{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T21:50:23Z","timestamp":1767909023460,"version":"3.49.0"},"reference-count":57,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2023,4,21]],"date-time":"2023-04-21T00:00:00Z","timestamp":1682035200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the Royal Physiographic Society of Lund","award":["2019-01066"],"award-info":[{"award-number":["2019-01066"]}]},{"name":"the Royal Physiographic Society of Lund","award":["857394"],"award-info":[{"award-number":["857394"]}]},{"DOI":"10.13039\/501100004359","name":"the Swedish Research Council","doi-asserted-by":"publisher","award":["2019-01066"],"award-info":[{"award-number":["2019-01066"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"the Swedish Research Council","doi-asserted-by":"publisher","award":["857394"],"award-info":[{"award-number":["857394"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the European Union\u2019s Horizon 2020 research and innovation program","award":["2019-01066"],"award-info":[{"award-number":["2019-01066"]}]},{"name":"the European Union\u2019s Horizon 2020 research and innovation program","award":["857394"],"award-info":[{"award-number":["857394"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biology"],"abstract":"<jats:p>Prepulse inhibition (PPI) is a widely investigated behavior to study the mechanisms of disorders such as anxiety, schizophrenia, and bipolar mania. PPI has been observed across various vertebrate and invertebrate species; however, it has not yet been reported in adult Drosophila melanogaster. In this study, we describe the first detection of PPI of visually evoked locomotor arousal in flies. To validate our findings, we demonstrate that PPI in Drosophila can be partially reverted by the N-methyl D-aspartate (NMDA) receptor antagonist MK-801, known for inducing sensorimotor gating deficits in rodent models. Additionally, we show that the visually evoked response can be inhibited by multiple stimuli presentation, which can also be affected by MK-801. Given the versatility of Drosophila as a model organism for genetic screening and analysis, our results suggest that high-throughput behavioral screenings of adult flies can become a valuable tool for investigating the mechanisms behind PPI.<\/jats:p>","DOI":"10.3390\/biology12040635","type":"journal-article","created":{"date-parts":[[2023,4,21]],"date-time":"2023-04-21T10:11:25Z","timestamp":1682071885000},"page":"635","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Evidence for Prepulse Inhibition of Visually Evoked Motor Response in Drosophila\u00a0melanogaster"],"prefix":"10.3390","volume":"12","author":[{"given":"Helgi B.","family":"Schi\u00f6th","sequence":"first","affiliation":[{"name":"Department of Surgical Sciences, Division of Functional Pharmacology and Neuroscience, Uppsala University, 751 24 Uppsala, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5617-5297","authenticated-orcid":false,"given":"Laura","family":"Donzelli","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, Division of Functional Pharmacology and Neuroscience, Uppsala University, 751 24 Uppsala, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicklas","family":"Arvidsson","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, Division of Functional Pharmacology and Neuroscience, Uppsala University, 751 24 Uppsala, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J.","family":"Williams","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, Division of Functional Pharmacology and Neuroscience, Uppsala University, 751 24 Uppsala, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7811-5383","authenticated-orcid":false,"given":"Thiago C.","family":"Moulin","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, Division of Functional Pharmacology and Neuroscience, Uppsala University, 751 24 Uppsala, Sweden"},{"name":"Department of Experimental Medical Science, Faculty of Medicine, Lund University, 221 84 Lund, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,4,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"ENEURO.0423-18.2019","DOI":"10.1523\/ENEURO.0423-18.2019","article-title":"A Computational Model of the Escape Response Latency in the Giant Fiber System of Drosophila melanogaster","volume":"6","author":"Augustin","year":"2019","journal-title":"eNeuro"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.semcdb.2005.11.011","article-title":"Making an Escape: Development and Function of the Drosophila Giant Fibre System","volume":"17","author":"Allen","year":"2006","journal-title":"Semin. 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