{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T03:16:31Z","timestamp":1784690191946,"version":"3.55.0"},"reference-count":65,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,9,3]],"date-time":"2022-09-03T00:00:00Z","timestamp":1662163200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biology"],"abstract":"<jats:p>Diabetic foot ulcers (DFUs) and their life-threatening complications, such as necrotizing fasciitis (NF) and osteomyelitis (OM), increase the healthcare cost, morbidity and mortality in patients with diabetes mellitus. While the early recognition of these complications could improve the clinical outcome of diabetic patients, it is not straightforward to achieve in the usual clinical settings. In this study, we proposed a classification model for diabetic foot, NF and OM. To select features for the classification model, multidisciplinary teams were organized and data were collected based on a literature search and automatic platform. A dataset of 1581 patients (728 diabetic foot, 76 NF, and 777 OM) was divided into training and validation datasets at a ratio of 7:3 to be analyzed. The final prediction models based on training dataset exhibited areas under the receiver operating curve (AUC) of the 0.80 and 0.73 for NF model and OM model, respectively, in validation sets. In conclusion, our classification models for NF and OM showed remarkable discriminatory power and easy applicability in patients with DFU.<\/jats:p>","DOI":"10.3390\/biology11091310","type":"journal-article","created":{"date-parts":[[2022,9,5]],"date-time":"2022-09-05T20:48:25Z","timestamp":1662410905000},"page":"1310","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Classification Model for Diabetic Foot, Necrotizing Fasciitis, and Osteomyelitis"],"prefix":"10.3390","volume":"11","author":[{"given":"Jiye","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Plastic Surgery, Yonsei University Wonju College of Medicine, Wonju 26411, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilsung","family":"Yoo","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Yonsei University Wonju College of Medicine, Wonju 26411, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0706-167X","authenticated-orcid":false,"given":"Taesic","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Data Mining and Computational Biology, Institute of Global Health Care and Development, Wonju Severance Christian Hospital, Wonju 26411, Korea"},{"name":"Department of Family Medicine, Yonsei University Wonju College of Medicine, Wonju 26411, Korea"},{"name":"Center for Precision Medicine and Genomics, Wonju Severance Christian Hospital, Wonju 26411, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8637-0798","authenticated-orcid":false,"given":"Jeong Ho","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Yonsei University Wonju College of Medicine, Wonju 26411, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2453-2015","authenticated-orcid":false,"given":"Dong Min","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Medical Information, Yonsei University Wonju College of Medicine, Wonju 26411, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juwon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Yonsei University Wonju College of Medicine, Wonju 26411, Korea"},{"name":"Center for Precision Medicine and Genomics, Wonju Severance Christian Hospital, Wonju 26411, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2367","DOI":"10.1056\/NEJMra1615439","article-title":"Diabetic Foot Ulcers and Their Recurrence","volume":"376","author":"Armstrong","year":"2017","journal-title":"N. 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