{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T21:59:18Z","timestamp":1773957558762,"version":"3.50.1"},"reference-count":44,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2023,4,15]],"date-time":"2023-04-15T00:00:00Z","timestamp":1681516800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Institutes of Health","award":["U19AG05537301"],"award-info":[{"award-number":["U19AG05537301"]}]},{"name":"National Institutes of Health","award":["R01AR069055"],"award-info":[{"award-number":["R01AR069055"]}]},{"name":"National Institutes of Health","award":["P20GM109036"],"award-info":[{"award-number":["P20GM109036"]}]},{"name":"National Institutes of Health","award":["R01MH104680"],"award-info":[{"award-number":["R01MH104680"]}]},{"name":"National Institutes of Health","award":["R01AG061917"],"award-info":[{"award-number":["R01AG061917"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biology"],"abstract":"<jats:p>The devastating effects of Alzheimer\u2019s disease (AD) are yet to be ameliorated due to the absence of curative treatment options. AD is an aging-related disease that affects cognition, and molecular imbalance is one of its hallmarks. There is a need to identify common causes of molecular imbalance in AD and their potential mechanisms for continuing research. A narrative synthesis of molecular mechanisms in AD from primary studies that employed single-cell sequencing (scRNA-seq) or spatial genomics was conducted using Embase and PubMed databases. We found that differences in molecular mechanisms in AD could be grouped into four key categories: sex-specific features, early-onset features, aging, and immune system pathways. The reported causes of molecular imbalance were alterations in bile acid (BA) synthesis, PITRM1, TREM2, olfactory mucosa (OM) cells, cholesterol catabolism, NFkB, double-strand break (DSB) neuronal damage, P65KD silencing, tau and APOE expression. What changed from previous findings in contrast to results obtained were explored to find potential factors for AD-modifying investigations.<\/jats:p>","DOI":"10.3390\/biology12040602","type":"journal-article","created":{"date-parts":[[2023,4,17]],"date-time":"2023-04-17T02:26:02Z","timestamp":1681698362000},"page":"602","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Potential Molecular Mechanisms of Alzheimer\u2019s Disease from Genetic Studies"],"prefix":"10.3390","volume":"12","author":[{"given":"Martin","family":"Nwadiugwu","sequence":"first","affiliation":[{"name":"Tulane Center for Biomedical Informatics and Genomics, Deming Department of Medicine, Tulane University School of Medicine, Tulane University, New Orleans, LA 70112, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Shen","sequence":"additional","affiliation":[{"name":"Tulane Center for Biomedical Informatics and Genomics, Deming Department of Medicine, Tulane University School of Medicine, Tulane University, New Orleans, LA 70112, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0387-8818","authenticated-orcid":false,"given":"Hong-Wen","family":"Deng","sequence":"additional","affiliation":[{"name":"Tulane Center for Biomedical Informatics and Genomics, Deming Department of Medicine, Tulane University School of Medicine, Tulane University, New Orleans, LA 70112, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,4,15]]},"reference":[{"key":"ref_1","unstructured":"NIA (2023, February 18). 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