{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T11:06:12Z","timestamp":1769511972614,"version":"3.49.0"},"reference-count":33,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2022,11,15]],"date-time":"2022-11-15T00:00:00Z","timestamp":1668470400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biology"],"abstract":"<jats:p>To retrospectively analyze local and systemic factors that resulted in the short-term tooth loss of teeth that were previously assigned a favorable prognosis in patients who were seen and treated over an observational five-year period. This retrospective study included the records of patients who had a minimum of two dental exams at least twelve months apart over a 5-year period. This study investigated extracted teeth with an initially favorable periodontal prognosis that were then divided into one of four categories based on the reason for extraction: caries, periodontal disease, endodontic reasons, or fracture. Patient- and tooth-related factors associated with the extracted teeth were recorded: crown-to-root ratio, initial pocket depth, initial periodontal diagnosis, maintenance interval, presence of existing restoration, furcation involvement, and systemic conditions. Data analysis was performed using a linear mixed model. A total of 50 patients with 111 teeth met the inclusion criteria for this study. A higher odds ratio (OR) for tooth loss due to caries, endodontic reasons, and fracture were found in teeth with a history of root canal treatment with an OR of 3.61, 3.86, and 2.52, respectively. For tooth loss due to periodontal disease, higher ORs were found in patients who were on anti-depressants (OR = 4.28) and patients who had an initial diagnosis of Stage III\/IV periodontitis (OR = 2.66). In addition, teeth with initial probing depths \u22655 mm (OR = 4.32) and with furcation involvement (OR = 1.93) showed a higher OR for tooth loss due to periodontal disease. Within the limitations of this study, previously root-canal-treated teeth present a higher OR for early loss due to caries, recurrent endodontic lesions, or fracture. In addition, patients with anti-depressant medication use, sporadic maintenance, initial probing depths \u22655 mm, and furcation involvement represent a significantly higher OR of tooth loss due to periodontal disease even for initially favorable teeth.<\/jats:p>","DOI":"10.3390\/biology11111664","type":"journal-article","created":{"date-parts":[[2022,11,16]],"date-time":"2022-11-16T02:27:34Z","timestamp":1668565654000},"page":"1664","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The Pattern of Tooth Loss for Periodontally Favorable Teeth: A Retrospective Study"],"prefix":"10.3390","volume":"11","author":[{"given":"Peter","family":"Yanni","sequence":"first","affiliation":[{"name":"Private Practice, Roseville, CA 95661, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald A.","family":"Curtis","sequence":"additional","affiliation":[{"name":"Department of Preventive & Restorative Dental Sciences, University of California, San Francisco, CA 94143, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard T.","family":"Kao","sequence":"additional","affiliation":[{"name":"Department of Orofacial Sciences, School of Dentistry, University of California, San Francisco, CA 94143, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1290-9994","authenticated-orcid":false,"given":"Guo-Hao","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Orofacial Sciences, School of Dentistry, University of California, San Francisco, CA 94143, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1902\/jop.2015.140520","article-title":"Update on prevalence of periodontitis in adults in the United States: NHANES 2009 to 2012","volume":"86","author":"Eke","year":"2015","journal-title":"J. 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The effectiveness of clinical parameters in developing an accurate prognosis","volume":"67","author":"McGuire","year":"1996","journal-title":"J. Periodontol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1902\/jop.1996.67.7.666","article-title":"Prognosis versus actual outcome. III. The effectiveness of clinical parameters in accurately predicting tooth survival","volume":"67","author":"McGuire","year":"1996","journal-title":"J. Periodontol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1902\/jop.1982.53.9.539","article-title":"Tooth loss in 100 treated patients with periodontal disease. A long-term study","volume":"53","author":"McFall","year":"1982","journal-title":"J. Periodontol."},{"key":"ref_8","first-page":"54","article-title":"The long term evaluation of periodontal treatment and maintenance in 95 patients","volume":"4","author":"Becker","year":"1984","journal-title":"Int. J. Periodontics Restor. Dent."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1902\/jop.1979.50.5.234","article-title":"Untreated periodontal disease: A longitudinal study","volume":"50","author":"Becker","year":"1979","journal-title":"J. Periodontol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1002\/JPER.20-0411","article-title":"Analyzing the predictability of the Kwok and Caton periodontal prognosis system: A retrospective study","volume":"92","author":"Nguyen","year":"2021","journal-title":"J. Periodontol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1034\/j.1600-0528.2002.300304.x","article-title":"Glycemic control of type 2 diabetes and severe periodontal disease in the US adult population","volume":"30","author":"Tsai","year":"2002","journal-title":"Community Dent. Oral Epidemiol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1902\/jop.1991.62.2.123","article-title":"Periodontal disease in non-insulin-dependent diabetes mellitus","volume":"62","author":"Emrich","year":"1991","journal-title":"J. Periodontol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/j.1601-0825.2008.01442.x","article-title":"Periodontal disease: Associations with diabetes, glycemic control and complications","volume":"14","author":"Taylor","year":"2008","journal-title":"Oral Dis."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1902\/jop.2000.71.5.743","article-title":"Smoking-attributable periodontitis in the United States: Findings from NHANES III. National Health and Nutrition Examination Survey","volume":"71","author":"Tomar","year":"2000","journal-title":"J. Periodontol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1902\/jop.1994.65.3.260","article-title":"Assessment of risk for periodontal disease. I. Risk indicators for attachment loss","volume":"65","author":"Grossi","year":"1994","journal-title":"J. Periodontol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1177\/0022034513492336","article-title":"Patient stratification for preventive care in dentistry","volume":"92","author":"Giannobile","year":"2013","journal-title":"J. Dent. Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/j.1601-1546.2006.00201.x","article-title":"Mechanisms and risk factors for fracture predilection in endodontically treated teeth","volume":"13","author":"Kishen","year":"2006","journal-title":"Endod. 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Endod."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1177\/0022034514549378","article-title":"Selective serotonin reuptake inhibitors and the risk of osseointegrated implant failure: A cohort study","volume":"93","author":"Wu","year":"2014","journal-title":"J. Dent. Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1902\/jop.1999.70.7.711","article-title":"Relationship of stress, distress and inadequate coping behaviors to periodontal disease","volume":"70","author":"Genco","year":"1999","journal-title":"J. Periodontol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"122","DOI":"10.4103\/jisp.jisp_210_19","article-title":"Effect of antidepressants on various periodontal parameters: A case-control study","volume":"24","author":"Bey","year":"2020","journal-title":"J. Indian Soc. Periodontol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1177\/0706743716632523","article-title":"No Mental Health without Oral Health","volume":"61","author":"Kisely","year":"2016","journal-title":"Can. J. Psychiatry"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1002\/JPER.18-0157","article-title":"A new classification scheme for periodontal and peri-implant diseases and conditions\u2014Introduction and key changes from the 1999 classification","volume":"89","author":"Caton","year":"2018","journal-title":"J. Periodontol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1111\/jcpe.13430","article-title":"The influence of the interaction between staging, grading and extent on tooth loss due to periodontitis","volume":"48","author":"Qazi","year":"2021","journal-title":"J. Clin. Periodontol."},{"key":"ref_27","first-page":"30","article-title":"The limits of subgingival scaling","volume":"1","author":"Stambaugh","year":"1981","journal-title":"Int. J. Periodontics Restor. Dent."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1111\/j.1600-051X.2008.01245.x","article-title":"Influence of residual pockets on progression of periodontitis and tooth loss: Results after 11 years of maintenance","volume":"35","author":"Matuliene","year":"2008","journal-title":"J. Clin. Periodontol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1902\/jop.1982.53.1.26","article-title":"Oral hygiene and maintenance of periodontal support","volume":"53","author":"Ramfjord","year":"1982","journal-title":"J. Periodontol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1111\/j.1600-051X.1984.tb00902.x","article-title":"Long-term maintenance of patients treated for advanced periodontal disease","volume":"11","author":"Lindhe","year":"1984","journal-title":"J. Clin. Periodontol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1902\/jop.1994.65.1.25","article-title":"The influence of molar furcation involvement and mobility on future clinical periodontal attachment loss","volume":"65","author":"Wang","year":"1994","journal-title":"J. Periodontol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1902\/jop.1989.60.7.402","article-title":"Scaling and root planing efficacy in multirooted teeth","volume":"60","author":"Fleischer","year":"1989","journal-title":"J. Periodontol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1902\/jop.1991.62.3.185","article-title":"Progression of probing attachment loss in adult periodontitis","volume":"62","author":"Jeffcoat","year":"1991","journal-title":"J. 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