{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T13:35:56Z","timestamp":1793799356616,"version":"4.6.1"},"reference-count":353,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,3,20]],"date-time":"2023-03-20T00:00:00Z","timestamp":1679270400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biology"],"abstract":"<jats:p>Aggression can be conceptualized as any behavior, physical or verbal, that involves attacking another person or animal with the intent of causing harm, pain or injury. Because of its high prevalence worldwide, aggression has remained a central clinical and public safety issue. Aggression can be caused by several risk factors, including biological and psychological, such as genetics and mental health disorders, and socioeconomic such as education, employment, financial status, and neighborhood. Research over the past few decades has also proposed a link between alcohol consumption and aggressive behaviors. Alcohol consumption can escalate aggressive behavior in humans, often leading to domestic violence or serious crimes. Converging lines of evidence have also shown that trauma and posttraumatic stress disorder (PTSD) could have a tremendous impact on behavior associated with both alcohol use problems and violence. However, although the link between trauma, alcohol, and aggression is well documented, the underlying neurobiological mechanisms and their impact on behavior have not been properly discussed. This article provides an overview of recent advances in understanding the translational neurobiological basis of aggression and its intricate links to alcoholism and trauma, focusing on behavior. It does so by shedding light from several perspectives, including in vivo imaging, genes, receptors, and neurotransmitters and their influence on human and animal behavior.<\/jats:p>","DOI":"10.3390\/biology12030469","type":"journal-article","created":{"date-parts":[[2023,3,20]],"date-time":"2023-03-20T04:33:31Z","timestamp":1679286811000},"page":"469","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Neurobiology of Aggression\u2014Review of Recent Findings and Relationship with Alcohol and Trauma"],"prefix":"10.3390","volume":"12","author":[{"given":"Michael","family":"Fritz","sequence":"first","affiliation":[{"name":"School of Health and Social Sciences, AKAD University of Applied Sciences, 70191 Stuttgart, Germany"},{"name":"Department of Forensic Psychiatry and Psychotherapy, Ulm University, BKH G\u00fcnzburg, Lindenallee 2, 89312 G\u00fcnzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah-Maria","family":"Soravia","sequence":"additional","affiliation":[{"name":"Department of Forensic Psychiatry and Psychotherapy, Ulm University, BKH G\u00fcnzburg, Lindenallee 2, 89312 G\u00fcnzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Dudeck","sequence":"additional","affiliation":[{"name":"Department of Forensic Psychiatry and Psychotherapy, Ulm University, BKH G\u00fcnzburg, Lindenallee 2, 89312 G\u00fcnzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Layal","family":"Malli","sequence":"additional","affiliation":[{"name":"Department of Natural Sciences, School of Arts and Sciences, Lebanese American University, Beirut P.O. Box 13-5053, Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9335-9308","authenticated-orcid":false,"given":"Marc","family":"Fakhoury","sequence":"additional","affiliation":[{"name":"Department of Natural Sciences, School of Arts and Sciences, Lebanese American University, Beirut P.O. Box 13-5053, Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1542\/pir.2016-0062","article-title":"Violence and Aggressive Behavior","volume":"38","author":"Austerman","year":"2017","journal-title":"Pediatr. Rev."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/978-981-15-7086-5_2","article-title":"Neurobiology and Neural Circuits of Aggression","volume":"1284","author":"Helmy","year":"2020","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1017\/S0003598X00067843","article-title":"A Bronze Age battlefield? Weapons and trauma in the Tollense Valley, north-eastern Germany","volume":"85","author":"Jantzen","year":"2011","journal-title":"Antiquity"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Roy, K. (2022). A Global History of Warfare and Technology, Springer Nature Singapore.","DOI":"10.1007\/978-981-19-3478-0"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s00787-005-0432-4","article-title":"Reactive and proactive aggression in children\u2014A review of theory, findings and the relevance for child and adolescent psychiatry","volume":"14","author":"Kempes","year":"2005","journal-title":"Eur. Child Adolesc. Psychiatry"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Goldstein, S., and Naglieri, J.A. (2011). Encyclopedia of Child Behavior and Development, Springer.","DOI":"10.1007\/978-0-387-79061-9"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"8430","DOI":"10.3402\/ejpt.v2i0.8430","article-title":"The Appetitive Aggression Scale-development of an instrument for the assessment of human\u2019s attraction to violence","volume":"2","author":"Weierstall","year":"2011","journal-title":"Eur. J. Psychotraumatol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1007\/s00213-020-05577-x","article-title":"Rage Against the Machine: Advancing the study of aggression ethology via machine learning","volume":"237","author":"Goodwin","year":"2020","journal-title":"Psychopharmacology"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.physbeh.2015.02.053","article-title":"Behavioural, hormonal and neurobiological mechanisms of aggressive behaviour in human and nonhuman primates","volume":"143","author":"Cabral","year":"2015","journal-title":"Physiol. Behav."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"107451","DOI":"10.1016\/j.neuropharm.2018.11.039","article-title":"Towards a neurobiology of female aggression","volume":"156","author":"Been","year":"2019","journal-title":"Neuropharmacology"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.copsyc.2017.03.030","article-title":"Gender differences in aggression","volume":"19","year":"2018","journal-title":"Curr. Opin. Psychol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.copsyc.2017.03.023","article-title":"Effects of Alcohol on Human Aggression","volume":"19","author":"Parrott","year":"2018","journal-title":"Curr. Opin. Psychol."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Florek, S., D\u0119bski, P., Piegza, M., Gorczyca, P., and Pudlo, R. (2021). Relationship between the Severity of Anxiety Symptoms, Aggression and Alcohol Consumption during the COVID-19 Pandemic Period. Medicina, 57.","DOI":"10.3390\/medicina57090959"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1016\/j.psyneuen.2012.04.011","article-title":"High and abnormal forms of aggression in rats with extremes in trait anxiety\u2014Involvement of the dopamine system in the nucleus accumbens","volume":"37","author":"Beiderbeck","year":"2012","journal-title":"Psychoneuroendocrinology"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1037\/tra0000227","article-title":"Relations between traumatic stress, dimensions of impulsivity, and reactive and appetitive aggression in individuals with refugee status","volume":"9","author":"Augsburger","year":"2017","journal-title":"Psychol. Trauma"},{"key":"ref_16","first-page":"e12322","article-title":"Associations between trauma exposure, posttraumatic stress disorder, and aggression perpetrated by women. A meta-analysis","volume":"27","author":"Augsburger","year":"2020","journal-title":"Clin. Psychol. Sci. Pract."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1126\/science.1072290","article-title":"Role of genotype in the cycle of violence in maltreated children","volume":"297","author":"Caspi","year":"2002","journal-title":"Science"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1523\/ENEURO.0331-20.2020","article-title":"The Dorsal Raphe Regulates the Duration of Attack through the Medial Orbitofrontal Cortex and Medial Amygdala","volume":"7","author":"Nordman","year":"2020","journal-title":"eNeuro"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.pscychresns.2009.03.012","article-title":"Prefrontal structural and functional brain imaging findings in antisocial, violent, and psychopathic individuals: A meta-analysis","volume":"174","author":"Yang","year":"2009","journal-title":"Psychiatry Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/s11920-020-01208-6","article-title":"Understanding Brain Mechanisms of Reactive Aggression","volume":"22","author":"Bertsch","year":"2020","journal-title":"Curr. Psychiatry Rep."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1176\/appi.ajp.2016.15081089","article-title":"Meta-Analysis of fMRI Studies of Disruptive Behavior Disorders","volume":"173","author":"Alegria","year":"2016","journal-title":"Am. J. Psychiatry"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1093\/brain\/awp011","article-title":"Size matters: Increased grey matter in boys with conduct problems and callous-unemotional traits","volume":"132","author":"Mechelli","year":"2009","journal-title":"Brain"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.1016\/j.cub.2021.03.062","article-title":"A central role for anterior cingulate cortex in the control of pathological aggression","volume":"31","author":"Tulva","year":"2021","journal-title":"Curr. Biol."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Chen, C.-Y., Raine, A., Chou, K.-H., Chen, I.-Y., Hung, D., and Lin, C.-P. (2016). Abnormal white matter integrity in rapists as indicated by diffusion tensor imaging. BMC Neurosci., 17.","DOI":"10.1186\/s12868-016-0278-3"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1093\/scan\/nsv018","article-title":"Reducing proactive aggression through non-invasive brain stimulation","volume":"10","author":"Dambacher","year":"2015","journal-title":"Soc. Cogn. Affect. Neurosci."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1093\/scan\/nsr012","article-title":"When anger leads to aggression: Induction of relative left frontal cortical activity with transcranial direct current stimulation increases the anger-aggression relationship","volume":"7","author":"Hortensius","year":"2012","journal-title":"Soc. Cogn. Affect. Neurosci."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Dambacher, F., Schuhmann, T., Lobbestael, J., Arntz, A., Brugman, S., and Sack, A.T. (2015). No Effects of Bilateral tDCS over Inferior Frontal Gyrus on Response Inhibition and Aggression. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0132170"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"6505","DOI":"10.1523\/JNEUROSCI.3317-17.2018","article-title":"Stimulation of the Prefrontal Cortex Reduces Intentions to Commit Aggression: A Randomized, Double-Blind, Placebo-Controlled, Stratified, Parallel-Group Trial","volume":"38","author":"Choy","year":"2018","journal-title":"J. Neurosci."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2757","DOI":"10.1523\/JNEUROSCI.2975-15.2016","article-title":"Brain Regions Influencing Implicit Violent Attitudes: A Lesion-Mapping Study","volume":"36","author":"Cristofori","year":"2016","journal-title":"J. Neurosci."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1080\/17470919.2012.720602","article-title":"Asymmetry in the dorsolateral prefrontal cortex and aggressive behavior: A continuous theta-burst magnetic stimulation study","volume":"8","author":"Tauber","year":"2013","journal-title":"Soc. Neurosci."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/s11292-020-09440-z","article-title":"Transcranial magnetic stimulation over the dorsolateral prefrontal cortex affects emotional processing: Accounting for individual differences in antisocial behavior","volume":"16","author":"Konikkou","year":"2020","journal-title":"J. Exp. Criminol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.cortex.2017.09.024","article-title":"Physical aggressiveness and gray matter deficits in ventromedial prefrontal cortex","volume":"97","author":"Chester","year":"2017","journal-title":"Cortex"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1093\/scan\/nsy025","article-title":"Neural mechanisms of the rejection-aggression link","volume":"13","author":"Chester","year":"2018","journal-title":"Soc. Cogn. Affect. Neurosci."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1002\/ab.21838","article-title":"Neural correlates of intertemporal choice in aggressive behavior","volume":"45","author":"Chester","year":"2019","journal-title":"Aggress. Behav."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"564","DOI":"10.3758\/s13415-015-0344-9","article-title":"Brain morphology of childhood aggressive behavior: A multi-informant study in school-age children","volume":"15","author":"Thijssen","year":"2015","journal-title":"Cogn. Affect. Behav. Neurosci."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.cobeha.2015.02.007","article-title":"Escalated Aggression in Animal Models: Shedding New Light on Mesocorticolimbic Circuits","volume":"3","author":"Miczek","year":"2015","journal-title":"Curr. Opin. Behav. Sci."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Takahashi, A., Nagayasu, K., Nishitani, N., Kaneko, S., and Koide, T. (2014). Control of intermale aggression by medial prefrontal cortex activation in the mouse. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0094657"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"4812","DOI":"10.1093\/cercor\/bhv173","article-title":"From Phineas Gage and Monsieur Leborgne to H.M.: Revisiting Disconnection Syndromes","volume":"25","author":"Ratiu","year":"2015","journal-title":"Cereb. Cortex"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.avb.2015.09.016","article-title":"Structural brain abnormalities in aggression and violent behavior","volume":"25","author":"Bannon","year":"2015","journal-title":"Aggress. Violent Behav."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"3057","DOI":"10.1093\/cercor\/bhu101","article-title":"Orbitofrontal Cortex Reactivity to Angry Facial Expression in a Social Interaction Correlates with Aggressive Behavior","volume":"25","author":"Beyer","year":"2015","journal-title":"Cereb. Cortex"},{"key":"ref_41","first-page":"250","article-title":"Chronic Inactivation of the Orbitofrontal Cortex Increases Anxiety-Like Behavior and Impulsive Aggression, but Decreases Depression-Like Behavior in Rats","volume":"10","author":"Kuniishi","year":"2016","journal-title":"Front. Behav. Neurosci."},{"key":"ref_42","first-page":"625","article-title":"Abnormal temporal lobe metabolism in violent subjects: Correlation of imaging and neuropsychiatric findings","volume":"18","author":"Seidenwurm","year":"1997","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pscychresns.2004.07.002","article-title":"Reduced temporal lobe volume in early onset conduct disorder","volume":"132","author":"Kruesi","year":"2004","journal-title":"Psychiatry Res."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1177\/1524838005275089","article-title":"Neuroimaging studies of aggressive and violent behavior: Current findings and implications for criminology and criminal justice","volume":"6","author":"Bufkin","year":"2005","journal-title":"Trauma Violence Abus."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"38538","DOI":"10.1038\/srep38538","article-title":"Endogenous testosterone is associated with lower amygdala reactivity to angry faces and reduced aggressive behavior in healthy young women","volume":"6","author":"Engelke","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.psychres.2018.11.025","article-title":"The neuromoral theory of antisocial, violent, and psychopathic behavior","volume":"277","author":"Raine","year":"2019","journal-title":"Psychiatry Res."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"110596","DOI":"10.1016\/j.pnpbp.2022.110596","article-title":"Brain responses in aggression-prone individuals: A systematic review and meta-analysis of functional magnetic resonance imaging (fMRI) studies of anger- and aggression-eliciting tasks","volume":"119","author":"Nikolic","year":"2022","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/1044-5765(92)90010-Y","article-title":"Functions of dopamine in the dorsal and ventral striatum","volume":"4","author":"Robbins","year":"1992","journal-title":"Semin. Neurosci."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1093\/scan\/nsx006","article-title":"Violent offenders respond to provocations with high amygdala and striatal reactivity","volume":"12","author":"Fisher","year":"2017","journal-title":"Soc. Cogn. Affect. Neurosci."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1002\/ab.21683","article-title":"Neural correlates of proactive and reactive aggression in adolescent twins","volume":"43","author":"Yang","year":"2017","journal-title":"Aggress. Behav."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.1002\/hbm.22316","article-title":"Punishing unfairness: Rewarding or the organization of a reactively aggressive response?","volume":"35","author":"White","year":"2014","journal-title":"Hum. Brain Mapp."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"3996","DOI":"10.1523\/JNEUROSCI.0151-19.2019","article-title":"Animal Models of (or for) Aggression Reward, Addiction, and Relapse: Behavior and Circuits","volume":"39","author":"Golden","year":"2019","journal-title":"J. Neurosci."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"2482","DOI":"10.1523\/JNEUROSCI.2409-18.2019","article-title":"Nucleus Accumbens Drd1-Expressing Neurons Control Aggression Self-Administration and Aggression Seeking in Mice","volume":"39","author":"Golden","year":"2019","journal-title":"J. Neurosci."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1111\/gbb.12310","article-title":"Persistent conditioned place preference to aggression experience in adult male sexually-experienced CD-1 mice","volume":"16","author":"Golden","year":"2017","journal-title":"Genes Brain Behav."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1038\/nn.4264","article-title":"Hypothalamic control of male aggression-seeking behavior","volume":"19","author":"Falkner","year":"2016","journal-title":"Nat. Neurosci."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1037\/pspp0000013","article-title":"Narcissistic rage revisited","volume":"108","author":"Krizan","year":"2015","journal-title":"J. Pers. Soc. Psychol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1152\/jn.1940.3.6.538","article-title":"forebrain and rage reactions","volume":"3","author":"Spiegel","year":"1940","journal-title":"J. Neurophysiol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.ijlp.2009.06.001","article-title":"Understanding human aggression: New insights from neuroscience","volume":"32","author":"Siegel","year":"2009","journal-title":"Int. J. Law Psychiatry"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.cub.2015.12.065","article-title":"Effective Modulation of Male Aggression through Lateral Septum to Medial Hypothalamus Projection","volume":"26","author":"Wong","year":"2016","journal-title":"Curr. Biol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1038\/s41593-020-00715-2","article-title":"Neural mechanisms of aggression across species","volume":"23","author":"Lischinsky","year":"2020","journal-title":"Nat. Neurosci."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"110059","DOI":"10.1016\/j.pnpbp.2020.110059","article-title":"The neurobiology of human aggressive behavior: Neuroimaging, genetic, and neurochemical aspects","volume":"106","author":"Cupaioli","year":"2021","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/s41586-018-0772-0","article-title":"A circuit from hippocampal CA2 to lateral septum disinhibits social aggression","volume":"564","author":"Leroy","year":"2018","journal-title":"Nature"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"6796","DOI":"10.1038\/s41467-021-27092-z","article-title":"Dopamine promotes aggression in mice via ventral tegmental area to lateral septum projections","volume":"12","author":"Mahadevia","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.tins.2021.10.010","article-title":"Neurobiology of the lateral septum: Regulation of social behavior","volume":"45","author":"Menon","year":"2022","journal-title":"Trends Neurosci."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"94","DOI":"10.3389\/fnsys.2017.00094","article-title":"Ventromedial Hypothalamus and the Generation of Aggression","volume":"11","author":"Hashikawa","year":"2017","journal-title":"Front. Syst. Neurosci."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/0306-4522(94)90302-6","article-title":"Efferent connections of the hypothalamic \u201caggression area\u201d in the rat","volume":"59","author":"Roeling","year":"1994","journal-title":"Neuroscience"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/nature09736","article-title":"Functional identification of an aggression locus in the mouse hypothalamus","volume":"470","author":"Lin","year":"2011","journal-title":"Nature"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"4065","DOI":"10.1523\/JNEUROSCI.3234-17.2018","article-title":"Task Division within the Prefrontal Cortex: Distinct Neuron Populations Selectively Control Different Aspects of Aggressive Behavior via the Hypothalamus","volume":"38","author":"Biro","year":"2018","journal-title":"J. Neurosci."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1093\/neuros\/nyy635","article-title":"Amygdala and Hypothalamus: Historical Overview with Focus on Aggression","volume":"85","author":"Gouveia","year":"2019","journal-title":"Neurosurgery"},{"key":"ref_70","first-page":"145","article-title":"Posteromedial hypothalamotomy in the treatment of violent, aggressive behaviour","volume":"44","author":"Sano","year":"1988","journal-title":"Acta Neurochir. Suppl."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"E11","DOI":"10.3171\/2010.5.FOCUS10102","article-title":"Deep brain stimulation of the orbitofrontal projections for the treatment of intermittent explosive disorder","volume":"29","author":"Maley","year":"2010","journal-title":"Neurosurg. Focus"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"S29.e11","DOI":"10.1016\/j.wneu.2012.06.038","article-title":"Deep-brain stimulation for aggressive and disruptive behavior","volume":"80","author":"Franzini","year":"2013","journal-title":"World Neurosurg."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"277","DOI":"10.3171\/2013.4.JNS121639","article-title":"Long-term results of posteromedial hypothalamic deep brain stimulation for patients with resistant aggressiveness","volume":"119","author":"Torres","year":"2013","journal-title":"J. Neurosurg."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"366","DOI":"10.3171\/2019.11.JNS192608","article-title":"Deep brain stimulation for aggressiveness: Long-term follow-up and tractography study of the stimulated brain areas","volume":"134","author":"Torres","year":"2020","journal-title":"J. Neurosurg."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1016\/j.celrep.2019.07.005","article-title":"The Ventral Hippocampus Controls Stress-Provoked Impulsive Aggression through the Ventromedial Hypothalamus in Post-Weaning Social Isolation Mice","volume":"28","author":"Chang","year":"2019","journal-title":"Cell Rep."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.jpsychires.2015.07.009","article-title":"Morphometric analysis of amygdla and hippocampus shape in impulsively aggressive and healthy control subjects","volume":"69","author":"Coccaro","year":"2015","journal-title":"J. Psychiatr. Res."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1111\/jcpp.12364","article-title":"Maternal depression in childhood and aggression in young adulthood: Evidence for mediation by offspring amygdala-hippocampal volume ratio","volume":"56","author":"Gilliam","year":"2015","journal-title":"J. Child Psychol. Psychiatry"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1097\/WNR.0000000000001127","article-title":"Resting-state functional connectivity as a biomarker of aggression in mild traumatic brain injury","volume":"29","author":"Dailey","year":"2018","journal-title":"Neuroreport"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.neubiorev.2017.09.017","article-title":"The role of central and medial amygdala in normal and abnormal aggression: A review of classical approaches","volume":"85","author":"Haller","year":"2018","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.celrep.2014.12.040","article-title":"Medial amygdalar aromatase neurons regulate aggression in both sexes","volume":"10","author":"Unger","year":"2015","journal-title":"Cell Rep."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1038\/s41593-020-0675-x","article-title":"Posterior amygdala regulates sexual and aggressive behaviors in male mice","volume":"23","author":"Yamaguchi","year":"2020","journal-title":"Nat. Neurosci."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1038\/s42003-022-03928-2","article-title":"Inhibition of the medial amygdala disrupts escalated aggression in lactating female mice after repeated exposure to male intruders","volume":"5","author":"Lanuza","year":"2022","journal-title":"Commun. Biol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1080\/17470919.2017.1421262","article-title":"Amygdala reactivity to fearful faces correlates positively with impulsive aggression","volume":"14","author":"Fisher","year":"2019","journal-title":"Soc. Neurosci."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.biopsych.2013.04.003","article-title":"Lower amygdala volume in men is associated with childhood aggression, early psychopathic traits, and future violence","volume":"75","author":"Pardini","year":"2014","journal-title":"Biol. Psychiatry"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"111416","DOI":"10.1016\/j.pscychresns.2021.111416","article-title":"Associations between amygdala nuclei volumes, psychosis, psychopathy, and violent offending","volume":"319","author":"Bell","year":"2022","journal-title":"Psychiatry Res. Neuroimaging"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1111\/jora.12349","article-title":"Longitudinal Associations Between Family Aggression, Externalizing Behavior, and the Structure and Function of the Amygdala","volume":"28","author":"Saxbe","year":"2018","journal-title":"J. Res. Adolesc."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1002\/(SICI)1099-0798(199822)16:3<319::AID-BSL311>3.0.CO;2-G","article-title":"Reduced prefrontal and increased subcortical brain functioning assessed using positron emission tomography in predatory and affective murderers","volume":"16","author":"Raine","year":"1998","journal-title":"Behav. Sci. Law"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.pscychresns.2017.06.012","article-title":"Proximity alert! Distance related cuneus activation in military veterans with anger and aggression problems","volume":"266","author":"Heesink","year":"2017","journal-title":"Psychiatry Res. Neuroimaging"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1093\/scan\/nsx113","article-title":"Resting-state functional connectivity in combat veterans suffering from impulsive aggression","volume":"12","author":"Varkevisser","year":"2017","journal-title":"Soc. Cogn. Affect. Neurosci."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"4371","DOI":"10.1093\/cercor\/bhab489","article-title":"Amygdala-prefrontal connectivity in children with maladaptive aggression is modulated by social impairment","volume":"32","author":"Ibrahim","year":"2022","journal-title":"Cereb. Cortex"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"e12686","DOI":"10.1111\/desc.12686","article-title":"Community violence exposure in early adolescence: Longitudinal associations with hippocampal and amygdala volume and resting state connectivity","volume":"21","author":"Saxbe","year":"2018","journal-title":"Dev. Sci."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1093\/scan\/nsab128","article-title":"Increased amygdala and decreased frontolimbic r esting- s tate functional connectivity in children with aggressive behavior","volume":"17","author":"Sukhodolsky","year":"2022","journal-title":"Soc. Cogn. Affect. Neurosci."},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Beyer, F., M\u00fcnte, T.F., Wiechert, J., Heldmann, M., and Kr\u00e4mer, U.M. (2014). Trait aggressiveness is not related to structural connectivity between orbitofrontal cortex and amygdala. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0101105"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1038\/mp.2014.45","article-title":"Optogenetic stimulation of DAergic VTA neurons increases aggression","volume":"19","author":"Yu","year":"2014","journal-title":"Mol. Psychiatry"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"12393","DOI":"10.1073\/pnas.1001394107","article-title":"Winning territorial disputes selectively enhances androgen sensitivity in neural pathways related to motivation and social aggression","volume":"107","author":"Fuxjager","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1038\/nn.2510","article-title":"Mesolimbic dopamine reward system hypersensitivity in individuals with psychopathic traits","volume":"13","author":"Buckholtz","year":"2010","journal-title":"Nat. Neurosci."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1007\/s11682-021-00535-3","article-title":"Altered Resting-State Functional Connectivity in the Default Mode Network in Male Juvenile Violent Offenders","volume":"16","author":"Sun","year":"2022","journal-title":"Brain Imaging Behav."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1007\/s00787-020-01601-9","article-title":"Aggression subtypes relate to distinct resting state functional connectivity in children and adolescents with disruptive behavior","volume":"30","author":"Werhahn","year":"2021","journal-title":"Eur. Child Adolesc. Psychiatry"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1038\/s41386-022-01296-3","article-title":"Neuronal responses in social-emotional information processing in impulsive aggressive individuals","volume":"47","author":"Coccaro","year":"2022","journal-title":"Neuropsychopharmacology"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.biopsycho.2013.12.008","article-title":"Increased neural reactivity to socio-emotional stimuli links social exclusion and aggression","volume":"96","author":"Beyer","year":"2014","journal-title":"Biol. Psychol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"7731","DOI":"10.1038\/s41598-019-44115-4","article-title":"Brain structures and functional connectivity associated with individual differences in trait proactive aggression","volume":"9","author":"Zhu","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1146\/annurev.med.60.042307.110802","article-title":"The expanded biology of serotonin","volume":"60","author":"Berger","year":"2009","journal-title":"Annu. Rev. Med."},{"key":"ref_103","first-page":"157","article-title":"International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (Serotonin)","volume":"46","author":"Hoyer","year":"1994","journal-title":"Pharmacol. Rev."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"2609","DOI":"10.1016\/0024-3205(83)90344-2","article-title":"Low cerebrospinal fluid 5-hydroxyindoleacetic acid concentration differentiates impulsive from nonimpulsive violent behavior","volume":"33","author":"Linnoila","year":"1983","journal-title":"Life Sci."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1037\/a0031544","article-title":"Revisiting the serotonin-aggression relation in humans: A meta-analysis","volume":"139","author":"Duke","year":"2013","journal-title":"Psychol. Bull."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1126\/science.1078197","article-title":"Synthesis of serotonin by a second tryptophan hydroxylase isoform","volume":"299","author":"Walther","year":"2003","journal-title":"Science"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1038\/s41598-018-37613-4","article-title":"Brain serotonin deficiency affects female aggression","volume":"9","author":"Richter","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"2974","DOI":"10.1021\/acschemneuro.2c00448","article-title":"Tryptophan Hydroxylase 2 Knockout Male Rats Exhibit a Strengthened Oxytocin System, Are Aggressive, and Are Less Anxious","volume":"13","author":"Meng","year":"2022","journal-title":"ACS Chem. Neurosci."},{"key":"ref_109","doi-asserted-by":"crossref","unstructured":"Svirin, E., Veniaminova, E., Costa-Nunes, J.P., Gorlova, A., Umriukhin, A., Kalueff, A.V., Proshin, A., Anthony, D.C., Nedorubov, A., and Tse, A.C.K. (2022). Predation Stress Causes Excessive Aggression in Female Mice with Partial Genetic Inactivation of Tryptophan Hydroxylase-2: Evidence for Altered Myelination-Related Processes. Cells, 11.","DOI":"10.3390\/cells11061036"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.jad.2020.04.014","article-title":"Stress-induced aggression in heterozygous TPH2 mutant mice is associated with alterations in serotonin turnover and expression of 5-HT6 and AMPA subunit 2A receptors","volume":"272","author":"Gorlova","year":"2020","journal-title":"J. Affect. Disord."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.neuropharm.2019.05.004","article-title":"Enhanced aggressive phenotype of Tph2 knockout rats is associated with diminished 5-HT1A receptor sensitivity","volume":"153","author":"Peeters","year":"2019","journal-title":"Neuropharmacology"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"156","DOI":"10.3389\/fnins.2014.00156","article-title":"Genetic mapping of escalated aggression in wild-derived mouse strain MSM\/Ms: Association with serotonin-related genes","volume":"8","author":"Takahashi","year":"2014","journal-title":"Front. Neurosci."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1159\/000318572","article-title":"Association between tryptophan hydroxylase 2 polymorphism and anger-related personality traits among young Korean women","volume":"62","author":"Yang","year":"2010","journal-title":"Neuropsychobiology"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.bbr.2012.03.001","article-title":"Impact of tryptophan hydroxylase 2 G-703T polymorphism on anger-related personality traits and orbitofrontal cortex","volume":"231","author":"Yoon","year":"2012","journal-title":"Behav. Brain Res."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1038\/mp.2011.79","article-title":"Tryptophan hydroxylase(2) gene polymorphisms predict brain serotonin synthesis in the orbitofrontal cortex in humans","volume":"17","author":"Booij","year":"2012","journal-title":"Mol. Psychiatry"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.jad.2017.03.045","article-title":"Nice guys: Homozygocity for the TPH2 -703G\/T (rs4570625) minor allele promotes low aggressiveness and low anxiety","volume":"215","author":"Laas","year":"2017","journal-title":"J. Affect. Disord."},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Studer, E., N\u00e4slund, J., Andersson, E., Nilsson, S., Westberg, L., and Eriksson, E. (2015). Serotonin depletion-induced maladaptive aggression requires the presence of androgens. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0126462"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"8678","DOI":"10.1523\/JNEUROSCI.2067-12.2013","article-title":"Suppression of serotonin neuron firing increases aggression in mice","volume":"33","author":"Audero","year":"2013","journal-title":"J. Neurosci."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1177\/0269881120913150","article-title":"Divergent pathways mediate 5-HT1A receptor agonist effects on close social interaction, grooming and aggressive behaviour in mice: Exploring the involvement of the oxytocin and vasopressin systems","volume":"34","author":"Tan","year":"2020","journal-title":"J. Psychopharmacol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"13233","DOI":"10.1073\/pnas.1610446113","article-title":"Serotonin and arginine-vasopressin mediate sex differences in the regulation of dominance and aggression by the social brain","volume":"113","author":"Terranova","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1007\/s00213-013-3164-z","article-title":"Aggression-reducing effects of F15599, a novel selective 5-HT1A receptor agonist, after microinjection into the ventral orbital prefrontal cortex, but not in infralimbic cortex in male mice","volume":"230","author":"Stein","year":"2013","journal-title":"Psychopharmacology"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"e00929","DOI":"10.1002\/brb3.929","article-title":"5-HT2CR antagonist\/5-HT2CR inverse agonist recovered the increased isolation-induced aggressive behavior of BALB\/c mice mediated by ADAR1 (p110) expression and Htr2c RNA editing","volume":"8","author":"Yu","year":"2018","journal-title":"Brain Behav."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s40101-018-0171-0","article-title":"Serotonergic gene polymorphisms (5-HTTLPR, 5HTR1A, 5HTR2A), and population differences in aggression: Traditional (Hadza and Datoga) and industrial (Russians) populations compared","volume":"37","author":"Butovskaya","year":"2018","journal-title":"J. Physiol. Anthropol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"110542","DOI":"10.1016\/j.pnpbp.2022.110542","article-title":"Serotonin 5-HT2A receptor polymorphisms are associated with irritability and aggression in conduct disorder","volume":"117","author":"Tudor","year":"2022","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"ref_125","doi-asserted-by":"crossref","unstructured":"Braccagni, G., Scheggi, S., and Bortolato, M. (2022). Elevated levels of serotonin 5-HT2A receptors in the orbitofrontal cortex of antisocial individuals. Eur. Arch. Psychiatry Clin. Neurosci., 1\u201315.","DOI":"10.1007\/s00406-022-01480-y"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.pscychresns.2012.09.007","article-title":"Trait aggression and trait impulsivity are not related to frontal cortex 5-HT2A receptor binding in healthy individuals","volume":"212","author":"Holst","year":"2013","journal-title":"Psychiatry Res."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.biopsych.2016.02.030","article-title":"Serotonin 1B Receptor Binding Is Associated with Trait Anger and Level of Psychopathy in Violent Offenders","volume":"82","author":"Hjordt","year":"2017","journal-title":"Biol. Psychiatry"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1007\/s10865-012-9452-y","article-title":"Serotonin receptor 1B genotype and hostility, anger and aggressive behavior through the lifespan: The Young Finns study","volume":"36","author":"Hakulinen","year":"2013","journal-title":"J. Behav. Med."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1093\/scan\/nsv140","article-title":"High trait aggression in men is associated with low 5-HT levels, as indexed by 5-HT4 receptor binding","volume":"11","author":"Fisher","year":"2016","journal-title":"Soc. Cogn. Affect. Neurosci."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1124\/pr.110.002642","article-title":"The physiology, signaling, and pharmacology of dopamine receptors","volume":"63","author":"Beaulieu","year":"2011","journal-title":"Pharmacol. Rev."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"5913","DOI":"10.1523\/JNEUROSCI.0296-18.2018","article-title":"Cell-Type-Specific Role of \u0394FosB in Nucleus Accumbens in Modulating Intermale Aggression","volume":"38","author":"Aleyasin","year":"2018","journal-title":"J. Neurosci."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"696834","DOI":"10.3389\/fncel.2021.696834","article-title":"Experimental Social Stress: Dopaminergic Receptors, Oxidative Stress, and c-Fos Protein Are Involved in Highly Aggressive Behavior","volume":"15","author":"Felippe","year":"2021","journal-title":"Front. Cell. Neurosci."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.neulet.2014.10.051","article-title":"High aggression in rats is associated with elevated stress, anxiety-like behavior, and altered catecholamine content in the brain","volume":"584","author":"Patki","year":"2015","journal-title":"Neurosci. Lett."},{"key":"ref_134","doi-asserted-by":"crossref","unstructured":"Smagin, D.A., Babenko, V.N., Redina, O.E., Kovalenko, I.L., Galyamina, A.G., and Kudryavtseva, N.N. (2021). Reduced Expression of Slc Genes in the VTA and NAcc of Male Mice with Positive Fighting Experience. Genes, 12.","DOI":"10.3390\/genes12071099"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"2593","DOI":"10.1007\/s00213-019-05229-9","article-title":"Methylphenidate administration promotes sociability and reduces aggression in a mouse model of callousness","volume":"236","author":"Zoratto","year":"2019","journal-title":"Psychopharmacology"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"e762","DOI":"10.1038\/tp.2016.12","article-title":"The effects of the dopamine stabilizer (-)-OSU6162 on aggressive and sexual behavior in rodents","volume":"6","author":"Studer","year":"2016","journal-title":"Transl. Psychiatry"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"662652","DOI":"10.3389\/fpsyt.2021.662652","article-title":"Effect of Methylphenidate on Resting-State Connectivity in Adolescents with a Disruptive Behavior Disorder: A Double-Blind Randomized Placebo-Controlled fMRI Study","volume":"12","author":"Pape","year":"2021","journal-title":"Front. Psychiatry"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1007\/s10802-013-9791-3","article-title":"Prediction of preschool aggression from DRD4 risk, parental ADHD symptoms, and home chaos","volume":"42","author":"Farbiash","year":"2014","journal-title":"J. Abnorm. Child Psychol."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"3089","DOI":"10.1007\/s00213-014-3484-7","article-title":"Interaction between prenatal stress and dopamine D4 receptor genotype in predicting aggression and cortisol levels in young adults","volume":"231","author":"Buchmann","year":"2014","journal-title":"Psychopharmacology"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.jcrimjus.2013.02.001","article-title":"Two dopamine receptor genes (DRD2 and DRD4) predict psychopathic personality traits in a sample of American adults","volume":"41","author":"Wu","year":"2013","journal-title":"J. Crim. Justice"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1080\/15622975.2017.1366056","article-title":"The polymorphism of dopamine receptor D4 (DRD4) and dopamine transporter (DAT) genes in the men with antisocial behaviour and mixed martial arts fighters","volume":"20","author":"Cherepkova","year":"2019","journal-title":"World J. Biol. Psychiatry"},{"key":"ref_142","doi-asserted-by":"crossref","unstructured":"Qadeer, M.I., Amar, A., Mann, J.J., and Hasnain, S. (2017). Polymorphisms in dopaminergic system genes; association with criminal behavior and self-reported aggression in violent prison inmates from Pakistan. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0173571"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"101875","DOI":"10.1016\/j.pneurobio.2020.101875","article-title":"The role of monoamine oxidase A in the neurobiology of aggressive, antisocial, and violent behavior: A tale of mice and men","volume":"194","author":"Kolla","year":"2020","journal-title":"Prog. Neurobiol."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1177\/1535370214529508","article-title":"Molecular genetics and antisocial behavior: Where do we stand?","volume":"239","author":"Iofrida","year":"2014","journal-title":"Exp. Biol. Med."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"802","DOI":"10.2174\/1570159X13666150612225836","article-title":"The Role of the Catechol-o-Methyltransferase (COMT) GeneVal158Met in Aggressive Behavior, a Review of Genetic Studies","volume":"13","author":"Qayyum","year":"2015","journal-title":"Curr. Neuropharmacol."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1007\/s10519-014-9661-y","article-title":"Candidate genes for aggression and antisocial behavior: A meta-analysis of association studies of the 5HTTLPR and MAOA-uVNTR","volume":"44","author":"Ficks","year":"2014","journal-title":"Behav. Genet."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.ijlp.2016.09.005","article-title":"The forensic use of behavioral genetics in criminal proceedings: Case of the MAOA-L genotype","volume":"50","author":"McSwiggan","year":"2017","journal-title":"Int. J. Law Psychiatry"},{"key":"ref_148","first-page":"235","article-title":"MAO-A and -B gene knock-out mice exhibit distinctly different behavior","volume":"7","author":"Shih","year":"1999","journal-title":"Neurobiology"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"3751","DOI":"10.1038\/s41380-019-0637-4","article-title":"Regulation of impulsive and aggressive behaviours by a novel lncRNA","volume":"26","author":"Abdallah","year":"2021","journal-title":"Mol. Psychiatry"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/mp.2014.10","article-title":"Dopamine and serotonin signaling during two sensitive developmental periods differentially impact adult aggressive and affective behaviors in mice","volume":"19","author":"Yu","year":"2014","journal-title":"Mol. Psychiatry"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jpsychires.2014.04.014","article-title":"The aggression and behavioral abnormalities associated with monoamine oxidase A deficiency are rescued by acute inhibition of serotonin reuptake","volume":"56","author":"Godar","year":"2014","journal-title":"J. Psychiatr. Res."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.euroneuro.2017.06.016","article-title":"Associations of multiple trauma types and MAOA with severe aggressive behavior and MAOA effects on training outcome","volume":"30","author":"Smeijers","year":"2020","journal-title":"Eur. Neuropsychopharmacol."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1038\/s42003-022-03297-w","article-title":"Interaction effects of the 5-HTT and MAOA-uVNTR gene variants on pre-attentive EEG activity in response to threatening voices","volume":"5","author":"Liao","year":"2022","journal-title":"Commun. Biol."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.bbr.2013.03.002","article-title":"MAOA-uVNTR genotype predicts interindividual differences in experimental aggressiveness as a function of the degree of provocation","volume":"247","author":"Kuepper","year":"2013","journal-title":"Behav. Brain Res."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"9607","DOI":"10.1038\/s41598-017-08351-w","article-title":"Association of monoamine oxidase-A genetic variants and amygdala morphology in violent offenders with antisocial personality disorder and high psychopathic traits","volume":"7","author":"Kolla","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.jpsychires.2014.07.006","article-title":"Association of low-activity MAOA allelic variants with violent crime in incarcerated offenders","volume":"58","author":"Stetler","year":"2014","journal-title":"J. Psychiatr. Res."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1097\/YPG.0000000000000125","article-title":"The interactive effect of the MAOA-VNTR genotype and childhood abuse on aggressive behaviors in Chinese male adolescents","volume":"26","author":"Zhang","year":"2016","journal-title":"Psychiatr. Genet."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1093\/cercor\/bhu249","article-title":"Evidence for a Sex-Dependent MAOA\u00d7 Childhood Stress Interaction in the Neural Circuitry of Aggression","volume":"26","author":"Holz","year":"2016","journal-title":"Cereb. Cortex"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1111\/gbb.12140","article-title":"The interactive effect of MAOA-LPR genotype and childhood physical neglect on aggressive behaviors in Italian male prisoners","volume":"13","author":"Gorodetsky","year":"2014","journal-title":"Genes Brain Behav."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3389\/fnbeh.2017.00017","article-title":"Gene-Gene-Environment Interactions of Serotonin Transporter, Monoamine Oxidase A and Childhood Maltreatment Predict Aggressive Behavior in Chinese Adolescents","volume":"11","author":"Zhang","year":"2017","journal-title":"Front. Behav. Neurosci."},{"key":"ref_161","doi-asserted-by":"crossref","unstructured":"Kant, T., Koyama, E., Zai, C.C., Beitchman, J.H., and Kennedy, J.L. (2022). COMT Val\/Met and Psychopathic Traits in Children and Adolescents: A Systematic Review and New Evidence of a Developmental Trajectory toward Psychopathy. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23031782"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"e12443","DOI":"10.1111\/gbb.12443","article-title":"COMT Val158 Met moderates the link between rank and aggression in a non-human primate","volume":"17","author":"Gutleb","year":"2018","journal-title":"Genes Brain Behav."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1037\/dev0000020","article-title":"Child exposure to serious life events, COMT, and aggression: Testing differential susceptibility theory","volume":"51","author":"Hygen","year":"2015","journal-title":"Dev. Psychol."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1111\/jcpp.12464","article-title":"Identifying mechanisms that underlie links between COMT genotype and aggression in male adolescents with ADHD","volume":"57","author":"Langley","year":"2016","journal-title":"J. Child Psychol. Psychiatry"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1002\/ajmg.b.32430","article-title":"Physical and verbal aggressive behavior and COMT genotype: Sensitivity to the environment","volume":"171","author":"Tuvblad","year":"2016","journal-title":"Am. J. Med. Genet. B Neuropsychiatr. Genet."},{"key":"ref_166","doi-asserted-by":"crossref","unstructured":"Fritz, M., R\u00f6sel, F., Dobler, H., Streb, J., and Dudeck, M. (2021). Childhood Trauma, the Combination of MAO-A and COMT Genetic Polymorphisms and the Joy of Being Aggressive in Forensic Psychiatric Patients. Brain Sci., 11.","DOI":"10.3390\/brainsci11081008"},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"106120","DOI":"10.1016\/j.biocel.2021.106120","article-title":"Anger management: Mechanisms of glutamate receptor-mediated synaptic plasticity underlying animal aggression","volume":"142","author":"Nordman","year":"2022","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1111\/j.1601-1848.2004.00075.x","article-title":"Reduced aggression in AMPA-type glutamate receptor GluR-A subunit-deficient mice","volume":"3","author":"Vekovischeva","year":"2004","journal-title":"Genes Brain Behav."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1017\/S1461145713001582","article-title":"Involvement of prefrontal AMPA receptors in encounter stimulation-induced hyperactivity in isolation-reared mice","volume":"17","author":"Araki","year":"2014","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.physbeh.2015.10.026","article-title":"The role of the AMPA receptor and 5-HT(3) receptor on aggressive behavior and depressive-like symptoms in chronic social isolation-reared mice","volume":"153","author":"Shimizu","year":"2016","journal-title":"Physiol. Behav."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"107517","DOI":"10.1016\/j.celrep.2020.03.081","article-title":"VMHvl-Projecting Vglut1+ Neurons in the Posterior Amygdala Gate Territorial Aggression","volume":"31","author":"Zha","year":"2020","journal-title":"Cell Rep."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"81","DOI":"10.4196\/kjpp.2019.23.1.81","article-title":"Chronic administration of ketamine ameliorates the anxiety- and aggressive-like behavior in adolescent mice induced by neonatal maternal separation","volume":"23","author":"Shin","year":"2019","journal-title":"Korean J. Physiol. Pharmacol."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.neuropharm.2018.09.019","article-title":"Mechanism underlying NMDA blockade-induced inhibition of aggression in post-weaning socially isolated mice","volume":"143","author":"Chang","year":"2018","journal-title":"Neuropharmacology"},{"key":"ref_174","doi-asserted-by":"crossref","unstructured":"Frau, R., Pardu, A., Godar, S., Bini, V., and Bortolato, M. (2022). Combined Antagonism of 5-HT2 and NMDA Receptors Reduces the Aggression of Monoamine Oxidase a Knockout Mice. Pharmaceuticals, 15.","DOI":"10.3390\/ph15020213"},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1111\/j.1601-183X.2009.00504.x","article-title":"Assessment of NMDA receptor NR1 subunit hypofunction in mice as a model for schizophrenia","volume":"8","author":"Halene","year":"2009","journal-title":"Genes Brain Behav."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"2144","DOI":"10.1038\/s41380-018-0132-3","article-title":"Amygdala GluN2B-NMDAR dysfunction is critical in abnormal aggression of neurodevelopmental origin induced by St8sia2 deficiency","volume":"25","author":"Bacq","year":"2020","journal-title":"Mol. Psychiatry"},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.ejphar.2006.08.055","article-title":"Antiaggressive effects of MPEP, a selective antagonist of mGlu5 receptors, in agonistic interactions between male mice","volume":"551","author":"Navarro","year":"2006","journal-title":"Eur. J. Pharmacol."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.biopsych.2015.07.021","article-title":"Metabotropic Glutamate Receptor and Fragile X Signaling in a Female Model of Escalated Aggression","volume":"79","author":"Been","year":"2016","journal-title":"Biol. Psychiatry"},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.neuron.2020.04.024","article-title":"VTA Glutamatergic Neurons Mediate Innate Defensive Behaviors","volume":"107","author":"Barbano","year":"2020","journal-title":"Neuron"},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.cortex.2019.08.017","article-title":"Distinct associations between fronto-striatal glutamate concentrations and callous-unemotional traits and proactive aggression in disruptive behavior","volume":"121","author":"Craig","year":"2019","journal-title":"Cortex"},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.pnpbp.2019.04.002","article-title":"Differential levels of prefrontal cortex glutamate+glutamine in adults with antisocial personality disorder and bipolar disorder: A proton magnetic resonance spectroscopy study","volume":"93","author":"Smaragdi","year":"2019","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1038\/npp.2015.153","article-title":"Impulsivity and Aggression in Female BPD and ADHD Patients: Association with ACC Glutamate and GABA Concentrations","volume":"41","author":"Ende","year":"2016","journal-title":"Neuropsychopharmacology"},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.neuropharm.2017.10.011","article-title":"Structural biology of GABAB receptor","volume":"136","author":"Frangaj","year":"2018","journal-title":"Neuropharmacology"},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1096\/fasebj.4.5.2155149","article-title":"Molecular biology of GABAA receptors","volume":"4","author":"Olsen","year":"1990","journal-title":"FASEB J."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"601","DOI":"10.3922\/j.psns.2014.4.20","article-title":"Aggressive behavior and three neurotransmitters: Dopamine, GABA, and serotonin\u2014A review of the last 10 years","volume":"7","author":"Narvaes","year":"2014","journal-title":"Psychol. Neurosci."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.euroneuro.2017.12.007","article-title":"Cortical control of aggression: GABA signalling in the anterior cingulate cortex","volume":"30","author":"Jager","year":"2020","journal-title":"Eur. Neuropsychopharmacol."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"147440","DOI":"10.1016\/j.brainres.2021.147440","article-title":"GABA-A receptor signaling in the anterior cingulate cortex modulates aggression and anxiety-related behaviors in socially isolated mice","volume":"1762","author":"Chaibi","year":"2021","journal-title":"Brain Res."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.brainres.2011.12.042","article-title":"GABAA receptor activation in the lateral septum reduces the expression of conditioned defeat and increases aggression in Syrian hamsters","volume":"1439","author":"McDonald","year":"2012","journal-title":"Brain Res."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s00213-019-05368-z","article-title":"Social experience and sex-dependent regulation of aggression in the lateral septum by extrasynaptic \u03b4GABAA receptors","volume":"237","author":"Borland","year":"2020","journal-title":"Psychopharmacology"},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"4359","DOI":"10.1007\/s00213-015-4069-9","article-title":"\u03b12-containing GABA(A) receptors: A requirement for midazolam-escalated aggression and social approach in mice","volume":"232","author":"Newman","year":"2015","journal-title":"Psychopharmacology"},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1016\/j.cell.2014.07.049","article-title":"Antagonistic control of social versus repetitive self-grooming behaviors by separable amygdala neuronal subsets","volume":"158","author":"Hong","year":"2014","journal-title":"Cell"},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"110850","DOI":"10.1016\/j.celrep.2022.110850","article-title":"Stimulation of medial amygdala GABA neurons with kinetically different channelrhodopsins yields opposite behavioral outcomes","volume":"39","author":"Baleisyte","year":"2022","journal-title":"Cell Rep."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"91","DOI":"10.3109\/13651501.2016.1144771","article-title":"Possible relationship between amino acids, aggression and psychopathy","volume":"20","author":"Gulsun","year":"2016","journal-title":"Int. J. Psychiatry Clin. Pract."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/j.euroneuro.2017.02.003","article-title":"Stressful life events increase aggression and alcohol use in young carriers of the GABRA2 rs279826\/rs279858 A-allele","volume":"27","author":"Kiive","year":"2017","journal-title":"Eur. Neuropsychopharmacol."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1002\/da.22084","article-title":"Cytokine targets in the brain: Impact on neurotransmitters and neurocircuits","volume":"30","author":"Miller","year":"2013","journal-title":"Depress. Anxiety"},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.immuni.2020.12.016","article-title":"Microglial activation elicits a negative affective state through prostaglandin-mediated modulation of striatal neurons","volume":"54","author":"Klawonn","year":"2021","journal-title":"Immunity"},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0306-4522(03)00264-1","article-title":"Interleukin-1 beta in the hypothalamus potentiates feline defensive rage: Role of serotonin-2 receptors","volume":"120","author":"Hassanain","year":"2003","journal-title":"Neuroscience"},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2005.04.086","article-title":"Potentiating role of interleukin-1beta (IL-1beta) and IL-1beta type 1 receptors in the medial hypothalamus in defensive rage behavior in the cat","volume":"1048","author":"Hassanain","year":"2005","journal-title":"Brain Res."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.bbi.2007.07.011","article-title":"Role of IL-1 beta and 5-HT2 receptors in midbrain periaqueductal gray (PAG) in potentiating defensive rage behavior in cat","volume":"22","author":"Bhatt","year":"2008","journal-title":"Brain Behav. Immun."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1016\/j.bbi.2010.05.005","article-title":"Lack of aggression and anxiolytic-like behavior in TNF receptor (TNF-R1 and TNF-R2) deficient mice","volume":"24","author":"Patel","year":"2010","journal-title":"Brain Behav. Immun."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"2563","DOI":"10.1038\/s41380-021-01110-4","article-title":"Neuromodulatory effect of interleukin 1\u03b2 in the dorsal raphe nucleus on individual differences in aggression","volume":"27","author":"Takahashi","year":"2022","journal-title":"Mol. Psychiatry"},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.neulet.2018.11.012","article-title":"Cytokine variations within brain structures in rats selected for differences in aggression","volume":"692","author":"Alperina","year":"2019","journal-title":"Neurosci. Lett."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1001\/jamapsychiatry.2013.3297","article-title":"Elevated plasma inflammatory markers in individuals with intermittent explosive disorder and correlation with aggression in humans","volume":"71","author":"Coccaro","year":"2014","journal-title":"JAMA Psychiatry"},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"pyv001","DOI":"10.1093\/ijnp\/pyv001","article-title":"Cerebrospinal fluid inflammatory cytokines and aggression in personality disordered subjects","volume":"18","author":"Coccaro","year":"2015","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"ref_205","doi-asserted-by":"crossref","unstructured":"Proven\u00e7al, N., Suderman, M.J., Vitaro, F., Szyf, M., and Tremblay, R.E. (2013). Childhood chronic physical aggression associates with adult cytokine levels in plasma. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0069481"},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"e2753","DOI":"10.1002\/brb3.2753","article-title":"Exploring the association of interleukin polymorphisms with aggression and internalizing behaviors in children and adolescents","volume":"12","author":"Pouget","year":"2022","journal-title":"Brain Behav."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/sj.mp.4001378","article-title":"A mu-opioid receptor single nucleotide polymorphism in rhesus monkey: Association with stress response and aggression","volume":"9","author":"Miller","year":"2004","journal-title":"Mol. Psychiatry"},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1111\/adb.12428","article-title":"OPRM1 genotype interacts with serotonin system dysfunction to predict alcohol-heightened aggression in primates","volume":"22","author":"Driscoll","year":"2017","journal-title":"Addict. Biol."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s12993-016-0107-y","article-title":"Transgenerational effects of paternal heroin addiction on anxiety and aggression behavior in male offspring","volume":"12","author":"James","year":"2016","journal-title":"Behav. Brain Funct."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"107467","DOI":"10.1016\/j.neuropharm.2018.12.014","article-title":"The influence of the OPRM1 (A118G) polymorphism on behavioral and neural correlates of aggression in healthy males","volume":"156","author":"Weidler","year":"2019","journal-title":"Neuropharmacology"},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"e01659","DOI":"10.1002\/brb3.1659","article-title":"The \u03bc-opioid receptor gene A118G polymorphism is associated with insecure attachment in children with disruptive mood regulation disorder and their mothers","volume":"10","author":"Cimino","year":"2020","journal-title":"Brain Behav."},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1038\/s41593-020-0617-7","article-title":"Orexin signaling in GABAergic lateral habenula neurons modulates aggressive behavior in male mice","volume":"23","author":"Flanigan","year":"2020","journal-title":"Nat. Neurosci."},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.pbb.2017.05.003","article-title":"An emerging role for the lateral habenula in aggressive behavior","volume":"162","author":"Flanigan","year":"2017","journal-title":"Pharmacol. Biochem. Behav."},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"107527","DOI":"10.1016\/j.neuropharm.2019.02.009","article-title":"Orexin\/hypocretin receptor gene (HCRTR1) variation is associated with aggressive behaviour","volume":"156","author":"Harro","year":"2019","journal-title":"Neuropharmacology"},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"147013","DOI":"10.1016\/j.brainres.2020.147013","article-title":"Association of orexin\/hypocretin receptor gene (HCRTR1) with reward sensitivity, and interaction with gender","volume":"1746","author":"Pulver","year":"2020","journal-title":"Brain Res."},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1016\/j.cub.2019.04.070","article-title":"Oxytocin Signaling in the Central Amygdala Modulates Emotion Discrimination in Mice","volume":"29","author":"Ferretti","year":"2019","journal-title":"Curr. Biol."},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.yfrne.2017.10.004","article-title":"Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery","volume":"51","author":"Song","year":"2018","journal-title":"Front. Neuroendocrinol."},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1146\/annurev-neuro-102320-102847","article-title":"Oxytocin, Neural Plasticity, and Social Behavior","volume":"44","author":"Froemke","year":"2021","journal-title":"Annu. Rev. Neurosci."},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.brainresbull.2012.10.003","article-title":"The neurobiology of abnormal manifestations of aggression\u2014A review of hypothalamic mechanisms in cats, rodents, and humans","volume":"93","author":"Haller","year":"2013","journal-title":"Brain Res. Bull."},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"3597","DOI":"10.1111\/j.1460-9568.2007.05974.x","article-title":"Differences in intermale aggression are accompanied by opposite vasopressin release patterns within the septum in rats bred for low and high anxiety","volume":"26","author":"Beiderbeck","year":"2007","journal-title":"Eur. J. Neurosci."},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.neuroscience.2011.03.056","article-title":"Glutamate-vasopressin interactions and the neurobiology of anabolic steroid-induced offensive aggression","volume":"185","author":"Carrillo","year":"2011","journal-title":"Neuroscience"},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1038\/sj.mp.4001195","article-title":"Vasopressin V1b receptor knockout reduces aggressive behavior in male mice","volume":"7","author":"Wersinger","year":"2002","journal-title":"Mol. Psychiatry"},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1152\/physrev.00031.2017","article-title":"The Oxytocin Receptor: From Intracellular Signaling to Behavior","volume":"98","author":"Jurek","year":"2018","journal-title":"Physiol. Rev."},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"2900","DOI":"10.1038\/s41467-021-23064-5","article-title":"Oxytocin and vasopressin within the ventral and dorsal lateral septum modulate aggression in female rats","volume":"12","author":"Oliveira","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"107573","DOI":"10.1016\/j.neuropharm.2019.03.016","article-title":"Oxytocin and vasopressin inhibit hyper-aggressive behaviour in socially isolated mice","volume":"156","author":"Tan","year":"2019","journal-title":"Neuropharmacology"},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"9664","DOI":"10.1038\/s41598-019-45953-y","article-title":"Vasopressin enhances human preemptive strike in both males and females","volume":"9","author":"Kawada","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_227","doi-asserted-by":"crossref","unstructured":"Akkoc Altinok, D.C., Votinov, M., Henzelmann, F., Jo, H., Eisert, A., Habel, U., and Wagels, L. (2021). A Combined Administration of Testosterone and Arginine Vasopressin Affects Aggressive Behavior in Males. Brain Sci., 11.","DOI":"10.3390\/brainsci11121623"},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1080\/17470919.2013.763654","article-title":"Vasopressin modulates neural responses during human reactive aggression","volume":"8","author":"Brunnlieb","year":"2013","journal-title":"Soc. Neurosci."},{"key":"ref_229","first-page":"123","article-title":"Emerging themes in preclinical research on alcohol and aggression","volume":"13","author":"Yudko","year":"1997","journal-title":"Recent Dev. Alcohol."},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s00213-006-0536-7","article-title":"The impact of moderate daily alcohol consumption on aggression and the formation of dominance hierarchies in rats","volume":"189","author":"Duncan","year":"2006","journal-title":"Psychopharmacology"},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1007\/s00213-013-3008-x","article-title":"Excessive aggression as model of violence: A critical evaluation of current preclinical methods","volume":"226","author":"Miczek","year":"2013","journal-title":"Psychopharmacology"},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1007\/BF02245516","article-title":"Prevention of the pro-aggressive effects of alcohol in rats and squirrel monkeys by benzodiazepine receptor antagonists","volume":"111","author":"Weerts","year":"1993","journal-title":"Psychopharmacology"},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s00213-001-0934-9","article-title":"Repeated alcohol: Behavioral sensitization and alcohol-heightened aggression in mice","volume":"160","author":"Fish","year":"2002","journal-title":"Psychopharmacology"},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"2888","DOI":"10.1038\/npp.2008.7","article-title":"Escalated aggression after alcohol drinking in male mice: Dorsal raph\u00e9 and prefrontal cortex serotonin and 5-HT(1B) receptors","volume":"33","author":"Faccidomo","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1007\/s002130000587","article-title":"Alcohol, allopregnanolone and aggression in mice","volume":"153","author":"Fish","year":"2001","journal-title":"Psychopharmacology"},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1111\/j.1530-0277.1998.tb03968.x","article-title":"Alcohol and heightened aggression in individual mice","volume":"22","author":"Miczek","year":"1998","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_237","first-page":"139","article-title":"Alcohol, GABAA-benzodiazepine receptor complex, and aggression","volume":"13","author":"Miczek","year":"1997","journal-title":"Recent Dev. Alcohol."},{"key":"ref_238","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1007\/s00213-010-1920-x","article-title":"GABA(A) receptors in the dorsal raph\u00e9 nucleus of mice: Escalation of aggression after alcohol consumption","volume":"211","author":"Takahashi","year":"2010","journal-title":"Psychopharmacology"},{"key":"ref_239","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/BF00426519","article-title":"Alcohol and chlordiazepoxide increase suppressed aggression in mice","volume":"69","author":"Miczek","year":"1980","journal-title":"Psychopharmacology"},{"key":"ref_240","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1152\/jn.00519.2020","article-title":"Cellular interactions between social experience, alcohol sensitivity, and GABAergic inhibition in a crayfish neural circuit","volume":"125","author":"Venuti","year":"2021","journal-title":"J. Neurophysiol."},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1007\/s002130050701","article-title":"Alcohol-heightened aggression in mice: Attenuation by 5-HT1A receptor agonists","volume":"139","author":"Miczek","year":"1998","journal-title":"Psychopharmacology"},{"key":"ref_242","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/s002130100831","article-title":"Oral drug self-administration in the home cage of mice: Alcohol-heightened aggression and inhibition by the 5-HT1B agonist anpirtoline","volume":"157","author":"Miczek","year":"2001","journal-title":"Psychopharmacology"},{"key":"ref_243","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1176\/ajp.151.10.1485","article-title":"Low CSF 5-HIAA concentrations and severe aggression and impaired impulse control in nonhuman primates","volume":"151","author":"Mehlman","year":"1994","journal-title":"Am. J. Psychiatry"},{"key":"ref_244","doi-asserted-by":"crossref","first-page":"e122","DOI":"10.1038\/tp.2012.44","article-title":"Exaggerated aggression and decreased anxiety in mice deficient in brain serotonin","volume":"2","author":"Mosienko","year":"2012","journal-title":"Transl. Psychiatry"},{"key":"ref_245","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/0006-3223(94)91215-7","article-title":"Serotonin and alcohol intake, abuse, and dependence: Findings of animal studies","volume":"36","author":"LeMarquand","year":"1994","journal-title":"Biol. Psychiatry"},{"key":"ref_246","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.euroneuro.2019.12.120","article-title":"Role of the serotonergic system in ethanol-induced aggression and anxiety: A pharmacological approach using the zebrafish model","volume":"32","author":"Ziani","year":"2020","journal-title":"Eur. Neuropsychopharmacol."},{"key":"ref_247","doi-asserted-by":"crossref","first-page":"24","DOI":"10.3389\/fncir.2016.00024","article-title":"Serotonin, Amygdala and Fear: Assembling the Puzzle","volume":"10","author":"Bocchio","year":"2016","journal-title":"Front. Neural Circuits"},{"key":"ref_248","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1080\/10253890500492787","article-title":"Modulation of anxiety circuits by serotonergic systems","volume":"8","author":"Lowry","year":"2005","journal-title":"Stress"},{"key":"ref_249","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.bbr.2011.01.019","article-title":"Differences of acute versus chronic ethanol exposure on anxiety-like behavioral responses in zebrafish","volume":"219","author":"Mathur","year":"2011","journal-title":"Behav. Brain Res."},{"key":"ref_250","doi-asserted-by":"crossref","first-page":"731","DOI":"10.3389\/fneur.2019.00731","article-title":"Enhanced Alcohol Preference and Anxiolytic Alcohol Effects in Niemann-Pick Disease Model in Mice","volume":"10","author":"Kalinichenko","year":"2019","journal-title":"Front. Neurol."},{"key":"ref_251","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1159\/000363102","article-title":"Increased aggression, improved spatial memory, and reduced anxiety-like behaviour in adult male mice exposed to fluoxetine early in life","volume":"36","author":"Kiryanova","year":"2014","journal-title":"Dev. Neurosci."},{"key":"ref_252","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1093\/alcalc\/agu047","article-title":"Increase in nucleus accumbens dopamine levels following local ethanol administration is not mediated by acetaldehyde","volume":"49","author":"Clarke","year":"2014","journal-title":"Alcohol Alcohol"},{"key":"ref_253","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1111\/acer.13141","article-title":"Medial Prefrontal Cortical Dopamine Responses During Operant Self-Administration of Sweetened Ethanol","volume":"40","author":"Doherty","year":"2016","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_254","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/S0197-0186(00)00037-1","article-title":"Alcohol enhances characteristic releases of dopamine and serotonin in the central nucleus of the amygdala","volume":"37","author":"Yoshimoto","year":"2000","journal-title":"Neurochem. Int."},{"key":"ref_255","doi-asserted-by":"crossref","first-page":"9320","DOI":"10.1523\/JNEUROSCI.20-24-09320.2000","article-title":"Aggressive behavior, increased accumbal dopamine, and decreased cortical serotonin in rats","volume":"20","author":"Miczek","year":"2000","journal-title":"J. Neurosci."},{"key":"ref_256","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1007\/s00213-006-0637-3","article-title":"Increased accumbal dopamine during daily alcohol consumption and subsequent aggressive behavior in rats","volume":"191","author":"Miczek","year":"2007","journal-title":"Psychopharmacology"},{"key":"ref_257","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1038\/sj.npp.1300833","article-title":"Repeated ethanol intoxication induces behavioral sensitization in the absence of a sensitized accumbens dopamine response in C57BL\/6J and DBA\/2J mice","volume":"31","author":"Zapata","year":"2006","journal-title":"Neuropsychopharmacology"},{"key":"ref_258","doi-asserted-by":"crossref","first-page":"e740","DOI":"10.1038\/tp.2016.6","article-title":"Dopamine cross-sensitization between psychostimulant drugs and stress in healthy male volunteers","volume":"6","author":"Booij","year":"2016","journal-title":"Transl. Psychiatry"},{"key":"ref_259","doi-asserted-by":"crossref","first-page":"5160","DOI":"10.1523\/JNEUROSCI.3387-15.2016","article-title":"Cannabidiol Counteracts Amphetamine-Induced Neuronal and Behavioral Sensitization of the Mesolimbic Dopamine Pathway through a Novel mTOR\/p70S6 Kinase Signaling Pathway","volume":"36","author":"Renard","year":"2016","journal-title":"J. Neurosci."},{"key":"ref_260","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1038\/s41386-020-0643-x","article-title":"Interruption of continuous opioid exposure exacerbates drug-evoked adaptations in the mesolimbic dopamine system","volume":"45","author":"Lefevre","year":"2020","journal-title":"Neuropsychopharmacology"},{"key":"ref_261","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.ejphar.2009.02.011","article-title":"Nicotine sensitization of monkey striatal dopamine release","volume":"607","author":"Domino","year":"2009","journal-title":"Eur. J. Pharmacol."},{"key":"ref_262","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/s41598-019-56884-z","article-title":"Phasic Dopamine Release Magnitude Tracks Individual Differences in Sensitization of Locomotor Response following a History of Nicotine Exposure","volume":"10","author":"Fennell","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_263","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s00213-011-2630-8","article-title":"Involvement of nucleus accumbens dopamine D1 receptors in ethanol drinking, ethanol-induced conditioned place preference, and ethanol-induced psychomotor sensitization in mice","volume":"222","author":"Bahi","year":"2012","journal-title":"Psychopharmacology"},{"key":"ref_264","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1111\/j.1530-0277.2009.00985.x","article-title":"Sensitization of ventral tegmental area dopamine neurons to the stimulating effects of ethanol","volume":"33","author":"Ding","year":"2009","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_265","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.pbb.2018.08.003","article-title":"Behavioural sensitization to alcohol: Bridging the gap between preclinical research and human models","volume":"173","author":"Nona","year":"2018","journal-title":"Pharmacol. Biochem. Behav."},{"key":"ref_266","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1038\/npp.2017.253","article-title":"A Role for Prefrontal Cortical NMDA Receptors in Murine Alcohol-Heightened Aggression","volume":"43","author":"Newman","year":"2018","journal-title":"Neuropsychopharmacology"},{"key":"ref_267","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s00213-012-2734-9","article-title":"NMDA receptor antagonism: Escalation of aggressive behavior in alcohol-drinking mice","volume":"224","author":"Newman","year":"2012","journal-title":"Psychopharmacology"},{"key":"ref_268","doi-asserted-by":"crossref","first-page":"2889","DOI":"10.1007\/s00213-015-3925-y","article-title":"Aggression and increased glutamate in the mPFC during withdrawal from intermittent alcohol in outbred mice","volume":"232","author":"Hwa","year":"2015","journal-title":"Psychopharmacology"},{"key":"ref_269","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/S0278-5846(03)00080-0","article-title":"Ketamine-induced changes in rat behaviour: A possible animal model of schizophrenia","volume":"27","author":"Becker","year":"2003","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"ref_270","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1111\/j.1465-3362.2009.00099.x","article-title":"The toxicology of homicide offenders and victims: A review","volume":"29","author":"Darke","year":"2010","journal-title":"Drug Alcohol Rev."},{"key":"ref_271","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.2105\/AJPH.92.12.1921","article-title":"Vodka and violence: Alcohol consumption and homicide rates in Russia","volume":"92","author":"Pridemore","year":"2002","journal-title":"Am. J. Public Health"},{"key":"ref_272","doi-asserted-by":"crossref","first-page":"277","DOI":"10.15288\/jsad.2012.73.277","article-title":"Attribution of alcohol to violence-related injury: Self and other\u2019s drinking in the event","volume":"73","author":"Cherpitel","year":"2012","journal-title":"J. Stud. Alcohol Drugs"},{"key":"ref_273","first-page":"58","article-title":"Alcohol-Related Intimate Partner Violence Among White, Black, and Hispanic Couples in the United States","volume":"25","author":"Caetano","year":"2001","journal-title":"Alcohol Res. Health"},{"key":"ref_274","doi-asserted-by":"crossref","first-page":"NP1718","DOI":"10.1177\/08862605221092068","article-title":"Longitudinal Association Between Intimate Partner Violence and Alcohol Use in a Population Cohort of South African Women","volume":"38","author":"Yalch","year":"2023","journal-title":"J. Interpers. Violence"},{"key":"ref_275","first-page":"191","article-title":"Alcohol consumption and domestic violence against mothers","volume":"7","author":"Sabia","year":"2004","journal-title":"J. Ment. Health Policy Econ."},{"key":"ref_276","doi-asserted-by":"crossref","unstructured":"Yu, R., Nevado-Holgado, A.J., Molero, Y., D\u2019Onofrio, B.M., Larsson, H., Howard, L.M., and Fazel, S. (2019). Mental disorders and intimate partner violence perpetrated by men towards women: A Swedish population-based longitudinal study. PLoS Med., 16.","DOI":"10.1371\/journal.pmed.1002995"},{"key":"ref_277","doi-asserted-by":"crossref","first-page":"34","DOI":"10.15288\/jsad.2011.72.34","article-title":"Alcohol dose and aggression: Another reason why drinking more is a bad idea","volume":"72","author":"Duke","year":"2011","journal-title":"J. Stud. Alcohol Drugs"},{"key":"ref_278","doi-asserted-by":"crossref","first-page":"178","DOI":"10.15288\/jsa.1996.57.178","article-title":"The effects of alcohol on the aggressive responding of women","volume":"57","author":"Dougherty","year":"1996","journal-title":"J. Stud. Alcohol"},{"key":"ref_279","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.euroneuro.2018.06.001","article-title":"Intoxicated aggression: Do alcohol and stimulants cause dose-related aggression? A review","volume":"30","author":"Kuypers","year":"2020","journal-title":"Eur. Neuropsychopharmacol."},{"key":"ref_280","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1016\/j.addbeh.2013.10.035","article-title":"Protracted impairment of impulse control under an acute dose of alcohol: A time-course analysis","volume":"39","author":"Miller","year":"2014","journal-title":"Addict. Behav."},{"key":"ref_281","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1037\/a0026110","article-title":"Acute tolerance to alcohol in at-risk binge drinkers","volume":"26","author":"Fillmore","year":"2012","journal-title":"Psychol. Addict. Behav."},{"key":"ref_282","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1016\/j.addbeh.2003.08.033","article-title":"Drugs of abuse and the elicitation of human aggressive behavior","volume":"28","author":"Hoaken","year":"2003","journal-title":"Addict. Behav."},{"key":"ref_283","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.drugalcdep.2014.08.009","article-title":"Deficits in behavioural inhibition in substance abuse and addiction: A meta-analysis","volume":"145","author":"Smith","year":"2014","journal-title":"Drug Alcohol Depend."},{"key":"ref_284","doi-asserted-by":"crossref","first-page":"24","DOI":"10.15288\/jsa.2000.61.24","article-title":"Alcohol effects on movement-related potentials: A measure of impulsivity?","volume":"61","author":"Marinkovic","year":"2000","journal-title":"J. Stud. Alcohol"},{"key":"ref_285","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1007\/s00426-021-01537-y","article-title":"Response inhibition deficits are positively associated with trait rumination, but attentional inhibition deficits are not: Aggressive behaviors and interpersonal stressors as mediators","volume":"86","author":"Hasegawa","year":"2022","journal-title":"Psychol. Res."},{"key":"ref_286","doi-asserted-by":"crossref","first-page":"558461","DOI":"10.3389\/fpsyg.2020.558461","article-title":"Reactive Aggression Affects Response Inhibition to Angry Expressions in Adolescents: An Event-Related Potential Study Using the Emotional Go\/No-Go Paradigm","volume":"11","author":"Sun","year":"2020","journal-title":"Front. Psychol."},{"key":"ref_287","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.drugalcdep.2012.05.010","article-title":"Comparison of alcohol impairment of behavioral and attentional inhibition","volume":"126","author":"Weafer","year":"2012","journal-title":"Drug Alcohol Depend."},{"key":"ref_288","doi-asserted-by":"crossref","first-page":"696","DOI":"10.15288\/jsa.2002.63.696","article-title":"Alcohol-related aggression in men and women: The influence of dispositional aggressivity","volume":"63","author":"Giancola","year":"2002","journal-title":"J. Stud. Alcohol"},{"key":"ref_289","first-page":"711","article-title":"Alcohol-related aggression-social and neurobiological factors","volume":"110","author":"Beck","year":"2013","journal-title":"Dtsch. Arztebl. Int."},{"key":"ref_290","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1111\/j.1530-0277.2007.00596.x","article-title":"Where, with whom, and how much alcohol is consumed on drinking events involving aggression? Event-level associations in a Canadian national survey of university students","volume":"32","author":"Wells","year":"2008","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_291","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1111\/j.1465-3362.2011.00296.x","article-title":"Alcohol\u2019s role in sexual violence perpetration: Theoretical explanations, existing evidence and future directions","volume":"30","author":"Abbey","year":"2011","journal-title":"Drug Alcohol Rev."},{"key":"ref_292","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1038\/nrn3042","article-title":"Cognitive and neurobiological mechanisms of alcohol-related aggression","volume":"12","author":"Heinz","year":"2011","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_293","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1177\/0269881114536476","article-title":"Effects of acute alcohol consumption and processing of emotion in faces: Implications for understanding alcohol-related aggression","volume":"28","author":"Attwood","year":"2014","journal-title":"J. Psychopharmacol."},{"key":"ref_294","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1037\/neu0000572","article-title":"Emotional processing and social cognition in alcohol use disorder","volume":"33","year":"2019","journal-title":"Neuropsychology"},{"key":"ref_295","doi-asserted-by":"crossref","unstructured":"Marinkovic, K., Rickenbacher, E., and Azma, S. (2012). Effects of Alcohol Intoxication on Response Conflict in a Flanker Task. J. Addict. Res. Ther., 002.","DOI":"10.4172\/2155-6105.S3-002"},{"key":"ref_296","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.bandc.2013.12.010","article-title":"Alcohol intoxication alters cognitive skills mediated by frontal and temporal brain regions","volume":"85","author":"Magrys","year":"2014","journal-title":"Brain Cogn."},{"key":"ref_297","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1037\/1064-1297.8.4.576","article-title":"Executive functioning: A conceptual framework for alcohol-related aggression","volume":"8","author":"Giancola","year":"2000","journal-title":"Exp. Clin. Psychopharmacol."},{"key":"ref_298","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1093\/scan\/nsm021","article-title":"Differential effects of tryptophan depletion on emotion processing according to face direction","volume":"2","author":"Williams","year":"2007","journal-title":"Soc. Cogn. Affect. Neurosci."},{"key":"ref_299","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1007\/s00213-010-1850-7","article-title":"Effects of acute tryptophan depletion on neural processing of facial expressions of emotion in humans","volume":"210","author":"Daly","year":"2010","journal-title":"Psychopharmacology"},{"key":"ref_300","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1111\/j.1469-7610.2008.02020.x","article-title":"Deficits in facial expression recognition in male adolescents with early-onset or adolescence-onset conduct disorder","volume":"50","author":"Fairchild","year":"2009","journal-title":"J. Child Psychol. Psychiatry"},{"key":"ref_301","doi-asserted-by":"crossref","first-page":"NP15058","DOI":"10.1177\/0886260521989848","article-title":"Facial Emotion Perceptual Tendency in Violent and Non-violent Offenders","volume":"37","author":"Zeng","year":"2022","journal-title":"J. Interpers. Violence"},{"key":"ref_302","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.1111\/j.1530-0277.2009.01026.x","article-title":"Alcoholism and dampened temporal limbic activation to emotional faces","volume":"33","author":"Marinkovic","year":"2009","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_303","doi-asserted-by":"crossref","first-page":"367","DOI":"10.3389\/fnins.2018.00367","article-title":"Stress-Induced Functional Alterations in Amygdala: Implications for Neuropsychiatric Diseases","volume":"12","author":"Zhang","year":"2018","journal-title":"Front. Neurosci."},{"key":"ref_304","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1152\/jn.00005.2017","article-title":"The role of the hippocampus in navigation is memory","volume":"117","author":"Eichenbaum","year":"2017","journal-title":"J. Neurophysiol."},{"key":"ref_305","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.euroneuro.2006.04.011","article-title":"CSF monoamine metabolites and lethality of suicide attempts in depressed patients with alcohol dependence","volume":"17","author":"Sher","year":"2007","journal-title":"Eur. Neuropsychopharmacol."},{"key":"ref_306","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.pnpbp.2015.06.010","article-title":"Association of GABAA receptor \u03b12 subunit gene (GABRA2) with alcohol dependence-related aggressive behavior","volume":"63","author":"Strac","year":"2015","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"ref_307","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1002\/jnr.24423","article-title":"Neuroimaging in alcohol use disorder: From mouse to man","volume":"100","author":"Fritz","year":"2022","journal-title":"J. Neurosci. Res."},{"key":"ref_308","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1111\/acer.13757","article-title":"Regional Brain Volume Changes in Alcohol-Dependent Individuals During Short-Term and Long-Term Abstinence","volume":"42","author":"Zou","year":"2018","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_309","doi-asserted-by":"crossref","first-page":"2886","DOI":"10.1038\/npp.2015.141","article-title":"Neural and Behavioral Correlates of Alcohol-Induced Aggression Under Provocation","volume":"40","author":"Gan","year":"2015","journal-title":"Neuropsychopharmacology"},{"key":"ref_310","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1002\/jnr.24587","article-title":"Heterogeneity in striatal dopamine circuits: Form and function in dynamic reward seeking","volume":"98","author":"Collins","year":"2020","journal-title":"J. Neurosci. Res."},{"key":"ref_311","doi-asserted-by":"crossref","first-page":"e10032","DOI":"10.7554\/eLife.10032","article-title":"Dopamine neurons projecting to the posterior striatum form an anatomically distinct subclass","volume":"4","author":"Menegas","year":"2015","journal-title":"Elife"},{"key":"ref_312","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1017\/S0033291715001981","article-title":"The epidemiology of traumatic event exposure worldwide: Results from the World Mental Health Survey Consortium","volume":"46","author":"Benjet","year":"2016","journal-title":"Psychol. Med."},{"key":"ref_313","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1023\/A:1014851823163","article-title":"The prevalence of potentially traumatic events in childhood and adolescence","volume":"15","author":"Costello","year":"2002","journal-title":"J. Trauma. Stress"},{"key":"ref_314","doi-asserted-by":"crossref","first-page":"25339","DOI":"10.3402\/ejpt.v5.25339","article-title":"Resilience after trauma: From surviving to thriving","volume":"5","author":"Nugent","year":"2014","journal-title":"Eur. J. Psychotraumatol."},{"key":"ref_315","doi-asserted-by":"crossref","first-page":"31","DOI":"10.3389\/fpsyt.2019.00031","article-title":"Trauma Exposure and Mental Health Problems Among Adults in Central Vietnam: A Randomized Cross-Sectional Survey","volume":"10","author":"Do","year":"2019","journal-title":"Front. Psychiatry"},{"key":"ref_316","doi-asserted-by":"crossref","first-page":"15057","DOI":"10.1038\/nrdp.2015.57","article-title":"Post-traumatic stress disorder","volume":"1","author":"Yehuda","year":"2015","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_317","doi-asserted-by":"crossref","first-page":"1353383","DOI":"10.1080\/20008198.2017.1353383","article-title":"Trauma and PTSD in the WHO World Mental Health Surveys","volume":"8","author":"Kessler","year":"2017","journal-title":"Eur. J. Psychotraumatol."},{"key":"ref_318","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1192\/bjp.bp.113.131227","article-title":"Rates of post-traumatic stress disorder in trauma-exposed children and adolescents: Meta-analysis","volume":"204","author":"Alisic","year":"2014","journal-title":"Br. J. Psychiatry"},{"key":"ref_319","unstructured":"Association, A.P. (2013). Diagnostic and Statistical Manual of Mental Disorders, American Psychiatric Association."},{"key":"ref_320","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1007\/s00127-014-0855-7","article-title":"A systematic review of the comorbidity between PTSD and alcohol misuse","volume":"49","author":"Debell","year":"2014","journal-title":"Soc. Psychiatry Psychiatr. Epidemiol."},{"key":"ref_321","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1002\/da.20751","article-title":"Substance use, childhood traumatic experience, and Posttraumatic Stress Disorder in an urban civilian population","volume":"27","author":"Khoury","year":"2010","journal-title":"Depress. Anxiety"},{"key":"ref_322","doi-asserted-by":"crossref","first-page":"4841050","DOI":"10.1155\/2020\/4841050","article-title":"Prevalence of Alcohol Use Disorders and Their Association with Sociodemographic Determinants and Depression\/Anxiety Disorders in a Representative Sample of the Greek General Population","volume":"2020","author":"Bellos","year":"2020","journal-title":"Psychiatry J."},{"key":"ref_323","first-page":"29","article-title":"Prevalence of alcohol abuse and alcoholism in general population of Mostar region, Bosnia and Herzegovina","volume":"34","year":"2010","journal-title":"Coll. Antropol."},{"key":"ref_324","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1300\/J020v18n03_04","article-title":"Posttraumatic Stress Disorder Symptoms and Situation-Specific Drinking in Women Substance Abusers","volume":"18","author":"Stewart","year":"2000","journal-title":"Alcohol. Treat. Q."},{"key":"ref_325","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/j.addbeh.2010.03.023","article-title":"PTSD symptom clusters in relationship to alcohol misuse among Iraq and Afghanistan war veterans seeking post-deployment VA health care","volume":"35","author":"Jakupcak","year":"2010","journal-title":"Addict. Behav."},{"key":"ref_326","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1002\/da.1022","article-title":"Variability and severity of depression and anxiety in post traumatic stress disorder and major depressive disorder","volume":"13","author":"Golier","year":"2001","journal-title":"Depress. Anxiety"},{"key":"ref_327","doi-asserted-by":"crossref","first-page":"141","DOI":"10.31887\/DCNS.2015.17.2\/jflory","article-title":"Comorbidity between post-traumatic stress disorder and major depressive disorder: Alternative explanations and treatment considerations","volume":"17","author":"Flory","year":"2015","journal-title":"Dialogues Clin. Neurosci."},{"key":"ref_328","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1002\/da.20677","article-title":"The use of alcohol and drugs to self-medicate symptoms of posttraumatic stress disorder","volume":"27","author":"Leeies","year":"2010","journal-title":"Depress. Anxiety"},{"key":"ref_329","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1037\/tra0000306","article-title":"Emotion regulation is associated with PTSD and depression among female adolescent survivors of childhood sexual abuse","volume":"10","author":"Chang","year":"2018","journal-title":"Psychol. Trauma"},{"key":"ref_330","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1037\/adb0000348","article-title":"The burden of co-occurring alcohol use disorder and PTSD in U.S. Military veterans: Comorbidities, functioning, and suicidality","volume":"32","author":"Norman","year":"2018","journal-title":"Psychol. Addict. Behav."},{"key":"ref_331","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1111\/acer.12926","article-title":"Prazosin for Veterans with Posttraumatic Stress Disorder and Comorbid Alcohol Dependence: A Clinical Trial","volume":"40","author":"Petrakis","year":"2016","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_332","first-page":"181","article-title":"Behavioral Treatments for Alcohol Use Disorder and Post-Traumatic Stress Disorder","volume":"39","author":"Flanagan","year":"2018","journal-title":"Alcohol Res."},{"key":"ref_333","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1080\/03069885.2010.550798","article-title":"Effective treatments for PTSD: Practice guidelines from the International Society for Traumatic Stress Studies","volume":"39","author":"Hudson","year":"2011","journal-title":"Br. J. Guid. Couns."},{"key":"ref_334","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.copsyc.2016.11.008","article-title":"Anger and aggression in PTSD","volume":"14","author":"Taft","year":"2017","journal-title":"Curr. Opin. Psychol."},{"key":"ref_335","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1037\/a0022196","article-title":"Posttraumatic stress disorder and intimate relationship problems: A meta-analysis","volume":"79","author":"Taft","year":"2011","journal-title":"J. Consult. Clin. Psychol."},{"key":"ref_336","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.3389\/fpsyg.2017.01394","article-title":"The Role of PTSD in Bi-directional Intimate Partner Violence in Military and Veteran Populations: A Research Review","volume":"8","author":"Misca","year":"2017","journal-title":"Front. Psychol."},{"key":"ref_337","doi-asserted-by":"crossref","unstructured":"Grattan, R.E., Lara, N., Botello, R.M., Tryon, V.L., Maguire, A.M., Carter, C.S., and Niendam, T.A. (2019). A History of Trauma is Associated with Aggression, Depression, Non-Suicidal Self-Injury Behavior, and Suicide Ideation in First-Episode Psychosis. J. Clin. Med., 8.","DOI":"10.3390\/jcm8071082"},{"key":"ref_338","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1001\/archgenpsychiatry.2008.537","article-title":"The intricate link between violence and mental disorder: Results from the National Epidemiologic Survey on Alcohol and Related Conditions","volume":"66","author":"Elbogen","year":"2009","journal-title":"Arch. Gen. Psychiatry"},{"key":"ref_339","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.cpr.2012.06.008","article-title":"A consideration of select pre-trauma factors as key vulnerabilities in PTSD","volume":"32","author":"Bomyea","year":"2012","journal-title":"Clin. Psychol. Rev."},{"key":"ref_340","doi-asserted-by":"crossref","first-page":"2470547019871901","DOI":"10.1177\/2470547019871901","article-title":"The Predictive Value of Early-Life Trauma, Psychopathy, and the Testosterone-Cortisol Ratio for Impulsive Aggression Problems in Veterans","volume":"3","author":"Korpel","year":"2019","journal-title":"Chronic Stress"},{"key":"ref_341","first-page":"22","article-title":"Comorbidity of psychiatric disorders and posttraumatic stress disorder","volume":"61","author":"Brady","year":"2000","journal-title":"J. Clin. Psychiatry"},{"key":"ref_342","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1176\/appi.ajp.158.8.1184","article-title":"Substance use disorders in patients with posttraumatic stress disorder: A review of the literature","volume":"158","author":"Jacobsen","year":"2001","journal-title":"Am. J. Psychiatry"},{"key":"ref_343","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1080\/15299732.2012.710184","article-title":"Trauma typology as a risk factor for aggression and self-harm in a complex PTSD population: The mediating role of alterations in self-perception","volume":"14","author":"Dyer","year":"2013","journal-title":"J. Trauma Dissociation"},{"key":"ref_344","doi-asserted-by":"crossref","first-page":"258","DOI":"10.3389\/fnbeh.2018.00258","article-title":"Treating PTSD: A Review of Evidence-Based Psychotherapy Interventions","volume":"12","author":"Watkins","year":"2018","journal-title":"Front. Behav. Neurosci."},{"key":"ref_345","first-page":"32","article-title":"Pharmacotherapy for Post-traumatic Stress Disorder in Combat Veterans: Focus on Antidepressants and Atypical Antipsychotic Agents","volume":"37","author":"Alexander","year":"2012","journal-title":"Pharm. Ther."},{"key":"ref_346","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1097\/00004714-200304000-00012","article-title":"Low-dose risperidone as adjunctive therapy for irritable aggression in posttraumatic stress disorder","volume":"23","author":"Monnelly","year":"2003","journal-title":"J. Clin. Psychopharmacol."},{"key":"ref_347","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1017\/S1461145713001090","article-title":"Genetic approaches to understanding post-traumatic stress disorder","volume":"17","author":"Almli","year":"2014","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"ref_348","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1017\/S0033291714002165","article-title":"The heritability of alcohol use disorders: A meta-analysis of twin and adoption studies","volume":"45","author":"Verhulst","year":"2015","journal-title":"Psychol. Med."},{"key":"ref_349","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/B978-0-12-380858-5.00007-1","article-title":"Human aggression across the lifespan: Genetic propensities and environmental moderators","volume":"75","author":"Tuvblad","year":"2011","journal-title":"Adv. Genet."},{"key":"ref_350","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1002\/da.22138","article-title":"Apolipoprotein e gene polymorphism, alcohol use, and their interactions in combat-related posttraumatic stress disorder","volume":"30","author":"Kim","year":"2013","journal-title":"Depress. Anxiety"},{"key":"ref_351","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.psyneuen.2016.04.001","article-title":"FKBP5 polymorphisms, childhood abuse, and PTSD symptoms: Results from the National Health and Resilience in Veterans Study","volume":"69","author":"Watkins","year":"2016","journal-title":"Psychoneuroendocrinology"},{"key":"ref_352","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1038\/npp.2010.37","article-title":"Interaction of FKBP5 with childhood adversity on risk for post-traumatic stress disorder","volume":"35","author":"Xie","year":"2010","journal-title":"Neuropsychopharmacology"},{"key":"ref_353","doi-asserted-by":"crossref","unstructured":"Frazzetto, G., Di Lorenzo, G., Carola, V., Proietti, L., Sokolowska, E., Siracusano, A., Gross, C., and Troisi, A. (2007). Early trauma and increased risk for physical aggression during adulthood: The moderating role of MAOA genotype. PLoS ONE, 2.","DOI":"10.1371\/journal.pone.0000486"}],"container-title":["Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-7737\/12\/3\/469\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:59:13Z","timestamp":1760122753000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-7737\/12\/3\/469"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,20]]},"references-count":353,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2023,3]]}},"alternative-id":["biology12030469"],"URL":"https:\/\/doi.org\/10.3390\/biology12030469","relation":{},"ISSN":["2079-7737"],"issn-type":[{"value":"2079-7737","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,20]]}}}