{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T21:29:42Z","timestamp":1791840582883,"version":"4.3.4"},"reference-count":43,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2023,4,22]],"date-time":"2023-04-22T00:00:00Z","timestamp":1682121600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biology"],"abstract":"<jats:p>Biological rhythms are important regulators of immune functions. In intensive care unit (ICU), sepsis is known to be associated with rhythm disruption. Our objectives were to determine factors associated with rhythm disruption of the body temperature and to assess the relationship between temperature and mortality in septic shock patients; In a cohort of septic shock, we recorded body temperature over a 24-h period on day 2 after ICU admission. For each patient, the temperature rhythmicity was assessed by defining period and amplitude, and the adjusted average (mesor) of the temperature by sinusoidal regression and cosinor analysis. Analyses were performed to assess factors associated with the three temperature parameters (period, amplitude, and mesor) and mortality. 162 septic shocks were enrolled. The multivariate analysis demonstrates that the period of temperature was associated with gender (women, coefficient \u22122.2 h, p = 0.031) and acetaminophen use (coefficient \u22124.3 h, p = 0.002). The mesor was associated with SOFA score (coefficient \u22120.05 \u00b0C per SOFA point, p = 0.046), procalcitonin (coefficient 0.001 \u00b0C per ng\/mL, p = 0.005), and hydrocortisone use (coefficient \u22120.5 \u00b0C, p = 0.002). The amplitude was associated with the dialysis (coefficient \u22120.5 \u00b0C, p = 0.002). Mortality at day 28 was associated with lower mesor (adjusted hazard ratio 0.50, 95% CI 0.28 to 0.90; p = 0.02), and higher amplitude (adjusted hazard ratio 5.48, 95% CI 1.66 to 18.12; p = 0.005) of temperature. Many factors, such as therapeutics, influence the body temperature during septic shock. Lower mesor and higher amplitude were associated with mortality and could be considered prognostic markers in ICU. In the age of artificial intelligence, the incorporation of such data in an automated scoring alert could compete with physicians to identify high-risk patients during septic shock.<\/jats:p>","DOI":"10.3390\/biology12050638","type":"journal-article","created":{"date-parts":[[2023,4,24]],"date-time":"2023-04-24T03:38:07Z","timestamp":1682307487000},"page":"638","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Changes in Body Temperature Patterns Are Predictive of Mortality in Septic Shock: An Observational Study"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8896-5346","authenticated-orcid":false,"given":"Benjamin","family":"Coiffard","sequence":"first","affiliation":[{"name":"IHU-M\u00e9diterran\u00e9e Infection, IRD, AP-HM, MEPHI, Aix Marseille Universit\u00e9, 13005 Marseille, France"},{"name":"M\u00e9decine Intensive-R\u00e9animation, APHM, H\u00f4pital Nord, Aix Marseille Universit\u00e9, 13015 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4670-1596","authenticated-orcid":false,"given":"Hamid","family":"Merdji","sequence":"additional","affiliation":[{"name":"Service de R\u00e9animation, Nouvel H\u00f4pital Civil, Universit\u00e9 de Strasbourg (UNISTRA), Facult\u00e9 de M\u00e9decine, H\u00f4pitaux Universitaires de Strasbourg, 67000 Strasbourg, France"},{"name":"UMR 1260, Regenerative Nano Medecine, INSERM, F\u00e9d\u00e9ration de M\u00e9decine Translationnelle de Strasbourg (FMTS), Universit\u00e9 de Strasbourg, 67000 Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Boucekine","sequence":"additional","affiliation":[{"name":"Health Service Research and Quality of Life Center, APHM, EA 3279 CEReSS, School of Medicine-La Timone Medical Campus, Aix Marseille Universit\u00e9, 13005 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Helms","sequence":"additional","affiliation":[{"name":"Service de R\u00e9animation, Nouvel H\u00f4pital Civil, Universit\u00e9 de Strasbourg (UNISTRA), Facult\u00e9 de M\u00e9decine, H\u00f4pitaux Universitaires de Strasbourg, 67000 Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rapha\u00ebl","family":"Clere-Jehl","sequence":"additional","affiliation":[{"name":"Service de R\u00e9animation, Nouvel H\u00f4pital Civil, Universit\u00e9 de Strasbourg (UNISTRA), Facult\u00e9 de M\u00e9decine, H\u00f4pitaux Universitaires de Strasbourg, 67000 Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Louis","family":"Mege","sequence":"additional","affiliation":[{"name":"IHU-M\u00e9diterran\u00e9e Infection, IRD, AP-HM, MEPHI, Aix Marseille Universit\u00e9, 13005 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1005-9095","authenticated-orcid":false,"given":"Ferhat","family":"Meziani","sequence":"additional","affiliation":[{"name":"Service de R\u00e9animation, Nouvel H\u00f4pital Civil, Universit\u00e9 de Strasbourg (UNISTRA), Facult\u00e9 de M\u00e9decine, H\u00f4pitaux Universitaires de Strasbourg, 67000 Strasbourg, France"},{"name":"UMR 1260, Regenerative Nano Medecine, INSERM, F\u00e9d\u00e9ration de M\u00e9decine Translationnelle de Strasbourg (FMTS), Universit\u00e9 de Strasbourg, 67000 Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,4,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.bj.2018.02.003","article-title":"The discoveries of molecular mechanisms for the circadian rhythm: The 2017 Nobel Prize in Physiology or Medicine","volume":"41","author":"Huang","year":"2018","journal-title":"Biomed. 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