo","year":"2000","journal-title":"Int. J. Leg. Med."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"101763","DOI":"10.1016\/j.legalmed.2020.101763","article-title":"Age prediction in living: Forensic epigenetic age estimation based on blood samples","volume":"47","author":"Cunha","year":"2020","journal-title":"Leg. Med."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"6459","DOI":"10.18632\/aging.202783","article-title":"Development of the VISAGE enhanced tool and statistical models for epigenetic age estimation in blood, buccal cells and bones","volume":"13","author":"Heidegger","year":"2021","journal-title":"Aging"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1111\/1556-4029.14460","article-title":"A new robust epigenetic model for forensic age prediction","volume":"65","author":"Montesanto","year":"2020","journal-title":"J. Forensic Sci."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.gde.2014.06.003","article-title":"Circadian clock: Linking epigenetics to aging","volume":"26","year":"2014","journal-title":"Curr. Opin. Genet. Dev."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"359","DOI":"10.5483\/BMBRep.2016.49.7.070","article-title":"Forensic DNA methylation profiling from evidence material for investigative leads","volume":"49","author":"Lee","year":"2016","journal-title":"BMB Rep."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/s13148-019-0677-2","article-title":"Circadian rhythms in the three-dimensional genome: Implications of chromatin interactions for cyclic transcription","volume":"11","year":"2019","journal-title":"Clin. Epigenetics"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1038\/81767","article-title":"Light induces chromatin modification in cells of the mammalian circadian clock","volume":"3","author":"Crosio","year":"2000","journal-title":"Nat. Neurosci."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1038\/s41467-018-03073-7","article-title":"Cytosine modifications exhibit circadian oscillations that are involved in epigenetic diversity and aging","volume":"9","author":"Oh","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.legalmed.2011.03.001","article-title":"Methylation analysis of circadian clock gene promoters in forensic autopsy specimens","volume":"13","author":"Nakatome","year":"2011","journal-title":"Leg. Med."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/nature01314","article-title":"Rhythmic histone acetylation underlies transcription in the mammalian circadian clock","volume":"421","author":"Etchegaray","year":"2003","journal-title":"Nature"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1126\/science.1226339","article-title":"Transcriptional architecture and chromatin landscape of the core circadian clock in mammals","volume":"338","author":"Koike","year":"2012","journal-title":"Science"},{"key":"ref_122","first-page":"549","article-title":"The epigenetic clock and physical development during childhood and adolescence: Longitudinal analysis from a UK birth cohort","volume":"46","author":"Simpkin","year":"2017","journal-title":"Int. J. Epidemiol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1186\/s13059-016-1030-0","article-title":"An epigenetic clock analysis of race\/ethnicity, sex, and coronary heart disease","volume":"17","author":"Horvath","year":"2016","journal-title":"Genome Biol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1038\/s41598-020-58413-9","article-title":"Chronotype assessment via a large scale socio-demographic survey favours yearlong Standard time over Daylight Saving Time in central Europe","volume":"10","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1242\/dev.063735","article-title":"Patterning embryos with oscillations: Structure, function and dynamics of the vertebrate segmentation clock","volume":"139","author":"Oates","year":"2012","journal-title":"Development"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/S0092-8674(00)80451-1","article-title":"Avian hairy gene expression identifies a molecular clock linked to vertebrate segmentation and somitogenesis","volume":"91","author":"Palmeirim","year":"1997","journal-title":"Cell"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1126\/science.aba7668","article-title":"Species-specific segmentation clock periods are due to differential biochemical reaction speeds","volume":"369","author":"Matsuda","year":"2020","journal-title":"Science"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"dev170480","DOI":"10.1242\/dev.170480","article-title":"Arthropod segmentation","volume":"146","author":"Clark","year":"2019","journal-title":"Development"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1038\/s41586-020-2144-9","article-title":"Recapitulating the human segmentation clock with pluripotent stem cells","volume":"580","author":"Matsuda","year":"2020","journal-title":"Nature"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/s41586-019-1885-9","article-title":"In vitro characterization of the human segmentation clock","volume":"580","author":"Wagner","year":"2020","journal-title":"Nature"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"100041","DOI":"10.1074\/mcp.RA120.002301","article-title":"Interspecies differences in proteome turnover kinetics are correlated with lifespans and energetic demands","volume":"20","author":"Swovick","year":"2020","journal-title":"Mol. Cell. Proteom."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1038\/d41586-021-01086-9","article-title":"These cellular clocks help explain why elephants are bigger than mice","volume":"592","author":"Marshall","year":"2021","journal-title":"Nature"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"R826","DOI":"10.1016\/j.cub.2008.07.017","article-title":"Modelling biological rhythms","volume":"18","author":"Roenneberg","year":"2008","journal-title":"Curr. Biol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"101771","DOI":"10.1016\/j.legalmed.2020.101771","article-title":"On the use of machine learning algorithms in forensic anthropology","volume":"47","author":"Nikita","year":"2020","journal-title":"Leg. Med."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"R784","DOI":"10.1016\/j.cub.2008.07.003","article-title":"Human responses to the geophysical daily, annual and lunar cycles","volume":"18","author":"Foster","year":"2008","journal-title":"Curr. Biol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"e2115725119","DOI":"10.1073\/pnas.2115725119","article-title":"Two light sensors decode moonlight versus sunlight to adjust a plastic circadian\/circalunidian clock to moon phase","volume":"119","author":"Zurl","year":"2022","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-7737\/11\/7\/1071\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:53:13Z","timestamp":1760140393000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-7737\/11\/7\/1071"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,18]]},"references-count":136,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2022,7]]}},"alternative-id":["biology11071071"],"URL":"https:\/\/doi.org\/10.3390\/biology11071071","relation":{},"ISSN":["2079-7737"],"issn-type":[{"value":"2079-7737","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,18]]}}}