{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T16:49:29Z","timestamp":1773247769078,"version":"3.50.1"},"reference-count":32,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T00:00:00Z","timestamp":1659052800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Chilean Agencia Nacional de Investigaci\u00f3n y Desarrollo (ANID)","award":["NCS2021_013"],"award-info":[{"award-number":["NCS2021_013"]}]},{"name":"Project COVID0739","award":["NCS2021_013"],"award-info":[{"award-number":["NCS2021_013"]}]},{"name":"Millennium Science Initiative","award":["NCS2021_013"],"award-info":[{"award-number":["NCS2021_013"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biology"],"abstract":"<jats:p>(1) Background: The diagnosis of COVID-19 is frequently made on the basis of a suggestive clinical history and the detection of SARS-CoV-2 RNA in respiratory secretions. However, the diagnostic accuracy of clinical features is unknown. (2) Objective: To assess the diagnostic accuracy of patient-reported clinical manifestations to identify cases of COVID-19. (3) Methodology: Cross-sectional study using data from a national registry in Chile. Infection by SARS-CoV-2 was confirmed using RT-PCR in all cases. Anonymised information regarding demographic characteristics and clinical features were assessed using sensitivity, specificity, and diagnostic odds ratios. A multivariable logistic regression model was constructed to combine epidemiological risk factors and clinical features. (4) Results: A total of 2,187,962 observations were available for analyses. Male participants had a mean age of 43.1 \u00b1 17.5 years. The most common complaints within the study were headache (39%), myalgia (32.7%), cough (31.6%), and sore throat (25.7%). The most sensitive features of disease were headache, myalgia, and cough, and the most specific were anosmia and dysgeusia\/ageusia. A multivariable model showed a fair diagnostic accuracy, with a ROC AUC of 0.744 (95% CI 0.743\u20130.746). (5) Discussion: No single clinical feature was able to fully confirm or exclude an infection by SARS-CoV-2. The combination of several demographic and clinical factors had a fair diagnostic accuracy in identifying patients with the disease. This model can help clinicians tailor the probability of COVID-19 and select diagnostic tests appropriate to their setting.<\/jats:p>","DOI":"10.3390\/biology11081136","type":"journal-article","created":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T01:41:16Z","timestamp":1659058876000},"page":"1136","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Sensitivity and Specificity of Patient-Reported Clinical Manifestations to Diagnose COVID-19 in Adults from a National Database in Chile: A Cross-Sectional Study"],"prefix":"10.3390","volume":"11","author":[{"given":"Felipe","family":"Martinez","sequence":"first","affiliation":[{"name":"Unidad de Cuidados Intensivos, Hospital Naval Almirante Nef, Vi\u00f1a del Mar 2520000, Chile"},{"name":"Facultad de Medicina, Escuela de Medicina, Universidad Andr\u00e9s Bello, Vi\u00f1a del Mar 2531015, Chile"},{"name":"Concentra Educaci\u00f3n e Investigaci\u00f3n Biom\u00e9dica, Vi\u00f1a del Mar 2552906, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8383-6599","authenticated-orcid":false,"given":"Sergio","family":"Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Departamento de Salud P\u00fablica-CIGES, Facultad de Medicina, Universidad de La Frontera, Francisco Salazar 1145, Temuco 4811230, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6527-6292","authenticated-orcid":false,"given":"Camilo","family":"Guerrero-Nancuante","sequence":"additional","affiliation":[{"name":"Escuela de Enfermer\u00eda, Universidad de Valpara\u00edso, Valpara\u00edso 2500000, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8318-4201","authenticated-orcid":false,"given":"Carla","family":"Taramasco","sequence":"additional","affiliation":[{"name":"Facultad de Ingenier\u00eda, Universidad Andr\u00e9s Bello, Millennium Nucleus on Sociomedicine, Vi\u00f1a del Mar 2520000, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/s41579-020-00459-7","article-title":"Characteristics of SARS-CoV-2 and COVID-19","volume":"19","author":"Hu","year":"2021","journal-title":"Nat. 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